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Philip P. Connell

TitleProfessor
InstitutionUniversity of Chicago
DepartmentRadiation and Cellular Oncology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Philip Connell, MD, is an expert in radiotherapy with a particular focus on sarcomas, thoracic cancers, and pediatric malignancies. This year he was again recognized by Newsweek as one of “America's Top Doctors” and by Chicago Magazine as a “Top Doctor” in the Chicagoland region.

    In addition to his clinical responsibilities, Dr. Connell is an active cancer researcher. He received laboratory training in cancer biology through a National Cancer Institute fellowship. His oncology research program is working to identify molecular markers of treatment resistance and to develop new anti-cancer agents that can overcome these molecular hurdles. His newest ongoing projects involve several novel, high-throughput assays designed to identify potential drugs that modify DNA repair. With these systems, researchers have the potential to discover new chemical compounds with wide-ranging impacts--from improving present oncology therapies to blocking the mutagenic effects of chemotherapy and radiotherapy.

    Dr. Connell has received several awards including the American Society of Clinical Oncology Merit Award, American Brachytherapy Society Research Award, Roentgen Society Research Award, Samuel Hellman Teacher of the Year Award, and American Society for Therapeutic Radiology and Oncology Junior Faculty Fellowship Award. He has authored numerous medical reports and textbook chapters, and he serves as a reviewer for numerous medical journals.


    Collapse Biography 
    Collapse education and training
    Tufts University, Medford, MABS1991Chemical engineering
    New York Medical College, Valhalla, NYMD1995Medicine
    St. Vincent’s Hospital, New York, NYInternship1996Internal medicine
    University of Chicago, Chicago, IlResidency2000Radiation Oncology
    University of Chicago, Chicago, IlNIH Research Fellow2001Cancer research
    Collapse awards and honors
    2015 - 2021Recognized as one of “America's Top Doctors” , Newsweek
    2015 - 2021Recognized as a “Top Doctor”, Chicago Magazine
    2016Best basic/translational science , Annual Meeting of the American Society for Radiation Oncology
    2004 - 2005American Society for Therapeutic Radiology and Oncology Junior Faculty , U Chicago
    2003Samuel Hellman Teaching Award, U Chicago
    2001Young Investigator Grant Award, Cancer Research Foundation
    1999Roentgen Society Research Award, Roentgen Society
    1999American Brachytherapy Society Research Award, American Brachytherapy Society
    1997American Society of Clinical Oncology Merit Award, American Society of Clinical Oncology

    Collapse Research 
    Collapse research activities and funding
    R21CA124557     (CONNELL, PHILIP PAUL)Jul 1, 2007 - Jun 30, 2010
    NIH
    Inhibition of Recombination DNA Repair in Pancreatic Cancer Cells
    Role: Principal Investigator
    R01CA142642     (CONNELL, PHILIP P)Dec 1, 2009 - Jun 30, 2020
    NIH
    RAD51 Inhibitors for Chemotherapy and Radiation Therapy
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Budke B, Zhong A, Sullivan K, Park C, Gittin DI, Kountz TS, Connell PP. Noncanonical NF-?B factor p100/p52 regulates homologous recombination and modulates sensitivity to DNA-damaging therapy. Nucleic Acids Res. 2022 06 24; 50(11):6251-6263. PMID: 35689636.
      View in: PubMed
    2. Xu J, Zhao L, Peng S, Chu H, Liang R, Tian M, Connell PP, Li G, Chen C, Wang HW. Mechanisms of distinctive mismatch tolerance between Rad51 and Dmc1 in homologous recombination. Nucleic Acids Res. 2021 12 16; 49(22):13135-13149. PMID: 34871438.
      View in: PubMed
    3. Zuo K, Yuan X, Liang X, Sun X, Liu S, Connell PP, Li X, Yang W. qRT-PCR-based DNA homologous recombination-associated 4-gene score predicts pathologic complete response to platinum-based neoadjuvant chemotherapy in triple-negative breast cancer. Breast Cancer Res Treat. 2022 Jan; 191(2):335-344. PMID: 34797456.
      View in: PubMed
    4. Pointer KB, Budke B, Connell PP. Targeting Non-Canonical NF?B2 to Determine the Effects on Radiation Sensitization. Int J Radiat Oncol Biol Phys. 2021 Nov 01; 111(3S):e229-e230. PMID: 34700966.
      View in: PubMed
    5. Gutiontov SI, Turchan WT, Spurr LF, Rouhani SJ, Chervin CS, Steinhardt G, Lager AM, Wanjari P, Malik R, Connell PP, Chmura SJ, Juloori A, Hoffman PC, Ferguson MK, Donington JS, Patel JD, Vokes EE, Weichselbaum RR, Bestvina CM, Segal JP, Pitroda SP. CDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer. Sci Rep. 2021 10 08; 11(1):20059. PMID: 34625620.
      View in: PubMed
    6. Rosenberg DM, Onderdonk B, Majeed NK, Guzman G, Farid Y, Connell PP, Son CH. Radiation-Induced Sarcoma After Heterotopic Ossification Prophylaxis: A Case Report. JBJS Case Connect. 2019 Dec; 9(4):e0146. PMID: 31815809.
      View in: PubMed
    7. Tatebe K, Chmura SJ, Connell PP. Elevated Radiation Therapy Toxicity in the Setting of Germline PTEN Mutation. Pract Radiat Oncol. 2019 Nov; 9(6):492-495. PMID: 31185301.
      View in: PubMed
    8. Ni L, Koshy M, Connell P, Pitroda S, Golden DW, Al-Hallaq H, Hubert G, Kauffman G, McCall A, Malik R. Heart V5 predicts cardiac events in unresectable lung cancer patients undergoing chemoradiation. J Thorac Dis. 2019 Jun; 11(6):2229-2239. PMID: 31372260.
      View in: PubMed
    9. Budke B, Tueckmantel W, Miles K, Kozikowski AP, Connell PP. Optimization of Drug Candidates That Inhibit the D-Loop Activity of RAD51. ChemMedChem. 2019 05 17; 14(10):1031-1040. PMID: 30957434.
      View in: PubMed
    10. Chlenski A, Park C, Dobratic M, Salwen HR, Budke B, Park JH, Miller R, Applebaum MA, Wilkinson E, Nakamura Y, Connell PP, Cohn SL. Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma. Mol Cancer Ther. 2019 03; 18(3):507-516. PMID: 30674566.
      View in: PubMed
    11. Chmura SJ, Connell PP, Weichselbaum RR. Retuning the Radio in Radiobiology. J Natl Cancer Inst. 2018 04 01; 110(4):325-326. PMID: 29126281.
      View in: PubMed
    12. Akthar AS, Koshy M, Ferguson MK, Murgu S, Hogarth DK, Golden DW, Connell PP, Davies EM, Kowalski E, Malik R. Effect of Endoscopic Bronchial Ultrasound on Outcomes for Stage I Non-Small-Cell Lung Cancer Patients Receiving Hypofractionated Radiotherapy. Clin Lung Cancer. 2018 03; 19(2):e227-e233. PMID: 28939097.
      View in: PubMed
    13. Ni L, Koshy M, Connell PP, Hubert G, Vokes EE, Patel JD, Hoffman P, Al-Hallaq HA, Malik R. Impact of Cardiac Dose on Cardiac Events and Survival in Unresectable Lung Cancer Patients. Int J Radiat Oncol Biol Phys. 2017 May 01; 98(1):247. PMID: 28587036.
      View in: PubMed
    14. Pitroda SP, Bao R, Andrade J, Weichselbaum RR, Connell PP. Low Recombination Proficiency Score (RPS) Predicts Heightened Sensitivity to DNA-Damaging Chemotherapy in Breast Cancer. Clin Cancer Res. 2017 Aug 01; 23(15):4493-4500. PMID: 28341751.
      View in: PubMed
    15. Budke B, Lv W, Kozikowski AP, Connell PP. Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy? ChemMedChem. 2016 11 21; 11(22):2468-2473. PMID: 27781374.
      View in: PubMed
    16. Lv W, Budke B, Pawlowski M, Connell PP, Kozikowski AP. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem. 2016 05 26; 59(10):4511-25. PMID: 27049177.
      View in: PubMed
    17. Spiotto MT, Connell PP. Strategies to Overcome Late Complications from Radiotherapy for Childhood Head and Neck Cancers. Oral Maxillofac Surg Clin North Am. 2016 Feb; 28(1):115-26. PMID: 26614704.
      View in: PubMed
    18. Thierry S, Benleulmi MS, Sinzelle L, Thierry E, Calmels C, Chaignepain S, Waffo-Teguo P, Merillon JM, Budke B, Pasquet JM, Litvak S, Ciuffi A, Sung P, Connell P, Hauber I, Hauber J, Andreola ML, Delelis O, Parissi V. Dual and Opposite Effects of hRAD51 Chemical Modulation on HIV-1 Integration. Chem Biol. 2015 Jun 18; 22(6):712-23. PMID: 26051216.
      View in: PubMed
    19. Mason JM, Dusad K, Wright WD, Grubb J, Budke B, Heyer WD, Connell PP, Weichselbaum RR, Bishop DK. RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells. Nucleic Acids Res. 2015 Mar 31; 43(6):3180-96. PMID: 25765654.
      View in: PubMed
    20. Mason JM, Logan HL, Budke B, Wu M, Pawlowski M, Weichselbaum RR, Kozikowski AP, Bishop DK, Connell PP. The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors. Cancer Res. 2014 Jul 01; 74(13):3546-55. PMID: 24753542.
      View in: PubMed
    21. Pitroda SP, Pashtan IM, Logan HL, Budke B, Darga TE, Weichselbaum RR, Connell PP. DNA repair pathway gene expression score correlates with repair proficiency and tumor sensitivity to chemotherapy. Sci Transl Med. 2014 Mar 26; 6(229):229ra42. PMID: 24670686.
      View in: PubMed
    22. Connell PP, Weichselbaum RR. Small molecule derived from a natural product that mitigates radiation injury. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18355-6. PMID: 24187150.
      View in: PubMed
    23. Budke B, Chan YL, Bishop DK, Connell PP. Real-time solution measurement of RAD51- and RecA-mediated strand assimilation without background annealing. Nucleic Acids Res. 2013 Jul; 41(13):e130. PMID: 23666628.
      View in: PubMed
    24. Liauw SL, Connell PP, Weichselbaum RR. New paradigms and future challenges in radiation oncology: an update of biological targets and technology. Sci Transl Med. 2013 Feb 20; 5(173):173sr2. PMID: 23427246.
      View in: PubMed
    25. Spraker MB, Bair E, Bair R, Connell PP, Mahmood U, Koshy M. An analysis of patient characteristics and clinical outcomes in primary pulmonary sarcoma. J Thorac Oncol. 2013 Feb; 8(2):147-51. PMID: 23263688.
      View in: PubMed
    26. Budke B, Kalin JH, Pawlowski M, Zelivianskaia AS, Wu M, Kozikowski AP, Connell PP. An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity. J Med Chem. 2013 Jan 10; 56(1):254-63. PMID: 23231413.
      View in: PubMed
    27. Budke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 2012 Aug; 40(15):7347-57. PMID: 22573178.
      View in: PubMed
    28. Hasselle MD, Haraf DJ, Rusthoven KE, Golden DW, Salgia R, Villaflor VM, Shah N, Hoffman PC, Chmura SJ, Connell PP, Vokes EE, Weichselbaum RR, Salama JK. Hypofractionated image-guided radiation therapy for patients with limited volume metastatic non-small cell lung cancer. J Thorac Oncol. 2012 Feb; 7(2):376-81. PMID: 22198429.
      View in: PubMed
    29. Salama JK, Hasselle MD, Chmura SJ, Malik R, Mehta N, Yenice KM, Villaflor VM, Stadler WM, Hoffman PC, Cohen EE, Connell PP, Haraf DJ, Vokes EE, Hellman S, Weichselbaum RR. Stereotactic body radiotherapy for multisite extracranial oligometastases: final report of a dose escalation trial in patients with 1 to 5 sites of metastatic disease. Cancer. 2012 Jun 01; 118(11):2962-70. PMID: 22020702.
      View in: PubMed
    30. Cosnefroy O, Tocco A, Lesbats P, Thierry S, Calmels C, Wiktorowicz T, Reigadas S, Kwon Y, De Cian A, Desfarges S, Bonot P, San Filippo J, Litvak S, Cam EL, Rethwilm A, Fleury H, Connell PP, Sung P, Delelis O, Andréola ML, Parissi V. Stimulation of the human RAD51 nucleofilament restricts HIV-1 integration in vitro and in infected cells. J Virol. 2012 Jan; 86(1):513-26. PMID: 22013044.
      View in: PubMed
    31. Connell PP, Weichselbaum RR. A downside to apoptosis in cancer therapy? Nat Med. 2011 Jul 07; 17(7):780-2. PMID: 21738153.
      View in: PubMed
    32. Shumway D, Corbin K, Salgia R, Hoffman P, Villaflor V, Malik RM, Haraf DJ, Vigneswaren WT, Shaikh AY, Connell PP, Ferguson MK, Salama JK. Pathologic response rates following definitive dose image-guided chemoradiotherapy and resection for locally advanced non-small cell lung cancer. Lung Cancer. 2011 Dec; 74(3):446-50. PMID: 21676484.
      View in: PubMed
    33. MacDermed DM, Miller LL, Peabody TD, Simon MA, Luu HH, Haydon RC, Montag AG, Undevia SD, Connell PP. Primary tumor necrosis predicts distant control in locally advanced soft-tissue sarcomas after preoperative concurrent chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2010 Mar 15; 76(4):1147-53. PMID: 19577863.
      View in: PubMed
    34. Connell PP, Hellman S. Advances in radiotherapy and implications for the next century: a historical perspective. Cancer Res. 2009 Jan 15; 69(2):383-92. PMID: 19147546.
      View in: PubMed
    35. Jayathilaka K, Sheridan SD, Bold TD, Bochenska K, Logan HL, Weichselbaum RR, Bishop DK, Connell PP. A chemical compound that stimulates the human homologous recombination protein RAD51. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15848-53. PMID: 18840682.
      View in: PubMed
    36. Martin RW, Connell PP, Bishop DK. The Yin and Yang of treating BRCA-deficient tumors. Cell. 2008 Mar 21; 132(6):919-20. PMID: 18358803.
      View in: PubMed
    37. Knab B, Connell PP. Radiotherapy for pediatric brain tumors: when and how. Expert Rev Anticancer Ther. 2007 Dec; 7(12 Suppl):S69-77. PMID: 18076312.
      View in: PubMed
    38. Shaikh AY, Haraf DJ, Salama JK, Salgia R, Hoffman PC, Ferguson MK, Connell PP. Chemotherapy and high dose radiotherapy followed by resection for locally advanced nonsmall cell lung cancers. Am J Clin Oncol. 2007 Jun; 30(3):258-63. PMID: 17551302.
      View in: PubMed
    39. Seiwert TY, Connell PP, Mauer AM, Hoffman PC, George CM, Szeto L, Salgia R, Posther KE, Nguyen B, Haraf DJ, Vokes EE. A phase I study of pemetrexed, carboplatin, and concurrent radiotherapy in patients with locally advanced or metastatic non-small cell lung or esophageal cancer. Clin Cancer Res. 2007 Jan 15; 13(2 Pt 1):515-22. PMID: 17255273.
      View in: PubMed
    40. Connell PP, Jayathilaka K, Haraf DJ, Weichselbaum RR, Vokes EE, Lingen MW. Pilot study examining tumor expression of RAD51 and clinical outcomes in human head cancers. Int J Oncol. 2006 May; 28(5):1113-9. PMID: 16596227.
      View in: PubMed
    41. Connell PP, Fulcher TP, Chacko E, O' Connor MJ, Moriarty P. Long term follow up of nasolacrimal intubation in adults. Br J Ophthalmol. 2006 Apr; 90(4):435-6. PMID: 16547322.
      View in: PubMed
    42. Seiwert TY, Connell PP, Mauer AM, Hoffman PC, George CM, Szeto L, Obasaju C, Haraf DJ, Salgia R, Vokes EE. A phase I dose-escalating study of combination pemetrexed-based chemotherapy and concomitant radiotherapy for locally advanced or metastatic non-small cell lung or esophageal cancer. J Clin Oncol. 2005 Jun; 23(16_suppl):7062. PMID: 27944519.
      View in: PubMed
    43. Connell P, McKevitt C, Low N. Investigating ethnic differences in sexual health: focus groups with young people. Sex Transm Infect. 2004 Aug; 80(4):300-5. PMID: 15295130.
      View in: PubMed
    44. Connell PP, Kron SJ, Weichselbaum RR. Relevance and irrelevance of DNA damage response to radiotherapy. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):1245-51. PMID: 15279813.
      View in: PubMed
    45. Connell PP, Siddiqui N, Hoffman S, Kuang A, Khatipov EA, Weichselbaum RR, Bishop DK. A hot spot for RAD51C interactions revealed by a peptide that sensitizes cells to cisplatin. Cancer Res. 2004 May 01; 64(9):3002-5. PMID: 15126333.
      View in: PubMed
    46. Connell PP, Weichselbaum RR. Gene therapy: the challenges of translating laboratory research into clinical practice. J Clin Oncol. 2003 Jun 15; 21(12):2230-1. PMID: 12805319.
      View in: PubMed
    47. Mundt AJ, Murphy KT, Rotmensch J, Waggoner SE, Yamada SD, Connell PP. Surgery and postoperative radiation therapy in FIGO Stage IIIC endometrial carcinoma. Int J Radiat Oncol Biol Phys. 2001 Aug 01; 50(5):1154-60. PMID: 11483324.
      View in: PubMed
    48. Mundt AJ, McBride R, Rotmensch J, Waggoner SE, Yamada SD, Connell PP. Significant pelvic recurrence in high-risk pathologic stage I--IV endometrial carcinoma patients after adjuvant chemotherapy alone: implications for adjuvant radiation therapy. Int J Radiat Oncol Biol Phys. 2001 Aug 01; 50(5):1145-53. PMID: 11483323.
      View in: PubMed
    49. Ashman JB, Connell PP, Yamada D, Rotmensch J, Waggoner SE, Mundt AJ. Outcome of endometrial carcinoma patients with involvement of the uterine serosa. Gynecol Oncol. 2001 Aug; 82(2):338-43. PMID: 11531290.
      View in: PubMed
    50. Connell PP, Ignacio L, Haraf D, Awan AM, Halpern H, Abdalla I, Nautiyal J, Jani AB, Weichselbaum RR, Vijayakumar S. Equivalent racial outcome after conformal radiotherapy for prostate cancer: a single departmental experience. J Clin Oncol. 2001 Jan 01; 19(1):54-61. PMID: 11134195.
      View in: PubMed
    51. Jani AB, Connell PP, Vesich VJ, O'Brien KM, Chen LM. Analysis of the role of adjuvant chemotherapy for invasive carcinoma of the esophagus. Am J Clin Oncol. 2000 Dec; 23(6):554-8. PMID: 11202794.
      View in: PubMed
    52. Mundt AJ, Waggoner S, Yamada D, Rotmensch J, Connell PP. Age as a prognostic factor for recurrence in patients with endometrial carcinoma. Gynecol Oncol. 2000 Oct; 79(1):79-85. PMID: 11006036.
      View in: PubMed
    53. Tran BN, Connell PP, Waggoner S, Rotmensch J, Mundt AJ. Characteristics and outcome of endometrial carcinoma patients age 45 years and younger. Am J Clin Oncol. 2000 Oct; 23(5):476-80. PMID: 11039507.
      View in: PubMed
    54. Castro IM, Connell PP, Waggoner S, Rotmensch J, Mundt AJ. Synchronous ovarian and endometrial malignancies. Am J Clin Oncol. 2000 Oct; 23(5):521-5. PMID: 11039516.
      View in: PubMed
    55. Mundt AJ, Connell PP. Do conventional pathologic features lose their prognostic significance following postoperative radiation therapy in pathologic stage I-II endometrial adenocarcinoma? Int J Cancer. 2000 Aug 20; 90(4):224-30. PMID: 10993962.
      View in: PubMed
    56. Rotmensch J, Connell PP, Yamada D, Waggoner SE, Mundt AJ. One versus two intracavitary brachytherapy applications in early-stage cervical cancer patients undergoing definitive radiation therapy. Gynecol Oncol. 2000 Jul; 78(1):32-8. PMID: 10873406.
      View in: PubMed
    57. Wollschlaeger K, Connell PP, Waggoner S, Rotmensch J, Mundt AJ. Acute problems during low-dose-rate intracavitary brachytherapy for cervical carcinoma. Gynecol Oncol. 2000 Jan; 76(1):67-72. PMID: 10620444.
      View in: PubMed
    58. Connell PP, Ignacio L, McBride RB, Weichselbaum RR, Vijayakumar S. Caution in interpreting biochemical control rates after treatment of prostate cancer: length of follow-up influences results. Urology. 1999 Nov; 54(5):875-9. PMID: 10565750.
      View in: PubMed
    59. Connell PP, Rotmensch J, Waggoner SE, Mundt AJ. Race and clinical outcome in endometrial carcinoma. Obstet Gynecol. 1999 Nov; 94(5 Pt 1):713-20. PMID: 10546716.
      View in: PubMed
    60. Calvin DP, Connell PP, Rotmensch J, Waggoner S, Mundt AJ. Surgery and postoperative radiation therapy in stage II endometrial carcinoma. Am J Clin Oncol. 1999 Aug; 22(4):338-43. PMID: 10440186.
      View in: PubMed
    61. Connell PP, Rotmensch J, Waggoner S, Mundt AJ. The significance of adnexal involvement in endometrial carcinoma. Gynecol Oncol. 1999 Jul; 74(1):74-9. PMID: 10385554.
      View in: PubMed
    62. Weiss MF, Connell PP, Waggoner S, Rotmensch J, Mundt AJ. External pelvic radiation therapy in stage IC endometrial carcinoma. Obstet Gynecol. 1999 Apr; 93(4):599-602. PMID: 10214841.
      View in: PubMed
    63. Mundt AJ, Connell PP, Mansur DB. What is the optimal treatment volume in Hodgkin's disease patients undergoing high-dose chemotherapy and adjuvant radiation therapy? Radiat Oncol Investig. 1999; 7(6):353-9. PMID: 10644058.
      View in: PubMed
    64. Mundt AJ, Connell PP, Campbell T, Hwang JH, Rotmensch J, Waggoner S. Race and clinical outcome in patients with carcinoma of the uterine cervix treated with radiation therapy. Gynecol Oncol. 1998 Nov; 71(2):151-8. PMID: 9826453.
      View in: PubMed
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