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Ronald N. Cohen

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
Email
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    Collapse Biography 
    Collapse education and training
    Harvard University , Cambridge, MAAB06/1987Mathematics
    Weill Cornell School of Medicine, New York, NYMD06/1992Medicine
    Beth Israel Hospital, Boston, MA06/1995Internal Medicine Residency
    Beth Israel Deaconess Medical Center, Boston, MA06/1998Endocrinology Fellowship

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yang F, Carmona A, Stojkova K, Garcia Huitron EI, Goddi A, Bhushan A, Cohen RN, Brey EM. A 3D human adipose tissue model within a microfluidic device. Lab Chip. 2021 01 21; 21(2):435-446. PMID: 33351023; PMCID: PMC7876365.
      Citations: 22     Fields:    Translation:HumansCells
    2. Kahn JH, Goddi A, Sharma A, Heiman J, Carmona A, Li Y, Hoffman A, Schoenfelt K, Ye H, Bobe AM, Becker L, Hollenberg AN, Cohen RN. SMRT Regulates Metabolic Homeostasis and Adipose Tissue Macrophage Phenotypes in Tandem. Endocrinology. 2020 10 01; 161(10). PMID: 32770234; PMCID: PMC7478322.
      Citations: 2     Fields:    Translation:AnimalsCells
    3. Yang F, Cohen RN, Brey EM. Optimization of Co-Culture Conditions for a Human Vascularized Adipose Tissue Model. Bioengineering (Basel). 2020 Sep 17; 7(3). PMID: 32957541; PMCID: PMC7552791.
      Citations: 17     
    4. Szigety KM, Liu F, Yuan CY, Moran DJ, Horrell J, Gochnauer HR, Cohen RN, Katz JP, Kaestner KH, Seykora JT, Tobias JW, Lazar MA, Xu M, Millar SE. HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity. Genes Dev. 2020 07 01; 34(13-14):973-988. PMID: 32467224; PMCID: PMC7328513.
      Citations: 16     Fields:    Translation:AnimalsCells
    5. Nanda R, Liu MC, Yau C, Shatsky R, Pusztai L, Wallace A, Chien AJ, Forero-Torres A, Ellis E, Han H, Clark A, Albain K, Boughey JC, Jaskowiak NT, Elias A, Isaacs C, Kemmer K, Helsten T, Majure M, Stringer-Reasor E, Parker C, Lee MC, Haddad T, Cohen RN, Asare S, Wilson A, Hirst GL, Singhrao R, Steeg K, Asare A, Matthews JB, Berry S, Sanil A, Schwab R, Symmans WF, van 't Veer L, Yee D, DeMichele A, Hylton NM, Melisko M, Perlmutter J, Rugo HS, Berry DA, Esserman LJ. Effect of Pembrolizumab Plus Neoadjuvant Chemotherapy on Pathologic Complete Response in Women With Early-Stage Breast Cancer: An Analysis of the Ongoing Phase 2 Adaptively Randomized I-SPY2 Trial. JAMA Oncol. 2020 05 01; 6(5):676-684. PMID: 32053137; PMCID: PMC7058271.
      Citations: 285     Fields:    Translation:HumansCTClinical Trials
    6. White JM, Piron MJ, Rangaraj VR, Hanlon EC, Cohen RN, Brady MJ. Reference Gene Optimization for Circadian Gene Expression Analysis in Human Adipose Tissue. J Biol Rhythms. 2020 02; 35(1):84-97. PMID: 31668115; PMCID: PMC7409766.
      Citations: 2     Fields:    Translation:Humans
    7. Shimizu H, Lu Y, Vella KR, Damilano F, Astapova I, Amano I, Ritter M, Gallop MR, Rosenzweig AN, Cohen RN, Hollenberg AN. Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action. PLoS One. 2019; 14(8):e0220717. PMID: 31404087; PMCID: PMC6690520.
      Citations: 5     Fields:    Translation:Animals
    8. Dickens LT, Cifu AS, Cohen RN. Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum Period. JAMA. 2019 May 21; 321(19):1928-1929. PMID: 31050702.
      Citations: 3     Fields:    Translation:Humans
    9. Casimiro I, Cohen RN. Severe Vasomotor Symptoms Post-Oophorectomy Despite Testosterone Therapy in a Transgender Man: A Unique Case Study. J Endocr Soc. 2019 Apr 01; 3(4):734-736. PMID: 30931422; PMCID: PMC6436763.
      Citations:    
    10. Tanataweethum N, Zelaya A, Yang F, Cohen RN, Brey EM, Bhushan A. Establishment and characterization of a primary murine adipose tissue-chip. Biotechnol Bioeng. 2018 08; 115(8):1979-1987. PMID: 29689639.
      Citations: 12     Fields:    Translation:AnimalsCells
    11. Vaicik MK, Blagajcevic A, Ye H, Morse MC, Yang F, Goddi A, Brey EM, Cohen RN. The Absence of Laminin a4 in Male Mice Results in Enhanced Energy Expenditure and Increased Beige Subcutaneous Adipose Tissue. Endocrinology. 2018 01 01; 159(1):356-367. PMID: 28973559; PMCID: PMC5761598.
      Citations: 18     Fields:    Translation:AnimalsCells
    12. Rochette AD, Spitznagel MB, Sweet LH, Cohen RA, Josephson R, Hughes J, Gunstad J. Gender Differences in Cognitive Test Performance in Adults With Heart Failure. J Cardiovasc Nurs. 2017 May/Jun; 32(3):212-217. PMID: 27028589; PMCID: PMC5042804.
      Citations: 3     Fields:    Translation:Humans
    13. Cohen RN, Davis AM. Management of Adult Patients With Thyroid Nodules and Differentiated Thyroid Cancer. JAMA. 2017 01 24; 317(4):434-435. PMID: 28118436.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    14. Nanda R, Stringer-Reasor EM, Saha P, Kocherginsky M, Gibson J, Libao B, Hoffman PC, Obeid E, Merkel DE, Khramtsova G, Skor M, Krausz T, Cohen RN, Ratain MJ, Fleming GF, Conzen SD. A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer. Springerplus. 2016; 5(1):947. PMID: 27386391; PMCID: PMC4929099.
      Citations: 19     
    15. Dickson LM, Gandhi S, Layden BT, Cohen RN, Wicksteed B. Protein kinase A induces UCP1 expression in specific adipose depots to increase energy expenditure and improve metabolic health. Am J Physiol Regul Integr Comp Physiol. 2016 07 01; 311(1):R79-88. PMID: 27097660; PMCID: PMC4967236.
      Citations: 26     Fields:    Translation:AnimalsCells
    16. Goldfarb Y, Kadouri N, Levi B, Sela A, Herzig Y, Cohen RN, Hollenberg AN, Abramson J. HDAC3 Is a Master Regulator of mTEC Development. Cell Rep. 2016 Apr 19; 15(3):651-665. PMID: 27068467; PMCID: PMC5849426.
      Citations: 16     Fields:    Translation:AnimalsCells
    17. Vaicik MK, Morse M, Blagajcevic A, Rios J, Larson J, Yang F, Cohen RN, Papavasiliou G, Brey EM. Hydrogel-Based Engineering of Beige Adipose Tissue. J Mater Chem B. 2015 Oct 28; 3(40):7903-7911. PMID: 26693015; PMCID: PMC4675174.
      Citations: 9     Fields:    
    18. Emont MP, Mantis S, Kahn JH, Landeche M, Han X, Sargis RM, Cohen RN. Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT) regulates glucocorticoid action in adipocytes. Mol Cell Endocrinol. 2015 May 15; 407:52-6. PMID: 25766503; PMCID: PMC4390535.
      Citations: 4     Fields:    Translation:AnimalsCells
    19. Shimizu H, Astapova I, Ye F, Bilban M, Cohen RN, Hollenberg AN. NCoR1 and SMRT play unique roles in thyroid hormone action in vivo. Mol Cell Biol. 2015 Feb; 35(3):555-65. PMID: 25421714; PMCID: PMC4285426.
      Citations: 31     Fields:    Translation:AnimalsCells
    20. Vaicik MK, Thyboll Kortesmaa J, Kortesmaa J, Soininen R, Chong LY, Emont M, Cohen RN, Brey EM, Tryggvason K, Movérare-Skrtic S, Bergström G, Ohlsson C, Rozell B. Laminin a4 deficient mice exhibit decreased capacity for adipose tissue expansion and weight gain. PLoS One. 2014; 9(10):e109854. PMID: 25310607; PMCID: PMC4195691.
      Citations: 28     Fields:    Translation:AnimalsCells
    21. Alikhan M, Koshy A, Hyjek E, Stenson K, Cohen RN, Yeo KT. Discrepant serum and urine ß-hCG results due to production of ß-hCG by a cribriform-morular variant of thyroid papillary carcinoma. Clin Chim Acta. 2015 Jan 01; 438:181-5. PMID: 25181612.
      Citations: 5     Fields:    Translation:Humans
    22. Bernardi LA, Cohen RN, Stephenson MD. Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss. Fertil Steril. 2013 Nov; 100(5):1326-31. PMID: 23954357.
      Citations: 17     Fields:    Translation:Humans
    23. Carmean CM, Cohen RN, Brady MJ. Systemic regulation of adipose metabolism. Biochim Biophys Acta. 2014 Mar; 1842(3):424-30. PMID: 23774083.
      Citations: 12     Fields:    Translation:HumansCells
    24. Hermanns P, Grasberger H, Cohen R, Freiberg C, Refetoff S, Pohlenz J, Dörr HG. Two cases of thyroid dysgenesis caused by different novel PAX8 mutations in the DNA-binding region: in vitro studies reveal different pathogenic mechanisms. Thyroid. 2013 Jul; 23(7):791-6. PMID: 23308388; PMCID: PMC3704082.
      Citations: 12     Fields:    Translation:Humans
    25. Tate DF, Sampat M, Harezlak J, Fiecas M, Hogan J, Dewey J, McCaffrey D, Branson D, Russell T, Conley J, Taylor M, Schifitto G, Schifitto G, Zhong J, Daar ES, Alger J, Brown M, Singer E, Campbell T, McMahon D, Tso Y, Matesan J, Letendre S, Paulose S, Gaugh M, Tripoli C, Yiannoutsos C, Bigler ED, Cohen RA, Guttmann CR, Navia B, HIV Neuroimaging Consortium. Regional areas and widths of the midsagittal corpus callosum among HIV-infected patients on stable antiretroviral therapies. J Neurovirol. 2011 Aug; 17(4):368-79. PMID: 21556960; PMCID: PMC4309645.
      Citations: 26     Fields:    Translation:HumansCells
    26. Markan KR, Jurczak MJ, Allison MB, Ye H, Sutanto MM, Cohen RN, Brady MJ. Enhanced glycogen metabolism in adipose tissue decreases triglyceride mobilization. Am J Physiol Endocrinol Metab. 2010 Jul; 299(1):E117-25. PMID: 20424138; PMCID: PMC2904045.
      Citations: 9     Fields:    Translation:AnimalsCells
    27. Sutanto MM, Ferguson KK, Sakuma H, Ye H, Brady MJ, Cohen RN. The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo. J Biol Chem. 2010 Jun 11; 285(24):18485-95. PMID: 20371609; PMCID: PMC2881774.
      Citations: 23     Fields:    Translation:AnimalsCells
    28. Biyashev D, Veliceasa D, Kwiatek A, Sutanto MM, Cohen RN, Volpert OV. Natural angiogenesis inhibitor signals through Erk5 activation of peroxisome proliferator-activated receptor gamma (PPARgamma). J Biol Chem. 2010 Apr 30; 285(18):13517-24. PMID: 20185831; PMCID: PMC2859512.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    29. Samarasinghe SP, Sutanto MM, Danos AM, Johnson DN, Brady MJ, Cohen RN. Altering PPARgamma ligand selectivity impairs adipogenesis by thiazolidinediones but not hormonal inducers. Obesity (Silver Spring). 2009 May; 17(5):965-72. PMID: 19165156; PMCID: PMC2674133.
      Citations: 5     Fields:    Translation:AnimalsCells
    30. Tate DF, Jefferson AL, Brickman AM, Hoth KF, Gunstad J, Bramley K, Paul RH, Poppas A, Cohen RA. Regional White Matter Signal Abnormalities and Cognitive Correlates Among Geriatric Patients with Treated Cardiovascular Disease. Brain Imaging Behav. 2008 Sep 01; 2(3):200-206. PMID: 19789657; PMCID: PMC2753539.
      Citations: 9     Fields:    
    31. Yuan W, Pan W, Kong J, Zheng W, Szeto FL, Wong KE, Cohen R, Klopot A, Zhang Z, Li YC. 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem. 2007 Oct 12; 282(41):29821-30. PMID: 17690094.
      Citations: 219     Fields:    Translation:HumansAnimalsCells
    32. Jefferson AL, Tate DF, Poppas A, Brickman AM, Paul RH, Gunstad J, Cohen RA. Lower cardiac output is associated with greater white matter hyperintensities in older adults with cardiovascular disease. J Am Geriatr Soc. 2007 Jul; 55(7):1044-8. PMID: 17608877; PMCID: PMC2721459.
      Citations: 60     Fields:    Translation:Humans
    33. Sutanto MM, Symons MS, Cohen RN. SMRT recruitment by PPARgamma is mediated by specific residues located in its carboxy-terminal interacting domain. Mol Cell Endocrinol. 2007 Mar 15; 267(1-2):138-43. PMID: 17668471.
      Citations: 3     Fields:    Translation:AnimalsCells
    34. Kim HH, Wolfe A, Cohen RN, Eames SC, Johnson AL, Wieland CN, Radovick S. In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone. Mol Endocrinol. 2007 Feb; 21(2):457-71. PMID: 17095579.
      Citations: 17     Fields:    Translation:AnimalsCells
    35. Sutanto MM, Symons MS, Cohen RN. SMRT recruitment by PPARgamma is mediated by specific residues located in its carboxy-terminal interacting domain. Mol Cell Endocrinol. 2006 Oct 19; 259(1-2):43-9. PMID: 16989944.
      Citations: 3     Fields:    Translation:AnimalsCells
    36. Cohen RN. Nuclear receptor corepressors and PPARgamma. Nucl Recept Signal. 2006; 4:e003. PMID: 16604166; PMCID: PMC1402213.
      Citations: 18     Fields:    
    37. Wu SY, Cohen RN, Simsek E, Senses DA, Yar NE, Grasberger H, Noel J, Refetoff S, Weiss RE. A novel thyroid hormone receptor-beta mutation that fails to bind nuclear receptor corepressor in a patient as an apparent cause of severe, predominantly pituitary resistance to thyroid hormone. J Clin Endocrinol Metab. 2006 May; 91(5):1887-95. PMID: 16464943.
      Citations: 14     Fields:    Translation:HumansCells
    38. Cohen RN, Brue T, Naik K, Houlihan CA, Wondisford FE, Radovick S. The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency. J Clin Endocrinol Metab. 2006 Jan; 91(1):239-47. PMID: 16263824.
      Citations: 8     Fields:    Translation:HumansCells
    39. Hashimoto K, Cohen RN, Yamada M, Markan KR, Monden T, Satoh T, Mori M, Wondisford FE. Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model. J Biol Chem. 2006 Jan 06; 281(1):295-302. PMID: 16260782.
      Citations: 27     Fields:    Translation:AnimalsCells
    40. Ortiga-Carvalho TM, Shibusawa N, Nikrodhanond A, Oliveira KJ, Machado DS, Liao XH, Cohen RN, Refetoff S, Wondisford FE. Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface. J Clin Invest. 2005 Sep; 115(9):2517-23. PMID: 16100573; PMCID: PMC1184039.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    41. Yu C, Markan K, Temple KA, Deplewski D, Brady MJ, Cohen RN. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. J Biol Chem. 2005 Apr 08; 280(14):13600-5. PMID: 15691842.
      Citations: 118     Fields:    Translation:AnimalsCells
    42. Lado-Abeal J, Dumitrescu AM, Liao XH, Cohen RN, Pohlenz J, Weiss RE, Lebrethon MC, Verloes A, Refetoff S. A de novo mutation in an already mutant nucleotide of the thyroid hormone receptor beta gene perpetuates resistance to thyroid hormone. J Clin Endocrinol Metab. 2005 Mar; 90(3):1760-7. PMID: 15598685.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    43. Temple KA, Cohen RN, Wondisford SR, Yu C, Deplewski D, Wondisford FE. An intact DNA-binding domain is not required for peroxisome proliferator-activated receptor gamma (PPARgamma) binding and activation on some PPAR response elements. J Biol Chem. 2005 Feb 04; 280(5):3529-40. PMID: 15572375.
      Citations: 15     Fields:    Translation:AnimalsCells
    44. Ortiga-Carvalho TM, Hashimoto K, Pazos-Moura CC, Geenen D, Cohen R, Lang RM, Wondisford FE. Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform. Endocrinology. 2004 Apr; 145(4):1625-33. PMID: 14684607.
      Citations: 5     Fields:    Translation:HumansAnimals
    45. Cohen RN, Cohen LE, Botero D, Yu C, Sagar A, Jurkiewicz M, Radovick S. Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. J Clin Endocrinol Metab. 2003 Oct; 88(10):4832-9. PMID: 14557462.
      Citations: 26     Fields:    Translation:HumansCells
    46. Shibusawa N, Hashimoto K, Nikrodhanond AA, Liberman MC, Applebury ML, Liao XH, Robbins JT, Refetoff S, Cohen RN, Wondisford FE. Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo. J Clin Invest. 2003 Aug; 112(4):588-97. PMID: 12925699; PMCID: PMC171393.
      Citations: 38     Fields:    Translation:AnimalsCells
    47. Makowski A, Brzostek S, Cohen RN, Hollenberg AN. Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor. Mol Endocrinol. 2003 Feb; 17(2):273-86. PMID: 12554754.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    48. Pohlenz J, Dumitrescu A, Zundel D, Koo E, Weiss RE, Cohen RN, Kimura S, Refetoff S, Martiné U, Schönberger W. Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice. J Clin Invest. 2002 Feb; 109(4):469-73. PMID: 11854318; PMCID: PMC150877.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    49. Cohen RN, Brzostek S, Kim B, Chorev M, Wondisford FE, Hollenberg AN. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol Endocrinol. 2001 Jul; 15(7):1049-61. PMID: 11435607.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    50. Hashimoto K, Curty FH, Borges PP, Lee CE, Abel ED, Elmquist JK, Cohen RN, Wondisford FE. An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3998-4003. PMID: 11274423; PMCID: PMC31168.
      Citations: 69     Fields:    Translation:Animals
    51. Cohen RN, Putney A, Wondisford FE, Hollenberg AN. The nuclear corepressors recognize distinct nuclear receptor complexes. Mol Endocrinol. 2000 Jun; 14(6):900-14. PMID: 10847591.
      Citations: 30     Fields:    Translation:Cells
    52. Oberste-Berghaus C, Zanger K, Hashimoto K, Cohen RN, Hollenberg AN, Wondisford FE. Thyroid hormone-independent interaction between the thyroid hormone receptor beta2 amino terminus and coactivators. J Biol Chem. 2000 Jan 21; 275(3):1787-92. PMID: 10636876.
      Citations: 23     Fields:    Translation:HumansCells
    53. Safer JD, Cohen RN, Hollenberg AN, Wondisford FE. Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone. J Biol Chem. 1998 Nov 13; 273(46):30175-82. PMID: 9804773.
      Citations: 24     Fields:    Translation:HumansCells
    54. Cohen RN, Wondisford FE, Hollenberg AN. Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements. Mol Endocrinol. 1998 Oct; 12(10):1567-81. PMID: 9773980.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    55. Sgroi D, Cohen RN, Lingenheld EG, Strong MK, Binder T, Goldschneider I, Greiner D, Grunnet M, Clark RB. T cell lines derived from the spinal cords of mice with experimental allergic encephalomyelitis are self reactive. J Immunol. 1986 Sep 15; 137(6):1850-4. PMID: 2427582.
      Citations: 7     Fields:    Translation:AnimalsCells
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