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Yan Li

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Research 
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    R01DK138355     (LI, YAN CHUN)Mar 1, 2024 - Jan 31, 2028
    Metabolic Regulation of Colonic Senescence and Pathological Implications: Epithelial and Microbial Interactions
    Role: Principal Investigator

    R01AI151162     (LI, YAN CHUN)Sep 22, 2020 - Aug 31, 2025
    Roles of m6A mRNA Methylation in Innate Immunity
    Role: Principal Investigator

    R21AI140152     (LI, YAN CHUN)May 25, 2018 - Apr 30, 2021
    Macrophage m6A mRNA Methylation in Sepsis
    Role: Principal Investigator

    R41DK100010     (WU-WONG, JINSHYUN RUTH)Sep 15, 2013 - Aug 31, 2015
    New drug VS-110 for treating inflammatory bowel diseases
    Role: Co-Principal Investigator

    R01CA180087     (LI, YAN CHUN)Sep 1, 2013 - Aug 31, 2018
    (PQA1) Mechanism of Vitamin D Chemoprevention Against Colon Cancer
    Role: Principal Investigator

    R41DK095627     (WU-WONG, JINSHYUN RUTH)Sep 1, 2012 - Aug 31, 2014
    Novel drug VS-105 for treatment of diabetic nephropathy
    Role: Co-Principal Investigator

    R01HL085793     (LI, YAN CHUN)Apr 15, 2007 - Mar 31, 2012
    Cardiovascular Effect of the Vitamin D Endocrine System.
    Role: Principal Investigator

    R21DK073183     (LI, YAN CHUN)Jul 1, 2006 - Jun 30, 2008
    Vitamin D and Diabetic Nephropathy
    Role: Principal Investigator

    R03CA117472     (LI, YAN CHUN)Aug 1, 2005 - Jul 31, 2007
    Preventive Role of VDR in Colorectal Carcinogenesis
    Role: Principal Investigator

    R21DK062072     (LI, YAN CHUN)Jul 1, 2002 - May 31, 2004
    Vitamin D: A Negative Regulator of Renin Expression
    Role: Principal Investigator

    K01DK059327     (LI, YAN CHUN)Aug 1, 2001 - Jun 30, 2006
    Regulation of minerals and fluids excretion in vitamin D
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Deb DK, Chen Y, Sun J, Wang Y, Li YC. ATP-citrate lyase is essential for high glucose-induced histone hyperacetylation and fibrogenic gene upregulation in mesangial cells. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F423-F429. PMID: 28490526.
      Citations: 22     Fields:    Translation:AnimalsCells
    2. Deb DK, Bao R, Li YC. Critical role of the cAMP-PKA pathway in hyperglycemia-induced epigenetic activation of fibrogenic program in the kidney. FASEB J. 2017 05; 31(5):2065-2075. PMID: 28148567; PMCID: PMC5388553.
      Citations: 20     Fields:    Translation:AnimalsCells
    3. Kupfer SS, Li YC, Bissonnette M. Vitamin D and Calcium for Colorectal Adenoma Chemoprevention. Nutr Cancer. 2017 01; 69(1):167. PMID: 27929663.
      Citations: 1     Fields:    Translation:Humans
    4. Yi B, Huang J, Zhang W, Li AM, Yang SK, Sun J, Wang JW, Li YC, Zhang H. Vitamin D Receptor Down-Regulation Is Associated With Severity of Albuminuria in Type 2 Diabetes Patients. J Clin Endocrinol Metab. 2016 11; 101(11):4395-4404. PMID: 27552538.
      Citations: 11     Fields:    Translation:HumansCells
    5. Chen L, Wang J, Mouser G, Li YC, Marcovici G. Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays. Phytother Res. 2016 Jun; 30(6):1016-20. PMID: 26990224.
      Citations: 1     Fields:    Translation:Humans
    6. Chen Y, Shi Y, Liu T, Cao Y, Tang Y, Ge X, Nie H, Zheng C, Li YC, Du J. 1,25-Dihydroxyvitamin D Protects Intestinal Epithelial Barrier by Regulating the Myosin Light Chain Kinase Signaling Pathway. Inflamm Bowel Dis. 2015 Nov; 21(11):2495-506. PMID: 26287999; PMCID: PMC4646414.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    7. Wang J, Chen L, Chen B, Meliton A, Liu SQ, Shi Y, Liu T, Deb DK, Solway J, Li YC. Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis. Sci Rep. 2015 Oct 23; 5:15561. PMID: 26494430; PMCID: PMC4616037.
      Citations: 30     Fields:    Translation:Animals
    8. Chen P, Li YC, Toback FG. AMP-18 Targets p21 to Maintain Epithelial Homeostasis. PLoS One. 2015; 10(4):e0125490. PMID: 25919700; PMCID: PMC4412538.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    9. Golan MA, Liu W, Shi Y, Chen L, Wang J, Liu T, Li YC. Transgenic Expression of Vitamin D Receptor in Gut Epithelial Cells Ameliorates Spontaneous Colitis Caused by Interleukin-10 Deficiency. Dig Dis Sci. 2015 Jul; 60(7):1941-7. PMID: 25894930; PMCID: PMC4466054.
      Citations: 13     Fields:    Translation:AnimalsCells
    10. Li YC, Chen Y, Du J. Critical roles of intestinal epithelial vitamin D receptor signaling in controlling gut mucosal inflammation. J Steroid Biochem Mol Biol. 2015 Apr; 148:179-83. PMID: 25603468; PMCID: PMC4361385.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    11. Liu SQ, Ma XL, Qin G, Liu Q, Li YC, Wu YH. Trans-system mechanisms against ischemic myocardial injury. Compr Physiol. 2015 Jan; 5(1):167-92. PMID: 25589268.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    12. Du J, Zhang Z, Liu T, Shi Y, Ge X, Li YC, Chen Y. MicroRNA-346 mediates tumor necrosis factor a-induced downregulation of gut epithelial vitamin D receptor in inflammatory bowel diseases. Inflamm Bowel Dis. 2014 Nov; 20(11):1910-8. PMID: 25192497; PMCID: PMC4586112.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    13. Li YC. Discovery of vitamin D hormone as a negative regulator of the renin-angiotensin system. Clin Chem. 2014 Mar; 60(3):561-2. PMID: 24363372.
      Citations: 3     Fields:    Translation:Animals
    14. Kong J, Zhu X, Shi Y, Liu T, Chen Y, Bhan I, Zhao Q, Thadhani R, Li YC. VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system. Mol Endocrinol. 2013 Dec; 27(12):2116-25. PMID: 24196349; PMCID: PMC3857197.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    15. Li YC, Chen Y, Liu W, Thadhani R. MicroRNA-mediated mechanism of vitamin D regulation of innate immune response. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:81-6. PMID: 24103701; PMCID: PMC3976893.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    16. Li YC. Vitamin D receptor signaling in renal and cardiovascular protection. Semin Nephrol. 2013 Sep; 33(5):433-47. PMID: 24119849; PMCID: PMC3796773.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    17. Liu W, Chen Y, Golan MA, Annunziata ML, Du J, Dougherty U, Kong J, Musch M, Huang Y, Pekow J, Zheng C, Bissonnette M, Hanauer SB, Li YC. Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis. J Clin Invest. 2013 Sep; 123(9):3983-96. PMID: 23945234; PMCID: PMC3754241.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    18. Li YC. Vitamin D in chronic kidney disease. Contrib Nephrol. 2013; 180:98-109. PMID: 23652553.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    19. Chen Y, Liu W, Sun T, Huang Y, Wang Y, Deb DK, Yoon D, Kong J, Thadhani R, Li YC. 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages. J Immunol. 2013 Apr 01; 190(7):3687-95. PMID: 23436936; PMCID: PMC3608760.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    20. Wang Y, Deb DK, Zhang Z, Sun T, Liu W, Yoon D, Kong J, Chen Y, Chang A, Li YC. Vitamin D receptor signaling in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2012 Dec; 23(12):1977-86. PMID: 23123403; PMCID: PMC3507366.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    21. Pekow J, Li YC, Hanauer SB. Association between higher predicted serum vitamin D levels and reduced incidence of inflammatory bowel diseases. Gastroenterology. 2012 Sep; 143(3):e28. PMID: 22841731.
      Citations:    Fields:    Translation:Humans
    22. Szeto FL, Reardon CA, Yoon D, Wang Y, Wong KE, Chen Y, Kong J, Liu SQ, Thadhani R, Getz GS, Li YC. Vitamin D receptor signaling inhibits atherosclerosis in mice. Mol Endocrinol. 2012 Jul; 26(7):1091-101. PMID: 22638071; PMCID: PMC3385794.
      Citations: 46     Fields:    Translation:AnimalsCells
    23. Wong KE, Kong J, Zhang W, Szeto FL, Ye H, Deb DK, Brady MJ, Li YC. Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice. J Biol Chem. 2011 Sep 30; 286(39):33804-10. PMID: 21840998; PMCID: PMC3190828.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    24. Li YC. Molecular mechanism of vitamin D in the cardiovascular system. J Investig Med. 2011 Aug; 59(6):868-71. PMID: 21307778; PMCID: PMC3645939.
      Citations: 24     Fields:    Translation:Humans
    25. Deb DK, Wang Y, Zhang Z, Nie H, Huang X, Yuan Z, Chen Y, Zhao Q, Li YC. Molecular mechanism underlying 1,25-dihydroxyvitamin D regulation of nephrin gene expression. J Biol Chem. 2011 Sep 16; 286(37):32011-7. PMID: 21803771; PMCID: PMC3173158.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    26. Li YC. Podocytes as target of vitamin D. Curr Diabetes Rev. 2011 Jan; 7(1):35-40. PMID: 21067507.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    27. Chen Y, Kong J, Sun T, Li G, Szeto FL, Liu W, Deb DK, Wang Y, Zhao Q, Thadhani R, Li YC. 1,25-Dihydroxyvitamin D3 suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor-?B activation. Arch Biochem Biophys. 2011 Mar 15; 507(2):241-7. PMID: 21176770; PMCID: PMC3049452.
      Citations: 37     Fields:    Translation:AnimalsCells
    28. Zhang Y, Kong J, Deb DK, Chang A, Li YC. Vitamin D receptor attenuates renal fibrosis by suppressing the renin-angiotensin system. J Am Soc Nephrol. 2010 Jun; 21(6):966-73. PMID: 20378820; PMCID: PMC2900963.
      Citations: 91     Fields:    Translation:AnimalsCells
    29. Deb DK, Sun T, Wong KE, Zhang Z, Ning G, Zhang Y, Kong J, Shi H, Chang A, Li YC. Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes. Kidney Int. 2010 Jun; 77(11):1000-9. PMID: 20182412.
      Citations: 64     Fields:    Translation:Animals
    30. Zhang Y, Deb DK, Kong J, Ning G, Wang Y, Li G, Chen Y, Zhang Z, Strugnell S, Sabbagh Y, Arbeeny C, Li YC. Long-term therapeutic effect of vitamin D analog doxercalciferol on diabetic nephropathy: strong synergism with AT1 receptor antagonist. Am J Physiol Renal Physiol. 2009 Sep; 297(3):F791-801. PMID: 19535571; PMCID: PMC2739712.
      Citations: 45     Fields:    Translation:AnimalsCells
    31. Li YC. Renoprotective effects of vitamin D analogs. Kidney Int. 2010 Jul; 78(2):134-9. PMID: 19471320.
      Citations: 54     Fields:    Translation:Humans
    32. Musch MW, Li YC, Chang EB. Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells. BMC Physiol. 2009 Apr 01; 9:5. PMID: 19338654; PMCID: PMC2669048.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    33. Deb DK, Chen Y, Zhang Z, Zhang Y, Szeto FL, Wong KE, Kong J, Li YC. 1,25-Dihydroxyvitamin D3 suppresses high glucose-induced angiotensinogen expression in kidney cells by blocking the NF-{kappa}B pathway. Am J Physiol Renal Physiol. 2009 May; 296(5):F1212-8. PMID: 19193728; PMCID: PMC2681355.
      Citations: 52     Fields:    Translation:AnimalsCells
    34. Wong KE, Szeto FL, Zhang W, Ye H, Kong J, Zhang Z, Sun XJ, Li YC. Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins. Am J Physiol Endocrinol Metab. 2009 Apr; 296(4):E820-8. PMID: 19176352; PMCID: PMC2670625.
      Citations: 107     Fields:    Translation:AnimalsCells
    35. Li YC. Vitamin D and diabetic nephropathy. Curr Diab Rep. 2008 Dec; 8(6):464-9. PMID: 18990303.
      Citations: 7     Fields:    Translation:HumansAnimals
    36. Zhang Z, Zhang Y, Ning G, Deb DK, Kong J, Li YC. Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: blockade of compensatory renin increase. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15896-901. PMID: 18838678; PMCID: PMC2562415.
      Citations: 122     Fields:    Translation:Animals
    37. Kong J, Zhang Z, Li D, Wong KE, Zhang Y, Szeto FL, Musch MW, Li YC. Loss of vitamin D receptor produces polyuria by increasing thirst. J Am Soc Nephrol. 2008 Dec; 19(12):2396-405. PMID: 18832438; PMCID: PMC2588110.
      Citations: 11     Fields:    Translation:AnimalsCells
    38. Kong J, Qiao G, Zhang Z, Liu SQ, Li YC. Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium. Kidney Int. 2008 Dec; 74(12):1577-81. PMID: 19034301.
      Citations: 55     Fields:    Translation:HumansAnimals
    39. Wang Q, Li YC, Wang J, Kong J, Qi Y, Quigg RJ, Li X. miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2889-94. PMID: 18287052; PMCID: PMC2268555.
      Citations: 154     Fields:    Translation:AnimalsCells
    40. Li YC. Investigating the Role of Vitamin D in IBD Pathophysiology and Treatment. Gastroenterol Hepatol (N Y). 2008 Jan; 4(1):20-1. PMID: 22798731; PMCID: PMC3394471.
      Citations: 4     
    41. Kong J, Zhang Z, Musch MW, Ning G, Sun J, Hart J, Bissonnette M, Li YC. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G208-16. PMID: 17962355.
      Citations: 296     Fields:    Translation:HumansAnimalsCells
    42. Li YC. Inhibition of renin: an updated review of the development of renin inhibitors. Curr Opin Investig Drugs. 2007 Sep; 8(9):750-7. PMID: 17729187.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    43. Yuan W, Pan W, Kong J, Zheng W, Szeto FL, Wong KE, Cohen R, Klopot A, Zhang Z, Li YC. 1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter. J Biol Chem. 2007 Oct 12; 282(41):29821-30. PMID: 17690094.
      Citations: 213     Fields:    Translation:HumansAnimalsCells
    44. Fichera A, Little N, Dougherty U, Mustafi R, Cerda S, Li YC, Delgado J, Arora A, Campbell LK, Joseph L, Hart J, Noffsinger A, Bissonnette M. A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model. J Surg Res. 2007 Oct; 142(2):239-45. PMID: 17574271.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    45. Szeto FL, Sun J, Kong J, Duan Y, Liao A, Madara JL, Li YC. Involvement of the vitamin D receptor in the regulation of NF-kappaB activity in fibroblasts. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):563-6. PMID: 17298882; PMCID: PMC2578814.
      Citations: 24     Fields:    Translation:AnimalsCells
    46. Liu W, Tretiakova M, Kong J, Turkyilmaz M, Li YC, Krausz T. Expression of vitamin D3 receptor in kidney tumors. Hum Pathol. 2006 Oct; 37(10):1268-78. PMID: 16949927.
      Citations: 6     Fields:    Translation:Humans
    47. Kong J, Grando SA, Li YC. Regulation of IL-1 family cytokines IL-1alpha, IL-1 receptor antagonist, and IL-18 by 1,25-dihydroxyvitamin D3 in primary keratinocytes. J Immunol. 2006 Mar 15; 176(6):3780-7. PMID: 16517748.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    48. Sun J, Kong J, Duan Y, Szeto FL, Liao A, Madara JL, Li YC. Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor. Am J Physiol Endocrinol Metab. 2006 Aug; 291(2):E315-22. PMID: 16507601.
      Citations: 97     Fields:    Translation:AnimalsCells
    49. Qiao G, Kong J, Uskokovic M, Li YC. Analogs of 1alpha,25-dihydroxyvitamin D(3) as novel inhibitors of renin biosynthesis. J Steroid Biochem Mol Biol. 2005 Jun; 96(1):59-66. PMID: 15878826.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    50. Bolt MJ, Cao LP, Kong J, Sitrin MD, Li YC. Vitamin D receptor is required for dietary calcium-induced repression of calbindin-D9k expression in mice. J Nutr Biochem. 2005 May; 16(5):286-90. PMID: 15866228.
      Citations: 3     Fields:    Translation:Animals
    51. Zheng W, Xie Y, Li G, Kong J, Feng JQ, Li YC. Critical role of calbindin-D28k in calcium homeostasis revealed by mice lacking both vitamin D receptor and calbindin-D28k. J Biol Chem. 2004 Dec 10; 279(50):52406-13. PMID: 15456794.
      Citations: 22     Fields:    Translation:AnimalsCells
    52. Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W, Liu W, Li X, Gardner DG, Li YC. Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E125-32. PMID: 15367398.
      Citations: 201     Fields:    Translation:AnimalsCells
    53. Bolt MJ, Liu W, Qiao G, Kong J, Zheng W, Krausz T, Cs-Szabo G, Sitrin MD, Li YC. Critical role of vitamin D in sulfate homeostasis: regulation of the sodium-sulfate cotransporter by 1,25-dihydroxyvitamin D3. Am J Physiol Endocrinol Metab. 2004 Oct; 287(4):E744-9. PMID: 15165995.
      Citations: 5     Fields:    Translation:AnimalsCells
    54. Li YC, Qiao G, Uskokovic M, Xiang W, Zheng W, Kong J. Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):387-92. PMID: 15225806.
      Citations: 219     Fields:    Translation:Humans
    55. Li X, Zheng W, Li YC. Altered gene expression profile in the kidney of vitamin D receptor knockout mice. J Cell Biochem. 2003 Jul 01; 89(4):709-19. PMID: 12858337.
      Citations: 16     Fields:    Translation:AnimalsCells
    56. Kong J, Li YC. Effect of ANG II type I receptor antagonist and ACE inhibitor on vitamin D receptor-null mice. Am J Physiol Regul Integr Comp Physiol. 2003 Jul; 285(1):R255-61. PMID: 12637346.
      Citations: 19     Fields:    Translation:Animals
    57. Li YC. Vitamin D regulation of the renin-angiotensin system. J Cell Biochem. 2003 Feb 01; 88(2):327-31. PMID: 12520534.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    58. Kong J, Li YC, Kong J, Li YC. Upregulation of interleukin-18 expression in mouse primary keratinocytes induced to differentiate by calcium. Arch Dermatol Res. 2002 Nov; 294(8):370-6. PMID: 12420106.
      Citations: 2     Fields:    Translation:AnimalsCells
    59. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest. 2002 Jul; 110(2):229-38. PMID: 12122115; PMCID: PMC151055.
      Citations: 731     Fields:    Translation:AnimalsCells
    60. Kong J, Li XJ, Gavin D, Jiang Y, Li YC. Targeted expression of human vitamin d receptor in the skin promotes the initiation of the postnatal hair follicle cycle and rescues the alopecia in vitamin D receptor null mice. J Invest Dermatol. 2002 Apr; 118(4):631-8. PMID: 11918709.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
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