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Last Name
Institution

Samuel Hellman

TitleEmeritus/Emerita, Professor
InstitutionUniversity of Chicago
DepartmentRadiation Oncology
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Author Correction: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nat Commun. 2018 11 13; 9(1):4827. PMID: 30425251.
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    2. Pitroda SP, Khodarev NN, Huang L, Uppal A, Wightman SC, Ganai S, Joseph N, Pitt J, Brown M, Forde M, Mangold K, Xue L, Weber C, Segal JP, Kadri S, Stack ME, Khan S, Paty P, Kaul K, Andrade J, White KP, Talamonti M, Posner MC, Hellman S, Weichselbaum RR. Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. Nat Commun. 2018 05 04; 9(1):1793. PMID: 29728604.
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    3. Oshima G, Stack ME, Wightman SC, Bryan D, Poli E, Xue L, Skowron KB, Uppal A, Pitroda SP, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN. Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones. J Vis Exp. 2016 11 30; (117). PMID: 27929457.
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    4. Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC, Bennett JM, Benz EJ, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA. In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc. 2015 Aug; 90(8):996-1000. PMID: 26211600.
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    5. Oshima G, Wightman SC, Uppal A, Stack ME, Pitroda SP, Oskvarek JJ, Huang X, Posner MC, Hellman S, Weichselbaum RR, Khodarev NN. Imaging of tumor clones with differential liver colonization. Sci Rep. 2015 Jun 22; 5:10946. PMID: 26094901.
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    6. Uppal A, Wightman SC, Mallon S, Oshima G, Pitroda SP, Zhang Q, Huang X, Darga TE, Huang L, Andrade J, Liu H, Ferguson MK, Greene GL, Posner MC, Hellman S, Khodarev NN, Weichselbaum RR. 14q32-encoded microRNAs mediate an oligometastatic phenotype. Oncotarget. 2015 Feb 28; 6(6):3540-52. PMID: 25686838.
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    7. DeVita VT, Eggermont AM, Hellman S, Kerr DJ. Clinical cancer research: the past, present and the future. Nat Rev Clin Oncol. 2014 Nov; 11(11):663-9. PMID: 25245981.
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    8. Hellman S. Learning while caring: medicine's epistemology. J Clin Oncol. 2014 Sep 01; 32(25):2804-8. PMID: 25092776.
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    9. Uppal A, Ferguson MK, Posner MC, Hellman S, Khodarev NN, Weichselbaum RR. Towards a molecular basis of oligometastatic disease: potential role of micro-RNAs. Clin Exp Metastasis. 2014 Aug; 31(6):735-48. PMID: 24968866.
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    10. Corbin KS, Hellman S, Weichselbaum RR. Extracranial oligometastases: a subset of metastases curable with stereotactic radiotherapy. J Clin Oncol. 2013 Apr 10; 31(11):1384-90. PMID: 23460715.
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    11. Lussier YA, Khodarev NN, Regan K, Corbin K, Li H, Ganai S, Khan SA, Gnerlich JL, Gnerlich J, Darga TE, Fan H, Karpenko O, Paty PB, Posner MC, Chmura SJ, Hellman S, Ferguson MK, Weichselbaum RR. Oligo- and polymetastatic progression in lung metastasis(es) patients is associated with specific microRNAs. PLoS One. 2012; 7(12):e50141. PMID: 23251360.
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    12. Lussier YA, Xing HR, Salama JK, Khodarev NN, Huang Y, Zhang Q, Khan SA, Yang X, Hasselle MD, Darga TE, Malik R, Fan H, Perakis S, Filippo M, Corbin K, Lee Y, Posner MC, Chmura SJ, Hellman S, Weichselbaum RR. MicroRNA expression characterizes oligometastasis(es). PLoS One. 2011; 6(12):e28650. PMID: 22174856.
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    13. Salama JK, Hasselle MD, Chmura SJ, Malik R, Mehta N, Yenice KM, Villaflor VM, Stadler WM, Hoffman PC, Cohen EE, Connell PP, Haraf DJ, Vokes EE, Hellman S, Weichselbaum RR. Stereotactic body radiotherapy for multisite extracranial oligometastases: final report of a dose escalation trial in patients with 1 to 5 sites of metastatic disease. Cancer. 2012 Jun 01; 118(11):2962-70. PMID: 22020702.
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    14. Weichselbaum RR, Hellman S. Oligometastases revisited. Nat Rev Clin Oncol. 2011 06; 8(6):378-82. PMID: 21423255.
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    15. Hellman S. On first looking into Kutcher's "Contested Medicine": ethical tensions in clinical research. Perspect Biol Med. 2010; 53(2):304-14. PMID: 20495265.
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    16. Connell PP, Hellman S. Advances in radiotherapy and implications for the next century: a historical perspective. Cancer Res. 2009 Jan 15; 69(2):383-92. PMID: 19147546.
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    17. Mauceri HJ, Beckett MA, Liang H, Sutton HG, Pitroda S, Galka E, Efimova E, Darga T, Khodarev NN, King CR, Posner MC, Hellman S, Kufe DW, Weichselbaum RR. Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy. Cancer Gene Ther. 2009 Apr; 16(4):373-81. PMID: 18974777.
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    18. Salama JK, Chmura SJ, Mehta N, Yenice KM, Stadler WM, Vokes EE, Haraf DJ, Hellman S, Weichselbaum RR. An initial report of a radiation dose-escalation trial in patients with one to five sites of metastatic disease. Clin Cancer Res. 2008 Aug 15; 14(16):5255-9. PMID: 18698045.
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    19. Hellman S, Botnick L, Mauch P. Stem-cell biology and cancer therapy: the more things change... J Clin Oncol. 2008 Feb 20; 26(6):821-2. PMID: 18281648.
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    20. Jani AB, Hellman S. Early prostate cancer: hedonic prices model of provider-patient interactions and decisions. Int J Radiat Oncol Biol Phys. 2008 Mar 15; 70(4):1158-68. PMID: 17881151.
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    21. Hellman S. Unintended consequences. Nat Clin Pract Oncol. 2007 Aug; 4(8):439. PMID: 17657250.
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    22. Hellman S. Irwin Freedberg and the changing times of academic medicine. J Invest Dermatol. 2006 Mar; 126(3):525-6. PMID: 16482183.
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    23. Hellman S. Evolving paradigms and perceptions of cancer. Nat Clin Pract Oncol. 2005 Dec; 2(12):618-24. PMID: 16341117.
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    24. Hellman S. Premise, promise, paradigm and prophesy. Nat Clin Pract Oncol. 2005 Jul; 2(7):325. PMID: 16075785.
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    25. Jani AB, Kao J, Heimann R, Hellman S. Hormone therapy and radiotherapy for early prostate cancer: a utility-adjusted number needed to treat (NNT) analysis. Int J Radiat Oncol Biol Phys. 2005 Mar 01; 61(3):687-94. PMID: 15708246.
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    26. Hellman S, Weichselbaum RR. Importance of local control in an era of systemic therapy. Nat Clin Pract Oncol. 2005 Feb; 2(2):60-1. PMID: 16264859.
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    27. Hellman S. Debunking dogma and developing theses. Eur J Cancer. 2005 Mar; 41(4):489-90. PMID: 15737551.
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    28. Mehta N, Mauer AM, Hellman S, Haraf DJ, Cohen EE, Vokes EE, Weichselbaum RR. Analysis of further disease progression in metastatic non-small cell lung cancer: implications for locoregional treatment. Int J Oncol. 2004 Dec; 25(6):1677-83. PMID: 15547705.
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    29. Lopez CA, Kimchi ET, Mauceri HJ, Park JO, Mehta N, Murphy KT, Beckett MA, Hellman S, Posner MC, Kufe DW, Weichselbaum RR. Chemoinducible gene therapy: a strategy to enhance doxorubicin antitumor activity. Mol Cancer Ther. 2004 Sep; 3(9):1167-75. PMID: 15367711.
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    30. Hellman S. Excision margins in high-risk malignant melanoma. N Engl J Med. 2004 May 27; 350(22):2305-6; author reply 2305-6. PMID: 15163784.
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    31. Singh R, Hellman S, Heimann R. The natural history of breast carcinoma in the elderly: implications for screening and treatment. Cancer. 2004 May 01; 100(9):1807-13. PMID: 15112260.
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    32. Hellman S, Hellman D. Letrozole in breast cancer. N Engl J Med. 2004 Feb 12; 350(7):727-30; author reply 727-30. PMID: 14971060.
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    33. Jani AB, Kao J, Hellman S. Hormone therapy adjuvant to external beam radiotherapy for locally advanced prostate carcinoma: a complication-adjusted number-needed-to-treat analysis. Cancer. 2003 Dec 01; 98(11):2351-61. PMID: 14635069.
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    34. Bartelink H, Benz C, Cleveland D, Dorn R, Gralow J, Gradishar WJ, Grant K, Heimann R, Hellman S, Hudis C, Kerbel R, Lippman M, Lung J, Posner MC, Steeg P, Vestal R, Weichselbaum RR, Zetter B. Expedition Inspiration Fund for Breast Cancer Research Meeting 2003. Breast Cancer Res Treat. 2003 Jul; 80(2):139-44. PMID: 12908816.
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    35. Jani AB, Hellman S. Early prostate cancer: clinical decision-making. Lancet. 2003 Mar 22; 361(9362):1045-53. PMID: 12660074.
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    36. Benz C, Clark G, Conzen S, Dorn R, Fuqua S, Gralow J, Greene G, Heimann R, Hellman S, Lippman M, Rosen N, Weiner L. Consensus statement: Expedition Inspiration fund for breast cancer research meeting 2002. Breast Cancer Res Treat. 2003 Mar; 78(1):127-31. PMID: 12611465.
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    37. Khodarev NN, Park J, Kataoka Y, Nodzenski E, Hellman S, Roizman B, Weichselbaum RR, Pelizzari CA. Receiver operating characteristic analysis: a general tool for DNA array data filtration and performance estimation. Genomics. 2003 Feb; 81(2):202-9. PMID: 12620398.
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    38. Jani AB, Basu A, Heimann R, Hellman S. Sentinel lymph node versus axillary lymph node dissection for early-stage breast carcinoma: a comparison using a utility-adjusted number needed to treat analysis. Cancer. 2003 Jan 15; 97(2):359-66. PMID: 12518360.
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    39. Weichselbaum RR, Kufe DW, Hellman S, Rasmussen HS, King CR, Fischer PH, Mauceri HJ. Radiation-induced tumour necrosis factor-alpha expression: clinical application of transcriptional and physical targeting of gene therapy. Lancet Oncol. 2002 Nov; 3(11):665-71. PMID: 12424068.
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    40. Park JO, Lopez CA, Gupta VK, Brown CK, Mauceri HJ, Darga TE, Manan A, Hellman S, Posner MC, Kufe DW, Weichselbaum RR. Transcriptional control of viral gene therapy by cisplatin. J Clin Invest. 2002 Aug; 110(3):403-10. PMID: 12163460.
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    41. Abdalla I, Basu A, Hellman S. An evidence-based analysis of the management of localized prostate cancer. Cancer J. 2002 Jan-Feb; 8(1):40-6. PMID: 11895202.
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    42. Hellman S. Sun Valley summary. Consensus and action items Expedition Inspiration meeting 2000. Breast Cancer Res Treat. 2001 Apr; 66(3):179-82. PMID: 11510688.
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    43. Salloum RM, Jaskowiak NT, Mauceri HJ, Seetharam S, Beckett MA, Koons AM, Hari DM, Gupta VK, Reimer C, Kalluri R, Posner MC, Hellman S, Kufe DW, Weichselbaum RR. NM-3, an isocoumarin, increases the antitumor effects of radiotherapy without toxicity. Cancer Res. 2000 Dec 15; 60(24):6958-63. PMID: 11156396.
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    44. Heimann R, Hellman S. Individual characterisation of the metastatic capacity of human breast carcinoma. Eur J Cancer. 2000 Aug; 36(13 Spec No):1631-9. PMID: 10959049.
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    45. Hellman S, Heimann R. The clinical significance of tumor progression: breast cancer as a model. Cancer J. 2000 Apr; 6 Suppl 2:S131-3. PMID: 10803827.
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    46. Heimann R, Hellman S. Clinical progression of breast cancer malignant behavior: what to expect and when to expect it. J Clin Oncol. 2000 Feb; 18(3):591-9. PMID: 10653874.
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    47. Heimann R, Lan F, McBride R, Hellman S. Separating favorable from unfavorable prognostic markers in breast cancer: the role of E-cadherin. Cancer Res. 2000 Jan 15; 60(2):298-304. PMID: 10667580.
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    48. Hellman S. The ethical lessons of managed care applied to clinical trials. Cancer Treat Res. 2000; 102:91-8. PMID: 10650483.
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    49. Gorski DH, Mauceri HJ, Salloum RM, Gately S, Hellman S, Beckett MA, Sukhatme VP, Soff GA, Kufe DW, Weichselbaum RR. Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. Cancer Res. 1998 Dec 15; 58(24):5686-9. PMID: 9865723.
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    50. Heimann R, Hellman S. Aging, progression, and phenotype in breast cancer. J Clin Oncol. 1998 Aug; 16(8):2686-92. PMID: 9704718.
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    51. Heimann R, Ferguson DJ, Hellman S. The relationship between nm23, angiogenesis, and the metastatic proclivity of node-negative breast cancer. Cancer Res. 1998 Jul 01; 58(13):2766-71. PMID: 9661889.
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    52. Heimann R, Bradley J, Hellman S. The benefits of mammography are not limited to women of ages older than 50 years. Cancer. 1998 Jun 01; 82(11):2221-6. PMID: 9610702.
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    53. Heimann R, Ferguson D, Gray S, Hellman S. Assessment of intratumoral vascularization (angiogenesis) in breast cancer prognosis. Breast Cancer Res Treat. 1998; 52(1-3):147-58. PMID: 10066079.
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    54. Vijayakumar S, Vaida F, Weichselbaum R, Hellman S. Race and the Will Rogers phenomenon in prostate cancer. Cancer J Sci Am. 1998 Jan-Feb; 4(1):27-34. PMID: 9467043.
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    55. Heimann R, Ferguson D, Recant WM, Hellman S. Breast cancer metastatic phenotype as predicted by histologic tumor markers. Cancer J Sci Am. 1997 Jul-Aug; 3(4):224-9. PMID: 9263628.
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    56. Hellman S. Darwin's clinical relevance. Cancer. 1997 Jun 15; 79(12):2275-81. PMID: 9191515.
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    57. Heimann R, Ferguson D, Powers C, Suri D, Weichselbaum RR, Hellman S. Race and clinical outcome in breast cancer in a series with long-term follow-up evaluation. J Clin Oncol. 1997 Jun; 15(6):2329-37. PMID: 9196147.
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    58. Vijayakumar S, Hellman S. Advances in radiation oncology. Lancet. 1997 May; 349 Suppl 2:SII1-3. PMID: 9164437.
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    59. Heimann R, Ferguson D, Powers C, Recant WM, Weichselbaum RR, Hellman S. Angiogenesis as a predictor of long-term survival for patients with node-negative breast cancer. J Natl Cancer Inst. 1996 Dec 04; 88(23):1764-9. PMID: 8944007.
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    60. Quiet CA, Ferguson DJ, Weichselbaum RR, Hellman S. Natural history of node-positive breast cancer: the curability of small cancers with a limited number of positive nodes. J Clin Oncol. 1996 Dec; 14(12):3105-11. PMID: 8955655.
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    61. Mauceri HJ, Hanna NN, Wayne JD, Hallahan DE, Hellman S, Weichselbaum RR. Tumor necrosis factor alpha (TNF-alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature. Cancer Res. 1996 Oct 01; 56(19):4311-4. PMID: 8813113.
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    62. Vijayakumar S, Weichselbaum R, Vaida F, Dale W, Hellman S. Prostate-specific antigen levels in African-Americans correlate with insurance status as an indicator of socioeconomic status. Cancer J Sci Am. 1996 Jul-Aug; 2(4):225-33. PMID: 9166537.
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    63. Hellman S, Weichselbaum RR. Radiation oncology. JAMA. 1996 Jun 19; 275(23):1852-3. PMID: 8642748.
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    64. Hellman S. Roentgen Centennial Lecture: discovering the past, inventing the future. Int J Radiat Oncol Biol Phys. 1996 Apr 01; 35(1):15-20. PMID: 8641912.
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    65. Hellman S. The patient and the public good. Monash Bioeth Rev. 1996 Jan; 15(1):S5-10. PMID: 15810187.
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    66. Seung LP, Mauceri HJ, Beckett MA, Hallahan DE, Hellman S, Weichselbaum RR. Genetic radiotherapy overcomes tumor resistance to cytotoxic agents. Cancer Res. 1995 Dec 01; 55(23):5561-5. PMID: 7585635.
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    67. Hellman S, Weichselbaum RR. Radiation oncology and the new biology. Cancer J Sci Am. 1995 Sep-Oct; 1(3):174-9. PMID: 9166470.
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    68. Hallahan DE, Mauceri HJ, Seung LP, Dunphy EJ, Wayne JD, Hanna NN, Toledano A, Hellman S, Kufe DW, Weichselbaum RR. Spatial and temporal control of gene therapy using ionizing radiation. Nat Med. 1995 Aug; 1(8):786-91. PMID: 7585181.
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    69. Hellman S. The patient and the public good. Nat Med. 1995 May; 1(5):400-2. PMID: 7585078.
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    70. Quiet CA, Ferguson DJ, Weichselbaum RR, Hellman S. Natural history of node-negative breast cancer: a study of 826 patients with long-term follow-up. J Clin Oncol. 1995 May; 13(5):1144-51. PMID: 7738620.
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    71. Hellman S. Karnofsky Memorial Lecture. Natural history of small breast cancers. J Clin Oncol. 1994 Oct; 12(10):2229-34. PMID: 7931493.
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    72. Hellman S, Weichselbaum RR. Radiation oncology. JAMA. 1994 Jun 01; 271(21):1712-4. PMID: 8182867.
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    73. Hellman S. Fin de siècle medicine. Avoiding the unintended consequences of health care reform. Brookings Rev. 1994; 12(2):12-5. PMID: 10133336.
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    74. Hellman S. The end of inevitability, or Frankenstein and the biological revolution. Pharos Alpha Omega Alpha Honor Med Soc. 1994; 57(2):41-3. PMID: 8022875.
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    75. Hellman S. Dogma and inquisition in medicine. Breast cancer as a case study. Cancer. 1993 Apr 01; 71(7):2430-3. PMID: 8453567.
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    76. Hellman S, Hellman DS. Of mice but not men. Problems of the randomized clinical trial. N Engl J Med. 1991 May 30; 324(22):1585-9. PMID: 2027362.
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    77. Hellman S. The intellectual quarantine of American medicine. Acad Med. 1991 May; 66(5):245-8. PMID: 2025350.
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    78. Hellman S. Thomas Hodgkin and Hodgkin's disease. Two paradigms appropriate to medicine today. JAMA. 1991 Feb 27; 265(8):1007-10. PMID: 1992194.
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