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Lucy Godley

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Hematology and Oncology
AddressChicago IL 60637
Email
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    Collapse Research 
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    U01HG013745     (FRANKLIN, PATRICIA D)Sep 23, 2024 - Jul 31, 2029
    NIH
    Transforming health at the intersection of implementation science, learning health systems, and genomics at Northwestern Medicine
    Role: Co-Principal Investigator
    U01CA257666     (GODLEY, LUCY ANN)May 1, 2022 - Apr 30, 2026
    NIH
    The role of inflammation in driving leukemogenesis in germline predisposition syndromes
    Role: Principal Investigator
    R01HL155426     (AGARWAL, ANUPRIYA)Jul 1, 2021 - May 31, 2025
    NIH
    Hematopoiesis in germline RUNX1mutation carriers: impact of inflammation and the bone marrow niche
    Role: Co-Principal Investigator
    U24CA258118     (GODLEY, LUCY ANN)Apr 20, 2021 - Jun 30, 2027
    NIH
    Myeloid Malignancy Variant Curation Expert Panel
    Role: Principal Investigator
    R21HG006367     (ZHANG, WEI)Aug 1, 2011 - May 31, 2015
    NIH
    Epigenetic and Genetic Dissection of Drug Response
    Role: Co-Principal Investigator
    R21CA138310     (GODLEY, LUCY ANN)Apr 1, 2009 - Mar 31, 2011
    NIH
    A chemical crosslinking strategy to determine DNA methylating protein complexes
    Role: Principal Investigator
    R01CA129831     (GODLEY, LUCY ANN)Apr 1, 2008 - Feb 28, 2013
    NIH
    The Role of DNMT3B in the DNA Methylation of Cancer Cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nakano Y, Kuiper RP, Nichols KE, Porter CC, Lesmana H, Meade J, Kratz CP, Godley LA, Maese LD, Achatz MI, Khincha PP, Savage SA, Doria AS, Greer MC, Chang VY, Wang LL, Plon SE, Walsh MF, Nakano Y, Kuiper RP, Nichols KE, Porter CC, Lesmana H, Meade J, Kratz CP, Godley LA, Maese LD, Achatz MI, Khincha PP, Savage SA, Doria AS, Greer MC, Chang VY, Wang LL, Plon SE, Walsh MF. Update on Recommendations for Cancer Screening and Surveillance in Children with Genomic Instability Disorders. Clin Cancer Res. 2024 Nov 15; 30(22):5009-5020. PMID: 39264246.
      Citations:    Fields:    
    2. Roloff GW, Kosuri S, Nawas MT, DuVall AS, Patel AA, Riedell PA, Odenike O, Stock W, Larson RA, Bishop MR, Nunley E, Godley LA, Hathaway F, Del Gaudio D, Das S, Canham LE, Drazer MW. Expedited evaluation of hereditary hematopoietic malignancies in the setting of stem cell transplantation. Haematologica. 2024 Nov 01; 109(11):3739-3744. PMID: 38618681; PMCID: PMC11532700.
      Citations:    Fields:    
    3. Zerella JR, Homan CC, Arts P, Lin X, Spinelli SJ, Venugopal P, Babic M, Brautigan P, Truong L, Arriola-Martinez LA, Moore S, Hollins R, Parker W, Nguyen H, Kassahn KS, Branford S, Feurstein SK, Larcher L, Sicre de Fontbrune F, Demirdas S, de Munnik S, Poirel HA, Brichard B, Mansour S, Gordon K, Network EVR, Wlodarski MW, Koppayi AL, Dobbins S, Mutsaers PGNJ, Nichols KE, Oak N, DeMille D, Mao R, Crawford A, McCarrier J, Basel D, Flores-Daboub J, Drazer MW, Phillips K, Poplawski N, Birdsey GM, Pirri D, Ostergaard P, Simons A, Godley LA, Ross DM, Hiwase DK, Soulier J, Brown AL, Carmichael CL, Scott HS, Hahn CN, Zerella JR, Homan CC, Arts P, Lin X, Spinelli SJ, Venugopal P, Babic M, Brautigan PJ, Truong L, Arriola-Martinez L, Moore S, Hollins R, Parker WT, Nguyen H, Kassahn KS, Branford S, Feurstein S, Larcher L, Sicre de Fontbrune F, Demirdas S, de Munnik S, Antoine-Poirel H, Brichard B, Mansour S, Gordon K, Wlodarski MW, Koppayi A, Dobbins S, Mutsaers PGNJ, Nichols KE, Oak N, DeMille D, Mao R, Crawford A, McCarrier J, Basel D, Flores-Daboub J, Drazer MW, Phillips K, Poplawski NK, Birdsey GM, Pirri D, Ostergaard P, Simons A, Godley LA, Ross DM, Hiwase DK, Soulier J, Brown AL, Carmichael CL, Scott HS, Hahn CN. Germ line ERG haploinsufficiency defines a new syndrome with cytopenia and hematological malignancy predisposition. Blood. 2024 10 24; 144(17):1765-1780. PMID: 38991192; PMCID: PMC11530364.
      Citations:    Fields:    Translation:HumansAnimals
    4. Bi H, Ren K, Wang P, Li E, Han X, Wang W, Yang J, Aydemir I, Tao K, Godley L, Liu Y, Shukla V, Bartom ET, Tang Y, Blanc L, Sukhanova M, Ji P. DDX41 dissolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death. bioRxiv. 2024 Oct 17. PMID: 39464073; PMCID: PMC11507670.
      Citations:    
    5. Maese LD, Wlodarski MW, Kim SY, Bertuch AA, Bougeard G, Chang VY, Godley LA, Khincha PP, Kuiper RP, Lesmana H, McGee RB, McReynolds LJ, Meade J, Plon SE, Savage SA, Scollon SR, Scott HS, Walsh MF, Nichols KE, Porter CC, Maese LD, Wlodarski MW, Kim SY, Bertuch AA, Bougeard G, Chang VY, Godley LA, Khincha PP, Kuiper RP, Lesmana H, McGee RB, McReynolds LJ, Meade J, Plon SE, Savage SA, Scollon SR, Scott HS, Walsh MF, Nichols KE, Porter CC. Update on Recommendations for Surveillance for Children with Predisposition to Hematopoietic Malignancy. Clin Cancer Res. 2024 Oct 01; 30(19):4286-4295. PMID: 39078402; PMCID: PMC11444884.
      Citations:    Fields:    Translation:Humans
    6. Döhner H, DiNardo CD, Wei AH, Löwenberg B, Appelbaum F, Craddock C, Dombret H, Ebert BL, Fenaux P, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele GJ, Röllig C, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A. Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations. Blood. 2024 Aug 12. PMID: 39133932.
      Citations: 1     Fields:    
    7. Vormittag-Nocito E, Sukhanova M, Godley LA. The impact of next-generation sequencing for diagnosis and disease understanding of myeloid malignancies. Expert Rev Mol Diagn. 2024 Jul; 24(7):591-600. PMID: 39054632.
      Citations:    Fields:    Translation:Humans
    8. Feng Q, Xu K, Shah M, Li S, Leavitt AD, Godley LA, De Smith AJ, Wiemels JL. Evaluation of the genetic basis of familial-associated early-onset hematologic cancers in an ancestral/ethnically diverse population. Haematologica. 2024 07 01; 109(7):2085-2091. PMID: 38205536; PMCID: PMC11215364.
      Citations:    Fields:    Translation:Humans
    9. Godley LA. What WAS disease risk then versus now? Blood. 2024 06 13; 143(24):2447-2448. PMID: 38869923.
      Citations:    Fields:    
    10. Godley LA, DiNardo CD, Bolton K. Germline Predisposition in Hematologic Malignancies: Testing, Management, and Implications. Am Soc Clin Oncol Educ Book. 2024 Jun; 44(3):e432218. PMID: 38768412.
      Citations:    Fields:    Translation:Humans
    11. Franco S, Godley LA. Myeloid neoplasms in individuals with breast and ovarian cancer and the association with deleterious germline variants. Gynecol Oncol. 2024 08; 187:235-240. PMID: 38823308.
      Citations:    Fields:    Translation:Humans
    12. Saygin C, Zhang P, Stauber J, Aldoss I, Sperling AS, Weeks LD, Luskin MR, Knepper TC, Wanjari P, Wang P, Lager AM, Fitzpatrick C, Segal JP, Gharghabi M, Gurbuxani S, Venkataraman G, Cheng JX, Eisfelder BJ, Bohorquez O, Patel AA, Umesh Nagalakshmi S, Jayaram S, Odenike OM, Larson RA, Godley LA, Arber DA, Gibson CJ, Munshi NC, Marcucci G, Ebert BL, Greally JM, Steidl U, Lapalombella R, Shah BD, Stock W. Acute Lymphoblastic Leukemia with Myeloid Mutations Is a High-Risk Disease Associated with Clonal Hematopoiesis. Blood Cancer Discov. 2024 May 01; 5(3):164-179. PMID: 38150184; PMCID: PMC11061587.
      Citations: 5     Fields:    Translation:Humans
    13. Cobaleda C, Godley LA, Nichols KE, Wlodarski MW, Sanchez-Garcia I. Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions. Cancer Discov. 2024 Mar 01; 14(3):396-405. PMID: 38426560; PMCID: PMC10913756.
      Citations: 1     Fields:    Translation:Humans
    14. Trottier AM, Feurstein S, Godley LA. Germline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders. Best Pract Res Clin Haematol. 2024 Mar; 37(1):101537. PMID: 38490765.
      Citations:    Fields:    Translation:HumansCells
    15. Stubbins RJ, Asom AS, Wang P, Lager AM, Gary A, Godley LA. Germline loss-of-function BRCA1 and BRCA2 mutations and risk of de novo hematopoietic malignancies. Haematologica. 2024 01 01; 109(1):351-356. PMID: 37139596; PMCID: PMC10772530.
      Citations: 3     Fields:    Translation:HumansCells
    16. Kraft IL, Basdag H, Koppayi A, Rodgers CV, Saygin C, Haribabu Y, Wanjari P, Niu N, Das S, de Jong JLO, Segal J, Godley LA. Sequential tumor molecular profiling identifies likely germline variants. Genet Med. 2024 03; 26(3):101037. PMID: 38054407; PMCID: PMC11401608.
      Citations:    Fields:    Translation:HumansCells
    17. Williams KM, Damm F, Porter CC, Williams LS, Gillis N, Bolton K, Deuitch NT, Farhadfar N, Gergis U, Keel SB, Michelis FV, Panch SR, Sucheston-Campbell L, Tamari R, Stefanski HE, Godley LA, Lai C. Donor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation. Transplant Cell Ther. 2024 Mar; 30(3):255-267. PMID: 37913908; PMCID: PMC10947964.
      Citations: 2     Fields:    Translation:Humans
    18. Gurnari C, Robin M, Godley LA, Drozd-Sokolowska J, Wlodarski MW, Raj K, Onida F, Worel N, Ciceri F, Carbacioglu S, Kenyon M, Aljurf M, Bonfim C, Makishima H, Niemeyer C, Fenaux P, Zebisch A, Hamad N, Chalandon Y, Hellström-Lindberg E, Voso MT, Mecucci C, Duarte FB, Sebert M, Sicre de Fontbrune F, Soulier J, Shimamura A, Lindsley RC, Maciejewski JP, Calado RT, Yakoub-Agha I, McLornan DP. Germline predisposition traits in allogeneic hematopoietic stem-cell transplantation for myelodysplastic syndromes: a survey-based study and position paper on behalf of the Chronic Malignancies Working Party of the EBMT. Lancet Haematol. 2023 Dec; 10(12):e994-e1005. PMID: 37898151.
      Citations: 3     Fields:    Translation:Humans
    19. Homan CC, Drazer MW, Yu K, Lawrence DM, Feng J, Arriola-Martinez L, Pozsgai MJ, McNeely KE, Ha T, Venugopal P, Arts P, King-Smith SL, Cheah J, Armstrong M, Wang P, Bödör C, Cantor AB, Cazzola M, Degelman E, DiNardo CD, Duployez N, Favier R, Fröhling S, Rio-Machin A, Klco JM, Krämer A, Kurokawa M, Lee J, Malcovati L, Morgan NV, Natsoulis G, Owen C, Patel KP, Preudhomme C, Raslova H, Rienhoff H, Ripperger T, Schulte R, Tawana K, Velloso E, Yan B, Kim E, Sood R, Hsu AP, Holland SM, Phillips K, Poplawski NK, Babic M, Wei AH, Forsyth C, Mar Fan H, Lewis ID, Cooney J, Susman R, Fox LC, Blombery P, Singhal D, Hiwase D, Phipson B, Schreiber AW, Hahn CN, Scott HS, Liu P, Godley LA, Brown AL, NISC Comparative Sequencing Program. Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41. Blood Adv. 2023 10 24; 7(20):6092-6107. PMID: 37406166; PMCID: PMC10582382.
      Citations: 10     Fields:    Translation:HumansCells
    20. Godley LA. Germ line risk variants: beyond cancer. Blood. 2023 08 17; 142(7):616-617. PMID: 37590029.
      Citations:    Fields:    Translation:Humans
    21. Roloff GW, Wen F, Ramsland A, Artz AS, Kosuri S, Stock W, Odenike O, Larson RA, Liu H, Godley LA, Thirman MJ, Patel AA, Daugherty CK, DuVall AS, Nawas MT, Dworkin E, Wool GD, Gurbuxani S, Fitzpatrick C, Segal JP, Wang P, Drazer MW. Clinical and molecular response of acute myeloid leukemia harboring non-canonical FLT3 N676K driver mutations to contemporary FLT3 inhibitors. Haematologica. 2023 08 01; 108(8):2234-2239. PMID: 36655425; PMCID: PMC10388285.
      Citations: 1     Fields:    Translation:Humans
    22. Liu J, Osman AEG, Bolton K, Godley LA. Germline predisposition to clonal hematopoiesis. Leuk Res. 2023 09; 132:107344. PMID: 37421681.
      Citations:    Fields:    Translation:HumansCells
    23. Gunn K, Myllykoski M, Cao JZ, Ahmed M, Huang B, Rouaisnel B, Diplas BH, Levitt MM, Looper R, Doench JG, Ligon KL, Kornblum HI, McBrayer SK, Yan H, Duy C, Godley LA, Koivunen P, Losman JA. (R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers. Cancer Discov. 2023 06 02; 13(6):1478-1497. PMID: 36847506; PMCID: PMC10238656.
      Citations: 9     Fields:    Translation:HumansCells
    24. Osman AEG, Mencia-Trinchant N, Saygin C, Moma L, Kim A, Housman G, Pozsgai M, Sinha E, Chandra P, Hassane DC, Sboner A, Sangani K, DiNardi N, Johnson C, Wallace SS, Jabri B, Luu H, Guzman ML, Desai P, Godley LA. Paired bone marrow and peripheral blood samples demonstrate lack of widespread dissemination of some CH clones. Blood Adv. 2023 05 09; 7(9):1910-1914. PMID: 36453641; PMCID: PMC10172868.
      Citations: 5     Fields:    Translation:HumansCells
    25. Saheb Kashaf S, Godley LA, Chadha A, Waldinger JB. Systemic mastocytosis, in the context of a deleterious germline SDHC variant, treated with ripretinib. JAAD Case Rep. 2023 Jul; 37:119-122. PMID: 37405177; PMCID: PMC10315773.
      Citations:    
    26. Jung MM, Shen S, Botten GA, Olender T, Katsumura KR, Johnson KD, Soukup AA, Liu P, Zhang Q, Jensvold ZD, Lewis PW, Beagrie RA, Low JK, Yang L, Mackay JP, Godley LA, Brand M, Xu J, Keles S, Bresnick EH. Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks. J Clin Invest. 2023 04 03; 133(7). PMID: 36809258; PMCID: PMC10065080.
      Citations: 3     Fields:    Translation:HumansCells
    27. Makishima H, Bowman TV, Godley LA. DDX41-associated susceptibility to myeloid neoplasms. Blood. 2023 03 30; 141(13):1544-1552. PMID: 36455200; PMCID: PMC10356560.
      Citations: 13     Fields:    Translation:HumansAnimals
    28. Saygin C, Roloff G, Hahn CN, Chhetri R, Gill S, Elmariah H, Talati C, Nunley E, Gao G, Kim A, Bishop M, Kosuri S, Das S, Singhal D, Venugopal P, Homan CC, Brown A, Scott HS, Hiwase D, Godley LA. Allogeneic hematopoietic stem cell transplant outcomes in adults with inherited myeloid malignancies. Blood Adv. 2023 02 28; 7(4):549-554. PMID: 36001442; PMCID: PMC9979761.
      Citations: 16     Fields:    Translation:Humans
    29. Makishima H, Saiki R, Nannya Y, Korotev S, Gurnari C, Takeda J, Momozawa Y, Best S, Krishnamurthy P, Yoshizato T, Atsuta Y, Shiozawa Y, Iijima-Yamashita Y, Yoshida K, Shiraishi Y, Nagata Y, Kakiuchi N, Onizuka M, Chiba K, Tanaka H, Kon A, Ochi Y, Nakagawa MM, Okuda R, Mori T, Yoda A, Itonaga H, Miyazaki Y, Sanada M, Ishikawa T, Chiba S, Tsurumi H, Kasahara S, Takaori-Kondo A, Ohyashiki K, Kiguchi T, Matsuda F, Jansen JH, Polprasert C, Blombery P, Kamatani Y, Miyano S, Malcovati L, Haferlach T, Kubo M, Cazzola M, Kulasekararaj AG, Godley LA, Maciejewski JP, Ogawa S, Müller-Tidow C. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms. Blood. 2023 02 02; 141(5):534-549. PMID: 36322930; PMCID: PMC10935555.
      Citations: 42     Fields:    Translation:HumansCells
    30. Godley LA. Prioritization of patients for germline testing based on tumor profiling of hematopoietic malignancies. Front Oncol. 2023; 13:1084736. PMID: 36793609; PMCID: PMC9923095.
      Citations: 1     
    31. Feurstein S, Trottier AM, Estrada-Merly N, Pozsgai M, McNeely K, Drazer MW, Ruhle B, Sadera K, Koppayi AL, Scott BL, Oran B, Nishihori T, Agrawal V, Saad A, Lindsley RC, Nakamura R, Kim S, Hu Z, Sobecks R, Spellman S, Saber W, Godley LA. Germ line predisposition variants occur in myelodysplastic syndrome patients of all ages. Blood. 2022 12 15; 140(24):2533-2548. PMID: 35969835; PMCID: PMC9918848.
      Citations: 28     Fields:    Translation:HumansCells
    32. Duncavage EJ, Bagg A, Hasserjian RP, DiNardo CD, Godley LA, Iacobucci I, Jaiswal S, Malcovati L, Vannucchi AM, Patel KP, Arber DA, Arcila ME, Bejar R, Berliner N, Borowitz MJ, Branford S, Brown AL, Cargo CA, Falini B, Garcia-Manero G, Haferlach T, Kim AS, Klco JM, Komrokji R, Lee-Cheun Loh M, Loghavi S, Mullighan CG, Ogawa S, Orazi A, Papaemmanuil E, Reiter A, Ross DM, Savona M, Shimamura A, Skoda RC, Stone RM, Tefferi A, Walter MJ, Wu D, Ebert BL, Cazzola M, Döhner H, Hellström-Lindberg E, Solé F. Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia. Blood. 2022 11 24; 140(21):2228-2247. PMID: 36130297; PMCID: PMC10488320.
      Citations: 47     Fields:    Translation:Humans
    33. Niemeyer CM, Shimamura A, Flotho C, Hasle H, Stieglitz E, Strahm B, Godley LA, Weinberg OK, Orazi A, Calvo KR, Rudelius M. Classification of rare pediatric myeloid neoplasia-Quo vadis? Leukemia. 2022 12; 36(12):2947-2948. PMID: 36271151.
      Citations: 1     Fields:    Translation:Humans
    34. Kubota Y, Zawit M, Durrani J, Shen W, Bahaj W, Kewan T, Ponvilawan B, Mori M, Meggendorfer M, Gurnari C, LaFramboise T, Feurstein S, Sekeres MA, Visconte V, Godley LA, Haferlach T, Maciejewski JP. Significance of hereditary gene alterations for the pathogenesis of adult bone marrow failure versus myeloid neoplasia. Leukemia. 2022 12; 36(12):2827-2834. PMID: 36266327.
      Citations: 8     Fields:    Translation:Humans
    35. Wei AH, Appelbaum FR, Craddock C, DiNardo CD, Ebert BL, Godley LA, Hasserjian RP, Larson RA, Levine RL, Miyazaki Y, Niederwieser D, Ossenkoppele G, Sierra J, Stein EM, Tallman MS, Tien HF, Wang J, Wierzbowska A, Döhner H, Dombret H, Fenaux P, Röllig C, Löwenberg B. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN. Blood. 2022 09 22; 140(12):1345-1377. PMID: 35797463.
      Citations: 651     Fields:    Translation:Humans
    36. Nam AS, Dusaj N, Izzo F, Murali R, Myers RM, Mouhieddine TH, Sotelo J, Benbarche S, Waarts M, Gaiti F, Tahri S, Levine R, Abdel-Wahab O, Godley LA, Chaligne R, Ghobrial I, Landau DA. Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation. Nat Genet. 2022 10; 54(10):1514-1526. PMID: 36138229; PMCID: PMC10068894.
      Citations: 44     Fields:    Translation:Humans
    37. Arber DA, Orazi A, Hasserjian RP, Borowitz MJ, Calvo KR, Wang SA, Bagg A, Barbui T, Branford S, Bueso-Ramos CE, Cortes JE, Dal Cin P, DiNardo CD, Duncavage EJ, Ebert BL, Estey EH, Facchetti F, Foucar K, Gangat N, Godley LA, Gotlib J, Hobbs GS, Hoffman R, Jabbour EJ, Larson RA, Le Beau MM, Loh ML, Malcovati L, Mullighan CG, Niemeyer C, Odenike OM, Ogawa S, Orfao A, Papaemmanuil E, Passamonti F, Porkka K, Pui CH, Radich JP, Reiter A, Rozman M, Rudelius M, Savona MR, Schiffer CA, Schmitt-Graeff A, Shimamura A, Sierra J, Stock WA, Stone RM, Tallman MS, Tien HF, Tzankov A, Vannucchi AM, Vyas P, Wei AH, Weinberg OK, Wierzbowska A, Cazzola M, Tefferi A, Kvasnicka HM, Dombret H, Gianelli U, Gökbuget N, Hellström-Lindberg E, Kiladjian JJ, Löwenberg B, Macintyre E, Thiele J, Döhner H. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022 09 15; 140(11):1200-1228. PMID: 35767897; PMCID: PMC9479031.
      Citations: 562     Fields:    Translation:Humans
    38. Feurstein S, Luo X, Shah M, Walker T, Mehta N, Wu D, Godley LA. Revision of RUNX1 variant curation rules. Blood Adv. 2022 08 23; 6(16):4726-4730. PMID: 35764482; PMCID: PMC9631670.
      Citations: 6     Fields:    
    39. Homan CC, Yu K, Segal JP, Wang P, Feng J, King-Smith SL, Kim E, Lawrence DM, Schreiber AW, Hahn CN, Scott HS, Sood R, NISC Comparative Sequencing Program, Velloso EDRP, Brown AL, Liu PP, Drazer MW, Cavalcante de Andrade Silva M, McNeely KE, Pozsgai MJ, Acevedo-Mendez MG, Korotev S, Godley LA. Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations. Blood Adv. 2022 08 09; 6(15):4357-4359. PMID: 35537115; PMCID: PMC9636309.
      Citations: 9     Fields:    Translation:Humans
    40. Hains AE, Uppal S, Cao JZ, Salwen HR, Applebaum MA, Cohn SL, Godley LA. MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia. Epigenetics. 2022 12; 17(13):2056-2074. PMID: 35942521; PMCID: PMC9665154.
      Citations: 1     Fields:    Translation:HumansCells
    41. Stubbins RJ, Korotev S, Godley LA. Germline CHEK2 and ATM Variants in Myeloid and Other Hematopoietic Malignancies. Curr Hematol Malig Rep. 2022 08; 17(4):94-104. PMID: 35674998.
      Citations: 13     Fields:    Translation:HumansCells
    42. DeRoin L, Petras K, Arndt K, Phillips N, Wanjari P, Subramanian HP, Montes D, McElherne J, Theissen M, Briese R, Das S, Godley LA, Segal J, Del Gaudio D, Fitzpatrick C, Churpek JE, Cavalcante de Andrade Silva M. Feasibility and limitations of cultured skin fibroblasts for germline genetic testing in hematologic disorders. Hum Mutat. 2022 07; 43(7):950-962. PMID: 35419889; PMCID: PMC9177640.
      Citations: 11     Fields:    Translation:HumansCells
    43. Feurstein S, Hahn CN, Mehta N, Godley LA. A practical guide to interpreting germline variants that drive hematopoietic malignancies, bone marrow failure, and chronic cytopenias. Genet Med. 2022 04; 24(4):931-954. PMID: 35063349.
      Citations: 7     Fields:    Translation:HumansCells
    44. Cao JZ, Bigelow K, Wickrema A, Godley LA. BET inhibitors enhance embryonic and fetal globin expression in erythroleukemia cell lines. Haematologica. 2021 12 01; 106(12):3223-3227. PMID: 34435481; PMCID: PMC8634195.
      Citations:    Fields:    Translation:HumansCells
    45. Pan M, Wright WC, Chapple RH, Zubair A, Sandhu M, Batchelder JE, Huddle BC, Low J, Blankenship KB, Wang Y, Gordon B, Archer P, Brady SW, Natarajan S, Posgai MJ, Schuetz J, Miller D, Kalathur R, Chen S, Connelly JP, Babu MM, Dyer MA, Pruett-Miller SM, Freeman BB, Chen T, Godley LA, Blanchard SC, Stewart E, Easton J, Geeleher P. The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. Nat Commun. 2021 11 09; 12(1):6468. PMID: 34753908; PMCID: PMC8578635.
      Citations: 28     Fields:    Translation:AnimalsCells
    46. Roloff GW, Drazer MW, Godley LA. Inherited Susceptibility to Hematopoietic Malignancies in the Era of Precision Oncology. JCO Precis Oncol. 2021 11; 5:107-122. PMID: 34994594.
      Citations: 12     Fields:    Translation:Humans
    47. Homan CC, King-Smith SL, Lawrence DM, Arts P, Feng J, Andrews J, Armstrong M, Ha T, Dobbins J, Drazer MW, Yu K, Cantor A, Cazzola M, Degelman E, DiNardo CD, Duployez N, Fitzgibbon J, Klco JM, Kurokawa M, Lee J, Malcovati L, Morgan NV, Natsoulis G, Owen C, Patel KP, Preudhomme C, Rienhoff H, Ripperger T, Schulte R, Tawana K, Velloso E, Yan B, Liu P, Godley LA, Schreiber AW, Hahn CN, Scott HS, Brown AL, Bödör C, Favier R, Fröhling S, Krämer A, Raslova H. The RUNX1 database (RUNX1db): establishment of an expert curated RUNX1 registry and genomics database as a public resource for familial platelet disorder with myeloid malignancy. Haematologica. 2021 11 01; 106(11):3004-3007. PMID: 34233450; PMCID: PMC8561292.
      Citations: 14     Fields:    Translation:Humans
    48. Patel AA, Rojek AE, Drazer MW, Weiner H, Godley LA, Le Beau MM, Larson RA. Therapy-related myeloid neoplasms in 109 patients after radiation monotherapy. Blood Adv. 2021 10 26; 5(20):4140-4148. PMID: 34492705; PMCID: PMC8945635.
      Citations: 10     Fields:    Translation:HumansCells
    49. Feurstein S, Drazer M, Godley LA. Germline predisposition to hematopoietic malignancies. Hum Mol Genet. 2021 10 01; 30(20):R225-R235. PMID: 34100074.
      Citations: 14     Fields:    Translation:Humans
    50. Godley LA. Anticipation in hematopoietic malignancies: biology, bias, or both? Leuk Lymphoma. 2021 12; 62(13):3070-3072. PMID: 34405775.
      Citations:    Fields:    Translation:Humans
    51. Saygin C, Godley LA. Genetics of Myelodysplastic Syndromes. Cancers (Basel). 2021 Jul 06; 13(14). PMID: 34298596; PMCID: PMC8304604.
      Citations: 6     
    52. Feng Q, Nickels E, Muskens IS, de Smith AJ, Gauderman WJ, Yee AC, Ricker C, Mack T, Leavitt AD, Godley LA, Wiemels JL. Increased burden of familial-associated early-onset cancer risk among minority Americans compared to non-Latino Whites. Elife. 2021 06 22; 10. PMID: 34155975; PMCID: PMC8219377.
      Citations: 3     Fields:    Translation:Humans
    53. Patel AA, Heng J, Dworkin E, Monick S, Derman BA, DuVall AS, Gurbuxani S, Kosuri S, Liu H, Thirman M, Godley LA, Odenike O, Larson RA, Stock W. Efficacy and tolerability of a modified pediatric-inspired intensive regimen for acute lymphoblastic leukemia in older adults. EJHaem. 2021 Aug; 2(3):413-420. PMID: 35844676; PMCID: PMC9175801.
      Citations: 3     
    54. St Martin EC, Ferrer A, Wudhikarn K, Mangaonkar A, Hogan W, Tefferi A, Gangat N, Lasho T, Altman JK, Godley LA, Patnaik MM. Clinical features and survival outcomes in patients with chronic myelomonocytic leukemia arising in the context of germline predisposition syndromes. Am J Hematol. 2021 09 01; 96(9):E327-E330. PMID: 34028844.
      Citations: 5     Fields:    Translation:HumansCells
    55. Borst S, Nations CC, Klein JG, Pavani G, Maguire JA, Camire RM, Drazer MW, Godley LA, French DL, Poncz M, Gadue P. Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model. Stem Cell Reports. 2021 06 08; 16(6):1458-1467. PMID: 34019812; PMCID: PMC8190596.
      Citations: 8     Fields:    Translation:HumansCells
    56. Samra N, Toubiana S, Tzur-Gilat A, Morani I, Itzkovich C, Giladi L, Abu Jabal K, Cao JZ, Godley LA, Mory A, Baris Feldman H, Tveten K, Selig S, Weiss K, Yttervik H. RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function. J Hum Genet. 2021 Nov; 66(11):1101-1112. PMID: 33980986.
      Citations:    Fields:    Translation:HumansAnimalsCells
    57. Singhal D, Hahn CN, Feurstein S, Wee LYA, Moma L, Kutyna MM, Chhetri R, Eshraghi L, Schreiber AW, Feng J, Wang PP, Babic M, Parker WT, Gao S, Moore S, Das S, Thomas D, Pattnaik S, Brown AL, D'Andrea RJ, Poplawski NK, Thomas D, Scott HS, Godley LA, Hiwase DK. Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer. Leukemia. 2021 11; 35(11):3245-3256. PMID: 33850299.
      Citations: 28     Fields:    Translation:Humans
    58. Godley LA. Germline mutations in MDS/AML predisposition disorders. Curr Opin Hematol. 2021 03 01; 28(2):86-93. PMID: 33394724.
      Citations: 8     Fields:    Translation:Humans
    59. Feurstein S, Churpek JE, Walsh T, Keel S, Hakkarainen M, Schroeder T, Germing U, Geyh S, Heuser M, Thol F, Pohlkamp C, Haferlach T, Gao J, Owen C, Goehring G, Schlegelberger B, Verma D, Krause DS, Gao G, Cronin T, Gulsuner S, Lee M, Pritchard CC, Subramanian HP, Del Gaudio D, Li Z, Das S, Kilpivaara O, Wartiovaara-Kautto U, Wang ES, Griffiths EA, King MC, Godley LA, Döhner K, Döhner H. Germline variants drive myelodysplastic syndrome in young adults. Leukemia. 2021 08; 35(8):2439-2444. PMID: 33510405; PMCID: PMC8725861.
      Citations: 22     Fields:    Translation:Humans
    60. Trottier AM, Godley LA. Inherited predisposition to haematopoietic malignancies: overcoming barriers and exploring opportunities. Br J Haematol. 2021 08; 194(4):663-676. PMID: 33615436.
      Citations: 10     Fields:    Translation:HumansAnimals
    61. Kraft IL, Godley LA. Identifying potential germline variants from sequencing hematopoietic malignancies. Hematology Am Soc Hematol Educ Program. 2020 12 04; 2020(1):219-227. PMID: 33275754; PMCID: PMC7727528.
      Citations: 16     Fields:    Translation:Humans
    62. Kraft IL, Godley LA. Identifying potential germline variants from sequencing hematopoietic malignancies. Blood. 2020 11 26; 136(22):2498-2506. PMID: 33236764.
      Citations: 18     Fields:    Translation:Humans
    63. Toubiana S, Larom G, Smoom R, Duszynski RJ, Godley LA, Selig S, Francastel C, Velasco G. Regulation of telomeric function by DNA methylation differs between humans and mice. Hum Mol Genet. 2020 11 25; 29(19):3197-3210. PMID: 32916696.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    64. Trottier AM, Druhan LJ, Kraft IL, Lance A, Feurstein S, Helgeson M, Segal JP, Das S, Avalos BR, Godley LA. Heterozygous germ line CSF3R variants as risk alleles for development of hematologic malignancies. Blood Adv. 2020 10 27; 4(20):5269-5284. PMID: 33108454; PMCID: PMC7594406.
      Citations: 11     Fields:    Translation:HumansCells
    65. Feurstein S, Adegunsoye A, Mojsilovic D, Vij R, West DePersia AH, Rajagopal PS, Osman A, Collins RH, Kim RH, Gore SD, Greenberg P, Godley LA, Li Z, Del Gaudio D, Subramanian HP, Das S, Walsh T, Gulsuner S, Segal JP, Husain AN, Gurbuxani S, King MC, Strek ME, Churpek JE. Telomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations. Blood Adv. 2020 10 13; 4(19):4873-4886. PMID: 33035329; PMCID: PMC7556157.
      Citations: 14     Fields:    Translation:Cells
    66. Roloff GW, Godley LA, Drazer MW. Assessment of technical heterogeneity among diagnostic tests to detect germline risk variants for hematopoietic malignancies. Genet Med. 2021 01; 23(1):211-214. PMID: 32807974; PMCID: PMC9299956.
      Citations: 6     Fields:    Translation:HumansCells
    67. Cao JZ, Liu H, Wickrema A, Godley LA. HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia. Blood Adv. 2020 07 14; 4(13):3053-3062. PMID: 32634239; PMCID: PMC7362358.
      Citations: 11     Fields:    Translation:HumansAnimals
    68. Katsumura KR, Mehta C, Bresnick EH, Godley LA, Cavalcante de Andrade Silva M, Velloso EDRP. Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome. Leukemia. 2021 01; 35(1):264-268. PMID: 32286542.
      Citations: 10     Fields:    Translation:HumansCells
    69. Brown AL, Arts P, Carmichael CL, Babic M, Dobbins J, Chong CE, Schreiber AW, Feng J, Phillips K, Wang PPS, Ha T, Homan CC, King-Smith SL, Rawlings L, Vakulin C, Dubowsky A, Burdett J, Moore S, McKavanagh G, Henry D, Wells A, Mercorella B, Nicola M, Suttle J, Wilkins E, Li XC, Michaud J, Brautigan P, Cannon P, Altree M, Jaensch L, Fine M, Butcher C, D'Andrea RJ, Lewis ID, Hiwase DK, Papaemmanuil E, Horwitz MS, Natsoulis G, Rienhoff HY, Patton N, Mapp S, Susman R, Morgan S, Cooney J, Currie M, Popat U, Bochtler T, Izraeli S, Bradstock K, Godley LA, Wei AH, Forsyth C, Mar Fan H, Poplawski NK, Hahn CN, Scott HS, Krämer A, Fröhling S. RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML. Blood Adv. 2020 03 24; 4(6):1131-1144. PMID: 32208489; PMCID: PMC7094007.
      Citations: 57     Fields:    Translation:HumansCells
    70. Wu D, Luo X, Feurstein S, Kesserwan C, Mohan S, Pineda-Alvarez DE, Godley LA, collaborative group of the American Society of Hematology - Clinical Genome Resource Myeloid Maligna. How I curate: applying American Society of Hematology-Clinical Genome Resource Myeloid Malignancy Variant Curation Expert Panel rules for RUNX1 variant curation for germline predisposition to myeloid malignancies. Haematologica. 2020 04; 105(4):870-887. PMID: 32165484; PMCID: PMC7109758.
      Citations: 12     Fields:    Translation:HumansCells
    71. Cahill KE, Karimi YH, Karrison TG, Jain N, Green M, Weiner H, Fulton N, Kadri S, Godley LA, Artz AS, Liu H, Thirman MJ, Le Beau MM, McNerney ME, Segal J, Larson RA, Stock W, Odenike O. A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia. Blood Adv. 2020 02 25; 4(4):599-606. PMID: 32074275; PMCID: PMC7042987.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    72. Qiu Z, Lin AP, Jiang S, Elkashef SM, Myers J, Srikantan S, Sasi B, Cao JZ, Godley LA, Rakheja D, Lyu Y, Zheng S, Madesh M, Shiio Y, Dahia PLM, Aguiar RCT. MYC Regulation of D2HGDH and L2HGDH Influences the Epigenome and Epitranscriptome. Cell Chem Biol. 2020 05 21; 27(5):538-550.e7. PMID: 32101699; PMCID: PMC7714266.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    73. Kewan T, Noss R, Godley LA, Rogers HJ, Carraway HE. Inherited Thrombocytopenia Caused by Germline ANKRD26 Mutation Should Be Considered in Young Patients With Suspected Myelodysplastic Syndrome. J Investig Med High Impact Case Rep. 2020 Jan-Dec; 8:2324709620938941. PMID: 32618208; PMCID: PMC7493274.
      Citations: 3     Fields:    Translation:Humans
    74. Applebaum MA, Barr EK, Karpus J, West-Szymanski DC, Oliva M, Sokol EA, Zhang S, Zhang Z, Zhang W, Chlenski A, Salwen HR, Wilkinson E, Dobratic M, Grossman RL, Godley LA, Stranger BE, He C, Cohn SL. 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma. Clin Cancer Res. 2020 03 15; 26(6):1309-1317. PMID: 31852832; PMCID: PMC7073281.
      Citations: 16     Fields:    Translation:HumansCells
    75. Brown AL, Hahn C, Hiwase D, Godley LA, Scott HS. Correct application of variant classification guidelines in germline RUNX1 mutated disorders to assist clinical diagnosis. Leuk Lymphoma. 2020 01; 61(1):246-247. PMID: 31647332.
      Citations: 1     Fields:    Translation:HumansCells
    76. Luo X, Feurstein S, Mohan S, Porter CC, Jackson SA, Keel S, Chicka M, Brown AL, Kesserwan C, Agarwal A, Luo M, Li Z, Ross JE, Baliakas P, Pineda-Alvarez D, DiNardo CD, Bertuch AA, Mehta N, Vulliamy T, Wang Y, Nichols KE, Malcovati L, Walsh MF, Rawlings LH, McWeeney SK, Routbort MJ, Zhang L, Ryan G, Speck NA, Plon SE, Wu D, Godley LA, Soulier J, Raimbault A. ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants. Blood Adv. 2019 10 22; 3(20):2962-2979. PMID: 31648317; PMCID: PMC6849945.
      Citations: 58     Fields:    Translation:Humans
    77. Godley LA. Inherited predisposition to myeloid malignancies. Blood Adv. 2019 09 10; 3(17):2688. PMID: 31506287; PMCID: PMC6737419.
      Citations: 2     Fields:    Translation:Humans
    78. Godley LA. FouNdER mutations confer risk for leukemias. Blood. 2019 06 20; 133(25):2636-2638. PMID: 31221794.
      Citations:    Fields:    Translation:HumansCells
    79. Applebaum MA, Barr EK, Karpus J, Nie J, Zhang Z, Armstrong AE, Uppal S, Sukhanova M, Zhang W, Chlenski A, Salwen HR, Wilkinson E, Dobratic M, Grossman R, Godley LA, Stranger BE, He C, Cohn SL. 5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype. JCO Precis Oncol. 2019; 3. PMID: 31179414; PMCID: PMC6553657.
      Citations: 14     Fields:    
    80. Trottier AM, Cavalcante de Andrade Silva M, Li Z, Godley LA. Somatic mutation panels: Time to clear their names. Cancer Genet. 2019 06; 235-236:84-92. PMID: 31101556.
      Citations: 8     Fields:    Translation:HumansCells
    81. Jeong JJ, Gu X, Nie J, Sundaravel S, Liu H, Kuo WL, Bhagat TD, Pradhan K, Cao J, Nischal S, McGraw KL, Bhattacharyya S, Bishop MR, Artz A, Thirman MJ, Moliterno A, Ji P, Levine RL, Godley LA, Steidl U, Bieker JJ, List AF, Saunthararajah Y, He C, Verma A, Wickrema A. Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis. Cancer Discov. 2019 06; 9(6):778-795. PMID: 30944118; PMCID: PMC6697164.
      Citations: 29     Fields:    Translation:HumansCells
    82. Moshfegh CM, Collins CW, Gunda V, Vasanthakumar A, Cao JZ, Singh PK, Godley LA, Case AJ. Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes. Redox Biol. 2019 10; 27:101141. PMID: 30819616; PMCID: PMC6859572.
      Citations: 16     Fields:    Translation:AnimalsCells
    83. Fan Y, Artz AS, van Besien K, Stock W, Larson RA, Odenike O, Godley LA, Kline J, Cunningham JM, LaBelle JL, Bishop MR, Liu H. Outcomes following second allogeneic stem cell transplant for disease relapse after T cell depleted transplant correlate with remission status and remission duration after the first transplant. Exp Hematol Oncol. 2019; 8:1. PMID: 30622841; PMCID: PMC6317199.
      Citations: 5     
    84. Akpan IJ, Osman AEG, Drazer MW, Godley LA. Hereditary Myelodysplastic Syndrome and Acute Myeloid Leukemia: Diagnosis, Questions, and Controversies. Curr Hematol Malig Rep. 2018 12; 13(6):426-434. PMID: 30259338.
      Citations: 4     Fields:    Translation:Humans
    85. Osman AEG, Anderson J, Churpek JE, Christ TN, Curran E, Godley LA, Liu H, Thirman MJ, Odenike T, Stock W, Larson RA. Treatment of Acute Promyelocytic Leukemia in Adults. J Oncol Pract. 2018 11; 14(11):649-657. PMID: 30423270.
      Citations: 28     Fields:    Translation:Humans
    86. Godley LA, Busque L. MBD4: guardian of the epigenetic galaxy. Blood. 2018 10 04; 132(14):1468-1469. PMID: 30287469.
      Citations:    Fields:    Translation:HumansCells
    87. Obrochta E, Godley LA. Identifying patients with genetic predisposition to acute myeloid leukemia. Best Pract Res Clin Haematol. 2018 12; 31(4):373-378. PMID: 30466750.
      Citations: 8     Fields:    Translation:Humans
    88. D'Angelo CR, Novitsky B, Mee Lee S, Godley LA, Kline J, Larson RA, Liu H, Odenike O, Stock W, Bishop MR, Artz AS. Characterization of cancer comorbidity prior to allogeneic hematopoietic cell transplantation. Leuk Lymphoma. 2019 03; 60(3):629-638. PMID: 30070150.
      Citations: 2     Fields:    Translation:Humans
    89. Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Godley LA, Barreiro LB, Jabri B, Buscarlet M, Busque L, Verdú EF. Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature. 2018 05; 557(7706):580-584. PMID: 29769727; PMCID: PMC6238954.
      Citations: 196     Fields:    Translation:AnimalsCells
    90. Wei X, Calvo-Vidal MN, Chen S, Wu G, Revuelta MV, Sun J, Zhang J, Walsh MF, Nichols KE, Joseph V, Snyder C, Vachon CM, McKay JD, Wang SP, Jayabalan DS, Jacobs LM, Becirovic D, Waller RG, Artomov M, Viale A, Patel J, Phillip J, Chen-Kiang S, Curtin K, Salama M, Atanackovic D, Niesvizky R, Landgren O, Slager SL, Godley LA, Churpek J, Garber JE, Anderson KC, Daly MJ, Roeder RG, Dumontet C, Lynch HT, Mullighan CG, Camp NJ, Offit K, Klein RJ, Yu H, Cerchietti L, Lipkin SM. Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma. Cancer Res. 2018 05 15; 78(10):2747-2759. PMID: 29559475; PMCID: PMC5955848.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    91. Drazer MW, Kadri S, Sukhanova M, Patil SA, West AH, Feurstein S, Calderon DA, Jones MF, Weipert CM, Daugherty CK, Raca G, Lingen MW, Li Z, Segal JP, Churpek JE, Godley LA, Ceballos-López AA. Prognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies. Blood Adv. 2018 01 23; 2(2):146-150. PMID: 29365323; PMCID: PMC5787862.
      Citations: 43     Fields:    Translation:HumansCells
    92. Wang AY, Weiner H, Green M, Chang H, Fulton N, Larson RA, Odenike O, Artz AS, Bishop MR, Godley LA, Thirman MJ, Kosuri S, Churpek JE, Curran E, Pettit K, Stock W, Liu H. A phase I study of selinexor in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia. J Hematol Oncol. 2018 01 05; 11(1):4. PMID: 29304833; PMCID: PMC5756334.
      Citations: 30     Fields:    Translation:HumansCTClinical Trials
    93. Tsai SB, Rhodes J, Liu H, Shore T, Bishop M, Cushing MM, Gergis U, Godley L, Kline J, Larson RA, Mayer S, Odenike O, Stock W, Wickrema A, van Besien K, Artz AS. Reduced-Intensity Allogeneic Transplant for Acute Myeloid Leukemia and Myelodysplastic Syndrome Using Combined CD34-Selected Haploidentical Graft and a Single Umbilical Cord Unit Compared with Matched Unrelated Donor Stem Cells in Older Adults. Biol Blood Marrow Transplant. 2018 05; 24(5):997-1004. PMID: 29288821.
      Citations: 7     Fields:    Translation:Humans
    94. Desai AV, Perpich M, Godley LA. Clinical Assessment and Diagnosis of Germline Predisposition to Hematopoietic Malignancies: The University of Chicago Experience. Front Pediatr. 2017; 5:252. PMID: 29270394; PMCID: PMC5723667.
      Citations: 7     
    95. Godley LA. Mutant RUNX1 and histone tales. Blood. 2017 11 16; 130(20):2156-2157. PMID: 29146818.
      Citations:    Fields:    Translation:Humans
    96. Bhattacharyya S, Pradhan K, Campbell N, Mazdo J, Vasantkumar A, Maqbool S, Bhagat TD, Gupta S, Suzuki M, Yu Y, Greally JM, Steidl U, Bradner J, Dawlaty M, Godley L, Maitra A, Verma A. Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways. Genome Res. 2017 11; 27(11):1830-1842. PMID: 28986391; PMCID: PMC5668941.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    97. McNerney ME, Godley LA, Le Beau MM. Therapy-related myeloid neoplasms: when genetics and environment collide. Nat Rev Cancer. 2017 08 24; 17(9):513-527. PMID: 28835720; PMCID: PMC5946699.
      Citations: 150     Fields:    Translation:HumansCellsPHPublic Health
    98. Godley LA, Shimamura A. Genetic predisposition to hematologic malignancies: management and surveillance. Blood. 2017 07 27; 130(4):424-432. PMID: 28600339; PMCID: PMC5533201.
      Citations: 66     Fields:    Translation:Humans
    99. Feurstein S, Godley LA. Germline ETV6 mutations and predisposition to hematological malignancies. Int J Hematol. 2017 Aug; 106(2):189-195. PMID: 28555414.
      Citations: 25     Fields:    Translation:HumansCells
    100. Brown AL, Churpek JE, Malcovati L, Godley LA, Döhner H. Recognition of familial myeloid neoplasia in adults. Semin Hematol. 2017 04; 54(2):60-68. PMID: 28637618.
      Citations: 21     Fields:    Translation:Humans
    101. Godley LA. DNAJC21: the new kid on the SDS block. Blood. 2017 03 16; 129(11):1413-1414. PMID: 28302692.
      Citations: 3     Fields:    
    102. Khan N, Hantel A, Knoebel RW, Artz A, Larson RA, Godley LA, Thirman MJ, Liu H, Churpek JE, King D, Odenike O, Stock W. Efficacy of single-agent decitabine in relapsed and refractory acute myeloid leukemia. Leuk Lymphoma. 2017 09; 58(9):1-7. PMID: 28278716.
      Citations: 12     Fields:    Translation:Humans
    103. Guidugli L, Johnson AK, Alkorta-Aranburu G, Nelakuditi V, Arndt K, Churpek JE, Godley LA, Townsley D, Young NS, Fitzpatrick C, Del Gaudio D, Das S, Li Z. Clinical utility of gene panel-based testing for hereditary myelodysplastic syndrome/acute leukemia predisposition syndromes. Leukemia. 2017 05; 31(5):1226-1229. PMID: 28104920; PMCID: PMC5420790.
      Citations: 25     Fields:    Translation:Humans
    104. Applebaum MA, Jha AR, Kao C, Hernandez KM, DeWane G, Salwen HR, Chlenski A, Dobratic M, Mariani CJ, Godley LA, Prabhakar N, White K, Stranger BE, Cohn SL. Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients. Oncotarget. 2016 Nov 22; 7(47):76816-76826. PMID: 27765905; PMCID: PMC5340231.
      Citations: 23     Fields:    Translation:HumansCells
    105. Drazer MW, Godley LA, Feurstein S. Genetic predisposition to leukemia and other hematologic malignancies. Semin Oncol. 2016 Oct; 43(5):598-608. PMID: 27899193.
      Citations: 30     Fields:    Translation:Humans
    106. Rojek K, Nickels E, Neistadt B, Marquez R, Wickrema A, Artz A, van Besien K, Larson RA, Lee MK, Segal JP, King MC, Walsh T, Shimamura A, Keel SB, Churpek JE, Godley LA. Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy. Biol Blood Marrow Transplant. 2016 11; 22(11):2100-2103. PMID: 27497531; PMCID: PMC5592729.
      Citations: 22     Fields:    Translation:Humans
    107. University of Chicago Hematopoietic Malignancies Cancer Risk Team. How I diagnose and manage individuals at risk for inherited myeloid malignancies. Blood. 2016 10 06; 128(14):1800-1813. PMID: 27471235; PMCID: PMC5813725.
      Citations: 72     Fields:    Translation:Humans
    108. Chapman CG, Mariani CJ, Wu F, Meckel K, Butun F, Chuang A, Madzo J, Bissonnette MB, Kwon JH, Godley LA. Corrigendum: TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer. Sci Rep. 2016 04 28; 6:24963. PMID: 27121680; PMCID: PMC4849087.
      Citations: 3     Fields:    
    109. DiNardo CD, Bannon SA, Routbort M, Franklin A, Mork M, Armanios M, Mace EM, Orange JS, Jeff-Eke M, Churpek JE, Takahashi K, Jorgensen JL, Garcia-Manero G, Kornblau S, Bertuch A, Cheung H, Bhalla K, Futreal A, Godley LA, Patel KP. Evaluation of Patients and Families With Concern for Predispositions to Hematologic Malignancies Within the Hereditary Hematologic Malignancy Clinic (HHMC). Clin Lymphoma Myeloma Leuk. 2016 07; 16(7):417-428.e2. PMID: 27210295; PMCID: PMC4925265.
      Citations: 41     Fields:    Translation:Humans
    110. Garcia-Manero G, Al-Kali A, Baer MR, Sekeres MA, Roboz GJ, Gaidano G, Scott BL, Greenberg P, Steensma DP, Kambhampati S, Godley LA, Atallah E, Collins R, Kantarjian H, Jabbour E, Wilhelm FE, Azarnia N, Silverman LR, ONTIME study investigators, Fenaux P, Platzbecker U, Kreuzer KA. Rigosertib versus best supportive care for patients with high-risk myelodysplastic syndromes after failure of hypomethylating drugs (ONTIME): a randomised, controlled, phase 3 trial. Lancet Oncol. 2016 Apr; 17(4):496-508. PMID: 26968357.
      Citations: 75     Fields:    Translation:HumansCellsCTClinical Trials
    111. Tsai SB, Liu H, Shore T, Fan Y, Bishop M, Cushing MM, Gergis U, Godley L, Kline J, Larson RA, Martinez G, Mayer S, Odenike O, Stock W, Wickrema A, van Besien K, Artz AS. Frequency and Risk Factors Associated with Cord Graft Failure after Transplant with Single-Unit Umbilical Cord Cells Supplemented by Haploidentical Cells with Reduced-Intensity Conditioning. Biol Blood Marrow Transplant. 2016 06; 22(6):1065-1072. PMID: 26912055; PMCID: PMC4867292.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    112. Vasanthakumar A, Godley LA. Erratum to "5-hydroxymethylcytosine in cancer: Significance in diagnosis and therapy" [Cancer Genet 208 (2015):167-177]. Cancer Genet. 2016 Apr; 209(4):177. PMID: 27085961.
      Citations:    Fields:    
    113. van Besien K, Hari P, Zhang MJ, Liu HT, Stock W, Godley L, Odenike O, Larson R, Bishop M, Wickrema A, Gergis U, Mayer S, Shore T, Tsai S, Rhodes J, Cushing MM, Korman S, Artz A. Reduced intensity haplo plus single cord transplant compared to double cord transplant: improved engraftment and graft-versus-host disease-free, relapse-free survival. Haematologica. 2016 05; 101(5):634-43. PMID: 26869630; PMCID: PMC5004373.
      Citations: 13     Fields:    Translation:HumansCellsCTClinical Trials
    114. Schulze I, Rohde C, Scheller-Wendorff M, Herbst F, Riemke P, Tschanter P, Linhart H, Godley LA, Glimm H, Rosenbauer F, Bäumer N, Krause A, Hebestreit K, Lin Q, Dugas M, Wagner W, Berdel WE, Müller-Tidow C. Increased DNA methylation of Dnmt3b targets impairs leukemogenesis. Blood. 2016 Mar 24; 127(12):1575-86. PMID: 26729896.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    115. Lewinsohn M, Brown AL, Weinel LM, Phung C, Rafidi G, Lee MK, Schreiber AW, Feng J, Babic M, Chong CE, Lee Y, Yong A, Suthers GK, Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D'Andrea RJ, Lewis ID, Medeiros BC, Pollyea DA, King MC, Walsh T, Shimamura A, Godley LA, Hahn CN, Churpek JE, Scott HS, Keel S. Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies. Blood. 2016 Feb 25; 127(8):1017-23. PMID: 26712909; PMCID: PMC4968341.
      Citations: 98     Fields:    Translation:Humans
    116. D'Angelo CR, Kocherginsky M, Pisano J, Bishop MR, Godley LA, Kline J, Larson RA, Liu H, Odenike O, Stock W, Artz AS. Incidence and predictors of respiratory viral infections by multiplex PCR in allogeneic hematopoietic cell transplant recipients 50 years and older including geriatric assessment. Leuk Lymphoma. 2016 08; 57(8):1807-13. PMID: 26699199.
      Citations: 10     Fields:    Translation:HumansCells
    117. Laukka T, Mariani CJ, Ihantola T, Cao JZ, Hokkanen J, Kaelin WG, Godley LA, Koivunen P. Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes. J Biol Chem. 2016 Feb 19; 291(8):4256-65. PMID: 26703470; PMCID: PMC4759199.
      Citations: 153     Fields:    Translation:HumansAnimalsCells
    118. Churpek JE, Marquez R, Neistadt B, Claussen K, Lee MK, Churpek MM, Huo D, Weiner H, Bannerjee M, Godley LA, Le Beau MM, Pritchard CC, Walsh T, King MC, Olopade OI, Larson RA. Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia. Cancer. 2016 Jan 15; 122(2):304-11. PMID: 26641009; PMCID: PMC4707981.
      Citations: 63     Fields:    Translation:Humans
    119. Vasanthakumar A, Arnovitz S, Marquez R, Lepore J, Rafidi G, Asom A, Weatherly M, Davis EM, Neistadt B, Duszynski R, Vardiman JW, Le Beau MM, Godley LA, Churpek JE. Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice. Blood. 2016 Jan 21; 127(3):310-3. PMID: 26644450; PMCID: PMC4722284.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    120. Chapman CG, Mariani CJ, Wu F, Meckel K, Butun F, Chuang A, Madzo J, Bissonnette MB, Kwon JH, Godley LA. TET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer. Sci Rep. 2015 Dec 03; 5:17568. PMID: 26631571; PMCID: PMC4668370.
      Citations: 27     Fields:    Translation:HumansCells
    121. Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, Elliott K, Heath S, Jiang A, Westervelt P, DiPersio JF, Link DC, Walter MJ, Welch J, Wilson R, Ley TJ, Godley LA, Graubert TA. Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia. Blood. 2015 Nov 26; 126(22):2484-90. PMID: 26492932; PMCID: PMC4661171.
      Citations: 123     Fields:    Translation:HumansCellsCTClinical Trials
    122. Churpek JE, Artz A, Bishop M, Liu H, Godley LA. Correspondence Regarding the Consensus Statement from the Worldwide Network for Blood and Marrow Transplantation Standing Committee on Donor Issues. Biol Blood Marrow Transplant. 2016 Jan; 22(1):183-4. PMID: 26478096.
      Citations: 11     Fields:    Translation:Humans
    123. Vasanthakumar A, Zullow H, Lepore JB, Thomas K, Young N, Anastasi J, Reardon CA, Godley LA. Epigenetic Control of Apolipoprotein E Expression Mediates Gender-Specific Hematopoietic Regulation. Stem Cells. 2015 Dec; 33(12):3643-54. PMID: 26417967; PMCID: PMC4713251.
      Citations: 3     Fields:    Translation:AnimalsCells
    124. Dominguez PM, Teater M, Chambwe N, Kormaksson M, Redmond D, Ishii J, Vuong B, Chaudhuri J, Melnick A, Vasanthakumar A, Godley LA, Papavasiliou FN, Elemento O, Shaknovich R. DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID. Cell Rep. 2015 Sep 29; 12(12):2086-98. PMID: 26365193; PMCID: PMC4591215.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    125. Moen EL, Litwin E, Arnovitz S, Zhang X, Zhang W, Dolan ME, Godley LA. Characterization of CpG sites that escape methylation on the inactive human X-chromosome. Epigenetics. 2015; 10(9):810-8. PMID: 26178744; PMCID: PMC4622068.
      Citations: 7     Fields:    Translation:HumansCells
    126. Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, He R, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Kantarjian HM, Liang S, Estecio MR, Godley LA, Issa JP. TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia. Cancer Res. 2015 Jul 15; 75(14):2833-43. PMID: 25972343; PMCID: PMC4506197.
      Citations: 49     Fields:    Translation:HumansCellsCTClinical Trials
    127. Polprasert C, Schulze I, Sekeres MA, Makishima H, Przychodzen B, Hosono N, Singh J, Padgett RA, Gu X, Phillips JG, Clemente M, Parker Y, Lindner D, Dienes B, Jankowsky E, Saunthararajah Y, Du Y, Oakley K, Nguyen N, Mukherjee S, Pabst C, Godley LA, Churpek JE, Pollyea DA, Krug U, Berdel WE, Klein HU, Dugas M, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Yoshida K, Ogawa S, Maciejewski JP, Müller-Tidow C. Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms. Cancer Cell. 2015 May 11; 27(5):658-70. PMID: 25920683; PMCID: PMC8713504.
      Citations: 186     Fields:    Translation:HumansAnimalsCells
    128. Vasanthakumar A, Godley LA. 5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy. Cancer Genet. 2015 May; 208(5):167-77. PMID: 25892122.
      Citations: 50     Fields:    Translation:HumansCells
    129. Balakrishnan KR, Whang JC, Hwang R, Hack JH, Godley LA, Sohn LL. Node-pore sensing enables label-free surface-marker profiling of single cells. Anal Chem. 2015 Mar 03; 87(5):2988-95. PMID: 25625182; PMCID: PMC4350414.
      Citations: 10     Fields:    Translation:HumansCells
    130. Brambert PR, Kelpsch DJ, Hameed R, Desai CV, Calafiore G, Godley LA, Raimondi SL. DNMT3B7 expression promotes tumor progression to a more aggressive phenotype in breast cancer cells. PLoS One. 2015; 10(1):e0117310. PMID: 25607950; PMCID: PMC4301645.
      Citations: 11     Fields:    Translation:HumansCells
    131. Zhang MY, Churpek JE, Walsh T, Lee MK, Loeb KR, Gulsuner S, Pritchard CC, Sanchez-Bonilla M, Delrow JJ, Basom RS, Forouhar M, Gyurkocza B, Schwartz BS, Neistadt B, Marquez R, Mariani CJ, Coats SA, Hofmann I, Lindsley RC, Williams DA, Abkowitz JL, Horwitz MS, King MC, Godley LA, Shimamura A, Keel SB. Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy. Nat Genet. 2015 Feb; 47(2):180-5. PMID: 25581430; PMCID: PMC4540357.
      Citations: 151     Fields:    Translation:HumansCells
    132. Moen EL, Mariani CJ, Zullow H, Jeff-Eke M, Litwin E, Nikitas JN, Godley LA. New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine. Immunol Rev. 2015 Jan; 263(1):36-49. PMID: 25510270; PMCID: PMC6691509.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    133. Odenike O, Halpern A, Godley LA, Madzo J, Karrison T, Green M, Fulton N, Mattison RJ, Yee KW, Bennett M, Koval G, Malnassy G, Larson RA, Ratain MJ, Stock W. A phase I and pharmacodynamic study of the histone deacetylase inhibitor belinostat plus azacitidine in advanced myeloid neoplasia. Invest New Drugs. 2015 Apr; 33(2):371-9. PMID: 25483416; PMCID: PMC4390421.
      Citations: 7     Fields:    Translation:HumansCellsCTClinical Trials
    134. Rampal R, Madzo J, Vasanthakumar A, Pronier E, Patel J, Li Y, Ahn J, Abdel-Wahab O, Shih A, Lu C, Ward PS, Tsai JJ, Hricik T, Tosello V, Tallman JE, Zhao X, Daniels D, Dai Q, Ciminio L, Aifantis I, He C, Tallman MS, Ferrando A, Nimer S, Paietta E, Thompson CB, Licht JD, Mason CE, Godley LA, Melnick A, Figueroa ME, Levine RL, Alkalin A, Fuks F. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. Cell Rep. 2014 Dec 11; 9(5):1841-1855. PMID: 25482556; PMCID: PMC4267494.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    135. Ustun C, Reiter A, Scott BL, Nakamura R, Damaj G, Kreil S, Shanley R, Hogan WJ, Perales MA, Shore T, Baurmann H, Stuart R, Gruhn B, Doubek M, Hsu JW, Tholouli E, Gromke T, Godley LA, Pagano L, Gilman A, Wagner EM, Shwayder T, Bornhäuser M, Papadopoulos EB, Böhm A, Vercellotti G, Van Lint MT, Schmid C, Rabitsch W, Pullarkat V, Legrand F, Yakoub-Agha I, Saber W, Barrett J, Hermine O, Hagglund H, Sperr WR, Popat U, Alyea EP, Devine S, Deeg HJ, Weisdorf D, Akin C, Valent P. Hematopoietic stem-cell transplantation for advanced systemic mastocytosis. J Clin Oncol. 2014 Oct 10; 32(29):3264-74. PMID: 25154823; PMCID: PMC4876356.
      Citations: 71     Fields:    Translation:Humans
    136. Godley LA. Inherited predisposition to acute myeloid leukemia. Semin Hematol. 2014 Oct; 51(4):306-21. PMID: 25311743.
      Citations: 47     Fields:    Translation:Humans
    137. Zhang X, Moen EL, Liu C, Mu W, Gamazon ER, Delaney SM, Wing C, Godley LA, Dolan ME, Zhang W. Linking the genetic architecture of cytosine modifications with human complex traits. Hum Mol Genet. 2014 Nov 15; 23(22):5893-905. PMID: 24943591; PMCID: PMC4204771.
      Citations: 26     Fields:    Translation:HumansCells
    138. Jasielec J, Saloura V, Godley LA. The mechanistic role of DNA methylation in myeloid leukemogenesis. Leukemia. 2014 Sep; 28(9):1765-73. PMID: 24913729.
      Citations: 16     Fields:    Translation:HumansCells
    139. Mariani CJ, Vasanthakumar A, Madzo J, Yesilkanal A, Bhagat T, Yu Y, Bhattacharyya S, Wenger RH, Cohn SL, Nanduri J, Verma A, Prabhakar NR, Godley LA. TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma. Cell Rep. 2014 Jun 12; 7(5):1343-1352. PMID: 24835990; PMCID: PMC4516227.
      Citations: 91     Fields:    Translation:HumansCells
    140. Muffly LS, Kocherginsky M, Stock W, Chu Q, Bishop MR, Godley LA, Kline J, Liu H, Odenike OM, Larson RA, van Besien K, Artz AS. Geriatric assessment to predict survival in older allogeneic hematopoietic cell transplantation recipients. Haematologica. 2014 Aug; 99(8):1373-9. PMID: 24816237; PMCID: PMC4116837.
      Citations: 103     Fields:    Translation:Humans
    141. Marquez R, Hantel A, Lorenz R, Neistadt B, Wong J, Churpek JE, Mardini NA, Shaukat I, Gurbuxani S, Miller JL, Godley LA. A new family with a germline ANKRD26 mutation and predisposition to myeloid malignancies. Leuk Lymphoma. 2014 Dec; 55(12):2945-6. PMID: 24628296; PMCID: PMC4206674.
      Citations: 13     Fields:    Translation:Humans
    142. Vasanthakumar A, Godley LA. On the origin of leukemic species. Cell Stem Cell. 2014 Apr 03; 14(4):421-2. PMID: 24702991.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    143. Moen EL, Stark AL, Zhang W, Dolan ME, Godley LA. The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide. Mol Cancer Ther. 2014 May; 13(5):1334-44. PMID: 24568970; PMCID: PMC4013207.
      Citations: 30     Fields:    Translation:HumansCells
    144. West AH, Godley LA, Churpek JE. Familial myelodysplastic syndrome/acute leukemia syndromes: a review and utility for translational investigations. Ann N Y Acad Sci. 2014 Mar; 1310:111-8. PMID: 24467820; PMCID: PMC3961519.
      Citations: 36     Fields:    Translation:Humans
    145. Chambwe N, Kormaksson M, Geng H, De S, Michor F, Johnson NA, Morin RD, Scott DW, Godley LA, Gascoyne RD, Melnick A, Campagne F, Shaknovich R. Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes. Blood. 2014 Mar 13; 123(11):1699-708. PMID: 24385541; PMCID: PMC3954051.
      Citations: 56     Fields:    Translation:HumansCells
    146. Madzo J, Liu H, Rodriguez A, Vasanthakumar A, Sundaravel S, Caces DBD, Looney TJ, Zhang L, Lepore JB, Macrae T, Duszynski R, Shih AH, Song CX, Yu M, Yu Y, Grossman R, Raumann B, Verma A, He C, Levine RL, Lavelle D, Lahn BT, Wickrema A, Godley LA. Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis. Cell Rep. 2014 Jan 16; 6(1):231-244. PMID: 24373966; PMCID: PMC3976649.
      Citations: 65     Fields:    Translation:HumansCells
    147. Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA, Göttgens B. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet. 2014 Jan; 46(1):17-23. PMID: 24270360; PMCID: PMC3920905.
      Citations: 195     Fields:    Translation:HumansAnimalsCells
    148. Clozel T, Yang S, Elstrom RL, Tam W, Martin P, Kormaksson M, Banerjee S, Vasanthakumar A, Culjkovic B, Scott DW, Wyman S, Leser M, Shaknovich R, Chadburn A, Tabbo F, Godley LA, Gascoyne RD, Borden KL, Inghirami G, Leonard JP, Melnick A, Cerchietti L. Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma. Cancer Discov. 2013 Sep; 3(9):1002-19. PMID: 23955273; PMCID: PMC3770813.
      Citations: 95     Fields:    Translation:HumansCellsCTClinical Trials
    149. Nickels EM, Soodalter J, Churpek JE, Godley LA. Recognizing familial myeloid leukemia in adults. Ther Adv Hematol. 2013 Aug; 4(4):254-69. PMID: 23926458; PMCID: PMC3734901.
      Citations: 27     
    150. Bhattacharyya S, Yu Y, Suzuki M, Campbell N, Mazdo J, Vasanthakumar A, Bhagat TD, Nischal S, Christopeit M, Parekh S, Steidl U, Godley L, Maitra A, Greally JM, Verma A. Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer. Nucleic Acids Res. 2013 Sep; 41(16):e157. PMID: 23861445; PMCID: PMC3763560.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    151. Mariani CJ, Madzo J, Moen EL, Yesilkanal A, Godley LA. Alterations of 5-hydroxymethylcytosine in human cancers. Cancers (Basel). 2013 Jun 25; 5(3):786-814. PMID: 24202321; PMCID: PMC3795365.
      Citations: 25     
    152. Moen EL, Zhang X, Mu W, Delaney SM, Wing C, McQuade J, Myers J, Godley LA, Dolan ME, Zhang W. Genome-wide variation of cytosine modifications between European and African populations and the implications for complex traits. Genetics. 2013 Aug; 194(4):987-96. PMID: 23792949; PMCID: PMC3730924.
      Citations: 73     Fields:    Translation:HumansCells
    153. Locke F, Agarwal R, Kunnavakkam R, van Besien K, Larson RA, Odenike O, Godley LA, Liu H, Le Beau MM, Gurbuxani S, Thirman MJ, Sipkins D, White C, Artz A, Stock W. A novel clofarabine bridge strategy facilitates allogeneic transplantation in patients with relapsed/refractory leukemia and high-risk myelodysplastic syndromes. Bone Marrow Transplant. 2013 Nov; 48(11):1437-43. PMID: 23771005; PMCID: PMC4279870.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    154. Garcia-Manero G, Jabbour E, Borthakur G, Faderl S, Estrov Z, Yang H, Maddipoti S, Godley LA, Gabrail N, Berdeja JG, Nadeem A, Kassalow L, Kantarjian H. Randomized open-label phase II study of decitabine in patients with low- or intermediate-risk myelodysplastic syndromes. J Clin Oncol. 2013 Jul 10; 31(20):2548-53. PMID: 23733767; PMCID: PMC4878053.
      Citations: 42     Fields:    Translation:HumansCTClinical Trials
    155. Lu Z, Tian Y, Salwen HR, Chlenski A, Godley LA, Raj JU, Yang Q. Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells. Anticancer Drugs. 2013 Jun; 24(5):484-93. PMID: 23466651; PMCID: PMC3649845.
      Citations: 31     Fields:    Translation:HumansCells
    156. Goodell MA, Godley LA. Perspectives and future directions for epigenetics in hematology. Blood. 2013 Jun 27; 121(26):5131-7. PMID: 23692857; PMCID: PMC3695360.
      Citations: 11     Fields:    Translation:Humans
    157. Jain N, Liu H, Artz AS, Anastasi J, Odenike O, Godley LA, Joseph L, Marino S, Kline J, Nguyen V, Schouten V, Kunnavakkam R, Larson RA, Stock W, Ulaszek J, Savage PA, Wickrema A, van Besien K. Immune reconstitution after combined haploidentical and umbilical cord blood transplant. Leuk Lymphoma. 2013 Jun; 54(6):1242-9. PMID: 23088744.
      Citations: 11     Fields:    Translation:HumansCells
    158. Vasanthakumar A, Lepore JB, Zegarek MH, Kocherginsky M, Singh M, Davis EM, Link PA, Anastasi J, Le Beau MM, Karpf AR, Godley LA. Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis. Blood. 2013 Mar 14; 121(11):2059-63. PMID: 23315164; PMCID: PMC3596965.
      Citations: 21     Fields:    Translation:AnimalsCells
    159. Yu Y, Mo Y, Ebenezer D, Bhattacharyya S, Liu H, Sundaravel S, Giricz O, Wontakal S, Cartier J, Caces B, Artz A, Nischal S, Bhagat T, Bathon K, Maqbool S, Gligich O, Suzuki M, Steidl U, Godley L, Skoultchi A, Greally J, Wickrema A, Verma A. High resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis. J Biol Chem. 2013 Mar 29; 288(13):8805-14. PMID: 23306203; PMCID: PMC3610956.
      Citations: 26     Fields:    Translation:HumansCells
    160. Madzo J, Vasanthakumar A, Godley LA. Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies. Semin Hematol. 2013 Jan; 50(1):61-9. PMID: 23507484.
      Citations: 11     Fields:    Translation:HumansAnimals
    161. Churpek JE, Nickels E, Marquez R, Rojek K, Liu B, Lorenz R, Lepore J, Madzo J, Wickrema A, Artz AS, van Besien K, Godley LA. Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia. Blood. 2012 Dec 20; 120(26):5247-9. PMID: 23258901.
      Citations: 8     Fields:    Translation:Humans
    162. Moen EL, Godley LA, Zhang W, Dolan ME. Pharmacogenomics of chemotherapeutic susceptibility and toxicity. Genome Med. 2012; 4(11):90. PMID: 23199206; PMCID: PMC3580423.
      Citations: 20     Fields:    
    163. Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z, Mollica L, Li J, Viale A, Heguy A, Hassimi M, Socci N, Bhatt PK, Gonen M, Mason CE, Melnick A, Godley LA, Brennan CW, Abdel-Wahab O, Levine RL. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis. Nat Genet. 2012 Nov; 44(11):1179-81. PMID: 23001125; PMCID: PMC3483435.
      Citations: 418     Fields:    Translation:HumansCells
    164. Godley LA. A drug that stops traffic at the nuclear border. Blood. 2012 Aug 30; 120(9):1759-60. PMID: 22936736.
      Citations: 1     Fields:    Translation:HumansAnimals
    165. Ostler KR, Yang Q, Looney TJ, Zhang L, Vasanthakumar A, Tian Y, Kocherginsky M, Raimondi SL, DeMaio JG, Salwen HR, Gu S, Chlenski A, Naranjo A, Gill A, Peddinti R, Lahn BT, Cohn SL, Godley LA. Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma. Cancer Res. 2012 Sep 15; 72(18):4714-23. PMID: 22815530; PMCID: PMC3445765.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    166. Churpek JE, Lorenz R, Nedumgottil S, Onel K, Olopade OI, Sorrell A, Owen CJ, Bertuch AA, Godley LA. Proposal for the clinical detection and management of patients and their family members with familial myelodysplastic syndrome/acute leukemia predisposition syndromes. Leuk Lymphoma. 2013 Jan; 54(1):28-35. PMID: 22691122.
      Citations: 44     Fields:    Translation:Humans
    167. Pollyea DA, Kohrt HE, Zhang B, Zehnder J, Schenkein D, Fantin V, Straley K, Vasanthakumar A, Abdel-Wahab O, Levine R, Godley LA, Medeiros BC. 2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels. Leuk Lymphoma. 2013 Feb; 54(2):408-10. PMID: 22680765; PMCID: PMC3688062.
      Citations: 8     Fields:    Translation:Humans
    168. Richa EM, Kunnavakkam R, Godley LA, Kline J, Odenike O, Larson RA, Nguyen V, Stock W, Wickrema A, Van Besien K, Artz AS. Influence of related donor age on outcomes after peripheral blood stem cell transplantation. Cytotherapy. 2012 Jul; 14(6):707-15. PMID: 22548695.
      Citations: 4     Fields:    Translation:Humans
    169. Godley LA. Profiles in leukemia. N Engl J Med. 2012 Mar 22; 366(12):1152-3. PMID: 22417205.
      Citations: 6     Fields:    Translation:HumansCells
    170. Godley LA, Le Beau MM. The histone code and treatments for acute myeloid leukemia. N Engl J Med. 2012 Mar 08; 366(10):960-1. PMID: 22397660.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    171. Larson SM, Campbell NP, Huo D, Artz A, Zhang Y, Gajria D, Green M, Weiner H, Daugherty C, Odenike O, Godley LA, Hyjek E, Gurbuxani S, Thirman M, Sipkins D, Van Besien K, Larson RA, Stock W. High dose cytarabine and mitoxantrone: an effective induction regimen for high-risk acute myeloid leukemia (AML). Leuk Lymphoma. 2012 Mar; 53(3):445-50. PMID: 21913806.
      Citations: 7     Fields:    Translation:Humans
    172. Yamazaki J, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Shen L, Kantarjian HM, Estecio MR, Jelinek J, Godley LA, Issa JP. Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. Epigenetics. 2012 Feb; 7(2):201-7. PMID: 22395470; PMCID: PMC3335912.
      Citations: 58     Fields:    Translation:HumansCells
    173. Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar NR. Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2515-20. PMID: 22232674; PMCID: PMC3289330.
      Citations: 71     Fields:    Translation:AnimalsCells
    174. Mankame TP, Langerman A, Ostler KR, Kanteti R, Best T, Onel K, Godley LA, Salgia R, Lingen MW, Doçi CL. Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer. Int J Gynecol Pathol. 2012 Jan; 31(1):15-24. PMID: 22123719; PMCID: PMC3237951.
      Citations: 6     Fields:    Translation:HumansCells
    175. Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2011 Dec 04; 44(1):23-31. PMID: 22138693; PMCID: PMC3637952.
      Citations: 567     Fields:    Translation:HumansAnimalsCells
    176. van Besien K, Stock W, Rich E, Odenike O, Godley LA, O'Donnell PH, Kline J, Nguyen V, Del Cerro P, Larson RA, Artz AS. Phase I-II study of clofarabine-melphalan-alemtuzumab conditioning for allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2012 Jun; 18(6):913-21. PMID: 22079470; PMCID: PMC3423318.
      Citations: 14     Fields:    Translation:HumansCTClinical Trials
    177. Szulwach KE, Li X, Li Y, Song CX, Wu H, Dai Q, Irier H, Upadhyay AK, Gearing M, Levey AI, Vasanthakumar A, Godley LA, Chang Q, Cheng X, He C, Jin P. 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci. 2011 Oct 30; 14(12):1607-16. PMID: 22037496; PMCID: PMC3292193.
      Citations: 433     Fields:    Translation:HumansAnimalsCells
    178. Liu H, Rich ES, Godley L, Odenike O, Joseph L, Marino S, Kline J, Nguyen V, Cunningham J, Larson RA, del Cerro P, Schroeder L, Pape L, Stock W, Wickrema A, Artz AS, van Besien K. Reduced-intensity conditioning with combined haploidentical and cord blood transplantation results in rapid engraftment, low GVHD, and durable remissions. Blood. 2011 Dec 08; 118(24):6438-45. PMID: 21976674; PMCID: PMC3236125.
      Citations: 69     Fields:    Translation:HumansCellsCTClinical Trials
    179. Shaknovich R, Cerchietti L, Tsikitas L, Kormaksson M, De S, Figueroa ME, Ballon G, Yang SN, Weinhold N, Reimers M, Clozel T, Luttrop K, Ekstrom TJ, Frank J, Vasanthakumar A, Godley LA, Michor F, Elemento O, Melnick A. DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation. Blood. 2011 Sep 29; 118(13):3559-69. PMID: 21828137; PMCID: PMC3186332.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    180. Pronier E, Almire C, Mokrani H, Vasanthakumar A, Simon A, da Costa Reis Monte Mor B, Carbonne B, Ravanat JL, Casadevall N, Bernard OA, Droin N, Solary E, Godley LA, Vainchenker W, Plo I, Massé A, Le Couédic JP, Pendino F, Larghero J, Delhommeau F. Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors. Blood. 2011 Sep 01; 118(9):2551-5. PMID: 21734233; PMCID: PMC3292425.
      Citations: 95     Fields:    Translation:HumansCells
    181. Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, Figueroa ME, Vasanthakumar A, Patel J, Zhao X, Perna F, Pandey S, Madzo J, Song C, Dai Q, He C, Ibrahim S, Beran M, Zavadil J, Nimer SD, Melnick A, Godley LA, Aifantis I, Levine RL. Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation. Cancer Cell. 2011 Jul 12; 20(1):11-24. PMID: 21723200; PMCID: PMC3194039.
      Citations: 718     Fields:    Translation:HumansAnimalsCells
    182. Quivoron C, Plo I, Wagner-Ballon O, Do Cruzeiro M, Delhommeau F, Arnulf B, Stern MH, Godley L, Opolon P, Solary E, Duffourd Y, Dessen P, Nguyen-Khac F, Vainchenker W, Bastard C, Mercher T, Bernard OA, Couronné L, Della Valle V, Lopez CK, Tilly H, Merle-Beral H, Fontenay M. TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell. 2011 Jul 12; 20(1):25-38. PMID: 21723201.
      Citations: 470     Fields:    Translation:HumansAnimalsCells
    183. Godley LA, Cunningham J, Dolan ME, Huang RS, Gurbuxani S, McNerney ME, Larson RA, Leong H, Lussier Y, Onel K, Odenike O, Stock W, White KP, Le Beau MM. An integrated genomic approach to the assessment and treatment of acute myeloid leukemia. Semin Oncol. 2011 Apr; 38(2):215-24. PMID: 21421111; PMCID: PMC5591437.
      Citations: 5     Fields:    Translation:HumansCells
    184. Odenike O, Thirman MJ, Artz AS, Godley LA, Larson RA, Stock W. Gene mutations, epigenetic dysregulation, and personalized therapy in myeloid neoplasia: are we there yet? Semin Oncol. 2011 Apr; 38(2):196-214. PMID: 21421110.
      Citations: 12     Fields:    Translation:Humans
    185. Godley LA, Mondragón A. Molecular biology. Preference by exclusion. Science. 2011 Feb 25; 331(6020):1017-8. PMID: 21350155.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    186. Woloszynska-Read A, Zhang W, Yu J, Link PA, Mhawech-Fauceglia P, Collamat G, Akers SN, Ostler KR, Godley LA, Odunsi K, Karpf AR. Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage. Clin Cancer Res. 2011 Apr 15; 17(8):2170-80. PMID: 21296871; PMCID: PMC3079045.
      Citations: 51     Fields:    Translation:HumansCells
    187. Levis M, Ravandi F, Wang ES, Baer MR, Perl A, Coutre S, Erba H, Stuart RK, Baccarani M, Cripe LD, Tallman MS, Meloni G, Godley LA, Langston AA, Amadori S, Lewis ID, Nagler A, Stone R, Yee K, Advani A, Douer D, Wiktor-Jedrzejczak W, Juliusson G, Litzow MR, Petersdorf S, Sanz M, Kantarjian HM, Sato T, Tremmel L, Bensen-Kennedy DM, Small D, Smith BD. Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse. Blood. 2011 Mar 24; 117(12):3294-301. PMID: 21270442; PMCID: PMC3069671.
      Citations: 174     Fields:    Translation:Humans
    188. Song CX, Szulwach KE, Fu Y, Dai Q, Yi C, Li X, Li Y, Chen CH, Zhang W, Jian X, Wang J, Zhang L, Looney TJ, Zhang B, Godley LA, Hicks LM, Lahn BT, Jin P, He C. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol. 2011 Jan; 29(1):68-72. PMID: 21151123; PMCID: PMC3107705.
      Citations: 525     Fields:    Translation:HumansAnimalsCells
    189. Kenkre VP, Horowitz S, Artz AS, Liao C, Cohen KS, Godley LA, Kline JP, Smith SM, Stock W, van Besien K. T-cell-depleted allogeneic transplant without donor leukocyte infusions results in excellent long-term survival in patients with multiply relapsed Lymphoma. Predictors for survival after transplant relapse. Leuk Lymphoma. 2011 Feb; 52(2):214-22. PMID: 21142785; PMCID: PMC3617078.
      Citations: 8     Fields:    Translation:Humans
    190. Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A, Löwenberg B. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010 Dec 14; 18(6):553-67. PMID: 21130701; PMCID: PMC4105845.
      Citations: 1429     Fields:    Translation:HumansCells
    191. Larson SM, Godley LA. Getting to the root of the stem cell in mutated chronic myeloid leukemia. Leuk Lymphoma. 2010 Dec; 51(12):2147-8. PMID: 21133735.
      Citations:    Fields:    Translation:HumansCells
    192. O'Donnell PH, Artz AS, Undevia SD, Pai RK, Del Cerro P, Horowitz S, Godley LA, Hart J, Innocenti F, Larson RA, Odenike OM, Stock W, Van Besien K. Phase I study of dose-escalated busulfan with fludarabine and alemtuzumab as conditioning for allogeneic hematopoietic stem cell transplant: reduced clearance at high doses and occurrence of late sinusoidal obstruction syndrome/veno-occlusive disease. Leuk Lymphoma. 2010 Dec; 51(12):2240-9. PMID: 20919852; PMCID: PMC4477684.
      Citations: 14     Fields:    Translation:HumansCellsCTClinical Trials
    193. Churpek JE, Garcia JS, Madzo J, Jackson SA, Onel K, Godley LA. Identification and molecular characterization of a novel 3′ mutation in RUNX1 in a family with familial platelet disorder. Leuk Lymphoma. 2010 Oct; 51(10):1931-5. PMID: 20846103.
      Citations: 16     Fields:    Translation:HumansCells
    194. Smith SM, Anastasi J, Cohen KS, Godley LA. The impact of MYC expression in lymphoma biology: beyond Burkitt lymphoma. Blood Cells Mol Dis. 2010 Dec 15; 45(4):317-23. PMID: 20817505.
      Citations: 25     Fields:    Translation:Humans
    195. Shah MY, Vasanthakumar A, Barnes NY, Figueroa ME, Kamp A, Hendrick C, Ostler KR, Davis EM, Lin S, Anastasi J, Le Beau MM, Moskowitz IP, Melnick A, Pytel P, Godley LA. DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res. 2010 Jul 15; 70(14):5840-50. PMID: 20587527; PMCID: PMC2905468.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    196. Garcia JS, Jain N, Godley LA. An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes. Onco Targets Ther. 2010 Jun 24; 3:1-13. PMID: 20616953; PMCID: PMC2895778.
      Citations: 15     
    197. Yang Q, Tian Y, Ostler KR, Chlenski A, Guerrero LJ, Salwen HR, Godley LA, Cohn SL. Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines. BMC Cancer. 2010 Jun 14; 10:286. PMID: 20546602; PMCID: PMC2897803.
      Citations: 14     Fields:    Translation:HumansCells
    198. Godley LA, Njiaju UO, Green M, Weiner H, Lin S, Odenike O, Rich ES, Artz A, Van Besien K, Daugherty CK, Zhang Y, Le Beau MM, Stock W, Larson RA. Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant. Leuk Lymphoma. 2010 Jun; 51(6):995-1006. PMID: 20536346.
      Citations: 10     Fields:    Translation:HumansCellsCTClinical Trials
    199. Godley LA, van Besien K. The next frontier for stem cell transplantation: finding a donor for all. JAMA. 2010 Apr 14; 303(14):1421-2. PMID: 20388899.
      Citations: 3     Fields:    Translation:Humans
    200. van Besien K, Dew A, Lin S, Joseph L, Godley LA, Larson RA, Odenike T, Rich E, Stock W, Wickrema A, Artz AS. Patterns and kinetics of T-cell chimerism after allo transplant with alemtuzumab-based conditioning: mixed chimerism protects from GVHD, but does not portend disease recurrence. Leuk Lymphoma. 2009 Nov; 50(11):1809-17. PMID: 19821799.
      Citations: 25     Fields:    Translation:Humans
    201. Steensma DP, Baer MR, Slack JL, Buckstein R, Godley LA, Garcia-Manero G, Albitar M, Larsen JS, Arora S, Cullen MT, Kantarjian H. Multicenter study of decitabine administered daily for 5 days every 4 weeks to adults with myelodysplastic syndromes: the alternative dosing for outpatient treatment (ADOPT) trial. J Clin Oncol. 2009 Aug 10; 27(23):3842-8. PMID: 19528372; PMCID: PMC4879689.
      Citations: 116     Fields:    Translation:HumansCTClinical Trials
    202. Godley LA. Deletion of the der(9q) in chronic myeloid leukemia: the controversy continues. Leuk Lymphoma. 2009 Jun; 50(6):871-2. PMID: 19479615.
      Citations:    Fields:    Translation:HumansCells
    203. Zhou Y, Goodenbour JM, Godley LA, Wickrema A, Pan T. High levels of tRNA abundance and alteration of tRNA charging by bortezomib in multiple myeloma. Biochem Biophys Res Commun. 2009 Jul 24; 385(2):160-4. PMID: 19450555; PMCID: PMC2774282.
      Citations: 39     Fields:    Translation:HumansCells
    204. Artz A, Larson RA, Kline J, Odenike O, Rich E, Godley L, Stock W, van Besien K, Poiré X. Allogeneic stem cell transplantation with alemtuzumab-based conditioning for patients with advanced chronic myelogenous leukemia. Leuk Lymphoma. 2009 Jan; 50(1):85-91. PMID: 19142796; PMCID: PMC3617055.
      Citations: 6     Fields:    Translation:Humans
    205. Artz AS, Wickrema A, Dinner S, Godley LA, Kocherginsky M, Odenike O, Rich ES, Stock W, Ulaszek J, Larson RA, van Besien K. Pretreatment C-reactive protein is a predictor for outcomes after reduced-intensity allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2008 Nov; 14(11):1209-16. PMID: 18940674; PMCID: PMC2668514.
      Citations: 36     Fields:    Translation:Humans
    206. Ozer O, Zhao YD, Ostler KR, Akin C, Anastasi J, Vardiman JW, Godley LA. The identification and characterisation of novel KIT transcripts in aggressive mast cell malignancies and normal CD34+ cells. Leuk Lymphoma. 2008 Aug; 49(8):1567-77. PMID: 18766971.
      Citations: 2     Fields:    Translation:HumansCells
    207. Godley LA, Larson RA. Therapy-related myeloid leukemia. Semin Oncol. 2008 Aug; 35(4):418-29. PMID: 18692692; PMCID: PMC2600445.
      Citations: 121     Fields:    Translation:Humans
    208. Carbonaro A, Mohanty SK, Huang H, Godley LA, Sohn LL. Cell characterization using a protein-functionalized pore. Lab Chip. 2008 Sep; 8(9):1478-85. PMID: 18818802.
      Citations: 12     Fields:    Translation:AnimalsCells
    209. Fackenthal JD, Godley LA. Aberrant RNA splicing and its functional consequences in cancer cells. Dis Model Mech. 2008 Jul-Aug; 1(1):37-42. PMID: 19048051; PMCID: PMC2561970.
      Citations: 56     Fields:    Translation:HumansCells
    210. Steensma DP, Baer MR, Slack JL, Buckstein R, Godley LA, Larsen JS, Arora S, Cullen MT, Kantarjian HM. A multicenter phase II trial of the decitabine alternative 5-day dosing regimen: Analysis of efficacy in various subgroups of patients with myelodysplastic syndromes (MDS). J Clin Oncol. 2008 May 20; 26(15_suppl):7032. PMID: 27950008.
      Citations:    
    211. Godley LA, Steensma DP, Baer MR, Slack JL, Buckstein R, Larsen JS, Arora S, Cullen MT, Kantarjian HM. Cytogenetic responses to a 5-day dosing schedule of decitabine in patients (Pts) with myelodysplastic syndromes (MDS). J Clin Oncol. 2008 May 20; 26(15_suppl):7030. PMID: 27950013.
      Citations:    
    212. Stock W, Undevia SD, Bivins C, Ravandi F, Odenike O, Faderl S, Rich E, Borthakur G, Godley L, Verstovsek S, Artz A, Wierda W, Larson RA, Zhang Y, Cortes J, Ratain MJ, Giles FJ. A phase I and pharmacokinetic study of XK469R (NSC 698215), a quinoxaline phenoxypropionic acid derivative, in patients with refractory acute leukemia. Invest New Drugs. 2008 Aug; 26(4):331-8. PMID: 18425419; PMCID: PMC4905709.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    213. Klisovic RB, Stock W, Cataland S, Klisovic MI, Liu S, Blum W, Green M, Odenike O, Godley L, Burgt JV, Van Laar E, Cullen M, Macleod AR, Besterman JM, Reid GK, Byrd JC, Marcucci G. A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia. Clin Cancer Res. 2008 Apr 15; 14(8):2444-9. PMID: 18413836.
      Citations: 25     Fields:    Translation:HumansCTClinical Trials
    214. Gordon MK, Sher D, Karrison T, Kebriaei P, Chuang K, Zhang Y, McDonnell D, Artz A, Godley L, Odenike O, Rich E, Michaelis L, Thirman MJ, Wickrema A, van Besien K, Larson RA, Stock W. Successful autologous stem cell collection in patients with chronic myeloid leukemia in complete cytogenetic response, with quantitative measurement of BCR-ABL expression in blood, marrow, and apheresis products. Leuk Lymphoma. 2008 Mar; 49(3):531-7. PMID: 18297531.
      Citations: 2     Fields:    Translation:Humans
    215. Godley LA. HMGA2 levels in CML: reflective of miRNA gene regulation in a hematopoietic tumor? Leuk Lymphoma. 2007 Oct; 48(10):1898-9. PMID: 17917958.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    216. Pollyea DA, Artz AS, Stock W, Daugherty C, Godley L, Odenike OM, Rich E, Smith SM, Zimmerman T, Zhang Y, Huo D, Larson R, van Besien K. Outcomes of patients with AML and MDS who relapse or progress after reduced intensity allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2007 Dec; 40(11):1027-32. PMID: 17846595.
      Citations: 28     Fields:    Translation:HumansCTClinical Trials
    217. Hill BT, Kondapalli L, Artz A, Smith S, Rich E, Godley L, Odenike O, Pursell KJ, Larson RA, Stock W, van Besien K. Successful allogeneic transplantation of patients with suspected prior invasive mold infection. Leuk Lymphoma. 2007 Sep; 48(9):1799-805. PMID: 17786717.
      Citations: 6     Fields:    Translation:Humans
    218. Kihslinger JE, Godley LA. The use of hypomethylating agents in the treatment of hematologic malignancies. Leuk Lymphoma. 2007 Sep; 48(9):1676-95. PMID: 17786703.
      Citations: 14     Fields:    Translation:HumansCells
    219. Mattison RJ, Ostler KR, Locke FL, Godley LA. Implications of FLT3 mutations in the therapy of acute myeloid leukemia. Rev Recent Clin Trials. 2007 May; 2(2):135-41. PMID: 18473998.
      Citations: 7     Fields:    Translation:Humans
    220. Ostler KR, Davis EM, Payne SL, Gosalia BB, Le Beau MM, Godley LA, Expósito-Céspedes J. Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins. Oncogene. 2007 Aug 16; 26(38):5553-63. PMID: 17353906; PMCID: PMC2435620.
      Citations: 76     Fields:    Translation:HumansCells
    221. Artz AS, Pollyea DA, Kocherginsky M, Stock W, Rich E, Odenike O, Zimmerman T, Smith S, Godley L, Thirman M, Daugherty C, Extermann M, Larson R, van Besien K. Performance status and comorbidity predict transplant-related mortality after allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2006 Sep; 12(9):954-64. PMID: 16920562.
      Citations: 41     Fields:    Translation:HumansCTClinical Trials
    222. Kline J, Pollyea DA, Stock W, Artz A, Rich E, Godley L, Zimmerman T, Thompson K, Pursell K, Larson RA, van Besien K. Pre-transplant ganciclovir and post transplant high-dose valacyclovir reduce CMV infections after alemtuzumab-based conditioning. Bone Marrow Transplant. 2006 Feb; 37(3):307-10. PMID: 16400339.
      Citations: 18     Fields:    Translation:HumansCTClinical Trials
    223. van Besien K, Artz A, Smith S, Cao D, Rich S, Godley L, Jones D, Del Cerro P, Bennett D, Casey B, Odenike O, Thirman M, Daugherty C, Wickrema A, Zimmerman T, Larson RA, Stock W. Fludarabine, melphalan, and alemtuzumab conditioning in adults with standard-risk advanced acute myeloid leukemia and myelodysplastic syndrome. J Clin Oncol. 2005 Aug 20; 23(24):5728-38. PMID: 16009946.
      Citations: 36     Fields:    Translation:HumansCTClinical Trials
    224. Qian Z, Fernald AA, Godley LA, Larson RA, Le Beau MM. Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14925-30. PMID: 12417757; PMCID: PMC137521.
      Citations: 49     Fields:    Translation:HumansCells
    225. Lai F, Godley LA, Joslin J, Fernald AA, Liu J, Espinosa R, Zhao N, Pamintuan L, Till BG, Larson RA, Qian Z, Le Beau MM. Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q). Genomics. 2001 Jan 15; 71(2):235-45. PMID: 11161817.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    226. Lai F, Godley LA, Fernald AA, Orelli BJ, Pamintuan L, Zhao N, Le Beau MM. cDNA cloning and genomic structure of three genes localized to human chromosome band 5q31 encoding potential nuclear proteins. Genomics. 2000 Nov 15; 70(1):123-30. PMID: 11087669.
      Citations: 5     Fields:    Translation:HumansCells
    227. Lai F, Orelli BJ, Till BG, Godley LA, Fernald AA, Pamintuan L, Le Beau MM. Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene. Genomics. 2000 May 15; 66(1):65-75. PMID: 10843806.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    228. Godley LA, Lai F, Liu J, Zhao N, Le Beau MM. TTID: A novel gene at 5q31 encoding a protein with titin-like features. Genomics. 1999 Sep 01; 60(2):226-33. PMID: 10486214.
      Citations: 4     Fields:    Translation:HumansCells
    229. Jones JM, Attardi L, Godley LA, Laucirica R, Medina D, Jacks T, Varmus HE, Donehower LA. Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis. Cell Growth Differ. 1997 Aug; 8(8):829-38. PMID: 9269892.
      Citations: 11     Fields:    Translation:Animals
    230. Broccoli D, Godley LA, Donehower LA, Varmus HE, de Lange T. Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol Cell Biol. 1996 Jul; 16(7):3765-72. PMID: 8668193; PMCID: PMC231372.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    231. Godley LA, Kopp JB, Eckhaus M, Paglino JJ, Owens J, Varmus HE. Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys. Genes Dev. 1996 Apr 01; 10(7):836-50. PMID: 8846920.
      Citations: 40     Fields:    Translation:AnimalsCells
    232. Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D, Varmus HE. The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model. Prog Clin Biol Res. 1996; 395:1-11. PMID: 8895979.
      Citations: 7     Fields:    Translation:Animals
    233. Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D, Varmus HE. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev. 1995 Apr 01; 9(7):882-95. PMID: 7705663.
      Citations: 80     Fields:    Translation:AnimalsCells
    234. Varmus HE, Godley LA, Roy S, Taylor IC, Yuschenkoff L, Shi YP, Pinkel D, Gray J, Pyle R, Aldaz CM, et al. Defining the steps in a multistep mouse model for mammary carcinogenesis. Cold Spring Harb Symp Quant Biol. 1994; 59:491-9. PMID: 7587104.
      Citations: 3     Fields:    Translation:HumansAnimals
    235. Godley L, Pfeifer J, Steinhauer D, Ely B, Shaw G, Kaufmann R, Suchanek E, Pabo C, Skehel JJ, Wiley DC, et al. Introduction of intersubunit disulfide bonds in the membrane-distal region of the influenza hemagglutinin abolishes membrane fusion activity. Cell. 1992 Feb 21; 68(4):635-45. PMID: 1739972.
      Citations: 90     Fields:    Translation:AnimalsCells
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