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James P. Zacny

TitleEmeritus/Emerita, Professor (CS)
InstitutionUniversity of Chicago
DepartmentAnesthesia & Critical Care
AddressChicago IL 60637
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    Collapse Research 
    Collapse research activities and funding
    R21DA031318     (ZACNY, JAMES P.)Sep 15, 2011 - Aug 31, 2013
    NIH
    Methylnaltrexone: Pharmacological Probe of Morphine Effects
    Role: Principal Investigator

    R01DA023969     (ZACNY, JAMES P.)Sep 24, 2007 - Jun 30, 2012
    NIH
    Abuse-Related Effects of Opioids and Adjuvant Drug Used by Chronic Pain Patients
    Role: Principal Investigator

    R01DA015934     (ZACNY, JAMES)Sep 30, 2002 - Jun 30, 2008
    NIH
    A Model of Inhalant Abuse Using Inhalant Responders
    Role: Principal Investigator

    R01DA012330     (ZACNY, JAMES P.)Sep 30, 1998 - Aug 31, 2001
    NIH
    GENDER &OPIOID EFFECTS, INCLUDING ANALGESIA
    Role: Principal Investigator

    R03DA009887     (ZACNY, JAMES P.)Jul 1, 1995 - Jun 30, 1997
    NIH
    PCA--A MODEL FOR TESTING BEHAVIORAL EFFECTS OF OPIATES
    Role: Principal Investigator

    R01DA008573     (ZACNY, JAMES P.)Mar 15, 1995 - Jun 30, 2011
    NIH
    Behavioral Effects of Opioids in Volunteers
    Role: Principal Investigator

    R37DA008573     (ZACNY, JAMES P.)Mar 15, 1995 - Aug 31, 2004
    NIH
    BEHAVIORAL EFFECTS OF OPIOIDS IN VOLUNTEERS
    Role: Principal Investigator

    R01DA008391     (ZACNY, JAMES P.)Jul 1, 1993 - Jun 30, 2005
    NIH
    CHARACTERIZING PSYCHOACTIVE EFFECTS OF INHALANTS
    Role: Principal Investigator

    R03DA007103     (ZACNY, JAMES P.)Jul 1, 1991 - Jun 30, 1993
    NIH
    BEHAVIORAL EFFECTS OF NITROUS OXIDE IN HUMANS
    Role: Principal Investigator

    R01DA005704     (ZACNY, JAMES P.)Sep 1, 1989 - Jun 30, 1996
    NIH
    BEHAVIORAL ECONOMICS OF DRUG CHOICE
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shah HA, Fischer JH, Venepalli NK, Danciu OC, Christian S, Russell MJ, Liu LC, Zacny JP, Dudek AZ. Phase I Study of Aurora A Kinase Inhibitor Alisertib (MLN8237) in Combination With Selective VEGFR Inhibitor Pazopanib for Therapy of Advanced Solid Tumors. Am J Clin Oncol. 2019 05; 42(5):413-420. PMID: 30973373.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    2. Fong R, Wang L, Zacny JP, Khokhar S, Apfelbaum JL, Fox AP, Xie Z. Caffeine Accelerates Emergence from Isoflurane Anesthesia in Humans: A Randomized, Double-blind, Crossover Study. Anesthesiology. 2018 11; 129(5):912-920. PMID: 30044241; PMCID: PMC6191316.
      Citations: 23     Fields:    Translation:Humans
    3. Saba R, Alsayed A, Zacny JP, Dudek AZ. The Role of Forkhead Box Protein M1 in Breast Cancer Progression and Resistance to Therapy. Int J Breast Cancer. 2016; 2016:9768183. PMID: 26942015; PMCID: PMC4752991.
      Citations: 33     
    4. Ojevwe FO, Ojevwe CD, Zacny JP, Dudek AZ, Lin A, Kohlitz P. Treatment of multiple unresectable basal cell carcinomas from Gorlin-Goltz syndrome: a case report. Anticancer Res. 2015 Mar; 35(3):1777-81. PMID: 25750342.
      Citations: 2     Fields:    Translation:Humans
    5. Zacny JP, Wroblewski K, Coalson DW. Methylnaltrexone: its pharmacological effects alone and effects on morphine in healthy volunteers. Psychopharmacology (Berl). 2015 Jan; 232(1):63-73. PMID: 24871705; PMCID: PMC4295206.
      Citations: 7     Fields:    Translation:Humans
    6. O'Connor AB, Turk DC, Dworkin RH, Katz NP, Colucci R, Haythornthwaite JA, Klein M, O'Brien C, Posner K, Rappaport BA, Reisfield G, Adams EH, Balster RL, Bigelow GE, Burke LB, Comer SD, Cone E, Cowan P, Denisco RA, Farrar JT, Foltin RW, Haddox DJ, Hertz S, Jay GW, Junor R, Kopecky EA, Leiderman DB, McDermott MP, Palmer PP, Raja SN, Rauschkolb C, Rowbotham MC, Sampaio C, Setnik B, Smith SM, Sokolowska M, Stauffer JW, Walsh SL, Zacny JP. Abuse liability measures for use in analgesic clinical trials in patients with pain: IMMPACT recommendations. Pain. 2013 Nov; 154(11):2324-2334. PMID: 24148704.
      Citations: 18     Fields:    Translation:HumansPHPublic Health
    7. Zacny JP, Apfelbaum SM, Perkins KA. Modulating roles of smoking status and sex on oxycodone-induced nausea and drug liking. Exp Clin Psychopharmacol. 2013 Apr; 21(2):103-11. PMID: 23421355.
      Citations: 2     Fields:    Translation:Humans
    8. Comer SD, Zacny JP, Dworkin RH, Turk DC, Bigelow GE, Foltin RW, Jasinski DR, Sellers EM, Adams EH, Balster R, Burke LB, Cerny I, Colucci RD, Cone E, Cowan P, Farrar JT, Haddox DJ, Haythornthwaite JA, Hertz S, Jay GW, Johanson CE, Junor R, Katz NP, Klein M, Kopecky EA, Leiderman DB, McDermott MP, O'Brien C, O'Connor AB, Palmer PP, Raja SN, Rappaport BA, Rauschkolb C, Rowbotham MC, Sampaio C, Setnik B, Sokolowska M, Stauffer JW, Walsh SL. Core outcome measures for opioid abuse liability laboratory assessment studies in humans: IMMPACT recommendations. Pain. 2012 Dec; 153(12):2315-2324. PMID: 22998781; PMCID: PMC3494795.
      Citations: 28     Fields:    Translation:Humans
    9. Turk DC, O'Connor AB, Dworkin RH, Chaudhry A, Katz NP, Adams EH, Brownstein JS, Comer SD, Dart R, Dasgupta N, Denisco RA, Klein M, Leiderman DB, Lubran R, Rappaport BA, Zacny JP, Ahdieh H, Burke LB, Cowan P, Jacobs P, Malamut R, Markman J, Michna E, Palmer P, Peirce-Sandner S, Potter JS, Raja SN, Rauschkolb C, Roland CL, Webster LR, Weiss RD, Wolf K. Research design considerations for clinical studies of abuse-deterrent opioid analgesics: IMMPACT recommendations. Pain. 2012 Oct; 153(10):1997-2008. PMID: 22770841; PMCID: PMC3617214.
      Citations: 18     Fields:    Translation:Humans
    10. Zacny JP, Paice JA, Coalson DW. Separate and combined psychopharmacological effects of alprazolam and oxycodone in healthy volunteers. Drug Alcohol Depend. 2012 Aug 01; 124(3):274-82. PMID: 22365897; PMCID: PMC3568773.
      Citations: 7     Fields:    Translation:Humans
    11. Zacny JP, Paice JA, Coalson DW. Subjective, psychomotor, and physiological effects of pregabalin alone and in combination with oxycodone in healthy volunteers. Pharmacol Biochem Behav. 2012 Jan; 100(3):560-5. PMID: 22085697; PMCID: PMC3242915.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    12. Kircher S, Zacny J, Apfelbaum SM, Passik S, Kirsch K, Burbage M, Lofwall M. Understanding and treating opioid addiction in a patient with cancer pain. J Pain. 2011 Oct; 12(10):1025-31. PMID: 21968264.
      Citations: 5     Fields:    Translation:Humans
    13. Zacny J. Ask the Experts: What do we know (and not know) about prescription opioid misuse in the context of chronic pain management? Pain Manag. 2011 Sep; 1(5):395-8. PMID: 24645705.
      Citations:    Fields:    
    14. Zacny JP, Paice JA, Coalson DW. Characterizing the subjective and psychomotor effects of carisoprodol in healthy volunteers. Pharmacol Biochem Behav. 2011 Nov; 100(1):138-43. PMID: 21884720; PMCID: PMC3183241.
      Citations: 9     Fields:    Translation:Humans
    15. Zacny JP, Paice JA, Coalson DW. Subjective and psychomotor effects of carisoprodol in combination with oxycodone in healthy volunteers. Drug Alcohol Depend. 2012 Jan 01; 120(1-3):229-32. PMID: 21840651; PMCID: PMC3240720.
      Citations: 7     Fields:    Translation:Humans
    16. Zacny JP, Gutierrez S. Subjective, psychomotor, and physiological effects of oxycodone alone and in combination with ethanol in healthy volunteers. Psychopharmacology (Berl). 2011 Dec; 218(3):471-81. PMID: 21603891.
      Citations: 19     Fields:    Translation:Humans
    17. Zacny JP, Gutierrez S, Kirulus K, McCracken SG. Psychopharmacological effects of oxycodone in volunteers with and without generalized anxiety disorder. Exp Clin Psychopharmacol. 2011 Apr; 19(2):85-94. PMID: 21463065.
      Citations: 1     Fields:    Translation:Humans
    18. Niesters M, Dahan A, Kest B, Zacny J, Stijnen T, Aarts L, Sarton E. Do sex differences exist in opioid analgesia? A systematic review and meta-analysis of human experimental and clinical studies. Pain. 2010 Oct; 151(1):61-68. PMID: 20692097.
      Citations: 83     Fields:    Translation:Humans
    19. Zacny JP, Jun JM. Lack of sex differences to the subjective effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend. 2010 Dec 01; 112(3):251-4. PMID: 20667429; PMCID: PMC2997192.
      Citations: 4     Fields:    Translation:Humans
    20. Zacny JP. A possible link between sensation-seeking status and positive subjective effects of oxycodone in healthy volunteers. Pharmacol Biochem Behav. 2010 Mar; 95(1):113-20. PMID: 20045020; PMCID: PMC2866088.
      Citations: 10     Fields:    Translation:Humans
    21. Zacny JP, Drum M. Psychopharmacological effects of oxycodone in healthy volunteers: roles of alcohol-drinking status and sex. Drug Alcohol Depend. 2010 Mar 01; 107(2-3):209-14. PMID: 19948383; PMCID: PMC2822039.
      Citations: 12     Fields:    Translation:Humans
    22. Zacny JP, de Wit H. The prescription opioid, oxycodone, does not alter behavioral measures of impulsivity in healthy volunteers. Pharmacol Biochem Behav. 2009 Nov; 94(1):108-13. PMID: 19660489; PMCID: PMC2753749.
      Citations: 23     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    23. Zacny JP, Gutierrez S. Within-subject comparison of the psychopharmacological profiles of oral hydrocodone and oxycodone combination products in non-drug-abusing volunteers. Drug Alcohol Depend. 2009 Apr 01; 101(1-2):107-14. PMID: 19118954.
      Citations: 30     Fields:    Translation:Humans
    24. Zacny JP, Walker DJ, Derus LM. Choice of nitrous oxide and its subjective effects in light and moderate drinkers. Drug Alcohol Depend. 2008 Nov 01; 98(1-2):163-8. PMID: 18640794; PMCID: PMC2566819.
      Citations: 6     Fields:    Translation:Humans
    25. Zacny JP, Gutierrez S. Subjective, psychomotor, and physiological effects profile of hydrocodone/acetaminophen and oxycodone/acetaminophen combination products. Pain Med. 2008 May-Jun; 9(4):433-43. PMID: 18489634.
      Citations: 14     Fields:    Translation:Humans
    26. Comer SD, Ashworth JB, Foltin RW, Johanson CE, Zacny JP, Walsh SL. The role of human drug self-administration procedures in the development of medications. Drug Alcohol Depend. 2008 Jul 01; 96(1-2):1-15. PMID: 18436394; PMCID: PMC2744317.
      Citations: 91     Fields:    Translation:Humans
    27. Zacny JP, Walker DJ, Drum M, Sells M. Choice of sevoflurane and its subjective and psychomotor effects in light and moderate drinkers. Drug Alcohol Depend. 2008 Apr 01; 94(1-3):101-8. PMID: 18077105; PMCID: PMC2288701.
      Citations: 2     Fields:    Translation:Humans
    28. Zacny JP, Lichtor SA. Nonmedical use of prescription opioids: motive and ubiquity issues. J Pain. 2008 Jun; 9(6):473-86. PMID: 18342577; PMCID: PMC2409193.
      Citations: 25     Fields:    Translation:Humans
    29. Zacny JP, Lichtor SA. Within-subject comparison of the psychopharmacological profiles of oral oxycodone and oral morphine in non-drug-abusing volunteers. Psychopharmacology (Berl). 2008 Jan; 196(1):105-16. PMID: 17899018; PMCID: PMC2562738.
      Citations: 41     Fields:    Translation:Humans
    30. Zacny JP. Chronic pain and driving: proceed with caution. Pain. 2006 May; 122(1-2):6-7. PMID: 16530967.
      Citations: 1     Fields:    Translation:Humans
    31. Beckman NJ, Zacny JP, Walker DJ. Within-subject comparison of the subjective and psychomotor effects of a gaseous anesthetic and two volatile anesthetics in healthy volunteers. Drug Alcohol Depend. 2006 Jan 04; 81(1):89-95. PMID: 16024183.
      Citations: 10     Fields:    Translation:HumansCells
    32. Zacny JP. Profiling the subjective, psychomotor, and physiological effects of tramadol in recreational drug users. Drug Alcohol Depend. 2005 Nov 01; 80(2):273-8. PMID: 16005162.
      Citations: 22     Fields:    Translation:Humans
    33. Zacny J, Zamakhshary M, Sketris I, Veldhuyzen van Zanten S. Systematic review: the efficacy of intermittent and on-demand therapy with histamine H2-receptor antagonists or proton pump inhibitors for gastro-oesophageal reflux disease patients. Aliment Pharmacol Ther. 2005 Jun 01; 21(11):1299-312. PMID: 15932360.
      Citations: 12     Fields:    Translation:Humans
    34. Hobbs GJ, Knaggs RD. Differential effects of morphine and codeine on pupil size: dosing issues. Anesth Analg. 2005 Feb; 100(2):598. PMID: 15673906.
      Citations:    Fields:    Translation:Humans
    35. Zacny JP, Gutierrez S, Bolbolan SA. Profiling the subjective, psychomotor, and physiological effects of a hydrocodone/acetaminophen product in recreational drug users. Drug Alcohol Depend. 2005 Jun 01; 78(3):243-52. PMID: 15893155.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    36. Walker DJ, Beckman NJ, Zacny JP. Reinforcing and subjective effects of the volatile anesthetic, sevoflurane. Drug Alcohol Depend. 2004 Nov 11; 76(2):191-201. PMID: 15488343.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    37. Zacny JP, Beckman NJ. The effects of a cold-water stimulus on butorphanol effects in males and females. Pharmacol Biochem Behav. 2004 Aug; 78(4):653-9. PMID: 15301918.
      Citations: 15     Fields:    Translation:HumansCTClinical Trials
    38. Gutierrez S, Ang-Lee MK, Walker DJ, Zacny JP. Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers. Pharmacol Biochem Behav. 2004 May; 78(1):57-64. PMID: 15159134.
      Citations: 9     Fields:    Translation:HumansAnimalsCTClinical Trials
    39. Zacny JP, Goldman RE. Characterizing the subjective, psychomotor, and physiological effects of oral propoxyphene in non-drug-abusing volunteers. Drug Alcohol Depend. 2004 Feb 07; 73(2):133-40. PMID: 14725952.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    40. Zacny JP, Gutierrez S. Characterizing the subjective, psychomotor, and physiological effects of oral oxycodone in non-drug-abusing volunteers. Psychopharmacology (Berl). 2003 Nov; 170(3):242-254. PMID: 12955305.
      Citations: 54     Fields:    Translation:HumansCTClinical Trials
    41. Zacny J, Bigelow G, Compton P, Foley K, Iguchi M, Sannerud C. College on Problems of Drug Dependence taskforce on prescription opioid non-medical use and abuse: position statement. Drug Alcohol Depend. 2003 Apr 01; 69(3):215-32. PMID: 12633908.
      Citations: 167     Fields:    Translation:Humans
    42. Walker DJ, Zacny JP. Bitonic dose-response functions for reinforcing and self-reported effects of nitrous oxide in humans. Pharmacol Biochem Behav. 2003 Mar; 74(4):851-7. PMID: 12667899.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    43. Zacny JP, Zacny JP. Characterizing the subjective, psychomotor, and physiological effects of a hydrocodone combination product (Hycodan) in non-drug-abusing volunteers. Psychopharmacology (Berl). 2003 Jan; 165(2):146-56. PMID: 12404072.
      Citations: 13     Fields:    Translation:HumansCTClinical Trials
    44. Walker DJ, Zacny JP, Walker DJ, Zacny JP. Analysis of the reinforcing and subjective effects of different doses of nitrous oxide using a free-choice procedure. Drug Alcohol Depend. 2002 Mar 01; 66(1):93-103. PMID: 11850141.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    45. Zacny JP, Hurst RJ, Graham L, Janiszewski DJ. Preoperative dental anxiety and mood changes during nitrous oxide inhalation. J Am Dent Assoc. 2002 Jan; 133(1):82-8. PMID: 11811748.
      Citations: 13     Fields:    Translation:Humans
    46. Walker DJ, Zacny JP. Lack of effects of ethanol pretreatment on the abuse liability of nitrous oxide in light and moderate drinkers. Addiction. 2001 Dec; 96(12):1839-45. PMID: 11784476.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    47. Walker DJ, Zacny JP. Within- and between-subject variability in the reinforcing and subjective effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend. 2001 Sep 01; 64(1):85-96. PMID: 11470344.
      Citations: 5     Fields:    Translation:Humans
    48. Walker DJ, Zacny JP, Galva KE, Lichtor JL. Subjective, psychomotor, and physiological effects of cumulative doses of mixed-action opioids in healthy volunteers. Psychopharmacology (Berl). 2001 Jun; 155(4):362-71. PMID: 11441425.
      Citations: 15     Fields:    Translation:HumansCTClinical Trials
    49. Zacny JP. Morphine responses in humans: a retrospective analysis of sex differences. Drug Alcohol Depend. 2001 Jun 01; 63(1):23-8. PMID: 11297828.
      Citations: 17     Fields:    Translation:HumansCTClinical Trials
    50. Draganich LF, Zacny J, Klafta J, Karrison T, Draganich LF, Zacny J, Klafta J, Karrison T. The effects of antidepressants on obstructed and unobstructed gait in healthy elderly people. J Gerontol A Biol Sci Med Sci. 2001 Jan; 56(1):M36-41. PMID: 11193231.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    51. Hill JL, Zacny JP. Comparing the subjective, psychomotor, and physiological effects of intravenous hydromorphone and morphine in healthy volunteers. Psychopharmacology (Berl). 2000 Sep; 152(1):31-9. PMID: 11041313.
      Citations: 20     Fields:    Translation:HumansCTClinical Trials
    52. Sadeghi P, Zacny JP. Anesthesia is a risk factor for drug and alcohol craving and relapse in ex-abusers. Med Hypotheses. 1999 Dec; 53(6):490-6. PMID: 10687890.
      Citations: 1     Fields:    Translation:HumansAnimals
    53. Zacny JP, Janiszewski D, Sadeghi P, Black ML. Reinforcing, subjective, and psychomotor effects of sevoflurane and nitrous oxide in moderate-drinking healthy volunteers. Addiction. 1999 Dec; 94(12):1817-28. PMID: 10717960.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    54. Zacny JP, Conran A, Pardo H, Coalson DW, Black M, Klock AP, Klafta JM. Effects of naloxone on nitrous oxide actions in healthy volunteers. Pain. 1999 Dec; 83(3):411-418. PMID: 10568848.
      Citations: 4     Fields:    Translation:Humans
    55. Walker DJ, Zacny JP. Subjective, psychomotor, and physiological effects of cumulative doses of opioid mu agonists in healthy volunteers. J Pharmacol Exp Ther. 1999 Jun; 289(3):1454-64. PMID: 10336539.
      Citations: 25     Fields:    Translation:HumansCTClinical Trials
    56. Janiszewski DJ, Galinkin JL, Klock PA, Coalson DW, Pardo H, Zacny JP. The effects of subanesthetic concentrations of sevoflurane and nitrous oxide, alone and in combination, on analgesia, mood, and psychomotor performance in healthy volunteers. Anesth Analg. 1999 May; 88(5):1149-54. PMID: 10320186.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    57. Black ML, Hill JL, Zacny JP. Behavioral and physiological effects of remifentanil and alfentanil in healthy volunteers. Anesthesiology. 1999 Mar; 90(3):718-26. PMID: 10078672.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    58. Zacny JP, Galinkin JL. Psychotropic drugs used in anesthesia practice: abuse liability and epidemiology of abuse. Anesthesiology. 1999 Jan; 90(1):269-88. PMID: 9915336.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    59. Walker DJ, Zacny JP. Subjective, psychomotor, and analgesic effects of oral codeine and morphine in healthy volunteers. Psychopharmacology (Berl). 1998 Nov; 140(2):191-201. PMID: 9860110.
      Citations: 24     Fields:    Translation:HumansCTClinical Trials
    60. Zacny JP, Camarillo VM, Sadeghi P, Black M. Effects of ethanol and nitrous oxide, alone and in combination, on mood, psychomotor performance and pain reports in healthy volunteers. Drug Alcohol Depend. 1998 Oct 01; 52(2):115-23. PMID: 9800141.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    61. Zacny JP, Hill JL, Black ML, Sadeghi P. Comparing the subjective, psychomotor and physiological effects of intravenous pentazocine and morphine in normal volunteers. J Pharmacol Exp Ther. 1998 Sep; 286(3):1197-207. PMID: 9732379.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    62. Zacny JP. Opioids and chronic pain. Clin J Pain. 1998 Mar; 14(1):89-90. PMID: 9535319.
      Citations: 1     Fields:    Translation:Humans
    63. Zacny JP, Cho AM, Toledano AY, Galinkin J, Coalson DW, Klock PA, Klafta JM, Young CJ. Effects of information on the reinforcing, subjective, and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1997 Nov 25; 48(2):85-95. PMID: 9363407.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    64. Galinkin JL, Janiszewski D, Young CJ, Klafta JM, Klock PA, Coalson DW, Apfelbaum JL, Zacny JP. Subjective, psychomotor, cognitive, and analgesic effects of subanesthetic concentrations of sevoflurane and nitrous oxide. Anesthesiology. 1997 Nov; 87(5):1082-8. PMID: 9366460.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    65. Zacny JP, Conley K, Galinkin J. Comparing the subjective, psychomotor and physiological effects of intravenous buprenorphine and morphine in healthy volunteers. J Pharmacol Exp Ther. 1997 Sep; 282(3):1187-97. PMID: 9316825.
      Citations: 35     Fields:    Translation:HumansCTClinical Trials
    66. Hasegawa AE, Zacny JP. The influence of three L-type calcium channel blockers on morphine effects in healthy volunteers. Anesth Analg. 1997 Sep; 85(3):633-8. PMID: 9296421.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    67. Young CJ, Coalson D, Klock PA, Klafta JM, Goldsher G, Apfelbaum JL, Zacny JP. Analgesic and psychomotor effects of thiopental at subanesthetic concentrations in human volunteers. Acta Anaesthesiol Scand. 1997 Aug; 41(7):903-10. PMID: 9265935.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    68. Conley KM, Toledano AY, Apfelbaum JL, Zacny JP. Modulating effects of a cold water stimulus on opioid effects in volunteers. Psychopharmacology (Berl). 1997 Jun; 131(4):313-20. PMID: 9226732.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    69. Cho AM, Coalson DW, Klock PA, Klafta JM, Marks S, Toledano AY, Apfelbaum JL, Zacny JP. The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1997 Apr 14; 45(1-2):63-70. PMID: 9179508.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    70. Zacny JP, Conley K, Marks S. Comparing the subjective, psychomotor and physiological effects of intravenous nalbuphine and morphine in healthy volunteers. J Pharmacol Exp Ther. 1997 Mar; 280(3):1159-69. PMID: 9067299.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    71. Zacny JP, Mitchell SH, Cramblett MJ, de Wit H. The effects of ethanol on the relative preference for cigarettes. Behav Pharmacol. 1997 Feb; 8(1):75-81. PMID: 9833003.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    72. Zacny JP, Klafta JM, Coalson DW, Marks S, Young CJ, Klock PA, Toledano AY, Jordan N, Apfelbaum JL. The reinforcing effects of brief exposures to nitrous oxide in healthy volunteers. Drug Alcohol Depend. 1996 Nov; 42(3):197-200. PMID: 8912802.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    73. Zacny JP. Should people taking opioids for medical reasons be allowed to work and drive? Addiction. 1996 Nov; 91(11):1581-4. PMID: 8972918.
      Citations: 7     Fields:    Translation:Humans
    74. Zacny JP, Coalson DW, Klafta JM, Klock PA, Alessi R, Rupani G, Young CJ, Patil PG, Apfelbaum JL. Midazolam does not influence intravenous fentanyl-induced analgesia in healthy volunteers. Pharmacol Biochem Behav. 1996 Oct; 55(2):275-80. PMID: 8951965.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    75. Zacny JP, McKay MA, Toledano AY, Marks S, Young CJ, Klock PA, Apfelbaum JL. The effects of a cold-water immersion stressor on the reinforcing and subjective effects of fentanyl in healthy volunteers. Drug Alcohol Depend. 1996 Oct; 42(2):133-42. PMID: 8889412.
      Citations: 22     Fields:    Translation:HumansCTClinical Trials
    76. Zacny JP, Coalson DW, Young CJ, Klafta JM, Lichtor JL, Rupani G, Thapar P, Apfelbaum JL. Propofol at conscious sedation doses produces mild analgesia to cold pressor-induced pain in healthy volunteers. J Clin Anesth. 1996 Sep; 8(6):469-74. PMID: 8872686.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    77. Yajnik S, Zacny JP, Young CJ, Lichtor JL, Rupani G, Klafta JM, Coalson DW, Apfelbaum JL. Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers. Pharmacol Biochem Behav. 1996 Jun; 54(2):501-8. PMID: 8743615.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    78. Zacny JP, Cho AM, Coalson DW, Rupani G, Young CJ, Klafta JM, Klock PA, Apfelbaum JL. Differential acute tolerance development to effects of nitrous oxide in humans. Neurosci Lett. 1996 May 10; 209(2):73-6. PMID: 8761985.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    79. Lichtor JL, Zacny J, Lane BS, Good ML. Research grant report: how does night call affect next-day performance in anesthesia? J Clin Monit. 1996 May; 12(3):277-8. PMID: 8823653.
      Citations: 1     Fields:    Translation:Humans
    80. Zacny JP, Lichtor JL, Klafta JM, Alessi R, Apfelbaum JL. The effects of transnasal butorphanol on mood and psychomotor functioning in healthy volunteers. Anesth Analg. 1996 May; 82(5):931-5. PMID: 8610901.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    81. Zacny JP, Lichtor JL, Coalson DW, Alessi R, Goldsher G, Young CJ, Apfelbaum JL, Conley KM. Examining the subjective, psychomotor and reinforcing effects of nitrous oxide in healthy volunteers: a dose-response analysis. Behav Pharmacol. 1996 Mar; 7(2):194-199. PMID: 11224411.
      Citations: 4     Fields:    
    82. Zacny JP, Yajnik S, Lichtor JL, Klafta JM, Young CJ, Thapar P, Rupani G, Coalson DW, Apfelbaum JL. The acute and residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations on cognitive and psychomotor performance in healthy volunteers. Anesth Analg. 1996 Jan; 82(1):153-7. PMID: 8712393.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    83. Patil PG, Apfelbaum JL, Zacny JP. Effects of a cold-water stressor on psychomotor and cognitive functioning in humans. Physiol Behav. 1995 Dec; 58(6):1281-6. PMID: 8623033.
      Citations: 18     Fields:    Translation:Humans
    84. Klafta JM, Zacny JP, Young CJ. Neurological and psychiatric adverse effects of anaesthetics: epidemiology and treatment. Drug Saf. 1995 Nov; 13(5):281-95. PMID: 8785016.
      Citations: 4     Fields:    Translation:Humans
    85. Zacny JP, Lichtor JL, Coalson DW, Apfelbaum JL. Nitrous oxide and the terminology of 'abuse' and 'use'. Addiction. 1995 Sep; 90(9):1265-6. PMID: 7580824.
      Citations: 1     Fields:    Translation:Humans
    86. Zacny JP, Yajnik S, Coalson D, Lichtor JL, Apfelbaum JL, Rupani G, Young C, Thapar P, Klafta J. Flumazenil may attenuate some subjective effects of nitrous oxide in humans: a preliminary report. Pharmacol Biochem Behav. 1995 Aug; 51(4):815-9. PMID: 7675863.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    87. Mitchell SH, de Wit H, Zacny JP. Caffeine withdrawal symptoms and self-administration following caffeine deprivation. Pharmacol Biochem Behav. 1995 Aug; 51(4):941-5. PMID: 7675881.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    88. Thapar P, Zacny JP, Choi M, Apfelbaum JL. Objective and subjective impairment from often-used sedative/analgesic combinations in ambulatory surgery, using alcohol as a benchmark. Anesth Analg. 1995 Jun; 80(6):1092-8. PMID: 7762835.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    89. Pirec V, Patterson TH, Thapar P, Apfelbaum JL, Zacny JP. Effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans. Pharmacol Biochem Behav. 1995 Jun-Jul; 51(2-3):323-9. PMID: 7667348.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    90. Mitchell SH, de Wit H, Zacny JP. Effects of varying ethanol dose on cigarette consumption in healthy normal volunteers. Behav Pharmacol. 1995 Jun; 6(4):359-365. PMID: 11224344.
      Citations: 35     Fields:    
    91. Zacny JP, Coalson D, Young C, Klafta J, Rupani G, Thapar P, Choi M, Apfelbaum JL. A dose-response study of the effects of intravenous midazolam on cold pressor-induced pain. Anesth Analg. 1995 Mar; 80(3):521-5. PMID: 7864418.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    92. Thapar P, Zacny JP, Thompson W, Apfelbaum JL. Using alcohol as a standard to assess the degree of impairment induced by sedative and analgesic drugs used in ambulatory surgery. Anesthesiology. 1995 Jan; 82(1):53-9. PMID: 7832334.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    93. Yajnik S, Thapar P, Lichtor JL, Patterson T, Zacny JP. Effects of marijuana history on the subjective, psychomotor, and reinforcing effects of nitrous oxide in humans. Drug Alcohol Depend. 1994 Dec; 36(3):227-36. PMID: 7889814.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    94. Zacny JP, Coalson DW, Lichtor JL, Yajnik S, Thapar P. Effects of naloxone on the subjective and psychomotor effects of nitrous oxide in humans. Pharmacol Biochem Behav. 1994 Nov; 49(3):573-8. PMID: 7862710.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    95. Zacny JP, Lichtor JL, Thapar P, Coalson DW, Flemming D, Thompson WK. Comparing the subjective, psychomotor and physiological effects of intravenous butorphanol and morphine in healthy volunteers. J Pharmacol Exp Ther. 1994 Aug; 270(2):579-88. PMID: 8071850.
      Citations: 11     Fields:    Translation:HumansCTClinical Trials
    96. Doty P, Zacny JP, de Wit H. Effects of ondansetron pretreatment on acute responses to ethanol in social drinkers. Behav Pharmacol. 1994 Aug; 5(4 And 5):461-469. PMID: 11224298.
      Citations: 6     Fields:    
    97. Zacny JP, Lichtor JL, Coalson DW, Apfelbaum JL, Flemming D, Foster V. Time course of effects of brief inhalations of nitrous oxide in normal volunteers. Addiction. 1994 Jul; 89(7):831-9. PMID: 8081181.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    98. Zacny JP, Sparacino G, Hoffmann P, Martin R, Lichtor JL. The subjective, behavioral and cognitive effects of subanesthetic concentrations of isoflurane and nitrous oxide in healthy volunteers. Psychopharmacology (Berl). 1994 Apr; 114(3):409-16. PMID: 7855199.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    99. Mitchell SH, de Wit H, Zacny JP. Effects of varying the "openness" of an economy on responding for cigarettes. Behav Pharmacol. 1994 Apr; 5(2):159-166. PMID: 11224264.
      Citations: 6     Fields:    
    100. Zacny JP, Lichtor JL, Flemming D, Coalson DW, Thompson WK. A dose-response analysis of the subjective, psychomotor and physiological effects of intravenous morphine in healthy volunteers. J Pharmacol Exp Ther. 1994 Jan; 268(1):1-9. PMID: 8301543.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    101. Dohrn CS, Lichtor JL, Coalson DW, Flemming D, Zacny JP. Reinforcing effects of extended inhalation of a low nitrous oxide concentration in humans. Pharmacol Biochem Behav. 1993 Dec; 46(4):927-32. PMID: 8309974.
      Citations: 2     Fields:    Translation:Humans
    102. Zacny JP, Yajnik S. Effects of calcium channel inhibitors on ethanol effects and pharmacokinetics in healthy volunteers. Alcohol. 1993 Nov-Dec; 10(6):505-9. PMID: 8123209.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    103. Wang WL, Cone EJ, Zacny J. Immunoassay evidence for fentanyl in hair of surgery patients. Forensic Sci Int. 1993 Sep; 61(1):65-72. PMID: 8225140.
      Citations: 2     Fields:    Translation:Humans
    104. Zacny JP, Lichtor JL, Thompson W, Apfelbaum JL. Propofol at a subanesthetic dose may have abuse potential in healthy volunteers. Anesth Analg. 1993 Sep; 77(3):544-52. PMID: 8368554.
      Citations: 16     Fields:    Translation:Humans
    105. Lichtor JL, Zacny JP, Coalson DW, Flemming DC, Uitvlugt A, Apfelbaum JL, Lane BS, Thisted RA. The interaction between alcohol and the residual effects of thiopental anesthesia. Anesthesiology. 1993 Jul; 79(1):28-35. PMID: 8342825.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    106. Zacny JP, Lichtor JL, Zaragoza JG, Coalson DW, Uitvlugt AM, Flemming DC, Binstock WB, Cutter T, Apfelbaum JL. Assessing the behavioral effects and abuse potential of propofol bolus injections in healthy volunteers. Drug Alcohol Depend. 1993 Mar; 32(1):45-57. PMID: 8486084.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    107. Dohrn CS, Lichtor JL, Coalson DW, Uitvlugt A, de Wit H, Zacny JP. Reinforcing effects of extended inhalation of nitrous oxide in humans. Drug Alcohol Depend. 1993 Feb; 31(3):265-80. PMID: 8462415.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    108. Zacny JP, Apfelbaum JL, Lichtor JL, Zaragoza JG. Effects of 5-hydroxytryptamine3 antagonist, ondansetron, on cigarette smoking, smoke exposure, and mood in humans. Pharmacol Biochem Behav. 1993 Feb; 44(2):387-91. PMID: 8446670.
      Citations: 6     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    109. Zacny JP, Lichtor JL, Binstock W, Coalson DW, Cutter T, Flemming DC, Glosten B. Subjective, behavioral and physiological responses to intravenous meperidine in healthy volunteers. Psychopharmacology (Berl). 1993; 111(3):306-14. PMID: 7870968.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    110. Zacny JP, Lichtor JL, Coalson DW, Finn RS, Uitvlugt AM, Glosten B, Flemming DC, Apfelbaum JL. Subjective and psychomotor effects of subanesthetic doses of propofol in healthy volunteers. Anesthesiology. 1992 May; 76(5):696-702. PMID: 1575336.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    111. Zacny JP, Lichtor JL, de Wit H. Subjective, behavioral, and physiologic responses to intravenous dezocine in healthy volunteers. Anesth Analg. 1992 Apr; 74(4):523-30. PMID: 1348168.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    112. Dohrn CS, Lichtor JL, Finn RS, Uitvlugt A, Coalson DW, Rupani G, de Wit H, Zacny JP. Subjective and psychomotor effects of nitrous oxide in healthy volunteers. Behav Pharmacol. 1992 Feb; 3(1):19-30. PMID: 11224098.
      Citations: 6     Fields:    
    113. Zacny JP, Lichtor JL, Zaragoza JG, de Wit H. Subjective and behavioral responses to intravenous fentanyl in healthy volunteers. Psychopharmacology (Berl). 1992; 107(2-3):319-26. PMID: 1615132.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    114. Zacny JP, Lichtor JL, Zaragoza JG, de Wit H. Effects of fasting on responses to intravenous fentanyl in healthy volunteers. J Subst Abuse. 1992; 4(2):197-207. PMID: 1504643.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    115. Zacny JP, Bodker BK, de Wit H. Effects of setting on the subjective and behavioral effects of d-amphetamine in humans. Addict Behav. 1992; 17(1):27-33. PMID: 1595423.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    116. Zacny JP, de Wit H. The effects of a restricted feeding regimen on cigarette smoking in humans. Addict Behav. 1992; 17(2):149-57. PMID: 1585842.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    117. Chait LD, Zacny JP. Reinforcing and subjective effects of oral delta 9-THC and smoked marijuana in humans. Psychopharmacology (Berl). 1992; 107(2-3):255-62. PMID: 1319601.
      Citations: 40     Fields:    Translation:HumansCTClinical Trials
    118. Evans SM, Zacny JP, Woolverton WL, Johanson CE. The discriminative stimulus effects of histamine H(1)-antagonists in pigeons. Behav Pharmacol. 1991 Dec; 2(6):447-460. PMID: 11224087.
      Citations: 2     Fields:    
    119. Lichtor JL, Zacny J, Apfelbaum JL, Lane BS, Rupani G, Thisted RA, Dohrn C, Korttila K. Alcohol after sedation with i.v. midazolam-fentanyl: effects on psychomotor functioning. Br J Anaesth. 1991 Nov; 67(5):579-84. PMID: 1751272.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    120. Zacny JP, de Wit H. Effects of food deprivation on subjective effects and self-administration of marijuana in humans. Psychol Rep. 1991 Jun; 68(3 Pt 2):1263-74. PMID: 1924625.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    121. Lichtor JL, Zacny J, Korttila K, Apfelbaum JL, Lane BS, Rupani G, Thisted RA, Dohrn C. Alcohol after midazolam sedation: does it really matter? Anesth Analg. 1991 May; 72(5):661-6. PMID: 2018224.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    122. Zacny JP, Chait LD. Response to marijuana as a function of potency and breathhold duration. Psychopharmacology (Berl). 1991; 103(2):223-6. PMID: 2027922.
      Citations: 6     Fields:    Translation:Humans
    123. Zacny JP, de Wit H. Effects of a 24-hour fast on cigarette smoking in humans. Br J Addict. 1990 Apr; 85(4):555-60. PMID: 2346795.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    124. Evans SM, Zacny JP, Johanson CE. Three-choice discrimination among (+)-amphetamine, fenfluramine and saline in pigeons. Pharmacol Biochem Behav. 1990 Apr; 35(4):971-80. PMID: 1971722.
      Citations:    Fields:    Translation:Animals
    125. Zacny JP, Virus RM, Woolverton WL. Tolerance and cross-tolerance to 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine and methylenedioxyamphetamine. Pharmacol Biochem Behav. 1990 Mar; 35(3):637-42. PMID: 1971112.
      Citations: 3     Fields:    Translation:Animals
    126. Zacny JP, Chait LD. Response to marijuana as a function of potency and breathhold duration. NIDA Res Monogr. 1990; 105:308-9. PMID: 1652073.
      Citations:    Fields:    Translation:HumansAnimals
    127. Zacny JP. Behavioral aspects of alcohol-tobacco interactions. Recent Dev Alcohol. 1990; 8:205-19. PMID: 2185518.
      Citations: 18     Fields:    Translation:Humans
    128. Zacny JP, de Wit H. Effects of food deprivation on subjective responses to d-amphetamine in humans. Pharmacol Biochem Behav. 1989 Dec; 34(4):791-5. PMID: 2623032.
      Citations: 3     Fields:    Translation:Humans
    129. Zacny JP, Woolverton WL. Discriminative stimulus properties of local anesthetics in d-amphetamine- and pentobarbital-trained pigeons. Pharmacol Biochem Behav. 1989 Jul; 33(3):527-31. PMID: 2587593.
      Citations: 1     Fields:    Translation:Animals
    130. Zacny JP, Chait LD. Breathhold duration and response to marijuana smoke. Pharmacol Biochem Behav. 1989 Jun; 33(2):481-4. PMID: 2554344.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    131. Zacny J, de Wit H. Effects of food deprivation on subjective responses to d-amphetamine and marijuana in humans. NIDA Res Monogr. 1989; 95:490-1. PMID: 2701322.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    132. Zacny JP, de Wit H. Effects of food deprivation on responses to marijuana in humans. Behav Pharmacol. 1989; 1(2):177-185. PMID: 11175401.
      Citations: 1     Fields:    
    133. Zacny JP. Discriminative stimulus effects of H(1)-anti-histamines in cocaine-trained pigeons. Behav Pharmacol. 1989; 1(3):261-265. PMID: 11224038.
      Citations: 2     Fields:    
    134. Zacny JP, Stitzer ML. Cigarette brand-switching: effects on smoke exposure and smoking behavior. J Pharmacol Exp Ther. 1988 Aug; 246(2):619-27. PMID: 3404450.
      Citations: 29     Fields:    Translation:HumansCTClinical Trials
    135. Zacny JP, Stitzer ML, Brown FJ, Yingling JE, Griffiths RR. Human cigarette smoking: effects of puff and inhalation parameters on smoke exposure. J Pharmacol Exp Ther. 1987 Feb; 240(2):554-64. PMID: 3806411.
      Citations: 48     Fields:    Translation:HumansAnimals
    136. Zacny JP, Stitzer ML, Yingling JE. Cigarette filter vent blocking: effects on smoking topography and carbon monoxide exposure. Pharmacol Biochem Behav. 1986 Dec; 25(6):1245-52. PMID: 3809227.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    137. Zacny JP, Stitzer ML. Effect of puff size instructions on puff volume. Addict Behav. 1986; 11(1):17-23. PMID: 3716912.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    138. Zacny JP, Stitzer ML. Effects of smoke deprivation interval on puff topography. Clin Pharmacol Ther. 1985 Jul; 38(1):109-15. PMID: 4006371.
      Citations: 11     Fields:    Translation:Humans
    139. Goodman I, Zacny J, Osman A, Azzaro A, Donovan C. Dopaminergic nature of feeding-induced behavioral stereotypies in stressed pigeons. Pharmacol Biochem Behav. 1983 Feb; 18(2):153-8. PMID: 6682226.
      Citations: 3     Fields:    Translation:HumansAnimals
    140. Goodman I, Zacny J, Osman A, Azzaro A, Donovan C. Lesion-produced telencephalic catecholamine imbalances and altered operant pecking rates in pigeons. Physiol Behav. 1982 Dec; 29(6):1045-50. PMID: 7163383.
      Citations: 2     Fields:    Translation:Animals
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