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Michelle M. Lebeau

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology and Oncology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Le Beau’s research focuses on the molecular analysis of the recurring chromosomal abnormalities in human leukemias and lymphomas, correlating specific abnormalities with morphological and clinical features and the development of risk-adapted therapy. Ongoing projects include the molecular cloning of haploinsufficient myeloid leukemia-related genes involved in the del(5q) characteristic of therapy-related acute myeloid leukemia; development and characterization of murine models recapitulating the genetic mutations in acute myeloid leukemia and identification of secondary, cooperating mutations and genetic pathways to leukemogenesis; and the application of murine models for pre-clinical drug testing.

    Collapse Biography 
    Collapse education and training
    University of Illinois Medical Center, Chicago, ILPhD06/1981Genetics
    University of Illinois Medical Center, Chicago, ILMS06/1978Genetics
    Collapse awards and honors
    2011Arthur and Marian Edelstein Professor of Medicine, University of Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Aschebrook-Kilfoy B, Kibriya MG, Jasmine F, Stepniak L, Gopalakrishnan R, Craver A, Zakin P, Tasmin S, Kim KE, Goss KH, List M, LeBeau M, Ahsan H. Cohort profile: the ChicagO Multiethnic Prevention and Surveillance Study (COMPASS). BMJ Open. 2020 09 16; 10(9):e038481. PMID: 32938600; PMCID: PMC7497521.
      Citations: 4     Fields:    Translation:Humans
    2. McNerney ME, Godley LA, Le Beau MM. Therapy-related myeloid neoplasms: when genetics and environment collide. Nat Rev Cancer. 2017 08 24; 17(9):513-527. PMID: 28835720; PMCID: PMC5946699.
      Citations: 129     Fields:    Translation:HumansCellsPHPublic Health
    3. Stoddart A, Wang J, Hu C, Fernald AA, Davis EM, Cheng JX, Le Beau MM. Inhibition of WNT signaling in the bone marrow niche prevents the development of MDS in the Apcdel/+ MDS mouse model. Blood. 2017 06 01; 129(22):2959-2970. PMID: 28348148; PMCID: PMC5454335.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    4. Burgess MR, Hwang E, Mroue R, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Evangelista M, Shannon K, Bielski CM, Taylor BS. KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer. Cell. 2017 02 23; 168(5):817-829.e15. PMID: 28215705; PMCID: PMC5541948.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    5. Yap KL, Furtado LV, Kiyotani K, Curran E, Stock W, McNeer JL, Kadri S, Segal JP, Nakamura Y, Le Beau MM, Gurbuxani S, Raca G. Diagnostic evaluation of RNA sequencing for the detection of genetic abnormalities associated with Ph-like acute lymphoblastic leukemia (ALL). Leuk Lymphoma. 2017 04; 58(4):950-958. PMID: 27855558; PMCID: PMC6077981.
      Citations: 8     Fields:    Translation:HumansCells
    6. Greenberg PL, Tuechler H, Sanz G, Garcia-Manero G, Bennett JM, Bowen D, Kantarjian H, Levis A, Malcovati L, Cazzola M, Cermak J, Fonatsch C, Le Beau MM, Slovak ML, Krieger O, Luebbert M, Maciejewski J, Magalhaes SM, Miyazaki Y, Sekeres M, Sperr WR, Stauder R, Tauro S, Valent P, Vallespi T, van de Loosdrecht AA, Schanz J, Solé F, Fenaux P, Dreyfus F, Kuendgen A, Pfeilstöcker M, Germing U, Haase D. Cytopenia levels for aiding establishment of the diagnosis of myelodysplastic syndromes. Blood. 2016 10 20; 128(16):2096-2097. PMID: 27535995; PMCID: PMC5341483.
      Citations: 16     Fields:    Translation:Humans
    7. Jiang X, Bugno J, Hu C, Yang Y, Qi J, Chen P, Gurbuxani S, Arnovitz S, Strong J, Ferchen K, Ulrich B, Weng H, Wang Y, Huang H, Li S, Neilly MB, Larson RA, Le Beau MM, Bohlander SK, Jin J, Li Z, Bradner JE, Hong S, Chen J, Herold T. Eradication of Acute Myeloid Leukemia with FLT3 Ligand-Targeted miR-150 Nanoparticles. Cancer Res. 2016 08 01; 76(15):4470-80. PMID: 27280396; PMCID: PMC4970973.
      Citations: 26     Fields:    Translation:HumansAnimals
    8. Jiang X, Hu C, Arnovitz S, Bugno J, Yu M, Zuo Z, Chen P, Huang H, Ulrich B, Gurbuxani S, Weng H, Strong J, Wang Y, Li Y, Salat J, Li S, Elkahloun AG, Yang Y, Neilly MB, Larson RA, Le Beau MM, Bohlander SK, Liu PP, Zhang J, Li Z, He C, Jin J, Hong S, Chen J, Herold T. miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia. Nat Commun. 2016 04 26; 7:11452. PMID: 27116251; PMCID: PMC5477496.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    9. Arber DA, Orazi A, Hasserjian R, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW, Thiele J. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016 05 19; 127(20):2391-405. PMID: 27069254.
      Citations: 3446     Fields:    Translation:HumansCells
    10. Meyer SE, Qin T, Muench DE, Masuda K, Venkatasubramanian M, Orr E, Suarez L, Gore SD, Delwel R, Paietta E, Tallman MS, Fernandez H, Melnick A, Le Beau MM, Kogan S, Salomonis N, Figueroa ME, Grimes HL. DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia. Cancer Discov. 2016 05; 6(5):501-15. PMID: 27016502; PMCID: PMC4861898.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    11. Stoddart A, Qian Z, Fernald AA, Bergerson RJ, Wang J, Karrison T, Anastasi J, Bartom ET, Sarver AL, McNerney ME, Largaespada DA, Le Beau MM. Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms. Haematologica. 2016 06; 101(6):e232-6. PMID: 26944478; PMCID: PMC5013937.
      Citations: 12     Fields:    Translation:AnimalsCells
    12. Vasanthakumar A, Arnovitz S, Marquez R, Lepore J, Rafidi G, Asom A, Weatherly M, Davis EM, Neistadt B, Duszynski R, Vardiman JW, Le Beau MM, Godley LA, Churpek JE. Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice. Blood. 2016 Jan 21; 127(3):310-3. PMID: 26644450; PMCID: PMC4722284.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    13. Churpek JE, Marquez R, Neistadt B, Claussen K, Lee MK, Churpek MM, Huo D, Weiner H, Bannerjee M, Godley LA, Le Beau MM, Pritchard CC, Walsh T, King MC, Olopade OI, Larson RA. Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia. Cancer. 2016 Jan 15; 122(2):304-11. PMID: 26641009; PMCID: PMC4707981.
      Citations: 56     Fields:    Translation:Humans
    14. Stoddart A, Nakitandwe J, Chen SC, Downing JR, Le Beau MM. Haploinsufficient loss of multiple 5q genes may fine-tune Wnt signaling in del(5q) therapy-related myeloid neoplasms. Blood. 2015 Dec 24; 126(26):2899-901. PMID: 26567158; PMCID: PMC4692148.
      Citations: 9     Fields:    Translation:Humans
    15. Sundaravel S, Duggan R, Bhagat T, Ebenezer DL, Liu H, Yu Y, Bartenstein M, Unnikrishnan M, Karmakar S, Liu TC, Torregroza I, Quenon T, Anastasi J, McGraw KL, Pellagatti A, Boultwood J, Yajnik V, Artz A, Le Beau MM, Steidl U, List AF, Evans T, Verma A, Wickrema A. Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):E6359-68. PMID: 26578796; PMCID: PMC4655581.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    16. Li Z, Chen P, Su R, Li Y, Hu C, Wang Y, Arnovitz S, He M, Gurbuxani S, Zuo Z, Elkahloun AG, Li S, Weng H, Huang H, Neilly MB, Wang S, Olson EN, Larson RA, Le Beau MM, Zhang J, Jiang X, Wei M, Jin J, Liu PP, Chen J. Overexpression and knockout of miR-126 both promote leukemogenesis. Blood. 2015 Oct 22; 126(17):2005-15. PMID: 26361793; PMCID: PMC4616234.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    17. Amabile G, Di Ruscio A, Welner RS, Yang H, Ebralidze AK, Zhang H, Levantini E, Qi L, Martinelli G, Brummelkamp T, Le Beau MM, Figueroa ME, Tenen DG, Müller F, Bock C. Dissecting the role of aberrant DNA methylation in human leukaemia. Nat Commun. 2015 May 22; 6:7091. PMID: 25997600; PMCID: PMC4443494.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    18. Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW. Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Nat Genet. 2015 May; 47(5):539-43. PMID: 25822087; PMCID: PMC4414804.
      Citations: 26     Fields:    Translation:AnimalsCells
    19. Wood AM, Rendtlew Danielsen JM, Lucas CA, Rice EL, Scalzo D, Shimi T, Goldman RD, Smith ED, Le Beau MM, Kosak ST. TRF2 and lamin A/C interact to facilitate the functional organization of chromosome ends. Nat Commun. 2014 Nov 17; 5:5467. PMID: 25399868; PMCID: PMC4235626.
      Citations: 74     Fields:    Translation:HumansCells
    20. Flach J, Bakker ST, Mohrin M, Conroy PC, Pietras EM, Reynaud D, Alvarez S, Diolaiti ME, Ugarte F, Forsberg EC, Le Beau MM, Stohr BA, Morrison CG, Méndez J, Passegué E. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature. 2014 Aug 14; 512(7513):198-202. PMID: 25079315; PMCID: PMC4456040.
      Citations: 322     Fields:    Translation:AnimalsCells
    21. McNerney ME, Brown CD, Peterson AL, Banerjee M, Larson RA, Anastasi J, Le Beau MM, White KP. The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q). Br J Haematol. 2014 Aug; 166(4):550-6. PMID: 24931631; PMCID: PMC5479678.
      Citations: 15     Fields:    Translation:HumansCells
    22. Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Zuber J, Lowe SW, Kogan S. MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell. 2014 May 12; 25(5):652-65. PMID: 24794707; PMCID: PMC4206212.
      Citations: 172     Fields:    Translation:HumansAnimalsCells
    23. Stoddart A, Fernald AA, Wang J, Davis EM, Karrison T, Anastasi J, Le Beau MM. Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice. Blood. 2014 Feb 13; 123(7):1069-78. PMID: 24381225; PMCID: PMC3924928.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    24. Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari F. ß-Catenin induces T-cell transformation by promoting genomic instability. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):391-6. PMID: 24371308; PMCID: PMC3890837.
      Citations: 44     Fields:    Translation:AnimalsCells
    25. Stoddart A, Wang J, Fernald AA, Karrison T, Anastasi J, Le Beau MM. Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc. Blood. 2014 Jan 09; 123(2):228-38. PMID: 24264229; PMCID: PMC3888289.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    26. Lee S, Chen J, Zhou G, Shi RZ, Bouffard GG, Kocherginsky M, Ge X, Sun M, Jayathilaka N, Kim YC, Emmanuel N, Bohlander SK, Minden M, Kline J, Ozer O, Larson RA, LeBeau MM, Green ED, Trent J, Karrison T, Liu PP, Wang SM, Rowley JD. Gene expression profiles in acute myeloid leukemia with common translocations using SAGE. Proc Natl Acad Sci U S A. 2006 Jan 24; 103(4):1030-5. PMID: 16418266; PMCID: PMC1347995.
      Citations: 17     Fields:    Translation:HumansCells
    27. Watson PA, Ellwood-Yen K, King JC, Wongvipat J, Lebeau MM, Sawyers CL. Context-dependent hormone-refractory progression revealed through characterization of a novel murine prostate cancer cell line. Cancer Res. 2005 Dec 15; 65(24):11565-71. PMID: 16357166.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    28. Le Beau MM, Davis EM, Patel B, Phan VT, Sohal J, Kogan SC. Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice identify cooperating events and genetic pathways to acute promyelocytic leukemia. Blood. 2003 Aug 01; 102(3):1072-4. PMID: 12689927.
      Citations: 23     Fields:    Translation:Animals
    29. Le Beau MM, Bitts S, Davis EM, Kogan SC. Recurring chromosomal abnormalities in leukemia in PML-RARA transgenic mice parallel human acute promyelocytic leukemia. Blood. 2002 Apr 15; 99(8):2985-91. PMID: 11929790.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    30. Qian Z, Lin C, Espinosa R, LeBeau M, Rosner MR. Cloning and characterization of MST4, a novel Ste20-like kinase. J Biol Chem. 2001 Jun 22; 276(25):22439-45. PMID: 11306563.
      Citations: 28     Fields:    Translation:HumansCells
    31. Cho JH, Nicolae DL, Ramos R, Fields CT, Rabenau K, Corradino S, Brant SR, Espinosa R, LeBeau M, Hanauer SB, Bodzin J, Bonen DK. Linkage and linkage disequilibrium in chromosome band 1p36 in American Chaldeans with inflammatory bowel disease. Hum Mol Genet. 2000 May 22; 9(9):1425-32. PMID: 10814724.
      Citations: 16     Fields:    Translation:HumansCells
    32. Bernstein J, Dastugue N, Haas OA, Harbott J, Heerema NA, Huret JL, Landman-Parker J, LeBeau MM, Leonard C, Mann G, Pages MP, Perot C, Pirc-Danoewinata H, Roitzheim B, Rubin CM, Slociak M, Viguie F. Nineteen cases of the t(1;22)(p13;q13) acute megakaryblastic leukaemia of infants/children and a review of 39 cases: report from a t(1;22) study group. Leukemia. 2000 Jan; 14(1):216-8. PMID: 10637500.
      Citations: 19     Fields:    Translation:HumansCells
    33. Camoretti-Mercado B, Forsythe SM, LeBeau MM, Espinosa R, Vieira JE, Halayko AJ, Willadsen S, Kurtz B, Ober C, Evans GA, Thweatt R, Shapiro S, Niu Q, Qin Y, Padrid PA, Solway J. Expression and cytogenetic localization of the human SM22 gene (TAGLN). Genomics. 1998 May 01; 49(3):452-7. PMID: 9615232.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    34. Chekmareva MA, Hollowell CM, Smith RC, Davis EM, LeBeau MM, Rinker-Schaeffer CW. Localization of prostate cancer metastasis-suppressor activity on human chromosome 17. Prostate. 1997 Dec 01; 33(4):271-80. PMID: 9397200.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    35. Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 1997 Mar 15; 89(6):2079-88. PMID: 9058730.
      Citations: 1128     Fields:    Translation:Humans
    36. Larson RA, LeBeau MM, Vardiman JW, Rowley JD. Myeloid leukemia after hematotoxins. Environ Health Perspect. 1996 Dec; 104 Suppl 6:1303-7. PMID: 9118910; PMCID: PMC1469761.
      Citations: 4     Fields:    Translation:HumansCells
    37. Brown LJ, Stoffel M, Moran SM, Fernald AA, Lehn DA, LeBeau MM, MacDonald MJ. Structural organization and mapping of the human mitochondrial glycerol phosphate dehydrogenase-encoding gene and pseudogene. Gene. 1996 Jun 26; 172(2):309-12. PMID: 8682323.
      Citations: 2     Fields:    Translation:HumansCells
    38. Wong DA, Davis EM, LeBeau M, Springer TA. Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit. Gene. 1996 Jun 01; 171(2):291-4. PMID: 8666289.
      Citations: 6     Fields:    Translation:HumansCells
    39. Tanabe S, Zeleznik-Le NJ, Kobayashi H, Vignon C, Espinosa R, LeBeau MM, Thirman MJ, Rowley JD. Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line. Genes Chromosomes Cancer. 1996 Apr; 15(4):206-16. PMID: 8703846.
      Citations: 7     Fields:    Translation:HumansCells
    40. Hidai H, Quertermous EE, Espinosa R, LeBeau MM, Quertermous T. Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2. Genomics. 1995 Dec 10; 30(3):598-601. PMID: 8825648.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    41. Lawrence HJ, Sauvageau G, Ahmadi N, Lopez AR, LeBeau MM, Link M, Humphries K, Largman C. Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells. Exp Hematol. 1995 Oct; 23(11):1160-6. PMID: 7556525.
      Citations: 19     Fields:    Translation:HumansCells
    42. Zhou J, Neidigh JL, Espinosa R, LeBeau MM, McClain DA. Human glutamine: fructose-6-phosphate amidotransferase: characterization of mRNA and chromosomal assignment to 2p13. Hum Genet. 1995 Jul; 96(1):99-101. PMID: 7607664.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    43. Mrozek K, Arthur D, Karakousis C, Koduru P, Lebeau M, Pettenati M, Tantravahi R, Mrozek E, Perezmesa C, Rao U, Frankel S, Davey F, Bloomfield C. Der(16)T(1-16) is a nonrandom secondary chromosome aberration in many types of human neoplasia, including myxoid liposarcoma, rhabdomyosarcoma and Philadelphia-chromosome-positive acute lymphoblastic-leukemia. Int J Oncol. 1995 Mar; 6(3):531-8. PMID: 21556567.
      Citations:    Fields:    
    44. Marlton P, Claxton DF, Liu P, Estey EH, Beran M, LeBeau M, Testa JR, Collins FS, Rowley JD, Siciliano MJ. Molecular characterization of 16p deletions associated with inversion 16 defines the critical fusion for leukemogenesis. Blood. 1995 Feb 01; 85(3):772-9. PMID: 7833479.
      Citations: 6     Fields:    Translation:HumansCells
    45. Ponnambalam S, Jackson AP, LeBeau MM, Pravtcheva D, Ruddle FH, Alibert C, Parham P. Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB). Genomics. 1994 Dec; 24(3):440-4. PMID: 7713494.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    46. Varanasi U, Chu R, Chu S, Espinosa R, LeBeau MM, Reddy JK. Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3107-11. PMID: 8159712; PMCID: PMC43524.
      Citations: 24     Fields:    Translation:HumansCells
    47. Vaxillaire M, Vionnet N, Vigouroux C, Sun F, Espinosa R, Lebeau MM, Stoffel M, Lehto M, Beckmann JS, Detheux M, et al. Search for a third susceptibility gene for maturity-onset diabetes of the young. Studies with eleven candidate genes. Diabetes. 1994 Mar; 43(3):389-95. PMID: 7508874.
      Citations: 9     Fields:    Translation:HumansCells
    48. Hayani A, Suarez CR, Molnar Z, LeBeau M, Godwin J. Acute myeloid leukaemia in a patient with Seckel syndrome. J Med Genet. 1994 Feb; 31(2):148-9. PMID: 8182723; PMCID: PMC1049679.
      Citations: 13     Fields:    Translation:Humans
    49. Ozer H, George SL, Schiffer CA, Rao K, Rao PN, Wurster-Hill DH, Arthur DD, Powell B, Gottlieb A, Peterson BA, Rai K, Testa JR, LeBeau M, Tantravahi R, Bloomfield CD. Prolonged subcutaneous administration of recombinant alpha 2b interferon in patients with previously untreated Philadelphia chromosome-positive chronic-phase chronic myelogenous leukemia: effect on remission duration and survival: Cancer and Leukemia Group B study 8583. Blood. 1993 Nov 15; 82(10):2975-84. PMID: 8219189.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    50. Zhang LQ, Downie PA, Goodell WR, McCabe NR, LeBeau MM, Morgan R, Sklar J, Raimondi SC, Miley D, Goldberg A, et al. Establishment of cell lines from B-cell precursor acute lymphoblastic leukemia. Leukemia. 1993 Nov; 7(11):1865-74. PMID: 8231254.
      Citations: 9     Fields:    Translation:HumansCells
    51. Nucifora G, Birn DJ, Espinosa R, Erickson P, LeBeau MM, Roulston D, McKeithan TW, Drabkin H, Rowley JD. Involvement of the AML1 gene in the t(3;21) in therapy-related leukemia and in chronic myeloid leukemia in blast crisis. Blood. 1993 May 15; 81(10):2728-34. PMID: 8490181.
      Citations: 27     Fields:    Translation:HumansCells
    52. Burnett RC, Espinosa R, Shows TB, Eddy RL, LeBeau MM, Rowley JD, Diaz MO. Molecular analysis of a t(11;14)(q23;q11) from a patient with null-cell acute lymphoblastic leukemia. Genes Chromosomes Cancer. 1993 May; 7(1):38-46. PMID: 7688554.
      Citations: 2     Fields:    Translation:HumansCells
    53. Lia KM, Bruns GA, LeBeau MM, Silverman GA. pMCT108.2 is a chimaeric clone which physically maps to human chromosome bands 9q33 (D9S203) and 18q21.1 (D18S24). Hum Mol Genet. 1993 Mar; 2(3):332. PMID: 8499927.
      Citations:    Fields:    Translation:HumansCells
    54. Silverman GA, Jenkins R, Bruns GA, LeBeau MM. Reassignment of pEFD70.3 (D18S23) to human chromosome band 21q22.2 (D21S412) by physical mapping. Hum Mol Genet. 1993 Mar; 2(3):331. PMID: 8499926.
      Citations:    Fields:    Translation:HumansCells
    55. Nucifora G, Birn DJ, Erickson P, Gao J, LeBeau MM, Drabkin HA, Rowley JD. Detection of DNA rearrangements in the AML1 and ETO loci and of an AML1/ETO fusion mRNA in patients with t(8;21) acute myeloid leukemia. Blood. 1993 Feb 15; 81(4):883-8. PMID: 8427996.
      Citations: 34     Fields:    Translation:HumansCells
    56. Ohagi S, LaMendola J, LeBeau MM, Espinosa R, Takeda J, Smeekens SP, Chan SJ, Steiner DF. Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues. Proc Natl Acad Sci U S A. 1992 Jun 01; 89(11):4977-81. PMID: 1594602; PMCID: PMC49211.
      Citations: 16     Fields:    Translation:HumansCells
    57. McKeithan TW, Warshawsky L, Espinosa R, LeBeau MM. Molecular cloning of the breakpoints of a complex Philadelphia chromosome translocation: identification of a repeated region on chromosome 17. Proc Natl Acad Sci U S A. 1992 Jun 01; 89(11):4923-7. PMID: 1594595; PMCID: PMC49200.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    58. Ziemin-van der Poel S, McCabe NR, Gill HJ, Espinosa R, Patel Y, Harden A, Rubinelli P, Smith SD, LeBeau MM, Rowley JD, et al. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10735-9. PMID: 1720549; PMCID: PMC53005.
      Citations: 157     Fields:    Translation:HumansCells
    59. Lowney P, Corral J, Detmer K, LeBeau MM, Deaven L, Lawrence HJ, Largman C. A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells. Nucleic Acids Res. 1991 Jun 25; 19(12):3443-9. PMID: 1676505; PMCID: PMC328346.
      Citations: 20     Fields:    Translation:HumansCells
    60. Staunton DE, Fisher RC, LeBeau MM, Lawrence JB, Barton DE, Francke U, Dustin M, Thorley-Lawson DA. Blast-1 possesses a glycosyl-phosphatidylinositol (GPI) membrane anchor, is related to LFA-3 and OX-45, and maps to chromosome 1q21-23. J Exp Med. 1989 Mar 01; 169(3):1087-99. PMID: 2466936; PMCID: PMC2189294.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    61. LeBeau MM, Rowley JD. Heritable fragile sites in cancer. Nature. 1984 Apr 12-18; 308(5960):607-8. PMID: 6709072.
      Citations: 35     Fields:    Translation:Humans
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