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GLYN DAWSON

TitleProfessor
InstitutionUniversity of Chicago
DepartmentPediatrics-Kennedy Center
AddressChicago IL 60637
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    Collapse Overview 
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    A major focus of the Dawson Lab is to better understand neurodegeneration and how to prevent or reverse childhood inherited lysosomal storage diseases. The 13 forms of Batten disease result from the failure to deliver, lysosomally degrade, or recycle brain proteins. We use a chemical biology approach to delivering enzymes across cell membranes by attaching a Histidine tag to the enzyme and binding it to the surface of solubilized fluorescent semi-conductor nanoparticles called Quantum dots (QDs). If we add a synthetic cell penetrating peptide, protein cargo is rapidly taken up by cells to replace lysosomal enzymes such as tripeptidylpeptidase 1, absent in the CLN2 form of Batten disease, in cell and mouse models of CLN2 Batten disease. We can design QDs to specifically target the enzyme to neurons or glia and can use a similar nanoparticle delivery system for both small molecule and gene silencing studies. When coupled to HPLC/mass-spectrometric analysis of lipids, we can also study the role of sphingolipids such as ceramides in reversing non-genetic diseases such as cancer and stroke. These sphingolipids promote cell death and drug resistance so we can target the enzymes, such as ceramide glucosyltransferase, by coupling gene silencing RNAs to our QD complexes.


    Collapse Biography 
    Collapse education and training
    University of Bristol UK, Bristol UKPhD 01/1968Biochemistry
    Univerity of Bristol UK, Bristol UKBSc1964Biological Chemistry

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Qin J, Kilkus JP, Dawson G. The cross roles of sphingosine kinase 1/2 and ceramide glucosyltransferase in cell growth and death. Biochem Biophys Res Commun. 2018 06 07; 500(3):597-602. PMID: 29673590.
      View in: PubMed
    2. Dawson G. Quantum dots and potential therapy for Krabbe's disease. J Neurosci Res. 2016 Nov; 94(11):1293-303. PMID: 27638611.
      View in: PubMed
    3. Getz T, Qin J, Medintz IL, Delehanty JB, Susumu K, Dawson PE, Dawson G. Quantum dot-mediated delivery of siRNA to inhibit sphingomyelinase activities in brain-derived cells. J Neurochem. 2016 Dec; 139(5):872-885. PMID: 27622309.
      View in: PubMed
    4. Henderson MX, Wirak GS, Zhang YQ, Dai F, Ginsberg SD, Dolzhanskaya N, Staropoli JF, Nijssen PC, Lam TT, Roth AF, Davis NG, Dawson G, Velinov M, Chandra SS. Neuronal ceroid lipofuscinosis with DNAJC5/CSPa mutation has PPT1 pathology and exhibit aberrant protein palmitoylation. Acta Neuropathol. 2016 Apr; 131(4):621-37. PMID: 26659577.
      View in: PubMed
    5. Qin J, Kilkus J, Dawson G. The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator-role of Ceramide in MU anti-tumor activity. Biochim Biophys Acta. 2016 Feb; 1861(2):78-90. PMID: 26548718.
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    6. Walters R, Medintz IL, Delehanty JB, Stewart MH, Susumu K, Huston AL, Dawson PE, Dawson G. The Role of Negative Charge in the Delivery of Quantum Dots to Neurons. ASN Neuro. 2015 Jul-Aug; 7(4). PMID: 26243591.
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    7. Agarwal R, Domowicz MS, Schwartz NB, Henry J, Medintz I, Delehanty JB, Stewart MH, Susumu K, Huston AL, Deschamps JR, Dawson PE, Palomo V, Dawson G. Delivery and tracking of quantum dot peptide bioconjugates in an intact developing avian brain. ACS Chem Neurosci. 2015 Mar 18; 6(3):494-504. PMID: 25688887.
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    8. Dawson G. Measuring brain lipids. Biochim Biophys Acta. 2015 Aug; 1851(8):1026-39. PMID: 25701718.
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    9. Testai FD, Xu HL, Kilkus J, Suryadevara V, Gorshkova I, Berdyshev E, Pelligrino DA, Dawson G. Changes in the metabolism of sphingolipids after subarachnoid hemorrhage. J Neurosci Res. 2015 May; 93(5):796-805. PMID: 25597763.
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    10. Testai FD, Kilkus JP, Berdyshev E, Gorshkova I, Natarajan V, Dawson G. Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia. J Neurochem. 2014 Nov; 131(4):530-40. PMID: 25060904.
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    11. Dawson G. Glycosignaling: a general review. Adv Neurobiol. 2014; 9:293-306. PMID: 25151384.
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    12. Boeneman K, Delehanty JB, Blanco-Canosa JB, Susumu K, Stewart MH, Oh E, Huston AL, Dawson G, Ingale S, Walters R, Domowicz M, Deschamps JR, Algar WR, Dimaggio S, Manono J, Spillmann CM, Thompson D, Jennings TL, Dawson PE, Medintz IL. Selecting improved peptidyl motifs for cytosolic delivery of disparate protein and nanoparticle materials. ACS Nano. 2013 May 28; 7(5):3778-96. PMID: 23710591.
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    13. Walters R, Kraig RP, Medintz I, Delehanty JB, Stewart MH, Susumu K, Huston AL, Dawson PE, Dawson G. Nanoparticle targeting to neurons in a rat hippocampal slice culture model. ASN Neuro. 2012 Oct 23; 4(6):383-92. PMID: 22973864.
      View in: PubMed
    14. Qin J, Dawson G. Evidence for coordination of lysosomal (ASMase) and plasma membrane (NSMase2) forms of sphingomyelinase from mutant mice. FEBS Lett. 2012 Nov 16; 586(22):4002-9. PMID: 23046545.
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    15. Testai FD, Hillmann M, Amin-Hanjani S, Gorshkova I, Berdyshev E, Gorelick PB, Dawson G. Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage. Stroke. 2012 Aug; 43(8):2066-70. PMID: 22713492.
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    16. Dawson G, Fuller M, Helmsley KM, Hopwood JJ. Abnormal gangliosides are localized in lipid rafts in Sanfilippo (MPS3a) mouse brain. Neurochem Res. 2012 Jun; 37(6):1372-80. PMID: 22484966.
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    17. Qin J, Berdyshev E, Poirer C, Schwartz NB, Dawson G. Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt. J Biol Chem. 2012 Apr 20; 287(17):13620-32. PMID: 22383528.
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    18. Testai FD, Aiyagari V, Hillmann M, Amin-Hanjani S, Dawson G, Gorelick P. Proof of concept: endogenous antiangiogenic factors predict the occurrence of symptomatic vasospasm post subarachnoid hemorrhage. Neurocrit Care. 2011 Dec; 15(3):416-20. PMID: 21590494.
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    19. Dougherty U, Mustafi R, Wang Y, Musch MW, Wang CZ, Konda VJ, Kulkarni A, Hart J, Dawson G, Kim KE, Yuan CS, Chang EB, Bissonnette M. American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR. BMC Complement Altern Med. 2011 Nov 09; 11:111. PMID: 22070864.
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    20. Dawson G, Qin J. Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants. Biochem Biophys Res Commun. 2011 Jan 07; 404(1):321-3. PMID: 21130737.
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    21. Dawson G, Schroeder C, Dawson PE. Palmitoyl:protein thioesterase (PPT1) inhibitors can act as pharmacological chaperones in infantile Batten disease. Biochem Biophys Res Commun. 2010 Apr 23; 395(1):66-9. PMID: 20346914.
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    22. Qin J, Berdyshev E, Goya J, Natarajan V, Dawson G. Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis. J Biol Chem. 2010 May 07; 285(19):14134-43. PMID: 20215115.
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    23. Saadat L, Dupree JL, Kilkus J, Han X, Traka M, Proia RL, Dawson G, Popko B. Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice. Glia. 2010 Mar; 58(4):391-8. PMID: 19705459.
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    24. Moskal JR, Kroes RA, Dawson G. The glycobiology of brain tumors: disease relevance and therapeutic potential. Expert Rev Neurother. 2009 Oct; 9(10):1529-45. PMID: 19831842.
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    25. Qin J, Testai FD, Dawson S, Kilkus J, Dawson G. Oxidized phosphatidylcholine formation and action in oligodendrocytes. J Neurochem. 2009 Sep; 110(5):1388-99. PMID: 19545281.
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    26. Qin J, Goswami R, Dawson S, Dawson G. Expression of the receptor for advanced glycation end products in oligodendrocytes in response to oxidative stress. J Neurosci Res. 2008 Aug 15; 86(11):2414-22. PMID: 18438937.
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    27. Kilkus JP, Goswami R, Dawson SA, Testai FD, Berdyshev EV, Han X, Dawson G. Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons. J Neurochem. 2008 Aug; 106(4):1745-57. PMID: 18489714.
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    28. Kroes RA, Dawson G, Moskal JR. Focused microarray analysis of glyco-gene expression in human glioblastomas. J Neurochem. 2007 Nov; 103 Suppl 1:14-24. PMID: 17986135.
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    29. Hobert JA, Dawson G. A novel role of the Batten disease gene CLN3: association with BMP synthesis. Biochem Biophys Res Commun. 2007 Jun 22; 358(1):111-6. PMID: 17482562.
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    30. Qin J, Goswami R, Balabanov R, Dawson G. Oxidized phosphatidylcholine is a marker for neuroinflammation in multiple sclerosis brain. J Neurosci Res. 2007 Apr; 85(5):977-84. PMID: 17304573.
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    31. Hobert JA, Dawson G. Neuronal ceroid lipofuscinoses therapeutic strategies: past, present and future. Biochim Biophys Acta. 2006 Oct; 1762(10):945-53. PMID: 17049436.
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    32. Goswami R, Singh D, Phillips G, Kilkus J, Dawson G. Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines. J Neurosci Res. 2005 Aug 15; 81(4):541-50. PMID: 15968641.
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    33. Goswami R, Ahmed M, Kilkus J, Han T, Dawson SA, Dawson G. Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2. J Neurosci Res. 2005 Jul 15; 81(2):208-17. PMID: 15929065.
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    34. Dawson G, Moskal JR, Dawson SA. Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death. J Neurochem. 2004 Jun; 89(6):1436-44. PMID: 15189346.
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    35. Testai FD, Landek MA, Goswami R, Ahmed M, Dawson G. Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myo-inositol 3,4,5-triphosphate in oligodendrocyte cell signaling. J Neurochem. 2004 May; 89(3):636-44. PMID: 15086520.
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    36. Testai FD, Landek MA, Dawson G. Regulation of sphingomyelinases in cells of the oligodendrocyte lineage. J Neurosci Res. 2004 Jan 01; 75(1):66-74. PMID: 14689449.
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    37. Kilkus J, Goswami R, Testai FD, Dawson G. Ceramide in rafts (detergent-insoluble fraction) mediates cell death in neurotumor cell lines. J Neurosci Res. 2003 Apr 01; 72(1):65-75. PMID: 12645080.
      View in: PubMed
    38. Dawson G, Dawson SA, Marinzi C, Dawson PE. Anti-tumor promoting effects of palmitoyl: protein thioesterase inhibitors against a human neurotumor cell line. Cancer Lett. 2002 Dec 10; 187(1-2):163-8. PMID: 12359364.
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    39. Goswami R, Kilkus J, Scurlock B, Dawson G. CrmA protects against apoptosis and ceramide formation in PC12 cells. Neurochem Res. 2002 Aug; 27(7-8):735-41. PMID: 12374208.
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    40. Krueger RC, Santore MT, Dawson G, Schwartz NB. Increased extracellular magnesium modulates proliferation in fetal neural cells in culture. Brain Res Dev Brain Res. 2001 Apr 30; 127(2):99-109. PMID: 11334997.
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    41. Cho S, Dawson PE, Dawson G. Role of palmitoyl-protein thioesterase in cell death: implications for infantile neuronal ceroid lipofuscinosis. Eur J Paediatr Neurol. 2001; 5 Suppl A:53-5. PMID: 11589008.
      View in: PubMed
    42. Cho S, Dawson PE, Dawson G. Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells. J Neurosci Res. 2000 Oct 15; 62(2):234-40. PMID: 11020216.
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    43. Dawson G, Kilkus J, Schieven GL. Selective phosphotyrosine phosphatase inhibition and increased ceramide formation is associated with B-cell death by apoptosis. FEBS Lett. 2000 Aug 04; 478(3):233-6. PMID: 10930574.
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    44. Goswami R, Dawson G. Does ceramide play a role in neural cell apoptosis? J Neurosci Res. 2000 Apr 15; 60(2):141-9. PMID: 10740218.
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    45. Dawson G, Cho S. Batten's disease: clues to neuronal protein catabolism in lysosomes. J Neurosci Res. 2000 Apr 15; 60(2):133-40. PMID: 10740217.
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    46. Cho S, Dawson G. Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells. J Neurochem. 2000 Apr; 74(4):1478-88. PMID: 10737604.
      View in: PubMed
    47. Dawson G. Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation. Int J Dev Neurosci. 2000 Apr-Jun; 18(2-3):247-57. PMID: 10715579.
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    48. Cho S, Dawson PE, Dawson G. In vitro depalmitoylation of neurospecific peptides: implication for infantile neuronal ceroid lipofuscinosis. J Neurosci Res. 2000 Jan 01; 59(1):32-8. PMID: 10658183.
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    49. Goswami R, Dawson SA, Dawson G. Multiple polyphosphoinositide pathways regulate apoptotic signalling in a dorsal root ganglion derived cell line. J Neurosci Res. 2000 Jan 01; 59(1):136-44. PMID: 10658194.
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    50. Goswami R, Kilkus J, Dawson SA, Dawson G. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli. J Neurosci Res. 1999 Sep 15; 57(6):884-93. PMID: 10467260.
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    51. Scurlock B, Dawson G. Differential responses of oligodendrocytes to tumor necrosis factor and other pro-apoptotic agents: role of ceramide in apoptosis. J Neurosci Res. 1999 Feb 15; 55(4):514-22. PMID: 10723061.
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    52. Cho S, Dawson G. Enzymatic and molecular biological analysis of palmitoyl protein thioesterase deficiency in infantile neuronal ceroid lipofuscinosis. J Neurochem. 1998 Jul; 71(1):323-9. PMID: 9648881.
      View in: PubMed
    53. Goswami R, Dawson SA, Dawson G. Cyclic AMP protects against staurosporine and wortmannin-induced apoptosis and opioid-enhanced apoptosis in both embryonic and immortalized (F-11kappa7) neurons. J Neurochem. 1998 Apr; 70(4):1376-82. PMID: 9523553.
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    54. Dawson G, Goswami R, Kilkus J, Wiesner D, Dawson S. The formation of ceramide from sphingomyelin is associated with cellular apoptosis. Acta Biochim Pol. 1998; 45(2):287-97. PMID: 9821861.
      View in: PubMed
    55. Mangoura D, Dawson G. Programmed cell death in cortical chick embryo astrocytes is associated with activation of protein kinase PK60 and ceramide formation. J Neurochem. 1998 Jan; 70(1):130-8. PMID: 9422355.
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    56. Dawson G, Dawson SA, Goswami R. Chronic exposure to kappa-opioids enhances the susceptibility of immortalized neurons (F-11kappa 7) to apoptosis-inducing drugs by a mechanism that may involve ceramide. J Neurochem. 1997 Jun; 68(6):2363-70. PMID: 9166729.
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    57. Wiesner DA, Kilkus JP, Gottschalk AR, Quintáns J, Dawson G. Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by bcl-XL. J Biol Chem. 1997 Apr 11; 272(15):9868-76. PMID: 9092523.
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    58. Dawson G, Cho S, Siakotos AN, Kilkus J. Low molecular weight storage material in infantile ceroid lipofuscinosis (CLN1). Neuropediatrics. 1997 Feb; 28(1):31-2. PMID: 9151317.
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    59. Dawson G, Kilkus J, Siakotos AN, Singh I. Mitochondrial abnormalities in CLN2 and CLN3 forms of Batten disease. Mol Chem Neuropathol. 1996 Oct-Dec; 29(2-3):227-35. PMID: 8971698.
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    60. Wiesner DA, Dawson G. Programmed cell death in neurotumour cells involves the generation of ceramide. Glycoconj J. 1996 Apr; 13(2):327-33. PMID: 8737258.
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    61. Wiesner DA, Dawson G. Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. J Neurochem. 1996 Apr; 66(4):1418-25. PMID: 8627293.
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    62. Banerjee P, Chromy BA, Berry-Kravis E, Hammond D, Singh JK, Dawson G. Stable expression and heterologous coupling of the kappa opioid receptor in cell lines of neural and nonneural origin. Life Sci. 1996; 58(15):1277-84. PMID: 8614281.
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    63. Mangoura D, Sogos V, Dawson G. Phorbol esters and PKC signaling regulate proliferation, vimentin cytoskeleton assembly and glutamine synthetase activity of chick embryo cerebrum astrocytes in culture. Brain Res Dev Brain Res. 1995 Jun 27; 87(1):1-11. PMID: 7554227.
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    64. Mangoura D, Sogos V, Pelletiere C, Dawson G. Differential regulation of phospholipases C and D by phorbol esters and the physiological activators carbachol and glutamate in astrocytes from chicken embryo cerebrum and cerebellum. Brain Res Dev Brain Res. 1995 Jun 27; 87(1):12-21. PMID: 7554228.
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    65. Qi Y, Jamindar TM, Dawson G. Hypoxia alters iron homeostasis and induces ferritin synthesis in oligodendrocytes. J Neurochem. 1995 Jun; 64(6):2458-64. PMID: 7760025.
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    66. Alexander JJ, Banerjee P, Dawson G, Tonsgard JH. Hyperammonemia increases serotonin 1A receptor expression in both rat hippocampus and a transfected hippocampal cell line, HN2-5. J Neurosci Res. 1995 May 01; 41(1):105-10. PMID: 7674372.
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    67. Gottschalk AR, McShan CL, Kilkus J, Dawson G, Quintáns J. Resistance to anti-IgM-induced apoptosis in a WEHI-231 subline is due to insufficient production of ceramide. Eur J Immunol. 1995 Apr; 25(4):1032-8. PMID: 7537668.
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    68. Qi Y, Dawson G. Hypoxia specifically and reversibly induces the synthesis of ferritin in oligodendrocytes and human oligodendrogliomas. J Neurochem. 1994 Oct; 63(4):1485-90. PMID: 7931301.
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    69. Quintans J, Kilkus J, McShan CL, Gottschalk AR, Dawson G. Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem Biophys Res Commun. 1994 Jul 29; 202(2):710-4. PMID: 8048941.
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    70. Banerjee P, Boyers MJ, Berry-Kravis E, Dawson G. Preferential beta-hexosaminidase (Hex) A (alpha beta) formation in the absence of beta-Hex B (beta beta) due to heterozygous point mutations present in beta-Hex beta-chain alleles of a motor neuron disease patient. J Biol Chem. 1994 Feb 18; 269(7):4819-26. PMID: 8106452.
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    71. Qi Y, Dawson G. Effects of hypoxia on oligodendrocyte signal transduction. J Neurochem. 1993 Sep; 61(3):1097-104. PMID: 7689639.
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    72. Banerjee P, Dasgupta A, Chromy BA, Dawson G. Differential solubilization of membrane lipids by detergents: coenrichment of the sheep brain serotonin 5-HT1A receptor with phospholipids containing predominantly saturated fatty acids. Arch Biochem Biophys. 1993 Aug 15; 305(1):68-77. PMID: 8342957.
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    73. Mangoura D, Sogos V, Dawson G. Protein kinase C-epsilon is a developmentally regulated, neuronal isoform in the chick embryo central nervous system. J Neurosci Res. 1993 Aug 01; 35(5):488-98. PMID: 8377222.
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    74. Banerjee P, Berry-Kravis E, Bonafede-Chhabra D, Dawson G. Heterologous expression of the serotonin 5-HT1A receptor in neural and non-neural cell lines. Biochem Biophys Res Commun. 1993 Apr 15; 192(1):104-10. PMID: 8476411.
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    75. Mangoura D, Dawson G. Opioid peptides activate phospholipase D and protein kinase C-epsilon in chicken embryo neuron cultures. Proc Natl Acad Sci U S A. 1993 Apr 01; 90(7):2915-9. PMID: 8464907.
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    76. Cook EH, Perry BD, Dawson G, Wainwright MS, Leventhal BL. Receptor inhibition by immunoglobulins: specific inhibition by autistic children, their relatives, and control subjects. J Autism Dev Disord. 1993 Mar; 23(1):67-78. PMID: 8463203.
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    77. Dawson G, Dawson SA, Post GR. Regulation of phospholipase D activity in a human oligodendroglioma cell line (HOG). J Neurosci Res. 1993 Feb 15; 34(3):324-30. PMID: 8455209.
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    78. Dawson G, Kilkus J, Siakotos AN. Reduced phospholipase activity, peptide storage and the pathogenesis of canine neuronal ceroid-lipofuscinosis. J Inherit Metab Dis. 1993; 16(2):330-4. PMID: 8411992.
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    79. Qi Y, Dawson G. Hypoxia induces synthesis of a novel 22-kDa protein in neonatal rat oligodendrocytes. J Neurochem. 1992 Nov; 59(5):1709-16. PMID: 1383425.
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    80. Banerjee P, Dawson G, Dasgupta A. Enrichment of saturated fatty acid containing phospholipids in sheep brain serotonin receptor preparations: use of microwave irradiation for rapid transesterification of phospholipids. Biochim Biophys Acta. 1992 Sep 21; 1110(1):65-74. PMID: 1390837.
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    81. Post GR, Dawson G. Characterization of a cell line derived from a human oligodendroglioma. Mol Chem Neuropathol. 1992 Jun; 16(3):303-17. PMID: 1329795.
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    82. Vartanian T, Szuchet S, Dawson G. Oligodendrocyte-substratum adhesion activates the synthesis of specific lipid species involved in cell signaling. J Neurosci Res. 1992 May; 32(1):69-78. PMID: 1321254.
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    83. Banerjee P, Dasgupta A, Siakotos AN, Dawson G. Evidence for lipase abnormality: high levels of free and triacylglycerol forms of unsaturated fatty acids in neuronal ceroid-lipofuscinosis tissue. Am J Med Genet. 1992 Feb 15; 42(4):549-54. PMID: 1609837.
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    84. Kendler A, Dawson G. Hypoxic injury to oligodendrocytes: reversible inhibition of ATP-dependent transport of ceramide from the endoplasmic reticulum to the Golgi. J Neurosci Res. 1992 Feb; 31(2):205-11. PMID: 1573674.
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    85. Post GR, Dawson G. Regulation of carbachol- and histamine-induced inositol phospholipid hydrolysis in a human oligodendroglioma. Glia. 1992; 5(2):122-30. PMID: 1315720.
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    86. Banerjee P, Siciliano L, Oliveri D, McCabe NR, Boyers MJ, Horwitz AL, Li SC, Dawson G. Molecular basis of an adult form of beta-hexosaminidase B deficiency with motor neuron disease. Biochem Biophys Res Commun. 1991 Nov 27; 181(1):108-15. PMID: 1720305.
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    87. Mangoura D, Dawson G. Chronic opioid treatment attenuates carbachol-mediated polyphosphoinositide hydrolysis in chick embryo neuronal cultures. Brain Res. 1991 May 10; 548(1-2):273-8. PMID: 1651142.
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    88. McCabe NR, Dawson G. A study of the heterogenous structure of guinea pig lysosomal beta-mannosidase using a polyclonal antibody. Biochim Biophys Acta. 1991 Apr 08; 1077(2):133-40. PMID: 2015286.
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    89. Johnson KF, Hancock LW, Dawson G. Synthesis and processing of lysosomal alpha-fucosidase in cultured human fibroblasts. Biochim Biophys Acta. 1991 Jan 23; 1073(1):120-8. PMID: 1899340.
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    90. Farrer RG, Dawson G. Acylation of exogenous glycosylsphingosines by intact neuroblastoma (NCB-20) cells. J Biol Chem. 1990 Dec 25; 265(36):22217-22. PMID: 2266123.
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    91. Dawson G. Glycosphingolipid function in cancer. Cancer Cells. 1990 Oct; 2(10):327-8. PMID: 1980824.
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    92. Salazar-Grueso EF, Holzer TJ, Gutierrez RA, Casey JM, Desai SM, Devare SG, Dawson G, Roos RP. Familial spastic paraparesis syndrome associated with HTLV-I infection. N Engl J Med. 1990 Sep 13; 323(11):732-7. PMID: 2388670.
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    93. Kendler A, Dawson G. Progressive hypoxia inhibits the de novo synthesis of galactosylceramide in cultured oligodendrocytes. J Biol Chem. 1990 Jul 25; 265(21):12259-66. PMID: 2115515.
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    94. Banerjee P, Buse JT, Dawson G. Asymmetric extraction of membrane lipids by CHAPS. Biochim Biophys Acta. 1990 Jun 14; 1044(3):305-14. PMID: 2142003.
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    95. Salazar-Grueso EF, Routbort MJ, Martin J, Dawson G, Roos RP. Polyclonal IgM anti-GM1 ganglioside antibody in patients with motor neuron disease and variants. Ann Neurol. 1990 May; 27(5):558-63. PMID: 2113790.
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    96. McAtee P, Dawson G. Phospholipase C activity in NCB-20 cells is inhibited by protein kinase A-mediated phosphorylation of low molecular mass GTP-binding proteins. J Biol Chem. 1990 Apr 25; 265(12):6788-93. PMID: 1691176.
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    97. McCabe NR, Biliter W, Dawson G. Preferential inhibition of lysosomal beta-mannosidase by sucrose. Enzyme. 1990; 43(3):137-45. PMID: 2095335.
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    98. McAtee P, Dawson G. Rapid dephosphorylation of protein kinase C substrates by protein kinase A activators results from inhibition of diacylglycerol release. J Biol Chem. 1989 Jul 05; 264(19):11193-9. PMID: 2472391.
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    99. Dawson G, McAtee P. Differential regulation of basic protein phosphorylation by calcium phospholipid and cyclic-AMP-dependent protein kinases. J Cell Biochem. 1989 Jul; 40(3):261-9. PMID: 2777906.
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    100. Karnezis TA, Tripathi BJ, Dawson G, Murphy MB, Tripathi RC. Effects of dopamine receptor activation on the level of cyclic AMP in the trabecular meshwork. Invest Ophthalmol Vis Sci. 1989 Jun; 30(6):1090-4. PMID: 2567286.
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    101. Vartanian T, Dawson G, Soliven B, Nelson DJ, Szuchet S. Phosphorylation of myelin basic protein in intact oligodendrocytes: inhibition by galactosylsphingosine and cyclic AMP. Glia. 1989; 2(5):370-9. PMID: 2478466.
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    102. Dawson G, Dawson SA, Siakotos AN. Phospholipases and the molecular basis for the formation of ceroid in Batten disease. Adv Exp Med Biol. 1989; 266:259-70; discussion 271. PMID: 2486153.
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    103. Francel PC, Keefer JF, Dawson G. Bradykinin analogs antagonize bradykinin-induced second messenger production in a sensory neuron cell line. Mol Pharmacol. 1989 Jan; 35(1):34-8. PMID: 2536466.
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    104. Scanu AM, Khalil A, Neven L, Tidore M, Dawson G, Pfaffinger D, Jackson E, Carey KD, McGill HC, Fless GM. Genetically determined hypercholesterolemia in a rhesus monkey family due to a deficiency of the LDL receptor. J Lipid Res. 1988 Dec; 29(12):1671-81. PMID: 3244017.
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    105. Kim DK, Nau GJ, Lancki DW, Dawson G, Fitch FW. Cholera toxin discriminates between murine T lymphocyte proliferation stimulated by activators of protein kinase C and proliferation stimulated by IL-2. Possible role for intracellular cAMP. J Immunol. 1988 Nov 15; 141(10):3429-37. PMID: 2846687.
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    106. Dawson G, Johnson K, McCabe NR, Hancock LW. Molecular heterogeneity in lysosomal storage diseases. Alpha-fucosidase and N-acetyl-beta-D-hexosaminidase deficiency variants. Neurochem Pathol. 1988 Jun; 8(3):203-17. PMID: 2978174.
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    107. Francel P, Dawson G. Bradykinin induces the bi-phasic production of lysophosphatidyl inositol and diacylglycerol in a dorsal root ganglion X neurotumor hybrid cell line, F-11. Biochem Biophys Res Commun. 1988 Apr 29; 152(2):724-31. PMID: 3259133.
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    108. Vartanian T, Sprinkle TJ, Dawson G, Szuchet S. Oligodendrocyte substratum adhesion modulates expression of adenylate cyclase-linked receptors. Proc Natl Acad Sci U S A. 1988 Feb; 85(3):939-43. PMID: 2448785.
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    109. Vartanian T, Dawson G, Szuchet S. Intracellular messengers. Influence of oligodendrocyte substratum adhesion. Ann N Y Acad Sci. 1988; 540:433-6. PMID: 2462818.
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    110. Dawson G, Glaser PT. Abnormal cathepsin B activity in Batten disease. Am J Med Genet Suppl. 1988; 5:209-20. PMID: 3146318.
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