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Howard Halpern

TitleProfessor
InstitutionUniversity of Chicago
DepartmentRadiation and Cellular Oncology
Email
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    Collapse Overview 
    Collapse overview
    Howard J. Halpern, MD, PhD, specializes in medical imaging techniques. He is an expert in very low frequency-imaging-electron paramagnetic resonance (VLF-I-EPR). This technique enables measurement of changes in oxygen content in tumor tissues--a key determinant of response to radiation therapy.

    Dr. Halpern is the co-author of a textbook on free radical biology. He serves as the principal investigator for the Oversight Committee for the Laboratory Training of Radiation Oncology Residents.

    Collapse Biography 
    Collapse education and training
    University of Wisconsin, Madison, WisconsinPhD06/1976High Energy Physics
    University of Miami, Miami, FloridaMD061980Medicine

    Collapse Research 
    Collapse research activities and funding
    R01CA236385     (CHEN, CHIN-TU)Jan 1, 2020 - Dec 31, 2024
    NIH
    Improved Radiation Therapy of Hypoxic Tumor Regions by Integrated PET, EPR, and MR Imaging - Resubmission 01
    Role: Co-Principal Investigator
    R21EB005382     (HALPERN, HOWARD J)Sep 15, 2005 - Aug 31, 2010
    NIH
    Magnitude Improvement of Molecular Signaling Imaging (RMI)
    Role: Principal Investigator
    R01CA098575     (HALPERN, HOWARD J)Jun 1, 2003 - Mar 31, 2024
    NIH
    Radiation Biology of EPR Oxygen Images
    Role: Principal Investigator
    P41EB002034     (HALPERN, HOWARD J)Sep 30, 1999 - May 31, 2019
    NIH
    Center for Electron Paramagnetic Resonance Imaging in Vivo Physiology
    Role: Principal Investigator
    P41RR012257     (HALPERN, HOWARD J)Sep 30, 1999 - Aug 31, 2004
    NIH
    VERY LOW FREQUENCY EPR IMAGING FOR IN VIVO PHYSIOLOGY
    Role: Principal Investigator
    R01CA069538     (HALPERN, HOWARD J)Jul 1, 1996 - Apr 30, 2001
    NIH
    IN VIVO DETECTION OF RADIATION INDUCED FREE RADICALS
    Role: Principal Investigator
    T32CA009675     (HALPERN, HOWARD J)Aug 15, 1992 - Jun 30, 2002
    NIH
    BIOLOGICAL, PHYSICAL&CHEMICAL BASIS OF RADIATION THERAPY
    Role: Principal Investigator
    R29CA050679     (HALPERN, HOWARD J)Aug 15, 1989 - Jul 31, 1994
    NIH
    IMAGING OXYGEN--LOW FREQUENCY ELECTRON SPIN RESONANCE
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Qiao Z, Liu P, Fang C, Redler G, Epel B, Halpern H. Directional TV algorithm for image reconstruction from sparse-view projections in EPR imaging. Phys Med Biol. 2024 May 30; 69(11). PMID: 38729205.
      Citations:    Fields:    
    2. Kim H, Hua Y, Chen CT, Epel B, Sundramoorthy S, Halpern H, Kao CM. Validation of the design of a high-sensitivity and high-resolution PET system for a preclinical PET/EPR hybrid scanner. Nucl Instrum Methods Phys Res A. 2024 Jun; 1063. PMID: 38736647; PMCID: PMC11086702.
      Citations:    
    3. Halpern HJ. Sensing and Imaging Molecular Oxygen in Mammals with Spin Lattice Relaxation Electron Paramagnetic Resonance. Mol Imaging Biol. 2024 Jun; 26(3):373-381. PMID: 38548994; PMCID: PMC11385933.
      Citations:    Fields:    Translation:HumansAnimals
    4. Zhang Z, Epel B, Chen B, Xia D, Sidky EY, Halpern H, Pan X. Accurate reconstruction of 4D spectral-spatial images from sparse-view data in continuous-wave EPRI. J Magn Reson. 2024 Apr; 361:107654. PMID: 38492546.
      Citations: 1     Fields:    
    5. Fang C, Xi Y, Epel B, Halpern H, Qiao Z. Directional TV algorithm for fast EPR imaging. J Magn Reson. 2024 Apr; 361:107652. PMID: 38457937; PMCID: PMC11091491.
      Citations:    Fields:    
    6. Gertsenshteyn I, Epel B, Giurcanu M, Barth E, Lukens J, Hall K, Martinez JF, Grana M, Maggio M, Miller RC, Sundramoorthy SV, Krzykawska-Serda M, Pearson E, Aydogan B, Weichselbaum RR, Tormyshev VM, Kotecha M, Halpern HJ. Corrigendum: Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models. Front Med (Lausanne). 2023; 10:1339872. PMID: 38116039; PMCID: PMC10728871.
      Citations:    
    7. Gertsenshteyn I, Epel B, Giurcanu M, Barth E, Lukens J, Hall K, Martinez JF, Grana M, Maggio M, Miller RC, Sundramoorthy SV, Krzykawska-Serda M, Pearson E, Aydogan B, Weichselbaum RR, Tormyshev VM, Kotecha M, Halpern HJ. Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models. Front Med (Lausanne). 2023; 10:1269689. PMID: 37904839; PMCID: PMC10613495.
      Citations: 2     
    8. Kim H, Hua Y, Epel B, Sundramoorthy S, Halpern H, Chen CT, Kao CM. A Preclinical Positron Emission Tomography (PET) and Electron-Paramagnetic-Resonance-Imaging (EPRI) Hybrid System: PET Detector Module. IEEE Trans Radiat Plasma Med Sci. 2023 Nov; 7(8):794-801. PMID: 37981977; PMCID: PMC10655702.
      Citations:    
    9. Epel B, Kao JPY, Eaton SS, Eaton GR, Halpern HJ. Direct Measurement and Imaging of Redox Status with Electron Paramagnetic Resonance. Antioxid Redox Signal. 2024 05; 40(13-15):850-862. PMID: 36680741; PMCID: PMC11386996.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Qiao Z, Redler G, Epel B, Halpern H. A Simple but Universal Fully Linearized ADMM Algorithm for Optimization Based Image Reconstruction. Res Sq. 2023 Apr 28. PMID: 37162853; PMCID: PMC10168464.
      Citations:    
    11. Zhang Z, Epel B, Chen B, Xia D, Sidky EY, Qiao Z, Halpern H, Pan X. 4D-image reconstruction directly from limited-angular-range data in continuous-wave electron paramagnetic resonance imaging. J Magn Reson. 2023 May; 350:107432. PMID: 37058955; PMCID: PMC10197356.
      Citations: 1     Fields:    
    12. Qiao Z, Lu Y, Liu P, Epel B, Halpern H. An iterative reconstruction algorithm without system matrix for EPR imaging. J Magn Reson. 2022 11; 344:107307. PMID: 36308904; PMCID: PMC11575469.
      Citations:    Fields:    
    13. Gertsenshteyn I, Epel B, Ahluwalia A, Kim H, Fan X, Barth E, Zamora M, Markiewicz E, Tsai HM, Sundramoorthy S, Leoni L, Lukens J, Bhuiyan M, Freifelder R, Kucharski A, Giurcanu M, Roman BB, Karczmar G, Kao CM, Halpern H, Chen CT. The optimal 18F-fluoromisonidazole PET threshold to define tumor hypoxia in preclinical squamous cell carcinomas using pO2 electron paramagnetic resonance imaging as reference truth. Eur J Nucl Med Mol Imaging. 2022 Oct; 49(12):4014-4024. PMID: 35792927; PMCID: PMC9529789.
      Citations: 8     Fields:    Translation:Animals
    14. Bader KB, Wallach EL, Shekhar H, Flores-Guzman F, Halpern HJ, Hernandez SL. Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging. Phys Med Biol. 2021 08 05; 66(16). PMID: 34271560; PMCID: PMC10680990.
      Citations: 1     Fields:    Translation:Animals
    15. Qiao Z, Redler G, Epel B, Halpern H. A balanced total-variation-Chambolle-Pock algorithm for EPR imaging. J Magn Reson. 2021 07; 328:107009. PMID: 34058712.
      Citations: 2     Fields:    
    16. Gertsenshteyn I, Epel B, Barth E, Leoni L, Markiewicz E, Tsai HM, Fan X, Giurcanu M, Bodero D, Zamora M, Sundramoorthy S, Kim H, Freifelder R, Bhuiyan M, Kucharski A, Karczmar G, Kao CM, Halpern H, Chen CT. Improving Tumor Hypoxia Location in 18F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic Resonance Partial Oxygen Pressure Images. Radiol Imaging Cancer. 2021 03; 3(2):e200104. PMID: 33817651; PMCID: PMC8011450.
      Citations: 6     Fields:    Translation:Animals
    17. Kim H, Epel B, Sundramoorthy S, Tsai HM, Barth E, Gertsenshteyn I, Halpern H, Hua Y, Xie Q, Chen CT, Kao CM. Development of a PET/EPRI combined imaging system for assessing tumor hypoxia. J Instrum. 2021 Mar; 16(3). PMID: 33868448; PMCID: PMC8045988.
      Citations: 5     
    18. Redler G, Pearson E, Liu X, Gertsenshteyn I, Epel B, Pelizzari C, Aydogan B, Weichselbaum R, Halpern HJ, Wiersma RD. Small Animal IMRT Using 3D-Printed Compensators. Int J Radiat Oncol Biol Phys. 2021 06 01; 110(2):551-565. PMID: 33373659; PMCID: PMC8122034.
      Citations: 6     Fields:    Translation:Animals
    19. Halpern HJ, Epel BM. Going Low in a World Going High: The Physiologic Use of Lower Frequency Electron Paramagnetic Resonance. Appl Magn Reson. 2020 Oct; 51(9-10):887-907. PMID: 33776216; PMCID: PMC7992374.
      Citations: 2     
    20. Swartz HM, Flood AB, Schaner PE, Halpern H, Williams BB, Pogue BW, Vaupel P, Gallez B. How best to interpret measures of levels of oxygen in tissues to make them effective clinical tools for care of patients with cancer and other oxygen-dependent pathologies. Physiol Rep. 2020 08; 8(15):e14541. PMID: 32786045; PMCID: PMC7422807.
      Citations: 22     Fields:    Translation:HumansAnimals
    21. Gertsenshteyn I, Giurcanu M, Vaupel P, Halpern H. Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue. J Physiol. 2021 03; 599(6):1759-1767. PMID: 32506448; PMCID: PMC7719598.
      Citations: 13     Fields:    Translation:Humans
    22. Waller J, Onderdonk B, Flood A, Swartz H, Shah J, Shah A, Aydogan B, Halpern H, Hasan Y. The clinical utility of imaging methods used to measure hypoxia in cervical cancer. Br J Radiol. 2020 Jul; 93(1111):20190640. PMID: 32286849; PMCID: PMC7336054.
      Citations: 4     Fields:    Translation:Humans
    23. Gonet M, Epel B, Halpern HJ, Elas M. Merging Preclinical EPR Tomography with other Imaging Techniques. Cell Biochem Biophys. 2019 Sep; 77(3):187-196. PMID: 31440878; PMCID: PMC6742609.
      Citations: 3     Fields:    Translation:Animals
    24. Chen NT, Barth ED, Lee TH, Chen CT, Epel B, Halpern HJ, Lo LW. Highly sensitive electron paramagnetic resonance nanoradicals for quantitative intracellular tumor oxymetric images. Int J Nanomedicine. 2019; 14:2963-2971. PMID: 31118615; PMCID: PMC6503311.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    25. Bodo S, Thin TH, Higginson DS, Vargas HA, Hua G, Fuller JD, Ackerstaff E, Russell J, Zhang Z, Klingler S, Cho H, Kaag MG, Mazaheri Y, Rimner A, Manova-Todorova K, Epel B, Zatcky J, Cleary CR, Rao SS, Yamada Y, Zelefsky MJ, Halpern HJ, Koutcher JA, Cordon-Cardo C, Greco C, Haimovitz-Friedman A, Sala E, Powell SN, Kolesnick R, Fuks Z, Campagne C. Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. J Clin Invest. 2019 02 01; 129(2):786-801. PMID: 30480549; PMCID: PMC6355243.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    26. Epel B, Maggio MC, Barth ED, Miller RC, Pelizzari CA, Krzykawska-Serda M, Sundramoorthy SV, Aydogan B, Weichselbaum RR, Tormyshev VM, Halpern HJ. Oxygen-Guided Radiation Therapy. Int J Radiat Oncol Biol Phys. 2019 03 15; 103(4):977-984. PMID: 30414912; PMCID: PMC6478443.
      Citations: 41     Fields:    Translation:AnimalsCells
    27. Qiao Z, Zhang Z, Pan X, Epel B, Redler G, Xia D, Halpern H. Optimization-based image reconstruction from sparsely sampled data in electron paramagnetic resonance imaging. J Magn Reson. 2018 09; 294:24-34. PMID: 30005191.
      Citations: 1     Fields:    Translation:Animals
    28. Qiao Z, Redler G, Qian Y, Tang S, Epel B, Halpern H. Investigation of the preconditioner-parameter in the preconditioned Chambolle-Pock algorithm applied to optimization-based image reconstruction. J Xray Sci Technol. 2018; 26(3):435-448. PMID: 29562580.
      Citations:    Fields:    Translation:Humans
    29. Qiao Z, Redler G, Gui Z, Qian Y, Epel B, Halpern H. Three novel accurate pixel-driven projection methods for 2D CT and 3D EPR imaging. J Xray Sci Technol. 2018; 26(1):83-102. PMID: 29036875.
      Citations: 2     Fields:    Translation:Humans
    30. Kotecha M, Epel B, Ravindran S, Dorcemus D, Nukavarapu S, Halpern H. Noninvasive Absolute Electron Paramagnetic Resonance Oxygen Imaging for the Assessment of Tissue Graft Oxygenation. Tissue Eng Part C Methods. 2018 01; 24(1):14-19. PMID: 28844179; PMCID: PMC5756934.
      Citations: 10     Fields:    Translation:HumansCells
    31. Epel B, Krzykawska-Serda M, Tormyshev V, Maggio MC, Barth ED, Pelizzari CA, Halpern HJ. Spin Lattice Relaxation EPR pO2 Images May Direct the Location of Radiation Tumor Boosts to Enhance Tumor Cure. Cell Biochem Biophys. 2017 Dec; 75(3-4):295-298. PMID: 28986856.
      Citations: 10     Fields:    Translation:Animals
    32. Boris E, Sundramoorthy SV, Halpern HJ. 250 MHz passive Q-modulator for reflection resonators. Concepts Magn Reson Part B Magn Reson Eng. 2017 Apr; 47B(2). PMID: 29576754; PMCID: PMC5863916.
      Citations:    
    33. Rinard GA, Quine RW, Buchanan LA, Eaton SS, Eaton GR, Epel B, Sundramoorthy SV, Halpern HJ. Resonators for In Vivo Imaging: Practical Experience. Appl Magn Reson. 2017 Dec; 48(11-12):1227-1247. PMID: 29391664; PMCID: PMC5788320.
      Citations: 6     
    34. Eaton SS, Shi Y, Woodcock L, Buchanan LA, McPeak J, Quine RW, Rinard GA, Epel B, Halpern HJ, Eaton GR. Rapid-scan EPR imaging. J Magn Reson. 2017 07; 280:140-148. PMID: 28579099; PMCID: PMC5523658.
      Citations: 15     Fields:    Translation:HumansAnimals
    35. Sundramoorthy SV, Epel B, Halpern HJ. A Pulse EPR 25 mT magnetometer with 10ppm resolution. Appl Magn Reson. 2017 Aug; 48(8):805-811. PMID: 29151678; PMCID: PMC5685537.
      Citations: 2     
    36. Epel B, Kotecha M, Halpern HJ. In vivo preclinical cancer and tissue engineering applications of absolute oxygen imaging using pulse EPR. J Magn Reson. 2017 07; 280:149-157. PMID: 28552587.
      Citations: 17     Fields:    Translation:HumansAnimals
    37. Shi Y, Quine RW, Rinard GA, Buchanan L, Eaton SS, Eaton GR, Epel B, Seagle SW, Halpern HJ. Triarylmethyl Radical OX063d24 Oximetry: Electron Spin Relaxation at 250 MHz and RF Frequency Dependence of Relaxation and Signal-to-Noise. Adv Exp Med Biol. 2017; 977:327-334. PMID: 28685462.
      Citations: 3     Fields:    
    38. Epel B, Maggio M, Pelizzari C, Halpern HJ. Electron Paramagnetic Resonance pO2 Image Tumor Oxygen-Guided Radiation Therapy Optimization. Adv Exp Med Biol. 2017; 977:287-296. PMID: 28685458.
      Citations: 6     Fields:    Translation:Animals
    39. Krzykawska-Serda M, Miller RC, Elas M, Epel B, Barth ED, Maggio M, Halpern HJ. Correlation Between Hypoxia Proteins and EPR-Detected Hypoxia in Tumors. Adv Exp Med Biol. 2017; 977:319-325. PMID: 28685461.
      Citations: 3     Fields:    Translation:Animals
    40. Rahimi R, Halpern HJ, Takui T. In Vivo EPR Resolution Enhancement Using Techniques Known from Quantum Computing Spin Technology. Adv Exp Med Biol. 2017; 977:335-339. PMID: 28685463.
      Citations:    Fields:    Translation:Humans
    41. Epel B, Sundramoorthy SV, Krzykawska-Serda M, Maggio MC, Tseytlin M, Eaton GR, Eaton SS, Rosen GM, Kao JPY, Halpern HJ. Imaging thiol redox status in murine tumors in vivo with rapid-scan electron paramagnetic resonance. J Magn Reson. 2017 Mar; 276:31-36. PMID: 28092786; PMCID: PMC5336491.
      Citations: 28     Fields:    Translation:AnimalsCells
    42. Serda M, Wu YK, Barth ED, Halpern HJ, Rawal VH. EPR Imaging Spin Probe Trityl Radical OX063: A Method for Its Isolation from Animal Effluent, Redox Chemistry of Its Quinone Methide Oxidation Product, and in Vivo Application in a Mouse. Chem Res Toxicol. 2016 12 19; 29(12):2153-2156. PMID: 27989135; PMCID: PMC5452419.
      Citations: 6     Fields:    Translation:AnimalsCells
    43. Shi Y, Quine RW, Rinard GA, Buchanan L, Eaton SS, Eaton GR, Epel B, Seagle SW, Halpern HJ. Triarylmethyl Radical: EPR Signal to Noise at Frequencies between 250 MHz and 1.5 GHz and Dependence of Relaxation on Radical and Salt Concentration and on Frequency. Z Phys Chem (N F). 2017 04; 231(4):923-937. PMID: 28392627; PMCID: PMC5380383.
      Citations: 3     
    44. Tseytlin M, Epel B, Sundramoorthy S, Tipikin D, Halpern HJ. Decoupling of excitation and receive coils in pulsed magnetic resonance using sinusoidal magnetic field modulation. J Magn Reson. 2016 11; 272:91-99. PMID: 27673275; PMCID: PMC5071169.
      Citations: 2     Fields:    
    45. Christodoulou AG, Redler G, Clifford B, Liang ZP, Halpern HJ, Epel B. Fast dynamic electron paramagnetic resonance (EPR) oxygen imaging using low-rank tensors. J Magn Reson. 2016 09; 270:176-182. PMID: 27498337; PMCID: PMC5127203.
      Citations: 14     Fields:    Translation:Animals
    46. Yang Z, Bridges MD, Rogozhnikova OY, Trukhin DV, Brooks EK, Tormyshev V, Halpern HJ, Hubbell WL, López CJ. A triarylmethyl spin label for long-range distance measurement at physiological temperatures using T1 relaxation enhancement. J Magn Reson. 2016 08; 269:50-54. PMID: 27214582; PMCID: PMC4958593.
      Citations: 16     Fields:    Translation:Cells
    47. Epel B, Redler G, Pelizzari C, Tormyshev VM, Halpern HJ. Approaching Oxygen-Guided Intensity-Modulated Radiation Therapy. Adv Exp Med Biol. 2016; 876:185-193. PMID: 26782211; PMCID: PMC4747097.
      Citations: 6     Fields:    Translation:Animals
    48. Epel B, Redler G, Tormyshev V, Halpern HJ. Towards Human Oxygen Images with Electron Paramagnetic Resonance Imaging. Adv Exp Med Biol. 2016; 876:363-369. PMID: 26782233; PMCID: PMC4745973.
      Citations: 14     Fields:    Translation:HumansAnimals
    49. Epel B, Halpern HJ. In Vivo pO2 Imaging of Tumors: Oxymetry with Very Low-Frequency Electron Paramagnetic Resonance. Methods Enzymol. 2015; 564:501-27. PMID: 26477263; PMCID: PMC4749023.
      Citations: 31     Fields:    Translation:HumansAnimals
    50. Qiao Z, Redler G, Epel B, Qian Y, Halpern H. 3D pulse EPR imaging from sparse-view projections via constrained, total variation minimization. J Magn Reson. 2015 Sep; 258:49-57. PMID: 26225440; PMCID: PMC4827344.
      Citations: 5     Fields:    Translation:Animals
    51. Ahn KH, Manger R, Halpern HJ, Aydogan B. Increased dose near the skin due to electromagnetic surface beacon transponder. J Appl Clin Med Phys. 2015 May 08; 16(3):4930. PMID: 26103472; PMCID: PMC5690107.
      Citations: 2     Fields:    Translation:HumansCells
    52. Epel B, Halpern HJ. Comparison of pulse sequences for R1-based electron paramagnetic resonance oxygen imaging. J Magn Reson. 2015 May; 254:56-61. PMID: 25828242; PMCID: PMC4420711.
      Citations: 13     Fields:    Translation:AnimalsCells
    53. Redler G, Qiao Z, Epel B, Halpern HJ. Real-Time Image Reconstruction for Pulse EPR Oxygen Imaging Using a GPU and Lookup Table Parameter Fitting. Concepts Magn Reson Part B Magn Reson Eng. 2015 Feb; 45(1):46-57. PMID: 26167137; PMCID: PMC4493913.
      Citations: 2     
    54. Redler G, Epel B, Halpern HJ. Maximally spaced projection sequencing in electron paramagnetic resonance imaging. Concepts Magn Reson Part B Magn Reson Eng. 2015 Feb; 45(1):33-45. PMID: 26185490; PMCID: PMC4500539.
      Citations: 6     
    55. Qiao Z, Redler G, Epel B, Qian Y, Halpern H. Implementation of GPU-accelerated back projection for EPR imaging. J Xray Sci Technol. 2015; 23(4):423-33. PMID: 26410654; PMCID: PMC4825055.
      Citations: 1     Fields:    
    56. Qiao Z, Redler G, Epel B, Halpern HJ. Comparison of parabolic filtration methods for 3D filtered back projection in pulsed EPR imaging. J Magn Reson. 2014 Nov; 248:42-53. PMID: 25314081; PMCID: PMC4324566.
      Citations: 2     Fields:    
    57. Sundramoorthy SV, Epel B, Halpern HJ. Orthogonal resonators for pulse in vivo electron paramagnetic imaging at 250 MHz. J Magn Reson. 2014 Mar; 240:45-51. PMID: 24530507; PMCID: PMC3974126.
      Citations: 7     Fields:    Translation:Animals
    58. Epel B, Redler G, Halpern HJ. How in vivo EPR measures and images oxygen. Adv Exp Med Biol. 2014; 812:113-119. PMID: 24729222; PMCID: PMC4319367.
      Citations: 13     Fields:    
    59. Redler G, Epel B, Halpern HJ. What we learn from in vivo EPR oxygen images. Adv Exp Med Biol. 2014; 812:121-126. PMID: 24729223; PMCID: PMC4313544.
      Citations: 2     Fields:    Translation:AnimalsCells
    60. Redler G, Epel B, Halpern HJ. EPR image based oxygen movies for transient hypoxia. Adv Exp Med Biol. 2014; 812:127-133. PMID: 24729224; PMCID: PMC4313543.
      Citations: 4     Fields:    Translation:Animals
    61. Majumdar S, Kotecha M, Triplett W, Epel B, Halpern H. A DTI study to probe tumor microstructure and its connection with hypoxia. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:738-41. PMID: 25570064; PMCID: PMC4324572.
      Citations: 2     Fields:    Translation:Animals
    62. Tormyshev VM, Rogozhnikova OY, Bowman MK, Trukhin DV, Troitskaya TI, Vasiliev VG, Shundrin LA, Halpern HJ. Preparation of Diversely Substituted Triarylmethyl Radicals by the Quenching of Tris(2,3,5,6-tetrathiaaryl)methyl Cations with C-, N-, P-, and S-Nucleophiles. European J Org Chem. 2014 Jan 01; 2014(2):371-380. PMID: 24883040; PMCID: PMC4038673.
      Citations: 5     
    63. Barrett HH, Kupinski MA, Halpern HJ, Morris JC, Dwyer R, Müeller S. Objective assessment of image quality VI: imaging in radiation therapy. Phys Med Biol. 2013 Nov 21; 58(22):8197-213. PMID: 24200954; PMCID: PMC4326059.
      Citations: 8     Fields:    Translation:Humans
    64. Liu GF, Ranck MC, Solanki AA, Cao H, Kolokythas A, Wenig BL, Chen L, Ard S, Weichselbaum RR, Halpern H, Spiotto MT. Racial parities in outcomes after radiotherapy for head and neck cancer. Cancer. 2014 Jan 15; 120(2):244-52. PMID: 24122486; PMCID: PMC4662546.
      Citations: 5     Fields:    Translation:Humans
    65. Qiao Z, Redler G, Halpern H. A simplified Katsevich algorithm motivated by the distribution properties of k-lines. J Electron Imaging. 2013 Oct 02; 22(4):043002. PMID: 25774077; PMCID: PMC4357848.
      Citations:    
    66. Epel B, Bowman MK, Mailer C, Halpern HJ. Absolute oxygen R1e imaging in vivo with pulse electron paramagnetic resonance. Magn Reson Med. 2014 Aug; 72(2):362-8. PMID: 24006331; PMCID: PMC4318240.
      Citations: 57     Fields:    Translation:AnimalsCells
    67. Elas M, Magwood JM, Butler B, Li C, Wardak R, DeVries R, Barth ED, Epel B, Rubinstein S, Pelizzari CA, Weichselbaum RR, Halpern HJ. EPR oxygen images predict tumor control by a 50% tumor control radiation dose. Cancer Res. 2013 Sep 01; 73(17):5328-35. PMID: 23861469; PMCID: PMC3913470.
      Citations: 32     Fields:    Translation:AnimalsCells
    68. Redler G, Barth ED, Bauer KS, Kao JP, Rosen GM, Halpern HJ. In vivo electron paramagnetic resonance imaging of differential tumor targeting using cis-3,4-di(acetoxymethoxycarbonyl)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl. Magn Reson Med. 2014 Apr; 71(4):1650-6. PMID: 23776127; PMCID: PMC4321903.
      Citations: 12     Fields:    Translation:AnimalsCells
    69. Rogozhnikova OY, Vasiliev VG, Troitskaya TI, Trukhin DV, Mikhalina TV, Halpern HJ, Tormyshev VM. Generation of Trityl Radicals by Nucleophilic Quenching of Tris(2,3,5,6-tetrathiaaryl)methyl Cations and Practical and Convenient Large-Scale Synthesis of Persistent Tris(4-carboxy-2,3,5,6-tetrathiaaryl)methyl Radical. European J Org Chem. 2013 Jun 01; 2013(16):3347-3355. PMID: 24772001; PMCID: PMC3998730.
      Citations: 17     
    70. Redler G, Epel B, Halpern HJ. Principal component analysis enhances SNR for dynamic electron paramagnetic resonance oxygen imaging of cycling hypoxia in vivo. Magn Reson Med. 2014 Jan; 71(1):440-50. PMID: 23401214; PMCID: PMC3796058.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    71. Redler G, Elas M, Epel B, Barth ED, Halpern HJ. Radiation oxygen biology with pulse electron paramagnetic resonance imaging in animal tumors. Adv Exp Med Biol. 2013; 789:399-404. PMID: 23852521; PMCID: PMC4319364.
      Citations: 2     Fields:    Translation:Animals
    72. Elas M, Ichikawa K, Halpern HJ. Oxidative stress imaging in live animals with techniques based on electron paramagnetic resonance. Radiat Res. 2012 Apr; 177(4):514-23. PMID: 22348251; PMCID: PMC3708477.
      Citations: 13     Fields:    Translation:AnimalsCells
    73. Tormyshev VM, Genaev AM, Sal'nikov GE, Rogozhnikova OY, Troitskaya TI, Trukhin DV, Mamatyuk VI, Fadeev DS, Halpern HJ. Triarylmethanols bearing bulky aryl groups and the NOESY/EXSY experimental observation of two-ring-flip mechanism for helicity reversal of molecular propellers. European J Org Chem. 2012 Jan; 2012(3). PMID: 24294110; PMCID: PMC3843112.
      Citations: 10     
    74. Elas M, Hleihel D, Barth ED, Haney CR, Ahn KH, Pelizzari CA, Epel B, Weichselbaum RR, Halpern HJ. Where it's at really matters: in situ in vivo vascular endothelial growth factor spatially correlates with electron paramagnetic resonance pO2 images in tumors of living mice. Mol Imaging Biol. 2011 Dec; 13(6):1107-13. PMID: 20960236; PMCID: PMC3210947.
      Citations: 18     Fields:    Translation:HumansAnimals
    75. Shin CS, Dunnam CR, Borbat PP, Dzikovski B, Barth ED, Halpern HJ, Freed JH. ESR Microscopy for Biological and Biomedical Applications. Nanosci Nanotechnol Lett. 2011 Aug; 3(4):561-567. PMID: 21984955; PMCID: PMC3188420.
      Citations: 3     
    76. Seifi P, Epel B, Sundramoorthy SV, Mailer C, Halpern HJ. Frequency bandwidth extension by use of multiple Zeeman field offsets for electron spin-echo EPR oxygen imaging of large objects. Med Phys. 2011 Jun; 38(6):3062-8. PMID: 21815379; PMCID: PMC3125082.
      Citations: 1     Fields:    
    77. Epel B, Sundramoorthy SV, Barth ED, Mailer C, Halpern HJ. Comparison of 250 MHz electron spin echo and continuous wave oxygen EPR imaging methods for in vivo applications. Med Phys. 2011 Apr; 38(4):2045-52. PMID: 21626937; PMCID: PMC3078157.
      Citations: 29     Fields:    Translation:Animals
    78. Tseitlin M, Quine RW, Eaton SS, Eaton GR, Halpern HJ, Ardenkjaer-Larsen JH. Use of the Frank sequence in pulsed EPR. J Magn Reson. 2011 Apr; 209(2):306-9. PMID: 21371924; PMCID: PMC3107679.
      Citations: 4     Fields:    
    79. Seifi P, Epel B, Mailer C, Halpern HJ. Multiple-stepped Zeeman field offset method applied in acquiring enhanced resolution spin-echo electron paramagnetic resonance images. Med Phys. 2010 Oct; 37(10):5412-20. PMID: 21089777; PMCID: PMC2962661.
      Citations: 3     Fields:    Translation:Animals
    80. Epel B, Haney CR, Hleihel D, Wardrip C, Barth ED, Halpern HJ. Electron paramagnetic resonance oxygen imaging of a rabbit tumor using localized spin probe delivery. Med Phys. 2010 Jun; 37(6):2553-9. PMID: 20632567; PMCID: PMC2881926.
      Citations: 29     Fields:    Translation:Animals
    81. Epel B, Haney CR, Hleihel D, Wardrip C, Barth ED, Halpern HJ. Electron paramagnetic resonance oxygen imaging of a rabbit tumor using localized spin probe delivery. Med Phys. 2010 Jun; 37(6Part1):2553-2559. PMID: 28512964.
      Citations:    
    82. Burks SR, Macedo LF, Barth ED, Tkaczuk KH, Martin SS, Rosen GM, Halpern HJ, Brodie AM, Kao JP. Anti-HER2 immunoliposomes for selective delivery of electron paramagnetic resonance imaging probes to HER2-overexpressing breast tumor cells. Breast Cancer Res Treat. 2010 Nov; 124(1):121-31. PMID: 20066490; PMCID: PMC4041539.
      Citations: 6     Fields:    Translation:HumansCells
    83. Burks SR, Barth ED, Halpern HJ, Rosen GM, Kao JP. Cellular uptake of electron paramagnetic resonance imaging probes through endocytosis of liposomes. Biochim Biophys Acta. 2009 Oct; 1788(10):2301-8. PMID: 19712666; PMCID: PMC2777986.
      Citations: 7     Fields:    Translation:AnimalsCells
    84. Haney CR, Parasca AD, Fan X, Bell RM, Zamora MA, Karczmar GS, Mauceri HJ, Halpern HJ, Weichselbaum RR, Pelizzari CA. Characterization of response to radiation mediated gene therapy by means of multimodality imaging. Magn Reson Med. 2009 Aug; 62(2):348-56. PMID: 19449382; PMCID: PMC2785132.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    85. Subramanian VS, Epel B, Mailer C, Halpern HJ. A passive dual-circulator based transmit/receive switch for use with reflection resonators in pulse EPR. Concepts Magn Reson Part B Magn Reson Eng. 2009 Aug; 35B(3):133-138. PMID: 20052312; PMCID: PMC2801570.
      Citations: 11     
    86. Cage B, McNeely JH, Russek SE, Halpern HJ. Thermomagnetic properties of the Finland trityl radical. J Appl Phys. 2009 Feb 15; 105(4):43905. PMID: 19529796; PMCID: PMC2685218.
      Citations: 2     
    87. Epel B, Sundramoorthy SV, Mailer C, Halpern HJ. A Versatile High Speed 250 MHz Pulse Imager for Biomedical Applications. Concepts Magn Reson Part B Magn Reson Eng. 2008 Jul 10; 33B(3):163-176. PMID: 19924261; PMCID: PMC2778030.
      Citations: 42     
    88. Elas M, Bell R, Hleihel D, Barth ED, McFaul C, Haney CR, Bielanska J, Pustelny K, Ahn KH, Pelizzari CA, Kocherginsky M, Halpern HJ. Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly correlates with tumor cure in FSa fibrosarcomas. Int J Radiat Oncol Biol Phys. 2008 Jun 01; 71(2):542-9. PMID: 18474313; PMCID: PMC2577780.
      Citations: 48     Fields:    Translation:Animals
    89. Haney CR, Fan X, Parasca AD, Karczmar GS, Halpern HJ, Pelizzari CA. Immobilization Using Dental Material Casts Facilitates Accurate Serial and Multimodality Small Animal Imaging. Concepts Magn Reson Part B Magn Reson Eng. 2008 Apr; 33B(2):138-144. PMID: 20827425; PMCID: PMC2933927.
      Citations: 16     
    90. Ahn KH, Subramanian VS, Halpern HJ. Scaling of EPR spectral-spatial images with size of sample: images of a sample greater than 5 cm in linear dimension. Med Phys. 2007 Dec; 34(12):4854-9. PMID: 18196811.
      Citations: 3     Fields:    Translation:Humans
    91. Kao JP, Barth ED, Burks SR, Smithback P, Mailer C, Ahn KH, Halpern HJ, Rosen GM. Very-low-frequency electron paramagnetic resonance (EPR) imaging of nitroxide-loaded cells. Magn Reson Med. 2007 Oct; 58(4):850-4. PMID: 17899588; PMCID: PMC3708470.
      Citations: 10     Fields:    Translation:HumansCells
    92. Ahn KH, Halpern HJ. Simulation of 4D spectral-spatial EPR images. J Magn Reson. 2007 Jul; 187(1):1-9. PMID: 17434772; PMCID: PMC2023876.
      Citations: 12     Fields:    
    93. Ahn KH, Halpern HJ. Comparison of local and global angular interpolation applied to spectral-spatial EPR image reconstruction. Med Phys. 2007 Mar; 34(3):1047-52. PMID: 17441251.
      Citations: 11     Fields:    Translation:Humans
    94. Pan X, Xia D, Halpern H. Targeted-ROI imaging in electron paramagnetic resonance imaging. J Magn Reson. 2007 Jul; 187(1):66-77. PMID: 17451981.
      Citations: 4     Fields:    
    95. Ahn KH, Halpern HJ. Object dependent sweep width reduction with spectral-spatial EPR imaging. J Magn Reson. 2007 May; 186(1):105-11. PMID: 17321174; PMCID: PMC2100385.
      Citations: 4     Fields:    
    96. Ahn KH, Halpern HJ. Spatially uniform sampling in 4-D EPR spectral-spatial imaging. J Magn Reson. 2007 Mar; 185(1):152-8. PMID: 17197215; PMCID: PMC2041928.
      Citations: 26     Fields:    
    97. Elas M, Ahn KH, Parasca A, Barth ED, Lee D, Haney C, Halpern HJ. Electron paramagnetic resonance oxygen images correlate spatially and quantitatively with Oxylite oxygen measurements. Clin Cancer Res. 2006 Jul 15; 12(14 Pt 1):4209-17. PMID: 16857793.
      Citations: 74     Fields:    Translation:AnimalsCells
    98. Haney CR, Parasca AD, Ichikawa K, Williams BB, Elas M, Pelizzari CA, Halpern HJ. Reduction of image artifacts in mice by bladder flushing with a novel double-lumen urethral catheter. Mol Imaging. 2006 Jul; 5(3):175-9. PMID: 16954032; PMCID: PMC2935137.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    99. Mailer C, Sundramoorthy SV, Pelizzari CA, Halpern HJ. Spin echo spectroscopic electron paramagnetic resonance imaging. Magn Reson Med. 2006 Apr; 55(4):904-12. PMID: 16526015.
      Citations: 32     Fields:    
    100. Williams BB, Pan X, Halpern HJ. EPR imaging: the relationship between CW spectra acquired from an extended sample subjected to fixed stepped gradients and the Radon transform of the resonance density. J Magn Reson. 2005 May; 174(1):88-96. PMID: 15809176.
      Citations: 11     Fields:    
    101. Bowman MK, Mailer C, Halpern HJ. The solution conformation of triarylmethyl radicals. J Magn Reson. 2005 Feb; 172(2):254-67. PMID: 15649753.
      Citations: 28     Fields:    Translation:Cells
    102. Dreher MR, Elas M, Ichikawa K, Barth ED, Chilkoti A, Rosen GM, Halpern HJ, Dewhirst M. Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry. Med Phys. 2004 Oct; 31(10):2755-62. PMID: 15543780.
      Citations: 9     Fields:    
    103. Rosen GM, Beselman A, Tsai P, Pou S, Mailer C, Ichikawa K, Robinson BH, Nielsen R, Halpern HJ, MacKerell AD. Influence of conformation on the EPR spectrum of 5,5-dimethyl-1-hydroperoxy-1-pyrrolidinyloxyl: a spin trapped adduct of superoxide. J Org Chem. 2004 Feb 20; 69(4):1321-30. PMID: 14961686.
      Citations: 5     Fields:    
    104. Tsai P, Ichikawa K, Mailer C, Pou S, Halpern HJ, Robinson BH, Nielsen R, Rosen GM. Esters of 5-carboxyl-5-methyl-1-pyrroline N-oxide: a family of spin traps for superoxide. J Org Chem. 2003 Oct 03; 68(20):7811-7. PMID: 14510560.
      Citations: 20     Fields:    Translation:Cells
    105. Carson PL, Giger M, Welch MJ, Halpern H, Kurdziel K, Vannier M, Evelhoch JL, Gazelle GS, Seltzer SE, Judy P, Hendee WR, Bourland JD. Biomedical Imaging Research Opportunities Workshop: report and recommendations. Radiology. 2003 Nov; 229(2):328-39. PMID: 12925715.
      Citations: 3     Fields:    Translation:Humans
    106. Welch MJ, Halpern H, Kurdziel KA. Example of imaging solutions to multi-disease biological challenge--imaging of hypoxia. Acad Radiol. 2003 Aug; 10(8):887-90. PMID: 12945924.
      Citations:    Fields:    Translation:Humans
    107. Mailer C, Robinson BH, Williams BB, Halpern HJ. Spectral fitting: the extraction of crucial information from a spectrum and a spectral image. Magn Reson Med. 2003 Jun; 49(6):1175-80. PMID: 12768596.
      Citations: 17     Fields:    
    108. Elas M, Williams BB, Parasca A, Mailer C, Pelizzari CA, Lewis MA, River JN, Karczmar GS, Barth ED, Halpern HJ. Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): methodology and comparison with blood oxygen level-dependent (BOLD) MRI. Magn Reson Med. 2003 Apr; 49(4):682-91. PMID: 12652539.
      Citations: 88     Fields:    Translation:Animals
    109. Elas M, Parasca A, Grdina DJ, Halpern HJ. Oral administration is as effective as intraperitoneal administration of amifostine in decreasing nitroxide EPR signal decay in vivo. Biochim Biophys Acta. 2003 Mar 20; 1637(2):151-5. PMID: 12633903.
      Citations: 5     Fields:    Translation:Animals
    110. al-Hallaq HA, Zamora MA, Fish BL, Halpern HJ, Moulder JE, Karczmar GS. Using high spectral and spatial resolution bold MRI to choose the optimal oxygenating treatment for individual cancer patients. Adv Exp Med Biol. 2003; 530:433-40. PMID: 14562738.
      Citations: 4     Fields:    Translation:HumansAnimals
    111. Macdonald RL, Zhang ZD, Curry D, Elas M, Aihara Y, Halpern H, Jahromi BS, Johns L. Intracisternal sodium nitroprusside fails to prevent vasospasm in nonhuman primates. Neurosurgery. 2002 Sep; 51(3):761-8; discussion 768-70. PMID: 12188956.
      Citations: 6     Fields:    Translation:Animals
    112. Reddy TJ, Iwama T, Halpern HJ, Rawal VH. General synthesis of persistent trityl radicals for EPR imaging of biological systems. J Org Chem. 2002 Jul 12; 67(14):4635-9. PMID: 12098269.
      Citations: 62     Fields:    Translation:Cells
    113. Williams BB, al Hallaq H, Chandramouli GV, Barth ED, Rivers JN, Lewis M, Galtsev VE, Karczmar GS, Halpern HJ. Imaging spin probe distribution in the tumor of a living mouse with 250 MHz EPR: correlation with BOLD MRI. Magn Reson Med. 2002 Apr; 47(4):634-8. PMID: 11948723.
      Citations: 21     Fields:    Translation:Animals
    114. Shao ZH, Vanden Hoek TL, Qin Y, Becker LB, Schumacker PT, Li CQ, Dey L, Barth E, Halpern H, Rosen GM, Yuan CS. Baicalein attenuates oxidant stress in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2002 Mar; 282(3):H999-H1006. PMID: 11834498.
      Citations: 43     Fields:    Translation:AnimalsCells
    115. Tsai P, Porasuphatana S, Halpern HJ, Barth ED, Rosen GM. In vivo in situ detection of nitric oxide using low-frequency EPR spectroscopy. Methods Mol Biol. 2002; 196:227-37. PMID: 12152203.
      Citations: 1     Fields:    Translation:Animals
    116. Yong L, Harbridge J, Quine RW, Rinard GA, Eaton SS, Eaton GR, Mailer C, Barth E, Halpern HJ. Electron spin relaxation of triarylmethyl radicals in fluid solution. J Magn Reson. 2001 Sep; 152(1):156-61. PMID: 11531374.
      Citations: 18     Fields:    
    117. Nakamura K, Bindokas VP, Kowlessur D, Elas M, Milstien S, Marks JD, Halpern HJ, Kang UJ. Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons. J Biol Chem. 2001 Sep 14; 276(37):34402-7. PMID: 11447224.
      Citations: 24     Fields:    Translation:AnimalsCells
    118. Connell PP, Ignacio L, Haraf D, Awan AM, Halpern H, Abdalla I, Nautiyal J, Jani AB, Weichselbaum RR, Vijayakumar S. Equivalent racial outcome after conformal radiotherapy for prostate cancer: a single departmental experience. J Clin Oncol. 2001 Jan 01; 19(1):54-61. PMID: 11134195.
      Citations: 5     Fields:    Translation:Humans
    119. Rosen GM, Tsai P, Barth ED, Dorey G, Casara P, Spedding M, Halpern HJ. A one-step synthesis of 2-(2-Pyridyl)-3H-indol-3-one N-oxide: is it an efficient spin trap for hydroxyl radical? J Org Chem. 2000 Jul 14; 65(14):4460-3. PMID: 10891156.
      Citations: 2     Fields:    Translation:Cells
    120. Halpern HJ, Chandramouli GV, Barth ED, Yu C, Peric M, Grdina DJ, Teicher BA. Diminished aqueous microviscosity of tumors in murine models measured with in vivo radiofrequency electron paramagnetic resonance. Cancer Res. 1999 Nov 15; 59(22):5836-41. PMID: 10582707.
      Citations: 22     Fields:    Translation:Animals
    121. Pou S, Tsai P, Porasuphatana S, Halpern HJ, Chandramouli GV, Barth ED, Rosen GM. Spin trapping of nitric oxide by ferro-chelates: kinetic and in vivo pharmacokinetic studies. Biochim Biophys Acta. 1999 Apr 19; 1427(2):216-26. PMID: 10216238.
      Citations: 11     Fields:    Translation:Cells
    122. Rosen GM, Pou S, Halpern HJ. In vivo detection of free radicals in real time by low-frequency electron paramagnetic resonance spectroscopy. Methods Mol Biol. 1998; 108:27-35. PMID: 9921513.
      Citations:    Fields:    Translation:Animals
    123. Roeske JC, Mundt AJ, Halpern H, Sweeney P, Sutton H, Powers C, Rotmensch J, Waggoner S, Weichselbaum RR. Late rectal sequelae following definitive radiation therapy for carcinoma of the uterine cervix: a dosimetric analysis. Int J Radiat Oncol Biol Phys. 1997 Jan 15; 37(2):351-8. PMID: 9069307.
      Citations: 10     Fields:    Translation:HumansPHPublic Health
    124. Halpern HJ, Peric M, Yu C, Barth ED, Chandramouli GV, Makinen MW, Rosen GM. In vivo spin-label murine pharmacodynamics using low-frequency electron paramagnetic resonance imaging. Biophys J. 1996 Jul; 71(1):403-9. PMID: 8804623; PMCID: PMC1233491.
      Citations: 11     Fields:    Translation:AnimalsCells
    125. Halpern HJ, Yu C, Peric M, Barth ED, Karczmar GS, River JN, Grdina DJ, Teicher BA. Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa murine fibrosarcomas with low-frequency electron paramagnetic resonance oximetry. Radiat Res. 1996 May; 145(5):610-8. PMID: 8619027.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    126. Vijayakumar S, Quadri SF, Dong L, Ignacio L, Kathuria IN, Sutton H, Halpern H. Results of a study to correlate serum prostate specific antigen and reproductive hormone levels in patients with localized prostate cancer. J Natl Med Assoc. 1995 Nov; 87(11):813-9. PMID: 8907816; PMCID: PMC2607949.
      Citations: 6     Fields:    Translation:Humans
    127. Yang FE, Vaida F, Ignacio L, Houghton A, Nauityal J, Halpern H, Sutton H, Vijayakumar S. Analysis of weekly complete blood counts in patients receiving standard fractionated partial body radiation therapy. Int J Radiat Oncol Biol Phys. 1995 Oct 15; 33(3):617-17. PMID: 7558950.
      Citations: 14     Fields:    Translation:Humans
    128. Halpern HJ, Yu C, Barth E, Peric M, Rosen GM. In situ detection, by spin trapping, of hydroxyl radical markers produced from ionizing radiation in the tumor of a living mouse. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):796-800. PMID: 7846054; PMCID: PMC42707.
      Citations: 14     Fields:    Translation:Animals
    129. Halpern HJ, Yu C, Peric M, Barth E, Grdina DJ, Teicher BA. Oxymetry deep in tissues with low-frequency electron paramagnetic resonance. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):13047-51. PMID: 7809170; PMCID: PMC45578.
      Citations: 66     Fields:    Translation:Animals
    130. Mundt AJ, Sibley GS, Williams S, Rubin SJ, Heimann R, Halpern H, Weichselbaum RR. Patterns of failure of complete responders following high-dose chemotherapy and autologous bone marrow transplantation for metastatic breast cancer: implications for the use of adjuvant radiation therapy. Int J Radiat Oncol Biol Phys. 1994 Aug 30; 30(1):151-60. PMID: 8083108.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    131. Halpern H, Cremonesi E, Ruiz-Neto PP. Rapid inhalation induction with halothane-nitrous oxide for myasthenic patients. Can J Anaesth. 1994 Feb; 41(2):102-6. PMID: 8131223.
      Citations:    Fields:    Translation:Humans
    132. Vijayakumar S, Roach M, Wara W, Chan SK, Ewing C, Rubin S, Sutton H, Halpern H, Awan A, Houghton A, et al. Effect of subcutaneous recombinant human erythropoietin in cancer patients receiving radiotherapy: preliminary results of a randomized, open-labeled, phase II trial. Int J Radiat Oncol Biol Phys. 1993 Jul 15; 26(4):721-9. PMID: 8331011.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    133. Vijayakumar S, Awan A, Karrison T, Culbert H, Chan S, Kolker J, Low N, Halpern H, Rubin S, Chen GT, et al. Acute toxicity during external-beam radiotherapy for localized prostate cancer: comparison of different techniques. Int J Radiat Oncol Biol Phys. 1993 Jan 15; 25(2):359-71. PMID: 8420886.
      Citations: 7     Fields:    Translation:Humans
    134. Boisvert WE, Mustafi D, Kasa S, Makinen MW, Halpern HJ, Yu C, Barth E, Peric M. Kinetically specific spin-label substrates of liver alcohol dehydrogenase and of liver aldehyde dehydrogenase. Adv Exp Med Biol. 1993; 328:501-12. PMID: 8388157.
      Citations:    Fields:    Translation:AnimalsCells
    135. Vijayakumar S, Quadri SF, Karrison TG, Trinidad CO, Chan SK, Halpern HJ, Rubin SJ, Sutton HG. Localized prostate cancer: use of serial prostate-specific antigen measurements during radiation therapy. Radiology. 1992 Jul; 184(1):271-4. PMID: 1376933.
      Citations: 2     Fields:    Translation:Humans
    136. Chen GT, Spelbring DR, Pelizzari CA, Balter JM, Myrianthopoulos LC, Vijayakumar S, Halpern H. The use of beam's eye view volumetrics in the selection of non-coplanar radiation portals. Int J Radiat Oncol Biol Phys. 1992; 23(1):153-63. PMID: 1572812.
      Citations: 1     Fields:    Translation:Humans
    137. Myrianthopoulos LC, Chen GT, Vijayakumar S, Halpern HJ, Spelbring DR, Pelizzari CA. Beam's eye view volumetrics: an aid in rapid treatment plan development and evaluation. Int J Radiat Oncol Biol Phys. 1992; 23(2):367-75. PMID: 1587758.
      Citations: 1     Fields:    Translation:Humans
    138. Vijayakumar S, Low N, Chen GT, Myrianthopoulos L, Culbert H, Chiru P, Spelbring D, Awan A, Rosenberg I, Halpern H, et al. Beams eye view-based photon radiotherapy I. Int J Radiat Oncol Biol Phys. 1991 Nov; 21(6):1575-86. PMID: 1657844.
      Citations: 1     Fields:    Translation:Humans
    139. Vijayakumar S, Myrianthopoulos LC, Rosenberg I, Halpern HJ, Low N, Chen GT. Optimization of radical radiotherapy with beam's eye view techniques for non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 1991 Aug; 21(3):779-88. PMID: 1651309.
      Citations: 2     Fields:    Translation:Humans
    140. Halpern HJ, Jaffe DR, Nguyen TD, Haraf DJ, Spencer DP, Bowman MK, Weichselbaum RR, Diamond AM. Measurement of bioreduction rates of cells with distinct responses to ionizing radiation and cisplatin. Biochim Biophys Acta. 1991 Jul 10; 1093(2-3):121-4. PMID: 1650577.
      Citations: 3     Fields:    Translation:AnimalsCells
    141. Pou S, Peric M, Halpern HJ, Rosen GM. Use of a low-frequency ESR spectrometer: implications for spin-trapping free radicals, in situ. Free Radic Res Commun. 1991; 12-13 Pt 1:39-46. PMID: 1649099.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    142. Kolker JD, Halpern HJ, Krishnasamy S, Brown F, Dohrmann G, Ferguson L, Hekmatpanah J, Mullan J, Wollman R, Blough R, et al. "Instant-mix" whole brain photon with neutron boost radiotherapy for malignant gliomas. Int J Radiat Oncol Biol Phys. 1990 Aug; 19(2):409-14. PMID: 2168355.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    143. Rader JS, Haraf DJ, Halpern HJ, Rotmensch J, Spelbring DR, Sutton H, Javaheri G, Weichselbaum RR. Radiation therapy in the treatment of cervical cancer: the University of Chicago/Michael Reese Hospital experience. J Surg Oncol. 1990 Jul; 44(3):157-65. PMID: 2370799.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    144. Rotmensch J, Rubin SJ, Sutton HG, Javaheri G, Halpern HJ, Schwartz JL, Stewart M, Weichselbaum RR, Herbst AL. Preoperative radiotherapy followed by radical vulvectomy with inguinal lymphadenectomy for advanced vulvar carcinomas. Gynecol Oncol. 1990 Feb; 36(2):181-4. PMID: 2298406.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    145. Rosen GM, Halpern HJ. Spin trapping biologically generated free radicals: correlating formation with cellular injury. Methods Enzymol. 1990; 186:611-21. PMID: 2172718.
      Citations: 3     Fields:    Translation:AnimalsCells
    146. Hallahan DE, Michel AG, Halpern HJ, Awan AM, Desser R, Bitran J, Recant W, Wyman B, Spelbring DR, Weichselbaum RR. Breast conserving surgery and definitive irradiation for early stage breast cancer. Int J Radiat Oncol Biol Phys. 1989 Dec; 17(6):1211-6. PMID: 2557305.
      Citations: 3     Fields:    Translation:Humans
    147. Rosen GM, Halpern HJ, Brunsting LA, Spencer DP, Strauss KE, Bowman MK, Wechsler AS. Direct measurement of nitroxide pharmacokinetics in isolated hearts situated in a low-frequency electron spin resonance spectrometer: implications for spin trapping and in vivo oxymetry. Proc Natl Acad Sci U S A. 1988 Oct; 85(20):7772-6. PMID: 2845421; PMCID: PMC282275.
      Citations: 6     Fields:    Translation:Animals
    148. Miller DC, Goodman ML, Pilch BZ, Shi SR, Dickersin GR, Halpern H, Norris CM. Mixed olfactory neuroblastoma and carcinoma. A report of two cases. Cancer. 1984 Nov 01; 54(9):2019-28. PMID: 6206941.
      Citations: 17     Fields:    Translation:HumansCells
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