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Kulandaivelu Vetrivel

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Deyts C, Clutter M, Pierce N, Chakrabarty P, Ladd TB, Goddi A, Rosario AM, Cruz P, Vetrivel K, Wagner SL, Thinakaran G, Golde TE, Parent AT. APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model. Cell Rep. 2019 04 30; 27(5):1345-1355.e6. PMID: 31042463; PMCID: PMC6508668.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    2. Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Holtzman DM, Thinakaran G, Buggia-Prévot V, Parent AT. Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9665-E9674. PMID: 29078331; PMCID: PMC5692556.
      Citations: 24     Fields:    Translation:AnimalsCells
    3. Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, Thinakaran G, Buggia-Prévot V. Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Mol Neurodegener. 2014 Jan 04; 9:1. PMID: 24386896; PMCID: PMC4031619.
      Citations: 55     Fields:    Translation:AnimalsCells
    4. Fernandez CG, Udayar V, Vetrivel KS, Elie A, Roseman J, Sasse VA, Lefkow M, Meckler X, Bhattacharyya S, George M, Kar S, Bindokas VP, Rajendran L, Band H, Vassar R, Thinakaran G, Buggia-Prévot V, Parent AT. A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aß production. Cell Rep. 2013 Dec 26; 5(6):1552-63. PMID: 24373286; PMCID: PMC3932704.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    5. Zeiger W, Vetrivel KS, Nguyen PD, Wagner SL, Villereal ML, Thinakaran G, Buggia-Prévot V. Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease ß-amyloid peptide secretion. J Biol Chem. 2013 Sep 13; 288(37):26955-66. PMID: 23902769; PMCID: PMC3772244.
      Citations: 20     Fields:    Translation:HumansCells
    6. Deyts C, Vetrivel KS, Das S, Shepherd YM, Thinakaran G, Dupré DJ, Parent AT. Novel GaS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain. J Neurosci. 2012 Feb 01; 32(5):1714-29. PMID: 22302812; PMCID: PMC3567462.
      Citations: 32     Fields:    Translation:AnimalsCells
    7. Gong P, Roseman J, Fernandez CG, Vetrivel KS, Bindokas VP, Zitzow LA, Kar S, Thinakaran G, Parent AT. Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice. Mol Neurodegener. 2011 Dec 28; 6:87. PMID: 22204304; PMCID: PMC3259059.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    8. Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G. Loss of cleavage at ß'-site contributes to apparent increase in ß-amyloid peptide (Aß) secretion by ß-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein. J Biol Chem. 2011 Jul 22; 286(29):26166-77. PMID: 21642424; PMCID: PMC3138254.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    9. Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Thinakaran G, Parent AT. Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates. J Biol Chem. 2010 Dec 03; 285(49):38042-52. PMID: 20921220; PMCID: PMC2992238.
      Citations: 21     Fields:    Translation:AnimalsCells
    10. Kodam A, Maulik M, Peake K, Amritraj A, Vetrivel KS, Thinakaran G, Vance JE, Kar S. Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains. Glia. 2010 Aug 15; 58(11):1267-81. PMID: 20607864; PMCID: PMC2914615.
      Citations: 24     Fields:    Translation:AnimalsCells
    11. Vetrivel KS, Thinakaran G. Membrane rafts in Alzheimer's disease beta-amyloid production. Biochim Biophys Acta. 2010 Aug; 1801(8):860-7. PMID: 20303415; PMCID: PMC2886169.
      Citations: 121     Fields:    Translation:HumansAnimalsCells
    12. Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem. 2009 Feb 06; 284(6):3793-803. PMID: 19074428; PMCID: PMC2635050.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    13. Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G. S-palmitoylation of gamma-secretase subunits nicastrin and APH-1. J Biol Chem. 2009 Jan 16; 284(3):1373-84. PMID: 19028695; PMCID: PMC2615504.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    14. Vetrivel KS, Kodam A, Gong P, Chen Y, Kar S, Thinakaran G, Parent AT. Localization and regional distribution of p23/TMP21 in the brain. Neurobiol Dis. 2008 Oct; 32(1):37-49. PMID: 18652896; PMCID: PMC2639720.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    15. Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Saido TC, Li YM, Sisodia SS, Thinakaran G, Parent AT. Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta. J Biol Chem. 2008 Jul 11; 283(28):19489-98. PMID: 18456655; PMCID: PMC2443668.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    16. Cheng H, Vetrivel KS, Gong P, Meckler X, Thinakaran G, Parent A. Mechanisms of disease: new therapeutic strategies for Alzheimer's disease--targeting APP processing in lipid rafts. Nat Clin Pract Neurol. 2007 Jul; 3(7):374-82. PMID: 17611486; PMCID: PMC2880530.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    17. Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas MZ, Thinakaran G. Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Mol Neurodegener. 2007 Feb 08; 2:4. PMID: 17288597; PMCID: PMC1803014.
      Citations: 39     Fields:    
    18. Kodam A, Vetrivel KS, Thinakaran G, Kar S. Cellular distribution of gamma-secretase subunit nicastrin in the developing and adult rat brains. Neurobiol Aging. 2008 May; 29(5):724-38. PMID: 17222950; PMCID: PMC2871253.
      Citations: 10     Fields:    Translation:AnimalsCells
    19. Vetrivel KS, Zhang YW, Xu H, Thinakaran G. Pathological and physiological functions of presenilins. Mol Neurodegener. 2006 Jun 12; 1:4. PMID: 16930451; PMCID: PMC1513131.
      Citations: 78     Fields:    
    20. Vetrivel KS, Thinakaran G. Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments. Neurology. 2006 Jan 24; 66(2 Suppl 1):S69-73. PMID: 16432149.
      Citations: 77     Fields:    Translation:HumansCells
    21. Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, Sisodia SS, Thinakaran G, Parent AT. Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J Biol Chem. 2005 Jul 08; 280(27):25892-900. PMID: 15886206; PMCID: PMC1201532.
      Citations: 113     Fields:    Translation:AnimalsCells
    22. Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components. J Biol Chem. 2005 Apr 29; 280(17):17020-6. PMID: 15711015; PMCID: PMC1201533.
      Citations: 54     Fields:    Translation:AnimalsCells
    23. Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G. Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes. J Biol Chem. 2004 Oct 22; 279(43):44945-54. PMID: 15322084; PMCID: PMC1201506.
      Citations: 194     Fields:    Translation:HumansAnimalsCells
    24. Prasad R, Sasikala V, Vetrivel KS, Dharmalingam K. A novel extracellular protein of Streptomyces peucetius binds to daunorubicin but does not inhibit the bioactivity of the antibiotic. Biochem Biophys Res Commun. 2003 Nov 14; 311(2):460-4. PMID: 14592436.
      Citations: 1     Fields:    Translation:Cells
    25. Vetrivel KS, Dharmalingam K. Isolation and characterization of stable mutants of Streptomyces peucetius defective in daunorubicin biosynthesis. J Genet. 2001 Apr; 80(1):31-8. PMID: 11910122.
      Citations: 3     Fields:    Translation:Cells
    26. Vetrivel KS, Pandian SK, Chaudhary U, Dharmalingam K. Purification, cloning, and DNA sequence analysis of a chitinase from an overproducing mutant of Streptomyces peucetius defective in daunorubicin biosynthesis. Can J Microbiol. 2001 Mar; 47(3):179-87. PMID: 11315108.
      Citations: 4     Fields:    Translation:Cells
    27. Vetrivel KS, Dharmalingam K. Isolation of a chitinase overproducing mutant of Streptomyces peucetius defective in daunorubicin biosynthesis. Can J Microbiol. 2000 Oct; 46(10):956-60. PMID: 11068684.
      Citations: 2     Fields:    Translation:Cells
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