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Urs C. Schmidt-Ott

TitleProfessor
InstitutionUniversity of Chicago
DepartmentOrg.Bio./Anatomy
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    The Schmidt-Ott lab uses experimental and genomic approaches to study the evolution of embryogenesis in flies, including midges and mosquitoes (Diptera).

    We seek to understand how and why, in embryos, morphogenesis, pattern formation, axis specification, gene regulation, and gene function change over time. For example, we discovered that the embryos of different fly species use structurally unrelated genes to establish embryo polarity and seek to understand why these essential developmental genes are frequently replaced in evolution and how they acquire this function. In another project, we discovered that the dynamics of a morphogen gradient required for tissue differentiation differs between species. We seek to understand how morphgogen gradient dynamics evolve and alter embryogenesis, including tissue specification and morphogenesis.

    In general, we welcome students and scholars who are interested in understanding how plasticity and robustness of embryogenesis shape the genetic basis of embryos over time.


    Collapse Biography 
    Collapse education and training
    Max-Planck-Institute f. Biophys. Chemistry, Göttingen (Germany)Postdoc1997Molecular Developmental Biology
    University of Mainz, Mainz (Germany)PhD1994Genetics
    University of Freiburg, Freiburg i. Br. (Germany)Diplom1990Biology
    Collapse awards and honors
    1989Fellow, Studienstiftung des Deutschen Volkes
    1994PhD summa cum laude, University of Mainz
    1995Dissertation Research Award, Association of Friends of the University of Mainz
    1995 - 1997Postdoctoral Fellowship, German Research Foundation (DFG)
    2001Habilitation, Technical University of Braunschweig (Germany)

    Collapse ORNG Applications 
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    Collapse Research 
    Collapse research activities and funding
    R01GM127366     (SCHMIDT-OTT, URS C)Sep 18, 2018 - Aug 31, 2020
    NIH
    Genetic variation and function of body axis determinants in midges and other flies
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yoon Y, Klomp J, Martin-Martin I, Criscione F, Calvo E, Ribeiro J, Schmidt-Ott U. Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms. Elife. 2019; 9:e46711.
    2. Liu Q, Onal P, Datta RR, Rogers JM, Schmidt-Ott U, Bulyk ML, Small S, Thornton JW. Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development. Elife. 2018 10 09; 7. PMID: 30298815.
      View in: PubMed
    3. Oppold AM, Schmidt H, Rose M, Hellmann SL, Dolze F, Ripp F, Weich B, Schmidt-Ott U, Schmidt E, Kofler R, Hankeln T, Pfenninger M. Chironomus riparius (Diptera) genome sequencing reveals the impact of minisatellite transposable elements on population divergence. Mol Ecol. 2017 Jun; 26(12):3256-3275. PMID: 28316106.
      View in: PubMed
    4. Kwan CW, Gavin-Smyth J, Ferguson EL, Schmidt-Ott U. Functional evolution of a morphogenetic gradient. Elife. 2016 12 22; 5. PMID: 28005004.
      View in: PubMed
    5. Schmidt-Ott U, Lynch JA. Emerging developmental genetic model systems in holometabolous insects. Curr Opin Genet Dev. 2016 08; 39:116-128. PMID: 27399647.
      View in: PubMed
    6. Schmidt-Ott U, Kwan CW. Morphogenetic functions of extraembryonic membranes in insects. Curr Opin Insect Sci. 2016 02; 13:86-92. PMID: 27436557.
      View in: PubMed
    7. Klomp J, Athy D, Kwan CW, Bloch NI, Sandmann T, Lemke S, Schmidt-Ott U. Embryo development. A cysteine-clamp gene drives embryo polarity in the midge Chironomus. Science. 2015 May 29; 348(6238):1040-2. PMID: 25953821.
      View in: PubMed
    8. Wotton KR, Jiménez-Guri E, Crombach A, Janssens H, Alcaine-Colet A, Lemke S, Schmidt-Ott U, Jaeger J. Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita. Elife. 2015 Jan 05; 4. PMID: 25560971.
      View in: PubMed
    9. Rafiqi AM, Park CH, Kwan CW, Lemke S, Schmidt-Ott U. BMP-dependent serosa and amnion specification in the scuttle fly Megaselia abdita. Development. 2012 Sep; 139(18):3373-82. PMID: 22874914.
      View in: PubMed
    10. Hallgrímsson B, Jamniczky HA, Young NM, Rolian C, Schmidt-Ott U, Marcucio RS. The generation of variation and the developmental basis for evolutionary novelty. J Exp Zool B Mol Dev Evol. 2012 Sep; 318(6):501-17. PMID: 22649039.
      View in: PubMed
    11. Lemke S, Antonopoulos DA, Meyer F, Domanus MH, Schmidt-Ott U. BMP signaling components in embryonic transcriptomes of the hover fly Episyrphus balteatus (Syrphidae). BMC Genomics. 2011 May 31; 12:278. PMID: 21627820.
      View in: PubMed
    12. Rafiqi AM, Lemke S, Schmidt-Ott U. Megaselia abdita: culturing and egg collection. Cold Spring Harb Protoc. 2011 Apr 01; 2011(4):pdb.prot5600. PMID: 21460049.
      View in: PubMed
    13. Rafiqi AM, Lemke S, Schmidt-Ott U. The scuttle fly Megaselia abdita (Phoridae): a link between Drosophila and Mosquito development. Cold Spring Harb Protoc. 2011 Apr 01; 2011(4):pdb.emo143. PMID: 21460041.
      View in: PubMed
    14. Rafiqi AM, Lemke S, Schmidt-Ott U. Megaselia abdita: fixing and devitellinizing embryos. Cold Spring Harb Protoc. 2011 Apr 01; 2011(4):pdb.prot5602. PMID: 21460051.
      View in: PubMed
    15. Rafiqi AM, Lemke S, Schmidt-Ott U. Megaselia abdita: preparing embryos for injection. Cold Spring Harb Protoc. 2011 Apr 01; 2011(4):pdb.prot5601. PMID: 21460050.
      View in: PubMed
    16. Rafiqi AM, Lemke S, Schmidt-Ott U. Megaselia abdita: cuticle preparation from injected embryos. Cold Spring Harb Protoc. 2011 Apr 01; 2011(4):pdb.prot5603. PMID: 21460052.
      View in: PubMed
    17. Wiegmann BM, Trautwein MD, Winkler IS, Barr NB, Kim JW, Lambkin C, Bertone MA, Cassel BK, Bayless KM, Heimberg AM, Wheeler BM, Peterson KJ, Pape T, Sinclair BJ, Skevington JH, Blagoderov V, Caravas J, Kutty SN, Schmidt-Ott U, Kampmeier GE, Thompson FC, Grimaldi DA, Beckenbach AT, Courtney GW, Friedrich M, Meier R, Yeates DK. Episodic radiations in the fly tree of life. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5690-5. PMID: 21402926.
      View in: PubMed
    18. Lemke S, Busch SE, Antonopoulos DA, Meyer F, Domanus MH, Schmidt-Ott U. Maternal activation of gap genes in the hover fly Episyrphus. Development. 2010 May; 137(10):1709-19. PMID: 20430746.
      View in: PubMed
    19. Rafiqi AM, Lemke S, Schmidt-Ott U. Postgastrular zen expression is required to develop distinct amniotic and serosal epithelia in the scuttle fly Megaselia. Dev Biol. 2010 May 01; 341(1):282-90. PMID: 20144604.
      View in: PubMed
    20. Schmidt-Ott U, Rafiqi AM, Lemke S. Hox3/zen and the evolution of extraembryonic epithelia in insects. Adv Exp Med Biol. 2010; 689:133-44. PMID: 20795328.
      View in: PubMed
    21. Schmidt-Ott U, Rafiqi AM, Sander K, Johnston JS. Extremely small genomes in two unrelated dipteran insects with shared early developmental traits. Dev Genes Evol. 2009 Apr; 219(4):207-10. PMID: 19308443.
      View in: PubMed
    22. Lemke S, Schmidt-Ott U. Evidence for a composite anterior determinant in the hover fly Episyrphus balteatus (Syrphidae), a cyclorrhaphan fly with an anterodorsal serosa anlage. Development. 2009 Jan; 136(1):117-27. PMID: 19060334.
      View in: PubMed
    23. Lemke S, Stauber M, Shaw PJ, Rafiqi AM, Prell A, Schmidt-Ott U. Bicoid occurrence and Bicoid-dependent hunchback regulation in lower cyclorrhaphan flies. Evol Dev. 2008 Jul-Aug; 10(4):413-20. PMID: 18638318.
      View in: PubMed
    24. Stauber M, Lemke S, Schmidt-Ott U. Expression and regulation of caudal in the lower cyclorrhaphan fly Megaselia. Dev Genes Evol. 2008 Feb; 218(2):81-7. PMID: 18214532.
      View in: PubMed
    25. Rafiqi AM, Lemke S, Ferguson S, Stauber M, Schmidt-Ott U. Evolutionary origin of the amnioserosa in cyclorrhaphan flies correlates with spatial and temporal expression changes of zen. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):234-9. PMID: 18172205.
      View in: PubMed
    26. Schmidt-Ott U. Insect serosa: a head line in comparative developmental genetics. Curr Biol. 2005 Apr 12; 15(7):R245-7. PMID: 15823522.
      View in: PubMed
    27. Bullock SL, Stauber M, Prell A, Hughes JR, Ish-Horowicz D, Schmidt-Ott U. Differential cytoplasmic mRNA localisation adjusts pair-rule transcription factor activity to cytoarchitecture in dipteran evolution. Development. 2004 Sep; 131(17):4251-61. PMID: 15280214.
      View in: PubMed
    28. Sander K, Schmidt-Ott U. Evo-devo aspects of classical and molecular data in a historical perspective. J Exp Zool B Mol Dev Evol. 2004 Jan 15; 302(1):69-91. PMID: 14760654.
      View in: PubMed
    29. Stauber M, Prell A, Schmidt-Ott U. A single Hox3 gene with composite bicoid and zerknullt expression characteristics in non-Cyclorrhaphan flies. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):274-9. PMID: 11773616.
      View in: PubMed
    30. Brown S, Fellers J, Shippy T, Denell R, Stauber M, Schmidt-Ott U. A strategy for mapping bicoid on the phylogenetic tree. Curr Biol. 2001 Jan 23; 11(2):R43-4. PMID: 11231138.
      View in: PubMed
    31. Schmidt-Ott U. Different ways to make a head. Bioessays. 2001 Jan; 23(1):8-11. PMID: 11135304.
      View in: PubMed
    32. Stauber M, Taubert H, Schmidt-Ott U. Function of bicoid and hunchback homologs in the basal cyclorrhaphan fly Megaselia (Phoridae). Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10844-9. PMID: 10995461.
      View in: PubMed
    33. Schmidt-Ott U. The amnioserosa is an apomorphic character of cyclorrhaphan flies. Dev Genes Evol. 2000 Jul; 210(7):373-6. PMID: 11180843.
      View in: PubMed
    34. Stauber M, Jäckle H, Schmidt-Ott U. The anterior determinant bicoid of Drosophila is a derived Hox class 3 gene. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3786-9. PMID: 10097115.
      View in: PubMed
    35. Rivera-Pomar R, Niessing D, Schmidt-Ott U, Gehring WJ, Jäckle H. RNA binding and translational suppression by bicoid. Nature. 1996 Feb 22; 379(6567):746-9. PMID: 8602224.
      View in: PubMed
    36. Schmidt-Ott U, González-Gaitán M, Technau GM. Analysis of neural elements in head-mutant Drosophila embryos suggests segmental origin of the optic lobes. Roux Arch Dev Biol. 1995 Sep; 205(1-2):31-44. PMID: 28306063.
      View in: PubMed
    37. Schmidt-Ott U, González-Gaitán M, Jäckle H, Technau GM. Number, identity, and sequence of the Drosophila head segments as revealed by neural elements and their deletion patterns in mutants. Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8363-7. PMID: 7915837.
      View in: PubMed
    38. Schmidt-Ott U, Martin Technau G. Fate-mapping in the procephalic region of the embryonic Drosopbila head. Roux Arch Dev Biol. 1994 Aug; 203(7-8):367-373. PMID: 28305941.
      View in: PubMed
    39. Schmidt-Ott U, Sander K, Technau GM. Expression of engrailed in embryos of a beetle and five dipteran species with special reference to the terminal regions. Roux Arch Dev Biol. 1994 May; 203(6):298-303. PMID: 28305822.
      View in: PubMed
    40. Schmidt-Ott U, Technau GM. Expression of en and wg in the embryonic head and brain of Drosophila indicates a refolded band of seven segment remnants. Development. 1992 Sep; 116(1):111-25. PMID: 1483381.
      View in: PubMed
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