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James Fackenthal

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fackenthal JD. Alternative mRNA Splicing and Promising Therapies in Cancer. Biomolecules. 2023 03 20; 13(3). PMID: 36979496; PMCID: PMC10046298.
      Citations: 3     Fields:    Translation:HumansCells
    2. Fackenthal JD, Yoshimatsu T, Zhang B, de Garibay GR, Colombo M, De Vecchi G, Ayoub SC, Lal K, Olopade OI, Wappenschmidt B, Becker A, Walker LC, Thomassen M, Parsons M, Whiley P, Blok MJ, Tserpelis D, Baralle D, Montalban G, Lazaro C, kConFaB Investigators, Spurdle AB, Radice P, Vega A, Santamariña M, Blanco A, Houdayer C, López-Perolio I, Brandão RD, Gutiérrez-Enríquez S, Díez O, de la Hoya M. Naturally occurring BRCA2 alternative mRNA splicing events in clinically relevant samples. J Med Genet. 2016 08; 53(8):548-58. PMID: 27060066.
      Citations: 27     Fields:    Translation:HumansCells
    3. Guindalini RS, Song A, Fackenthal JD, Olopade OI, Huo D. Genetic anticipation in BRCA1/BRCA2 families after controlling for ascertainment bias and cohort effect. Cancer. 2016 06 15; 122(12):1913-20. PMID: 26992017; PMCID: PMC4892951.
      Citations: 6     Fields:    Translation:Humans
    4. Churpek JE, Walsh T, Zheng Y, Moton Z, Thornton AM, Lee MK, Casadei S, Watts A, Neistadt B, Churpek MM, Huo D, Zvosec C, Liu F, Niu Q, Marquez R, Zhang J, Fackenthal J, King MC, Olopade OI. Inherited predisposition to breast cancer among African American women. Breast Cancer Res Treat. 2015 Jan; 149(1):31-9. PMID: 25428789; PMCID: PMC4298662.
      Citations: 69     Fields:    Translation:Humans
    5. Sighoko D, Fackenthal JD, Hainaut P. Changes in the pattern of breast cancer burden among African American women: evidence based on 29 states and District of Columbia during 1998 to 2010. Ann Epidemiol. 2015 Jan; 25(1):15-25.e10. PMID: 25442056.
      Citations: 3     Fields:    Translation:Humans
    6. Colombo M, Blok MJ, Whiley P, Becker A, Smith LD, De Vecchi G, Tserpelis D, Brown M, Bonache S, Foglia C, Fackenthal JD, Baralle D, Wappenschmidt B, kConFaB Investigators, Walker L, Spurdle AB, Radice P, Santamariña M, Gutiérrez-Enríquez S, Romero A, Garre P, Brandão RD, Blanco A, Menéndez M, Houdayer C, Díaz-Rubio E, Caldés T, Díez O, Vega A, De La Hoya M. Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: a report from the ENIGMA consortium. Hum Mol Genet. 2014 Jul 15; 23(14):3666-80. PMID: 24569164.
      Citations: 45     Fields:    Translation:HumansCells
    7. Hou N, Ogundiran T, Ojengbede O, Morhason-Bello I, Zheng Y, Fackenthal J, Adebamowo C, Anetor I, Akinleye S, Olopade OI, Huo D. Risk factors for pregnancy-associated breast cancer: a report from the Nigerian Breast Cancer Study. Ann Epidemiol. 2013 Sep; 23(9):551-7. PMID: 23880155; PMCID: PMC3770152.
      Citations: 14     Fields:    Translation:Humans
    8. Fackenthal JD, Lee Y, Olopade OI. Hidden dangers: a cryptic exon disrupts BRCA2 mRNA. Clin Cancer Res. 2012 Sep 15; 18(18):4865-7. PMID: 22869870; PMCID: PMC4536549.
      Citations: 1     Fields:    Translation:HumansCells
    9. Zhang J, Fackenthal JD, Zheng Y, Huo D, Hou N, Niu Q, Zvosec C, Ogundiran TO, Hennis AJ, Leske MC, Nemesure B, Wu SY, Olopade OI. Recurrent BRCA1 and BRCA2 mutations in breast cancer patients of African ancestry. Breast Cancer Res Treat. 2012 Jul; 134(2):889-94. PMID: 22739995.
      Citations: 33     Fields:    Translation:HumansCells
    10. Wang X, Liu L, Fackenthal J, Chang P, Newstead G, Chmura S, Foster I, Olopade OI. Towards an Oncology Database (ONCOD) Using a Warehousing Approach. AMIA Jt Summits Transl Sci Proc. 2012; 2012:105. PMID: 22779060; PMCID: PMC3392051.
      Citations: 4     
    11. Fackenthal JD, Zhang J, Zhang B, Zheng Y, Hagos F, Burrill DR, Niu Q, Huo D, Sveen WE, Ogundiran T, Adebamowo C, Odetunde A, Falusi AG, Olopade OI. High prevalence of BRCA1 and BRCA2 mutations in unselected Nigerian breast cancer patients. Int J Cancer. 2012 Sep 01; 131(5):1114-23. PMID: 22034289.
      Citations: 55     Fields:    Translation:Humans
    12. Stacey SN, Sulem P, Zanon C, Gudjonsson SA, Thorleifsson G, Helgason A, Jonasdottir A, Besenbacher S, Kostic JP, Fackenthal JD, Huo D, Adebamowo C, Ogundiran T, Olson JE, Fredericksen ZS, Wang X, Look MP, Sieuwerts AM, Martens JW, Pajares I, Garcia-Prats MD, Ramon-Cajal JM, de Juan A, Panadero A, Ortega E, Aben KK, Vermeulen SH, Asadzadeh F, van Engelenburg KC, Margolin S, Shen CY, Wu PE, Lenner P, Henriksson R, Johansson R, Enquist K, Jonsson T, Sigurdsson H, Alexiusdottir K, Gudmundsson J, Sigurdsson A, Frigge ML, Gudmundsson L, Kristjansson K, Halldorsson BV, Styrkarsdottir U, Gulcher JR, Hemminki K, Lindblom A, Kiemeney LA, Mayordomo JI, Foekens JA, Couch FJ, Olopade OI, Gudbjartsson DF, Thorsteinsdottir U, Rafnar T, Johannsson OT, Stefansson K, Försti A, Hallmans G. Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus. PLoS Genet. 2010 Jul 22; 6(7):e1001029. PMID: 20661439; PMCID: PMC2908678.
      Citations: 59     Fields:    Translation:HumansCells
    13. Zhang J, Fackenthal JD, Huo D, Zheng Y, Olopade OI. Searching for large genomic rearrangements of the BRCA1 gene in a Nigerian population. Breast Cancer Res Treat. 2010 Nov; 124(2):573-7. PMID: 20596889.
      Citations: 14     Fields:    Translation:HumansCells
    14. Varela E, Schlecht U, Moina A, Fackenthal JD, Washburn BK, Niederhauser-Wiederkehr C, Tsai-Pflugfelder M, Primig M, Gasser SM, Esposito RE. Mitotic expression of Spo13 alters M-phase progression and nucleolar localization of Cdc14 in budding yeast. Genetics. 2010 Jul; 185(3):841-54. PMID: 20407133; PMCID: PMC2897760.
      Citations: 3     Fields:    Translation:Cells
    15. Wang X, Liu L, Fackenthal J, Cummings S, Cook M, Hope K, Silverstein JC, Olopade OI. Translational integrity and continuity: personalized biomedical data integration. J Biomed Inform. 2009 Feb; 42(1):100-12. PMID: 18760382; PMCID: PMC2675887.
      Citations: 12     Fields:    Translation:Humans
    16. Zhang B, Fackenthal JD, Niu Q, Huo D, Sveen WE, DeMarco T, Adebamowo CA, Ogundiran T, Olopade OI. Evidence for an ancient BRCA1 mutation in breast cancer patients of Yoruban ancestry. Fam Cancer. 2009; 8(1):15-22. PMID: 18679828.
      Citations: 14     Fields:    Translation:HumansCells
    17. Fackenthal JD, Godley LA. Aberrant RNA splicing and its functional consequences in cancer cells. Dis Model Mech. 2008 Jul-Aug; 1(1):37-42. PMID: 19048051; PMCID: PMC2561970.
      Citations: 54     Fields:    Translation:HumansCells
    18. Stacey SN, Manolescu A, Sulem P, Thorlacius S, Gudjonsson SA, Jakobsdottir M, Bergthorsson JT, Gudmundsson J, Aben KK, Strobbe LJ, Swinkels DW, van Engelenburg KC, Henderson BE, Kolonel LN, Le Marchand L, Millastre E, Andres R, Saez B, Lambea J, Godino J, Polo E, Tres A, Picelli S, Rantala J, Margolin S, Jonsson T, Sigurdsson H, Jonsdottir T, Hrafnkelsson J, Johannsson J, Sveinsson T, Myrdal G, Grimsson HN, Sveinsdottir SG, Alexiusdottir K, Saemundsdottir J, Sigurdsson A, Kostic J, Gudmundsson L, Kristjansson K, Masson G, Fackenthal JD, Adebamowo C, Ogundiran T, Olopade OI, Haiman CA, Lindblom A, Mayordomo JI, Kiemeney LA, Gulcher JR, Rafnar T, Thorsteinsdottir U, Johannsson OT, Kong A, Stefansson K, Jonsson GF. Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet. 2008 Jun; 40(6):703-6. PMID: 18438407.
      Citations: 269     Fields:    Translation:HumansCells
    19. Huo D, Adebamowo CA, Ogundiran TO, Akang EE, Campbell O, Adenipekun A, Cummings S, Fackenthal J, Ademuyiwa F, Ahsan H, Olopade OI. Parity and breastfeeding are protective against breast cancer in Nigerian women. Br J Cancer. 2008 Mar 11; 98(5):992-6. PMID: 18301401; PMCID: PMC2266848.
      Citations: 53     Fields:    Translation:Humans
    20. Fackenthal JD, Olopade OI. Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. Nat Rev Cancer. 2007 Dec; 7(12):937-48. PMID: 18034184.
      Citations: 195     Fields:    Translation:Humans
    21. Wei M, Xu J, Dignam J, Nanda R, Sveen L, Fackenthal J, Grushko TA, Olopade OI. Estrogen receptor alpha, BRCA1, and FANCF promoter methylation occur in distinct subsets of sporadic breast cancers. Breast Cancer Res Treat. 2008 Sep; 111(1):113-20. PMID: 17932744; PMCID: PMC4535794.
      Citations: 42     Fields:    Translation:HumansCells
    22. Huo D, Kim HJ, Adebamowo CA, Ogundiran TO, Akang EE, Campbell O, Adenipekun A, Niu Q, Sveen L, Fackenthal JD, Fackenthal DL, Das S, Cox N, Di Rienzo A, Olopade OI. Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and breast cancer risk in Africans. Breast Cancer Res Treat. 2008 Jul; 110(2):367-76. PMID: 17909964; PMCID: PMC4384416.
      Citations: 16     Fields:    Translation:Humans
    23. Chen Y, Borowicz S, Fackenthal J, Collart FR, Myatt E, Moy S, Babnigg G, Wilton R, Boernke WE, Schiffer M, Stevens FJ, Olopade OI. Primary structure-based function characterization of BRCT domain replicates in BRCA1. Biochem Biophys Res Commun. 2006 Jun 23; 345(1):188-96. PMID: 16677609.
      Citations: 1     Fields:    Translation:HumansCells
    24. Wei M, Grushko TA, Dignam J, Hagos F, Nanda R, Sveen L, Xu J, Fackenthal J, Tretiakova M, Das S, Olopade OI. BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy. Cancer Res. 2005 Dec 01; 65(23):10692-9. PMID: 16322213.
      Citations: 72     Fields:    Translation:HumansCells
    25. Nanda R, Schumm LP, Cummings S, Fackenthal JD, Sveen L, Ademuyiwa F, Cobleigh M, Esserman L, Lindor NM, Neuhausen SL, Olopade OI. Genetic testing in an ethnically diverse cohort of high-risk women: a comparative analysis of BRCA1 and BRCA2 mutations in American families of European and African ancestry. JAMA. 2005 Oct 19; 294(15):1925-33. PMID: 16234499.
      Citations: 101     Fields:    Translation:Humans
    26. Fackenthal JD, Sveen L, Gao Q, Kohlmeir EK, Adebamowo C, Ogundiran TO, Adenipekun AA, Oyesegun R, Campbell O, Rotimi C, Akang EE, Das S, Olopade OI. Complete allelic analysis of BRCA1 and BRCA2 variants in young Nigerian breast cancer patients. J Med Genet. 2005 Mar; 42(3):276-81. PMID: 15744044; PMCID: PMC1736005.
      Citations: 20     Fields:    Translation:Humans
    27. Lamba V, Lamba J, Yasuda K, Strom S, Davila J, Hancock ML, Fackenthal JD, Rogan PK, Ring B, Wrighton SA, Schuetz EG. Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression. J Pharmacol Exp Ther. 2003 Dec; 307(3):906-22. PMID: 14551287.
      Citations: 129     Fields:    Translation:HumansCells
    28. Olopade OI, Fackenthal JD, Dunston G, Tainsky MA, Collins F, Whitfield-Broome C. Breast cancer genetics in African Americans. Cancer. 2003 Jan 01; 97(1 Suppl):236-45. PMID: 12491487.
      Citations: 64     Fields:    Translation:Humans
    29. Fackenthal JD, Cartegni L, Krainer AR, Olopade OI. BRCA2 T2722R is a deleterious allele that causes exon skipping. Am J Hum Genet. 2002 Sep; 71(3):625-31. PMID: 12145750; PMCID: PMC379197.
      Citations: 30     Fields:    Translation:HumansCells
    30. Fackenthal JD, Marsh DJ, Richardson AL, Cummings SA, Eng C, Robinson BG, Olopade OI. Male breast cancer in Cowden syndrome patients with germline PTEN mutations. J Med Genet. 2001 Mar; 38(3):159-64. PMID: 11238682; PMCID: PMC1734834.
      Citations: 44     Fields:    Translation:Humans
    31. Gao Q, Tomlinson G, Das S, Cummings S, Sveen L, Fackenthal J, Schumm P, Olopade OI. Prevalence of BRCA1 and BRCA2 mutations among clinic-based African American families with breast cancer. Hum Genet. 2000 Aug; 107(2):186-91. PMID: 11030417.
      Citations: 30     Fields:    Translation:Humans
    32. Gao Q, Adebamowo CA, Fackenthal J, Das S, Sveen L, Falusi AG, Olopade OI. Protein truncating BRCA1 and BRCA2 mutations in African women with pre-menopausal breast cancer. Hum Genet. 2000 Aug; 107(2):192-4. PMID: 11030418.
      Citations: 14     Fields:    Translation:Humans
    33. Olufunmilayo I, Olopade MD, Fackenthal JD, Olufunmilayo I, Olopade MD, Fackenthal JD. Breast cancer genetics. Implications of clinical practice. Hematol Oncol Clin North Am. 2000 Jun; 14(3):705-25. PMID: 11203330.
      Citations:    Fields:    Translation:Humans
    34. Raff EC, Fackenthal JD, Hutchens JA, Hoyle HD, Turner FR. Microtubule architecture specified by a beta-tubulin isoform. Science. 1997 Jan 03; 275(5296):70-3. PMID: 8974394.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    35. Fackenthal JD, Hutchens JA, Turner FR, Raff EC. Structural analysis of mutations in the Drosophila beta 2-tubulin isoform reveals regions in the beta-tubulin molecular required for general and for tissue-specific microtubule functions. Genetics. 1995 Jan; 139(1):267-86. PMID: 7705629; PMCID: PMC1206324.
      Citations: 16     Fields:    Translation:AnimalsCells
    36. Fackenthal JD, Turner FR, Raff EC. Tissue-specific microtubule functions in Drosophila spermatogenesis require the beta 2-tubulin isotype-specific carboxy terminus. Dev Biol. 1993 Jul; 158(1):213-27. PMID: 8330671.
      Citations: 22     Fields:    Translation:AnimalsCells
    37. Stephenson EC, Chao YC, Fackenthal JD. Molecular analysis of the swallow gene of Drosophila melanogaster. Genes Dev. 1988 Dec; 2(12A):1655-65. PMID: 3145902.
      Citations: 19     Fields:    Translation:Animals
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