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Shilpa Keerthivasan

TitlePostdoctoral Fellow
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cherry C, Andorko JI, Krishnan K, Nguyen HH, Stivers KB, Gray-Gaillard EF, Ruta A, Han J, Hamada N, Hamada M, Sturmlechner I, Trewartha S, Michel JH, Davenport Huyer L, Wolf MT, Tam AJ, Keerthivasan S, Le Saux CJ, Fertig EJ, Baker DJ, Housseau F, van Deursen JM, Pardoll DM, Elisseeff JH, Mejías JC, Peña AN. Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies. Geroscience. 2023 Aug; 45(4):2559-2587. PMID: 37079217; PMCID: PMC10651581.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    2. Huseni MA, Wang L, Klementowicz JE, Yuen K, Breart B, Orr C, Liu LF, Li Y, Gupta V, Li C, Rishipathak D, Peng J, Senbabaoglu Y, Modrusan Z, Keerthivasan S, Madireddi S, Chen YJ, Fraser EJ, Leng N, Hamidi H, Koeppen H, Ziai J, Hashimoto K, Williams P, McDermott DF, Rosenberg JE, Powles T, Emens LA, Hegde PS, Mellman I, Turley SJ, Wilson MS, Mariathasan S, Molinero L, Merchant M, West NR, Fassò M. CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy. Cell Rep Med. 2023 01 17; 4(1):100878. PMID: 36599350; PMCID: PMC9873827.
      Citations: 16     Fields:    Translation:AnimalsCells
    3. Grout JA, Sirven P, Leader AM, Maskey S, Hector E, Puisieux I, Steffan F, Cheng E, Tung N, Maurin M, Vaineau R, Karpf L, Plaud M, Begue AL, Ganesh K, Casanova-Acebes M, Tabachnikova A, Keerthivasan S, Lansky A, Berichel JL, Walker L, Rahman AH, Gnjatic S, Girard N, Lefevre M, Adam J, Martin JC, Wolf A, Flores RM, Beasley MB, Pradhan R, Muller S, Marron TU, Turley SJ, Merad M, Kenigsberg E, Mesple J, Damotte D, Salmon H. Spatial Positioning and Matrix Programs of Cancer-Associated Fibroblasts Promote T-cell Exclusion in Human Lung Tumors. Cancer Discov. 2022 11 02; 12(11):2606-2625. PMID: 36027053; PMCID: PMC9633420.
      Citations: 34     Fields:    Translation:HumansCells
    4. Astarita JL, Keerthivasan S, Husain B, Senbabaoglu Y, Verschueren E, Gierke S, Pham VC, Peterson SM, Chalouni C, Pierce AA, Lill JR, Gonzalez LC, Martinez-Martin N, Turley SJ. The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology. PLoS One. 2021; 16(12):e0260800. PMID: 34879110; PMCID: PMC8654239.
      Citations: 7     Fields:    Translation:HumansCells
    5. Keerthivasan S, Senbabaoglu Y, Martinez-Martin N, Husain B, Verschueren E, Wong A, Yang YA, Sun Y, Pham V, Hinkle T, Oei Y, Madireddi S, Corpuz R, Tam L, Carlisle S, Roose-Girma M, Modrusan Z, Ye Z, Koerber JT, Turley SJ. Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1. Immunity. 2021 07 13; 54(7):1511-1526.e8. PMID: 34260887.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    6. Kapoor VN, Keerthivasan S, Brown M, Chalouni C, Storm EE, Castiglioni A, Lane R, Nitschke M, Dominguez CX, Astarita JL, Krishnamurty AT, Carbone CB, Senbabaoglu Y, Wang AW, Wu X, Cremasco V, Roose-Girma M, Tam L, Doerr J, Chen MZ, Lee WP, Modrusan Z, Yang YA, Bourgon R, Sandoval W, Shaw AS, de Sauvage FJ, Mellman I, Moussion C, Turley SJ, Müller S. Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues. Nat Immunol. 2021 05; 22(5):571-585. PMID: 33903764.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    7. Yuen KC, Liu LF, Gupta V, Madireddi S, Keerthivasan S, Li C, Rishipathak D, Williams P, Kadel EE, Koeppen H, Chen YJ, Modrusan Z, Grogan JL, Banchereau R, Leng N, Thastrom A, Shen X, Hashimoto K, Tayama D, van der Heijden MS, Rosenberg JE, McDermott DF, Powles T, Hegde PS, Huseni MA, Mariathasan S. Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade. Nat Med. 2021 Mar; 27(3):560. PMID: 33547461.
      Citations: 1     Fields:    
    8. Udyavar AR, Ryner L, Kozlowski C, Guan Y, Lu S, Fortin JP, Koeppen H, Ziai J, Chang CW, Keerthivasan S, Bourgon R, Bais C, Hegde P, Daemen A, Turley S, Wang Y, Desbois M, Dürrbaum M, Plante M. Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer. Nat Commun. 2020 11 04; 11(1):5583. PMID: 33149148; PMCID: PMC7642433.
      Citations: 61     Fields:    Translation:HumansCells
    9. Yuen KC, Liu LF, Gupta V, Madireddi S, Keerthivasan S, Li C, Rishipathak D, Williams P, Kadel EE, Koeppen H, Chen YJ, Modrusan Z, Grogan JL, Banchereau R, Leng N, Thastrom A, Shen X, Hashimoto K, Tayama D, van der Heijden MS, Rosenberg JE, McDermott DF, Powles T, Hegde PS, Huseni MA, Mariathasan S. High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade. Nat Med. 2020 05; 26(5):693-698. PMID: 32405063; PMCID: PMC8286544.
      Citations: 160     Fields:    Translation:Humans
    10. Wu TD, Madireddi S, de Almeida PE, Banchereau R, Chen YJ, Chitre AS, Chiang EY, Iftikhar H, O'Gorman WE, Au-Yeung A, Takahashi C, Goldstein LD, Poon C, Keerthivasan S, de Almeida Nagata DE, Du X, Lee HM, Banta KL, Mariathasan S, Das Thakur M, Huseni MA, Ballinger M, Estay I, Caplazi P, Modrusan Z, Mellman I, Bourgon R, Grogan JL, Delamarre L. Peripheral T cell expansion predicts tumour infiltration and clinical response. Nature. 2020 03; 579(7798):274-278. PMID: 32103181.
      Citations: 277     Fields:    Translation:HumansCells
    11. McCarthy N, Manieri E, Storm EE, Saadatpour A, Luoma AM, Kapoor VN, Madha S, Gaynor LT, Cox C, Keerthivasan S, Wucherpfennig K, Yuan GC, de Sauvage FJ, Turley SJ, Shivdasani RA. Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020 03 05; 26(3):391-402.e5. PMID: 32084389; PMCID: PMC7412576.
      Citations: 120     Fields:    Translation:Cells
    12. Dominguez CX, Keerthivasan S, Koeppen H, Hung J, Gierke S, Breart B, Foreman O, Bainbridge TW, Castiglioni A, Senbabaoglu Y, Modrusan Z, Liang Y, Junttila MR, Klijn C, Bourgon R, Turley SJ, Müller S. Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy. Cancer Discov. 2020 02; 10(2):232-253. PMID: 31699795.
      Citations: 265     Fields:    Translation:HumansAnimalsCells
    13. Cremasco V, Astarita JL, Grauel AL, Keerthivasan S, MacIsaac K, Woodruff MC, Wu M, Spel L, Santoro S, Amoozgar Z, Laszewski T, Migoni SC, Knoblich K, Fletcher AL, LaFleur M, Wucherpfennig KW, Pure E, Dranoff G, Carroll MC, Turley SJ. FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors. Cancer Immunol Res. 2018 12; 6(12):1472-1485. PMID: 30266714; PMCID: PMC6597261.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    14. Shin HM, Tilahun ME, Cho OH, Chandiran K, Kuksin CA, Keerthivasan S, Fauq AH, Golde TE, Miele L, Thome M, Osborne BA, Minter LM. NOTCH1 Can Initiate NF-?B Activation via Cytosolic Interactions with Components of the T Cell Signalosome. Front Immunol. 2014; 5:249. PMID: 24904593; PMCID: PMC4033603.
      Citations: 25     Fields:    
    15. Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, Mulcahy M, Keshavarzian A, Ramos EM, Blatner N, Khazaie K, Gounari F. ß-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med. 2014 Feb 26; 6(225):225ra28. PMID: 24574339; PMCID: PMC4020714.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    16. Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari F. ß-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):391-6. PMID: 24371308; PMCID: PMC3890837.
      Citations: 44     Fields:    Translation:AnimalsCells
    17. Aghajani K, Keerthivasan S, Yu Y, Gounari F. Generation of CD4CreER(T²) transgenic mice to study development of peripheral CD4-T-cells. Genesis. 2012 Dec; 50(12):908-13. PMID: 22887772; PMCID: PMC3535561.
      Citations: 31     Fields:    Translation:AnimalsCells
    18. Keerthivasan S, Suleiman R, Lawlor R, Roderick J, Bates T, Minter L, Anguita J, Juncadella I, Nickoloff BJ, Le Poole IC, Miele L, Osborne BA. Notch signaling regulates mouse and human Th17 differentiation. J Immunol. 2011 Jul 15; 187(2):692-701. PMID: 21685328; PMCID: PMC3131467.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    19. Keerthivasan S, Keerthivasan G, Mittal S, Chauhan SS. Transcriptional upregulation of human cathepsin L by VEGF in glioblastoma cells. Gene. 2007 Sep 15; 399(2):129-36. PMID: 17574778.
      Citations: 11     Fields:    Translation:HumansCells
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