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Robert Nishikawa

TitleASSOCIATE PROFESSOR
InstitutionUniversity of Chicago
DepartmentBSD Comprehensive Cancer Center
AddressChicago IL 60637
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    Collapse Research 
    Collapse research activities and funding
    R21CA216495     (NISHIKAWA, ROBERT M)Mar 3, 2017 - Feb 28, 2019
    NIH
    Detecting Mammographically-Occult Cancer in Women with Dense Breasts
    Role: Principal Investigator
    R01EB013680     (NISHIKAWA, ROBERT M)Sep 1, 2013 - Aug 31, 2019
    NIH
    A new approach to optimizing and evaluating computer-aided detection schemes
    Role: Principal Investigator
    R21EB015053     (NISHIKAWA, ROBERT M)Aug 1, 2012 - Jul 31, 2015
    NIH
    Quantitative Evaluation of Reconstruction Algorithms - Resubmission 01
    Role: Principal Investigator
    S10RR021039     (NISHIKAWA, ROBERT M)Apr 1, 2007 - Mar 31, 2009
    NIH
    High-Performance Computer Cluster for Image Analysis
    Role: Principal Investigator
    R33CA109963     (NISHIKAWA, ROBERT M)Sep 22, 2006 - Aug 31, 2009
    NIH
    Computerized Lesion Detection in Breast Tomosynthesis
    Role: Principal Investigator
    R21EB004021     (NISHIKAWA, ROBERT M)Sep 30, 2005 - Aug 31, 2007
    NIH
    Using CAD As A Surrogate Reader In Observer Studies
    Role: Principal Investigator
    R03EB005456     (NISHIKAWA, ROBERT M)Sep 1, 2005 - Aug 31, 2007
    NIH
    A Novel Method for Determining Image Similarity
    Role: Principal Investigator
    R21CA109963     (NISHIKAWA, ROBERT M)Aug 26, 2004 - Jul 31, 2006
    NIH
    Computerized Lesion Detection in Breast Tomosynthesis
    Role: Principal Investigator
    R01CA102337     (NISHIKAWA, ROBERT M)Jun 1, 2003 - May 31, 2006
    NIH
    Improving the softcopy reading of mammograms using CAD
    Role: Principal Investigator
    R01CA060187     (NISHIKAWA, ROBERT M)Jan 1, 1994 - Dec 31, 2002
    NIH
    COMPUTER-AIDED DIAGNOSIS IN DIGITAL MAMMOGRAPHY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lee J, Mustafaev T, Nishikawa RM. Impact of GAN artifacts for simulating mammograms on identifying mammographically occult cancer. J Med Imaging (Bellingham). 2023 Sep; 10(5):054503. PMID: 37840849; PMCID: PMC10569795.
      Citations:    
    2. Yoon JH, Strand F, Baltzer PAT, Conant EF, Gilbert FJ, Lehman CD, Morris EA, Mullen LA, Nishikawa RM, Sharma N, Vejborg I, Moy L, Mann RM. Standalone AI for Breast Cancer Detection at Screening Digital Mammography and Digital Breast Tomosynthesis: A Systematic Review and Meta-Analysis. Radiology. 2023 Jun; 307(5):e222639. PMID: 37219445; PMCID: PMC10315526.
      Citations: 2     Fields:    Translation:Humans
    3. Hossain MB, Nishikawa RM, Lee J. Developing breast lesion detection algorithms for digital breast tomosynthesis: Leveraging false positive findings. Med Phys. 2022 Dec; 49(12):7596-7608. PMID: 35916103; PMCID: PMC10156088.
      Citations: 1     Fields:    Translation:Humans
    4. Nishikawa RM, Deserno TM, Madabhushi A, Krupinski EA, Summers RM, Hoeschen C, Mello-Thoms C, Myers KJ, Kupinski MA, Siewerdsen JH. Fifty years of SPIE Medical Imaging proceedings papers. J Med Imaging (Bellingham). 2022 Feb; 9(Suppl 1):012207. PMID: 35761820; PMCID: PMC9231637.
      Citations:    
    5. Lee J, Nishikawa RM. Identifying Women With Mammographically- Occult Breast Cancer Leveraging GAN-Simulated Mammograms. IEEE Trans Med Imaging. 2022 01; 41(1):225-236. PMID: 34460371; PMCID: PMC8799372.
      Citations: 2     Fields:    Translation:Humans
    6. Lee J, Nishikawa RM. Cross-organ, cross-modality transfer learning: feasibility study for segmentation and classification. IEEE Access. 2020; 8:210194-210205. PMID: 33680628; PMCID: PMC7935042.
      Citations: 3     
    7. Samei E, Kinahan P, Nishikawa RM, Maidment A. Virtual Clinical Trials: Why and What (Special Section Guest Editorial). J Med Imaging (Bellingham). 2020 Jul; 7(4):042801. PMID: 32715021; PMCID: PMC7364111.
      Citations: 2     Translation:CTClinical Trials
    8. Astley SM, Chen W, Myers KJ, Nishikawa RM. Special Section Guest Editorial: Evaluation Methodologies for Clinical AI. J Med Imaging (Bellingham). 2020 Jan; 7(1):012701. PMID: 32206681; PMCID: PMC7047131.
      Citations:    
    9. Lee J, Nishikawa RM. Detecting mammographically occult cancer in women with dense breasts using deep convolutional neural network and Radon Cumulative Distribution Transform. J Med Imaging (Bellingham). 2019 Oct; 6(4):044502. PMID: 31890746; PMCID: PMC6929683.
      Citations: 6     
    10. Wu CC, D'Ardenne NM, Nishikawa RM, Wolfe JM. Gist processing in digital breast tomosynthesis. J Med Imaging (Bellingham). 2020 Mar; 7(2):022403. PMID: 31853462; PMCID: PMC6917568.
      Citations: 5     
    11. Nishikawa RM, Marcomini KD, Fleury EFC, Oliveira VM, Carneiro AAO, Schiabel H. Evaluation of a Computer-Aided Diagnosis System in the Classification of Lesions in Breast Strain Elastography Imaging. Bioengineering (Basel). 2018 Aug 09; 5(3). PMID: 30096868; PMCID: PMC6165254.
      Citations: 2     
    12. Zuley ML, Nishikawa RM, Lee CS, Burnside E, Rosenberg R, Sickles EA, Berg W, Leung J, Harvey J, Sengupta D, Gur D. Linkage of the ACR National Mammography Database to the Network of State Cancer Registries: Proof of Concept Evaluation by the ACR National Mammography Database Committee. J Am Coll Radiol. 2019 Jan; 16(1):8-14. PMID: 30100161; PMCID: PMC6371782.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    13. Lee J, Nishikawa RM, Reiser I, Boone JM. Relationship between computer segmentation performance and computer classification performance in breast CT: A simulation study using RGI segmentation and LDA classification. Med Phys. 2018 Jun 19. PMID: 29920684; PMCID: PMC7935026.
      Citations:    Fields:    
    14. Lee J, Nishikawa RM, Reiser I, Boone JM. Neutrosophic segmentation of breast lesions for dedicated breast computed tomography. J Med Imaging (Bellingham). 2018 Jan; 5(1):014505. PMID: 29541650; PMCID: PMC5839418.
      Citations: 1     
    15. Lee J, Nishikawa RM. Automated mammographic breast density estimation using a fully convolutional network. Med Phys. 2018 Mar; 45(3):1178-1190. PMID: 29363774; PMCID: PMC7153401.
      Citations: 33     Fields:    Translation:Humans
    16. Nishikawa RM, Yang Y, Sainz de Cea MV. Locally adaptive decision in detection of clustered microcalcifications in mammograms. Phys Med Biol. 2018 02 15; 63(4):045014. PMID: 29364138; PMCID: PMC5987532.
      Citations:    Fields:    Translation:Humans
    17. Nishikawa RM, Bae KT. Importance of Better Human-Computer Interaction in the Era of Deep Learning: Mammography Computer-Aided Diagnosis as a Use Case. J Am Coll Radiol. 2018 01; 15(1 Pt A):49-52. PMID: 29097047; PMCID: PMC7209770.
      Citations: 11     Fields:    Translation:Humans
    18. Chakraborty DP, Nishikawa RM, Orton CG. Due to potential concerns of bias and conflicts of interest, regulatory bodies should not do evaluation methodology research related to their regulatory missions. Med Phys. 2017 09; 44(9):4403-4406. PMID: 28547782.
      Citations:    Fields:    Translation:Humans
    19. Wang J, Nishikawa RM, Yang Y. Quantitative comparison of clustered microcalcifications in for-presentation and for-processing mammograms in full-field digital mammography. Med Phys. 2017 Jul; 44(7):3726-3738. PMID: 28477395.
      Citations: 4     Fields:    Translation:Humans
    20. Lee J, Nishikawa RM, Reiser I, Zuley ML, Boone JM. Lack of agreement between radiologists: implications for image-based model observers. J Med Imaging (Bellingham). 2017 Apr; 4(2):025502. PMID: 28491908; PMCID: PMC5414890.
      Citations: 2     
    21. Wang J, Nishikawa RM, Yang Y. Global detection approach for clustered microcalcifications in mammograms using a deep learning network. J Med Imaging (Bellingham). 2017 Apr; 4(2):024501. PMID: 28466029; PMCID: PMC5400890.
      Citations: 4     
    22. Lee J, Nishikawa RM, Reiser I, Boone JM. Optimal reconstruction and quantitative image features for computer-aided diagnosis tools for breast CT. Med Phys. 2017 May; 44(5):1846-1856. PMID: 28295405; PMCID: PMC5467730.
      Citations: 3     Fields:    Translation:Humans
    23. Sainz de Cea MV, Nishikawa RM, Yang Y. Estimating the Accuracy Level Among Individual Detections in Clustered Microcalcifications. IEEE Trans Med Imaging. 2017 05; 36(5):1162-1171. PMID: 28103550; PMCID: PMC5595422.
      Citations: 2     Fields:    Translation:Humans
    24. Wu S, Berg WA, Zuley ML, Kurland BF, Jankowitz RC, Nishikawa R, Gur D, Sumkin JH. Breast MRI contrast enhancement kinetics of normal parenchyma correlate with presence of breast cancer. Breast Cancer Res. 2016 07 22; 18(1):76. PMID: 27449059; PMCID: PMC4957890.
      Citations: 14     Fields:    Translation:Humans
    25. Wang J, Nishikawa RM, Yang Y. Improving the accuracy in detection of clustered microcalcifications with a context-sensitive classification model. Med Phys. 2016 Jan; 43(1):159. PMID: 26745908; PMCID: PMC4691250.
      Citations: 7     Fields:    
    26. Lee J, Nishikawa RM, Reiser I, Boone JM, Lindfors KK. Local curvature analysis for classifying breast tumors: Preliminary analysis in dedicated breast CT. Med Phys. 2015 Sep; 42(9):5479-89. PMID: 26328996; PMCID: PMC4552705.
      Citations: 7     Fields:    Translation:Humans
    27. Gur D, Nishikawa RM, Sumkin JH. New screening technologies and practices: a different approach to estimation of performance improvement by using data from the transition period. Radiology. 2015 Apr; 275(1):9-12. PMID: 25799332.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    28. de Sisternes L, Brankov JG, Zysk AM, Schmidt RA, Nishikawa RM, Wernick MN. A computational model to generate simulated three-dimensional breast masses. Med Phys. 2015 Feb; 42(2):1098-118. PMID: 25652522; PMCID: PMC4320152.
      Citations: 22     Fields:    Translation:Humans
    29. Tanaka R, Takamori M, Uchiyama Y, Nishikawa RM, Shiraishi J. Using breast radiographers' reports as a second opinion for radiologists' readings of microcalcifications in digital mammography. Br J Radiol. 2015 Mar; 88(1047):20140565. PMID: 25536443; PMCID: PMC4651194.
      Citations:    Fields:    Translation:Humans
    30. Nishikawa RM, Gur D. CADe for early detection of breast cancer-current status and why we need to continue to explore new approaches. Acad Radiol. 2014 Oct; 21(10):1320-1. PMID: 25086951.
      Citations: 15     Fields:    Translation:HumansPHPublic Health
    31. Wang J, Jing H, Wernick MN, Nishikawa RM, Yang Y. Analysis of perceived similarity between pairs of microcalcification clusters in mammograms. Med Phys. 2014 May; 41(5):051904. PMID: 24784383; PMCID: PMC4000405.
      Citations: 1     Fields:    Translation:Humans
    32. Chen X, Nishikawa RM, Chan ST, Lau BA, Zhang L, Mou X. Algorithmic scatter correction in dual-energy digital mammography. Med Phys. 2013 Nov; 40(11):111919. PMID: 24320452.
      Citations: 2     Fields:    Translation:Humans
    33. Reiser I, Edwards A, Nishikawa RM. Validation of a power-law noise model for simulating small-scale breast tissue. Phys Med Biol. 2013 Sep 07; 58(17):6011-27. PMID: 23938858; PMCID: PMC3802539.
      Citations: 4     Fields:    Translation:Humans
    34. Nishikawa RM, Pesce LL. Estimating sensitivity and specificity for technology assessment based on observer studies. Acad Radiol. 2013 Jul; 20(7):825-30. PMID: 23660073.
      Citations: 1     Fields:    Translation:Humans
    35. Altman MB, Flynn MJ, Nishikawa RM, Chetty IJ, Barton KN, Movsas B, Kim JH, Brown SL. The potential of iodine for improving breast cancer diagnosis and treatment. Med Hypotheses. 2013 Jan; 80(1):94-8. PMID: 23171625.
      Citations:    Fields:    Translation:Humans
    36. D'Orsi CJ, Getty DJ, Pickett RM, Sechopoulos I, Newell MS, Gundry KR, Bates SR, Nishikawa RM, Sickles EA, Karellas A, D'Orsi EM. Stereoscopic digital mammography: improved specificity and reduced rate of recall in a prospective clinical trial. Radiology. 2013 Jan; 266(1):81-8. PMID: 23150865.
      Citations: 13     Fields:    Translation:Humans
    37. Cole EB, Zhang Z, Marques HS, Nishikawa RM, Hendrick RE, Yaffe MJ, Padungchaichote W, Kuzmiak C, Chayakulkheeree J, Conant EF, Fajardo LL, Baum J, Gatsonis C, Pisano E. Assessing the stand-alone sensitivity of computer-aided detection with cancer cases from the Digital Mammographic Imaging Screening Trial. AJR Am J Roentgenol. 2012 Sep; 199(3):W392-401. PMID: 22915432; PMCID: PMC3649852.
      Citations: 5     Fields:    Translation:Humans
    38. Nishikawa RM, Fenton JJ, Orton CG. Point/counterpoint: computer-aided detection should be used routinely to assist screening mammogram interpretation. Med Phys. 2012 Sep; 39(9):5305-7. PMID: 22957598.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    39. Jing H, Yang Y, Nishikawa RM. Regularization in retrieval-driven classification of clustered microcalcifications for breast cancer. Int J Biomed Imaging. 2012; 2012:463408. PMID: 22919363; PMCID: PMC3418652.
      Citations:    
    40. Jing H, Yang Y, Wernick MN, Yarusso LM, Nishikawa RM. A comparison study of image features between FFDM and film mammogram images. Med Phys. 2012 Jul; 39(7):4386-94. PMID: 22830771; PMCID: PMC3396708.
      Citations: 3     Fields:    Translation:Humans
    41. Jing H, Yang Y, Wernick MN, Yarusso LM, Nishikawa RM. A comparison study of image features between FFDM and film mammogram images. Med Phys. 2012 Jul; 39(7Part1):4386-4394. PMID: 28516604.
      Citations:    
    42. Lau BA, Reiser I, Nishikawa RM, Bakic PR. A statistically defined anthropomorphic software breast phantom. Med Phys. 2012 Jun; 39(6):3375-85. PMID: 22755718; PMCID: PMC3371078.
      Citations: 14     Fields:    
    43. Nishikawa RM, Schmidt RA, Linver MN, Edwards AV, Papaioannou J, Stull MA. Clinically missed cancer: how effectively can radiologists use computer-aided detection? AJR Am J Roentgenol. 2012 Mar; 198(3):708-16. PMID: 22358014.
      Citations: 16     Fields:    Translation:Humans
    44. Jing H, Yang Y, Nishikawa RM. Retrieval boosted computer-aided diagnosis of clustered microcalcifications for breast cancer. Med Phys. 2012 Feb; 39(2):676-85. PMID: 22320777; PMCID: PMC3267793.
      Citations: 3     Fields:    Translation:Humans
    45. Reiser I, Nishikawa RM, Giger ML, Boone JM, Lindfors KK, Yang K. Automated detection of mass lesions in dedicated breast CT: a preliminary study. Med Phys. 2012 Feb; 39(2):866-73. PMID: 22320796; PMCID: PMC3277607.
      Citations: 8     Fields:    Translation:Humans
    46. Nishikawa R, Suzumori N, Nishiyama T, Nishikawa H, Arakawa A, Sugiura-Ogasawara M. Clinical significance of serum growth-regulated oncogene alpha (GROalpha) in patients with gynecological cancer. Eur J Gynaecol Oncol. 2012; 33(2):138-41. PMID: 22611950.
      Citations: 8     Fields:    Translation:Humans
    47. Nishikawa RM, Giger ML, Jiang Y, Metz CE. Re: effectiveness of computer-aided detection in community mammography practice. J Natl Cancer Inst. 2012 Jan 04; 104(1):77; author reply 78-9. PMID: 22186178; PMCID: PMC3692379.
      Citations: 2     Fields:    Translation:Humans
    48. Reiser I, Lee S, Nishikawa RM. On the orientation of mammographic structure. Med Phys. 2011 Oct; 38(10):5303-6. PMID: 21992347; PMCID: PMC3189972.
      Citations: 12     Fields:    Translation:Humans
    49. Jing H, Yang Y, Nishikawa RM. Detection of clustered microcalcifications using spatial point process modeling. Phys Med Biol. 2011 Jan 07; 56(1):1-17. PMID: 21119233; PMCID: PMC3169193.
      Citations: 7     Fields:    Translation:Humans
    50. Oto A, Kulkarni K, Nishikawa R, Baron RL. Contrast enhancement of hepatic hemangiomas on multiphase MDCT: Can we diagnose hepatic hemangiomas by comparing enhancement with blood pool? AJR Am J Roentgenol. 2010 Aug; 195(2):381-6. PMID: 20651193.
      Citations: 3     Fields:    Translation:Humans
    51. Reiser I, Nishikawa RM. Task-based assessment of breast tomosynthesis: effect of acquisition parameters and quantum noise. Med Phys. 2010 Apr; 37(4):1591-600. PMID: 20443480; PMCID: PMC2852443.
      Citations: 60     Fields:    Translation:Humans
    52. Sidky EY, Pan X, Reiser IS, Nishikawa RM, Moore RH, Kopans DB. Enhanced imaging of microcalcifications in digital breast tomosynthesis through improved image-reconstruction algorithms. Med Phys. 2009 Nov; 36(11):4920-32. PMID: 19994501; PMCID: PMC2773453.
      Citations: 53     Fields:    Translation:Humans
    53. Nishikawa RM, Pesce LL. Computer-aided detection evaluation methods are not created equal. Radiology. 2009 Jun; 251(3):634-6. PMID: 19474371.
      Citations: 4     Fields:    Translation:Humans
    54. Wei L, Yang Y, Nishikawa RM. Microcalcification classification assisted by content-based image retrieval for breast cancer diagnosis. Pattern Recognit. 2009 Jun; 42(6):1126-1132. PMID: 20161326; PMCID: PMC2678744.
      Citations: 13     
    55. Engstrom E, Reiser I, Nishikawa R. Comparison of power spectra for tomosynthesis projections and reconstructed images. Med Phys. 2009 May; 36(5):1753-8. PMID: 19544793; PMCID: PMC2832032.
      Citations: 23     Fields:    Translation:Humans
    56. Nishikawa RM, Acharyya S, Gatsonis C, Pisano ED, Cole EB, Marques HS, D'Orsi CJ, Farria DM, Kanal KM, Mahoney MC, Rebner M, Staiger MJ, Digital Mammography Image Screening Trial investigator group. Comparison of soft-copy and hard-copy reading for full-field digital mammography. Radiology. 2009 Apr; 251(1):41-9. PMID: 19332845; PMCID: PMC2663585.
      Citations: 5     Fields:    Translation:Humans
    57. Reiser I, Nishikawa RM, Edwards AV, Kopans DB, Schmidt RA, Papaioannou J, Moore RH. Automated detection of microcalcification clusters for digital breast tomosynthesis using projection data only: a preliminary study. Med Phys. 2008 Apr; 35(4):1486-93. PMID: 18491543; PMCID: PMC2811555.
      Citations: 17     Fields:    Translation:Humans
    58. Nishikawa RM, Schmidt RA, Metz CE. Computer-aided screening mammography. N Engl J Med. 2007 Jul 05; 357(1):84; author reply 85. PMID: 17615630.
      Citations: 1     Fields:    Translation:Humans
    59. Nishikawa RM. Current status and future directions of computer-aided diagnosis in mammography. Comput Med Imaging Graph. 2007 Jun-Jul; 31(4-5):224-35. PMID: 17386998.
      Citations: 39     Fields:    Translation:Humans
    60. Hu B, Guo P, Bar-Joseph I, Imanishi Y, Jarzynka MJ, Bogler O, Mikkelsen T, Hirose T, Nishikawa R, Cheng SY. Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway. Oncogene. 2007 Aug 16; 26(38):5577-86. PMID: 17369861; PMCID: PMC2846324.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    61. Rana RS, Jiang Y, Schmidt RA, Nishikawa RM, Liu B. Independent evaluation of computer classification of malignant and benign calcifications in full-field digital mammograms. Acad Radiol. 2007 Mar; 14(3):363-70. PMID: 17307670; PMCID: PMC3654797.
      Citations: 6     Fields:    Translation:Humans
    62. Reiser I, Nishikawa RM. Identification of simulated microcalcifications in white noise and mammographic backgrounds. Med Phys. 2006 Aug; 33(8):2905-11. PMID: 16964867.
      Citations: 6     Fields:    
    63. Nishikawa RM. Computer-aided detection, in its present form, is not an effective aid for screening mammography. For the proposition. Med Phys. 2006 Apr; 33(4):811-2. PMID: 16696454.
      Citations: 11     Fields:    Translation:HumansPHPublic Health
    64. Reiser I, Nishikawa RM, Giger ML, Wu T, Rafferty EA, Moore R, Kopans DB. Computerized mass detection for digital breast tomosynthesis directly from the projection images. Med Phys. 2006 Feb; 33(2):482-91. PMID: 16532956.
      Citations: 33     Fields:    Translation:Humans
    65. Jiang Y, Nishikawa RM, Schmidt RA, Metz CE. Comparison of independent double readings and computer-aided diagnosis (CAD) for the diagnosis of breast calcifications. Acad Radiol. 2006 Jan; 13(1):84-94. PMID: 16399036.
      Citations: 14     Fields:    Translation:Humans
    66. Wei L, Yang Y, Nishikawa RM, Wernick MN, Edwards A. Relevance vector machine for automatic detection of clustered microcalcifications. IEEE Trans Med Imaging. 2005 Oct; 24(10):1278-85. PMID: 16229415.
      Citations: 18     Fields:    Translation:Humans
    67. Edwards DC, Metz CE, Nishikawa RM. The hypervolume under the ROC hypersurface of "near-guessing" and "near-perfect" observers in N-class classification tasks. IEEE Trans Med Imaging. 2005 Mar; 24(3):293-9. PMID: 15754980.
      Citations: 8     Fields:    
    68. Wei L, Yang Y, Nishikawa RM, Jiang Y. A study on several machine-learning methods for classification of malignant and benign clustered microcalcifications. IEEE Trans Med Imaging. 2005 Mar; 24(3):371-80. PMID: 15754987.
      Citations: 55     Fields:    Translation:Humans
    69. Reiser I, Nishikawa RM, Giger ML, Wu T, Rafferty E, Moore RH, Kopans DB. Computerized detection of mass lesions in digital breast tomosynthesis images using two- and three dimensional radial gradient index segmentation. Technol Cancer Res Treat. 2004 Oct; 3(5):437-41. PMID: 15453808.
      Citations: 15     Fields:    Translation:Humans
    70. El-Naqa I, Yang Y, Galatsanos NP, Nishikawa RM, Wernick MN. A similarity learning approach to content-based image retrieval: application to digital mammography. IEEE Trans Med Imaging. 2004 Oct; 23(10):1233-44. PMID: 15493691.
      Citations: 41     Fields:    Translation:HumansCTClinical Trials
    71. Paquerault S, Yarusso LM, Papaioannou J, Jiang Y, Nishikawa RM. Radial gradient-based segmentation of mammographic microcalcifications: observer evaluation and effect on CAD performance. Med Phys. 2004 Sep; 31(9):2648-57. PMID: 15487748.
      Citations: 6     Fields:    Translation:Humans
    72. Wilkie JR, Giger ML, Chinander MR, Vokes TJ, Nishikawa RM, Carlin MD. Investigation of physical image quality indices of a bone densitometry system. Med Phys. 2004 Apr; 31(4):873-81. PMID: 15125005.
      Citations: 3     Fields:    Translation:Humans
    73. Edwards DC, Lan L, Metz CE, Giger ML, Nishikawa RM. Estimating three-class ideal observer decision variables for computerized detection and classification of mammographic mass lesions. Med Phys. 2004 Jan; 31(1):81-90. PMID: 14761024.
      Citations: 10     Fields:    Translation:Humans
    74. Nishikawa RM, Jiang Y, Papaioannou J, Salfity MF. The use of a priori information in the detection of mammographic microcalcifications to improve their classification. Med Phys. 2003 May; 30(5):823-31. PMID: 12772990.
      Citations: 8     Fields:    Translation:Humans
    75. Edwards DC, Kupinski MA, Metz CE, Nishikawa RM. Maximum likelihood fitting of FROC curves under an initial-detection-and-candidate-analysis model. Med Phys. 2002 Dec; 29(12):2861-70. PMID: 12512721.
      Citations: 26     Fields:    Translation:Humans
    76. El-Naqa I, Yang Y, Wernick MN, Galatsanos NP, Nishikawa RM. A support vector machine approach for detection of microcalcifications. IEEE Trans Med Imaging. 2002 Dec; 21(12):1552-63. PMID: 12588039.
      Citations: 52     Fields:    Translation:Humans
    77. Beiden SV, Wagner RF, Doi K, Nishikawa RM, Freedman M, Lo SC, Xu XW. Independent versus sequential reading in ROC studies of computer-assist modalities: analysis of components of variance. Acad Radiol. 2002 Sep; 9(9):1036-43. PMID: 12238545.
      Citations: 8     Fields:    Translation:Humans
    78. Jiang Y, Nishikawa RM, Papaioannou J, Jiang Y, Nishikawa RM, Papaioannou J. Dependence of computer classification of clustered microcalcifications on the correct detection of microcalcifications. Med Phys. 2001 Sep; 28(9):1949-57. PMID: 11585226.
      Citations: 6     Fields:    Translation:Humans
    79. Jiang Y, Nishikawa RM, Schmidt RA, Toledano AY, Doi K, Jiang Y, Nishikawa RM, Schmidt RA, Toledano AY, Doi K. Potential of computer-aided diagnosis to reduce variability in radiologists' interpretations of mammograms depicting microcalcifications. Radiology. 2001 Sep; 220(3):787-94. PMID: 11526283.
      Citations: 22     Fields:    Translation:Humans
    80. Pisano ED, Cole EB, Major S, Zong S, Hemminger BM, Muller KE, Johnston RE, Walsh R, Conant E, Fajardo LL, Feig SA, Nishikawa RM, Yaffe MJ, Williams MB, Aylward SR. Radiologists' preferences for digital mammographic display. The International Digital Mammography Development Group. Radiology. 2000 Sep; 216(3):820-30. PMID: 10966717.
      Citations: 13     Fields:    Translation:HumansPHPublic Health
    81. Vyborny CJ, Giger ML, Nishikawa RM. Computer-aided detection and diagnosis of breast cancer. Radiol Clin North Am. 2000 Jul; 38(4):725-40. PMID: 10943274.
      Citations: 16     Fields:    Translation:Humans
    82. Nishikawa RM. Computer-aided diagnosis complements full-field digital mammography. Diagn Imaging (San Franc). 1999 Sep; 21(9):47-51, 75. PMID: 10623317.
      Citations: 2     Fields:    Translation:Humans
    83. Doi K, MacMahon H, Katsuragawa S, Nishikawa RM, Jiang Y. Computer-aided diagnosis in radiology: potential and pitfalls. Eur J Radiol. 1999 Aug; 31(2):97-109. PMID: 10565509.
      Citations: 30     Fields:    Translation:Humans
    84. Jiang Y, Nishikawa RM, Schmidt RA, Metz CE, Giger ML, Doi K. Improving breast cancer diagnosis with computer-aided diagnosis. Acad Radiol. 1999 Jan; 6(1):22-33. PMID: 9891149.
      Citations: 50     Fields:    Translation:Humans
    85. Anastasio MA, Kupinski MA, Nishikawa RM. Optimization and FROC analysis of rule-based detection schemes using a multiobjective approach. IEEE Trans Med Imaging. 1998 Dec; 17(6):1089-93. PMID: 10048867.
      Citations: 2     Fields:    Translation:Humans
    86. Anastasio MA, Yoshida H, Nagel R, Nishikawa RM, Doi K. A genetic algorithm-based method for optimizing the performance of a computer-aided diagnosis scheme for detection of clustered microcalcifications in mammograms. Med Phys. 1998 Sep; 25(9):1613-20. PMID: 9775365.
      Citations: 5     Fields:    Translation:Humans
    87. Nagel RH, Nishikawa RM, Papaioannou J, Doi K. Analysis of methods for reducing false positives in the automated detection of clustered microcalcifications in mammograms. Med Phys. 1998 Aug; 25(8):1502-6. PMID: 9725141.
      Citations: 2     Fields:    Translation:Humans
    88. Nishikawa RM. Mammographic databases. Breast Dis. 1998 Aug; 10(3-4):137-50. PMID: 15687570.
      Citations: 2     Fields:    
    89. Zhang W, Yoshida H, Nishikawa RM, Doi K. Optimally weighted wavelet transform based on supervised training for detection of microcalcifications in digital mammograms. Med Phys. 1998 Jun; 25(6):949-56. PMID: 9650185.
      Citations: 1     Fields:    Translation:Humans
    90. Nishikawa RM. Comment on "Quantitative classification of breast tumors in digitized mammograms" [Med. Phys. 23, 1337-1345 (1996)]. Med Phys. 1997 Feb; 24(2):313, 315. PMID: 9048373.
      Citations:    Fields:    Translation:Humans
    91. Krupinski EA, Nishikawa RM. Comparison of eye position versus computer identified microcalcification clusters on mammograms. Med Phys. 1997 Jan; 24(1):17-23. PMID: 9029538.
      Citations: 5     Fields:    Translation:Humans
    92. Jiang Y, Metz CE, Nishikawa RM. A receiver operating characteristic partial area index for highly sensitive diagnostic tests. Radiology. 1996 Dec; 201(3):745-50. PMID: 8939225.
      Citations: 50     Fields:    
    93. Bick U, Giger ML, Schmidt RA, Nishikawa RM, Doi K. Density correction of peripheral breast tissue on digital mammograms. Radiographics. 1996 Nov; 16(6):1403-11. PMID: 8946544.
      Citations: 8     Fields:    Translation:Humans
    94. Carlin MD, Nishikawa RM, MacMahon H, Doi K. The effect of x-ray beam alignment on the performance of antiscatter grids. Med Phys. 1996 Aug; 23(8):1347-50. PMID: 8873031.
      Citations: 2     Fields:    Translation:Humans
    95. Yoshida H, Doi K, Nishikawa RM, Giger ML, Schmidt RA. An improved computer-assisted diagnostic scheme using wavelet transform for detecting clustered microcalcifications in digital mammograms. Acad Radiol. 1996 Aug; 3(8):621-7. PMID: 8796725.
      Citations: 8     Fields:    Translation:Humans
    96. Zhang W, Doi K, Giger ML, Nishikawa RM, Schmidt RA. An improved shift-invariant artificial neural network for computerized detection of clustered microcalcifications in digital mammograms. Med Phys. 1996 Apr; 23(4):595-601. PMID: 8860907.
      Citations: 9     Fields:    Translation:Humans
    97. Huda W, Boone JM, Connors S, Fenster A, Gore JC, Honeyman JC, Madsen M, Nickoloff EL, Nishikawa RM, Wagner LK. Medical physics. Radiology. 1996 Mar; 198(3):941-9. PMID: 8628902.
      Citations:    Fields:    Translation:Humans
    98. Jiang Y, Nishikawa RM, Wolverton DE, Metz CE, Giger ML, Schmidt RA, Vyborny CJ, Doi K. Malignant and benign clustered microcalcifications: automated feature analysis and classification. Radiology. 1996 Mar; 198(3):671-8. PMID: 8628853.
      Citations: 25     Fields:    Translation:Humans
    99. Nagane M, Shibui S, Nishikawa R, Oyama H, Nakanishi Y, Nomura K. Triple primary malignant neoplasms including a malignant brain tumor: report of two cases and review of the literature. Surg Neurol. 1996 Mar; 45(3):219-29. PMID: 8638217.
      Citations: 6     Fields:    Translation:Humans
    100. Metz CE, Wagner RF, Doi K, Brown DG, Nishikawa RM, Myers KJ. Toward consensus on quantitative assessment of medical imaging systems. Med Phys. 1995 Jul; 22(7):1057-61. PMID: 7565380.
      Citations: 20     Fields:    Translation:Humans
    101. Nishikawa RM, Giger ML, Doi K, Vyborny CJ, Schmidt RA. Computer-aided detection of clustered microcalcifications on digital mammograms. Med Biol Eng Comput. 1995 Mar; 33(2):174-8. PMID: 7643656.
      Citations: 10     Fields:    Translation:Humans
    102. Nishikawa RM, Doi K, Giger ML, Schmidt RA, Vyborny CJ, Monnier-Cholley L, Papaioannou J, Lu P. Computerized detection of clustered microcalcifications: evaluation of performance on mammograms from multiple centers. Radiographics. 1995 Mar; 15(2):443-52. PMID: 7761647.
      Citations: 3     Fields:    Translation:Humans
    103. Ema T, Doi K, Nishikawa RM, Jiang Y, Papaioannou J. Image feature analysis and computer-aided diagnosis in mammography: reduction of false-positive clustered microcalcifications using local edge-gradient analysis. Med Phys. 1995 Feb; 22(2):161-9. PMID: 7565347.
      Citations: 4     Fields:    Translation:Humans
    104. Doi K, Giger ML, Nishikawa RM, Hoffmann KR, MacMahon H, Schmidt RA. Potential usefulness of digital imaging in clinical diagnostic radiology: computer-aided diagnosis. J Digit Imaging. 1995 Feb; 8(1 Suppl 1):2-7. PMID: 7734533.
      Citations:    Fields:    Translation:Humans
    105. Schmidt RA, Nishikawa RM. Clinical use of digital mammography: the present and the prospects. J Digit Imaging. 1995 Feb; 8(1 Suppl 1):74-9. PMID: 7734545.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    106. Bick U, Giger ML, Schmidt RA, Nishikawa RM, Wolverton DE, Doi K. Automated segmentation of digitized mammograms. Acad Radiol. 1995 Jan; 2(1):1-9. PMID: 9419517.
      Citations: 6     Fields:    Translation:Humans
    107. Hoffmann KR, Doi K, MacMahon H, Giger ML, Nishikawa RM, Xu XW, Yao L, Kano A, Carlin M. Development of a digital duplication system for portable chest radiographs. J Digit Imaging. 1994 Aug; 7(3):146-53. PMID: 7948174.
      Citations: 1     Fields:    Translation:Humans
    108. Zhang W, Doi K, Giger ML, Wu Y, Nishikawa RM, Schmidt RA. Computerized detection of clustered microcalcifications in digital mammograms using a shift-invariant artificial neural network. Med Phys. 1994 Apr; 21(4):517-24. PMID: 8058017.
      Citations: 31     Fields:    Translation:Humans
    109. Nishikawa RM, Giger ML, Doi K, Metz CE, Yin FF, Vyborny CJ, Schmidt RA. Effect of case selection on the performance of computer-aided detection schemes. Med Phys. 1994 Feb; 21(2):265-9. PMID: 8177159.
      Citations: 26     Fields:    Translation:Humans
    110. Nishikawa RM, Giger ML, Doi K, Vyborny CJ, Schmidt RA. Computer-aided detection of clustered microcalcifications: an improved method for grouping detected signals. Med Phys. 1993 Nov-Dec; 20(6):1661-6. PMID: 8309438.
      Citations: 4     Fields:    Translation:Humans
    111. Doi K, Giger ML, Nishikawa RM, Hoffmann KR, MacMahon H, Schmidt RA, Chua KG. Digital radiography. A useful clinical tool for computer-aided diagnosis by quantitative analysis of radiographic images. Acta Radiol. 1993 Sep; 34(5):426-39. PMID: 8369177.
      Citations: 5     Fields:    Translation:Humans
    112. Giger ML, Doi K, MacMahon H, Nishikawa RM, Hoffmann KR, Vyborny CJ, Schmidt RA, Jia H, Abe K, Chen X, et al. An "intelligent" workstation for computer-aided diagnosis. Radiographics. 1993 May; 13(3):647-56. PMID: 8316671.
      Citations: 5     Fields:    Translation:Humans
    113. Wu Y, Doi K, Giger ML, Nishikawa RM. Computerized detection of clustered microcalcifications in digital mammograms: applications of artificial neural networks. Med Phys. 1992 May-Jun; 19(3):555-60. PMID: 1508089.
      Citations: 14     Fields:    Translation:Humans
    114. Doi K, Giger ML, MacMahon H, Hoffmann KR, Nishikawa RM, Schmidt RA, Chua KG, Katsuragawa S, Nakamori N, Sanada S, et al. Computer-aided diagnosis: development of automated schemes for quantitative analysis of radiographic images. Semin Ultrasound CT MR. 1992 Apr; 13(2):140-52. PMID: 1599732.
      Citations: 6     Fields:    Translation:Humans
    115. Yin FF, Giger ML, Doi K, Yoshimura H, Xu XW, Nishikawa RM. Evaluation of imaging properties of a laser film digitizer. Phys Med Biol. 1992 Jan; 37(1):273-80. PMID: 1741429.
      Citations: 3     Fields:    Translation:Humans
    116. Shibui S, Nishikawa R, Nomura K. [Treatment of metastatic brain tumor from renal cell carcinoma]. No Shinkei Geka. 1990 Oct; 18(10):935-8. PMID: 2234294.
      Citations: 2     Fields:    Translation:Humans
    117. Nishikawa RM, Yaffe MJ. Effect of various noise sources on the detective quantum efficiency of phosphor screens. Med Phys. 1990 Sep-Oct; 17(5):887-93. PMID: 2233576.
      Citations: 3     Fields:    
    118. Nishikawa RM, Yaffe MJ. Model of the spatial-frequency-dependent detective quantum efficiency of phosphor screens. Med Phys. 1990 Sep-Oct; 17(5):894-904. PMID: 2233577.
      Citations: 5     Fields:    
    119. Nishikawa RM, Yaffe MJ, Holmes RB. Effect of finite phosphor thickness on detective quantum efficiency. Med Phys. 1989 Sep-Oct; 16(5):773-80. PMID: 2811759.
      Citations: 8     Fields:    
    120. Nishikawa RM, Mawdsley GE, Fenster A, Yaffe MJ. Scanned-projection digital mammography. Med Phys. 1987 Sep-Oct; 14(5):717-27. PMID: 3683300.
      Citations: 10     Fields:    Translation:Humans
    121. Yaffe MJ, Johns PC, Nishikawa RM, Mawdsley GE, Caldwell CB. Anthropomorphic radiologic phantoms. Radiology. 1986 Feb; 158(2):550-2. PMID: 3941885.
      Citations: 3     Fields:    Translation:Humans
    122. Nishikawa RM, Yaffe MJ. Signal-to-noise properties of mammographic film-screen systems. Med Phys. 1985 Jan-Feb; 12(1):32-9. PMID: 3974523.
      Citations: 6     Fields:    Translation:Humans
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