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Ilaria Rebay

TitleProfessor
InstitutionUniversity of Chicago
DepartmentBen May Department of Cancer Research
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    The long-term goal of research in the Rebay Lab is to understand how signaling networks, cytoskeletal dynamics and tissue geometry work together to direct specific developmental decisions and programs. We use the developing Drosophila eye and heart as tractable model systems in which to explore how cell fates are specified and organized into functional tissues and organs. Our experimental approach is multidisciplinary, and incorporates molecular genetics, genomics, quantitative imaging, biochemistry and mathematical modeling. Current projects are focused on transcriptional networks and cellular mechanisms that regulate and stabilize the transition from uncommitted progenitor to specified fate and on signaling mechanisms and tissue-level biomechanical properties that together drive terminal differentiation and morphogenesis.
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    Collapse Biography 
    Collapse education and training
    Columbia University, New YorkBA05/1987Mathematics
    Yale University, New HavenPhD08/1993Biology
    University of California, BerkeleyPostdoc08/1997Biology
    Collapse awards and honors
    2015Quantrell Award for Excellence in Undergraduate Teaching, University of Chicago
    2007 - 2008J. and J. Neubauer Faculty Development Fellowship, University of Chicago
    1998 - 2001Rita Allen Foundation Scholar Award
    1995 - 2000Burroughs Wellcome Fund Career Award
    1993 - 1995Life Sciences Research Foundation Postdoctoral Fellowship
    1988 - 1993HHMI Pre-Doctoral Fellowship

    Collapse Research 
    Collapse research activities and funding
    R21EY030199     (REBAY, ILARIA)May 1, 2019 - Apr 30, 2021
    NIH
    Specificity and dynamics of transcriptional repression in retinal development
    Role: Principal Investigator
    R01EY025957     (REBAY, ILARIA)Jun 1, 2016 - May 31, 2020
    NIH
    A systems-level study of signaling networks and differentiation
    Role: Principal Investigator
    R01GM080372     (REBAY, ILARIA)Jul 1, 2007 - Jul 31, 2024
    NIH
    Function and Regulation of the ETS Transcriptional Repressor Tel-1/YAN
    Role: Principal Investigator
    R01EY012549     (REBAY, ILARIA)May 3, 1999 - Jun 30, 2021
    NIH
    Cell-Cell Signaling In Embryonic and Retinal Development
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sun X, Decker J, Sanchez-Luege N, Rebay I. Inter-plane feedback coordinates cell morphogenesis and maintains 3D tissue organization in the Drosophila pupal retina. Development. 2024 Mar 15; 151(6). PMID: 38533736; PMCID: PMC11006395.
      Citations:    Fields:    Translation:Animals
    2. Bernasek SM, Hur SSJ, Bakker R, Navarro HT, Sanchez-Luege N, Bagheri N, Rebay I, Carthew RW, Peláez-Restrepo N, Boisclair Lachance JF, Amaral LAN. Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila. Development. 2023 04 15; 150(8). PMID: 36942737; PMCID: PMC10163347.
      Citations: 3     Fields:    Translation:Animals
    3. Sun X, Decker J, Sanchez-Luege N, Rebay I. Orthogonal coupling of a 3D cytoskeletal scaffold coordinates cell morphogenesis and maintains tissue organization in the Drosophila pupal retina. bioRxiv. 2023 Mar 07. PMID: 36945525; PMCID: PMC10028844.
      Citations:    
    4. Wu C, Ludwig MZ, Rebay I, Boisclair Lachance JF. A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition. PLoS Genet. 2020 11; 16(11):e1009216. PMID: 33253156; PMCID: PMC7728396.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Hope CM, Webber JL, Tokamov SA, Rebay I. Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression. Elife. 2018 11 09; 7. PMID: 30412049; PMCID: PMC6226293.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Webber JL, Zhang J, Massey A, Sanchez-Luege N, Rebay I. Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila. Development. 2018 07 02; 145(13). PMID: 29848501; PMCID: PMC6053666.
      Citations: 11     Fields:    Translation:Animals
    7. Webber JL, Hong L, Dinner AR, Rebay I, Boisclair Lachance JF. Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. Genes Dev. 2018 03 01; 32(5-6):389-401. PMID: 29535190; PMCID: PMC5900712.
      Citations: 9     Fields:    Translation:AnimalsCells
    8. Davis TL, Rebay I. Pleiotropy in Drosophila organogenesis: Mechanistic insights from Combgap and the retinal determination gene network. Fly (Austin). 2018 01 02; 12(1):62-70. PMID: 29125381; PMCID: PMC5927687.
      Citations: 1     Fields:    Translation:AnimalsCells
    9. Davis TL, Hoi CSL, Rebay I. Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila. PLoS One. 2017; 12(11):e0187546. PMID: 29108015; PMCID: PMC5673202.
      Citations: 5     Fields:    Translation:Animals
    10. Davis TL, Rebay I. Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina. Development. 2017 07 15; 144(14):2640-2651. PMID: 28619818; PMCID: PMC5536924.
      Citations: 3     Fields:    Translation:Animals
    11. Hope CM, Rebay I, Reinitz J. DNA Occupancy of Polymerizing Transcription Factors: A Chemical Model of the ETS Family Factor Yan. Biophys J. 2017 Jan 10; 112(1):180-192. PMID: 28076810; PMCID: PMC5232354.
      Citations: 6     Fields:    Translation:AnimalsCells
    12. Davis TL, Rebay I. Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks. Dev Biol. 2017 Jan 15; 421(2):93-107. PMID: 27979656; PMCID: PMC5496713.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    13. Hoi CS, Xiong W, Rebay I. Retinal Axon Guidance Requires Integration of Eya and the Jak/Stat Pathway into Phosphotyrosine-Based Signaling Circuitries in Drosophila. Genetics. 2016 07; 203(3):1283-95. PMID: 27194748; PMCID: PMC4937463.
      Citations: 5     Fields:    Translation:AnimalsCells
    14. Rebay I. Multiple Functions of the Eya Phosphotyrosine Phosphatase. Mol Cell Biol. 2015 Dec 14; 36(5):668-77. PMID: 26667035; PMCID: PMC4760226.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    15. Gavalda-Miralles A, Wang B, Navarro HT, Gudjonson H, Rebay I, Dinner AR, Katsaggelos AK, Carthew RW, Peláez N, Amaral LA. Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation. Elife. 2015 Nov 19; 4. PMID: 26583752; PMCID: PMC4720516.
      Citations: 25     Fields:    Translation:Animals
    16. Webber JL, Rebay I. Long-range integration of repressive and patterning inputs. Cell Cycle. 2014; 13(11):1653-4. PMID: 24809701; PMCID: PMC4111706.
      Citations:    Fields:    Translation:AnimalsCells
    17. Zhou Q, Zhang T, Jemc JC, Chen Y, Chen R, Rebay I, Pignoni F. Onset of atonal expression in Drosophila retinal progenitors involves redundant and synergistic contributions of Ey/Pax6 and So binding sites within two distant enhancers. Dev Biol. 2014 Feb 01; 386(1):152-64. PMID: 24247006; PMCID: PMC5223736.
      Citations: 12     Fields:    Translation:AnimalsCells
    18. Cassidy JJ, Webber JL, Rebay I, Carthew RW, Boisclair Lachance JF, Peláez N. A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling. Dev Biol. 2014 Jan 15; 385(2):263-78. PMID: 24240101; PMCID: PMC3947276.
      Citations: 21     Fields:    Translation:AnimalsCells
    19. Webber JL, Zhang J, Mitchell-Dick A, Rebay I. 3D chromatin interactions organize Yan chromatin occupancy and repression at the even-skipped locus. Genes Dev. 2013 Nov 01; 27(21):2293-8. PMID: 24186975; PMCID: PMC3828515.
      Citations: 11     Fields:    Translation:AnimalsCells
    20. Qi J, Wang B, Pelaez N, Rebay I, Carthew RW, Katsaggelos AK, Nunes Amaral LA. Drosophila Eye Nuclei Segmentation Based on Graph Cut and Convex Shape Prior. Int Conf Signal Process Proc. 2013 Sep 18; 670-674. PMID: 25089515; PMCID: PMC4116101.
      Citations: 3     
    21. Webber JL, Rebay I. Chromatin occupancy patterns of the ETS repressor Yan: a mechanism for buffering gene expression against noise? Fly (Austin). 2013 Apr-Jun; 7(2):92-8. PMID: 23575308; PMCID: PMC3732337.
      Citations:    Fields:    Translation:AnimalsCells
    22. Xiong W, Morillo SA, Rebay I. The Abelson tyrosine kinase regulates Notch endocytosis and signaling to maintain neuronal cell fate in Drosophila photoreceptors. Development. 2013 Jan 01; 140(1):176-84. PMID: 23175629; PMCID: PMC3513998.
      Citations: 7     Fields:    Translation:AnimalsCells
    23. Webber JL, Zhang J, Cote L, Vivekanand P, Ni X, Zhou J, Carthew RW, White KP, Rebay I, Nègre N. The relationship between long-range chromatin occupancy and polymerization of the Drosophila ETS family transcriptional repressor Yan. Genetics. 2013 Feb; 193(2):633-49. PMID: 23172856; PMCID: PMC3567750.
      Citations: 20     Fields:    Translation:AnimalsCells
    24. Vivekanand P, Rebay I. The SAM domain of human TEL2 can abrogate transcriptional output from TEL1 (ETV-6) and ETS1/ETS2. PLoS One. 2012; 7(5):e37151. PMID: 22615925; PMCID: PMC3355116.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    25. Morillo SA, Braid LR, Verheyen EM, Rebay I. Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination. Dev Biol. 2012 May 01; 365(1):267-76. PMID: 22394486; PMCID: PMC3603580.
      Citations: 9     Fields:    Translation:AnimalsCells
    26. Xiong W, Rebay I. Abelson tyrosine kinase is required for Drosophila photoreceptor morphogenesis and retinal epithelial patterning. Dev Dyn. 2011 Jul; 240(7):1745-55. PMID: 21674685; PMCID: PMC3314402.
      Citations: 6     Fields:    Translation:AnimalsCells
    27. Rebay I, Fehon RG. Determining fusion protein antiserum quality by staining of transfected Drosophila S2 cultured cells. Cold Spring Harb Protoc. 2011 Jan 01; 2011(1):pdb.prot4999. PMID: 21205843.
      Citations:    Fields:    Translation:AnimalsCells
    28. Rebay I, Fehon RG. Dot blot assay for determining fusion protein antiserum quality. Cold Spring Harb Protoc. 2011 Jan 01; 2011(1):pdb.prot4998. PMID: 21205842.
      Citations:    Fields:    Translation:Animals
    29. Graham TG, Tabei SM, Dinner AR, Rebay I. Modeling bistable cell-fate choices in the Drosophila eye: qualitative and quantitative perspectives. Development. 2010 Jul; 137(14):2265-78. PMID: 20570936; PMCID: PMC2889600.
      Citations: 33     Fields:    Translation:AnimalsCells
    30. Zhang J, Graham TG, Vivekanand P, Cote L, Cetera M, Rebay I. Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor Yan. Mol Cell Biol. 2010 Mar; 30(5):1158-70. PMID: 20048052; PMCID: PMC2820895.
      Citations: 17     Fields:    Translation:AnimalsCells
    31. Rebay I, Fehon RG. Preparation of soluble GST fusion proteins. Cold Spring Harb Protoc. 2009 Nov; 2009(11):pdb.prot4996. PMID: 20150052.
      Citations: 3     Fields:    Translation:Cells
    32. Rebay I, Fehon RG. Preparation of insoluble GST fusion proteins. Cold Spring Harb Protoc. 2009 Nov; 2009(11):pdb.prot4997. PMID: 20150053.
      Citations: 1     Fields:    Translation:Cells
    33. Xiong W, Dabbouseh NM, Rebay I. Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm. Dev Cell. 2009 Feb; 16(2):271-9. PMID: 19217428; PMCID: PMC2670569.
      Citations: 40     Fields:    Translation:AnimalsCells
    34. Rebay I, Fehon RG. Streamlined protocol for antibody staining of large numbers of samples in Drosophila. CSH Protoc. 2008 Sep 01; 2008:pdb.prot5000. PMID: 21356907.
      Citations:    
    35. Rebay I, Fehon RG. Antibody staining of Drosophila tissues--helpful hints. CSH Protoc. 2008 Sep 01; 2008:pdb.ip56. PMID: 21356899.
      Citations: 1     
    36. Jemc J, Rebay I. Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent. Dev Biol. 2007 Oct 15; 310(2):416-29. PMID: 17714699; PMCID: PMC2075104.
      Citations: 48     Fields:    Translation:AnimalsCells
    37. Doroquez DB, Orr-Weaver TL, Rebay I. Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development. Mech Dev. 2007 Sep-Oct; 124(9-10):792-806. PMID: 17588724; PMCID: PMC2231642.
      Citations: 20     Fields:    Translation:AnimalsCells
    38. Jemc J, Rebay I. The eyes absent family of phosphotyrosine phosphatases: properties and roles in developmental regulation of transcription. Annu Rev Biochem. 2007; 76:513-38. PMID: 17341163.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    39. Doroquez DB, Rebay I. Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk. Crit Rev Biochem Mol Biol. 2006 Nov-Dec; 41(6):339-85. PMID: 17092823.
      Citations: 74     Fields:    Translation:AnimalsCells
    40. Jemc J, Rebay I. Characterization of the split ends-like gene spenito reveals functional antagonism between SPOC family members during Drosophila eye development. Genetics. 2006 May; 173(1):279-86. PMID: 16547102; PMCID: PMC1461450.
      Citations: 11     Fields:    Translation:AnimalsCells
    41. Vivekanand P, Rebay I. Intersection of signal transduction pathways and development. Annu Rev Genet. 2006; 40:139-57. PMID: 16771628.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    42. Jemc J, Rebay I. Targeting Drosophila eye development. Genome Biol. 2006; 7(7):226. PMID: 16879729; PMCID: PMC1779560.
      Citations: 7     Fields:    Translation:Animals
    43. Badenhorst P, Xiao H, Cherbas L, Kwon SY, Voas M, Rebay I, Cherbas P, Wu C. The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis. Genes Dev. 2005 Nov 01; 19(21):2540-5. PMID: 16264191; PMCID: PMC1276728.
      Citations: 77     Fields:    Translation:AnimalsCells
    44. Schober M, Rebay I, Perrimon N. Function of the ETS transcription factor Yan in border cell migration. Development. 2005 Aug; 132(15):3493-504. PMID: 16014514.
      Citations: 30     Fields:    Translation:AnimalsCells
    45. Mutsuddi M, Rebay I. Molecular genetics of spinocerebellar ataxia type 8 (SCA8). RNA Biol. 2005 Apr; 2(2):49-52. PMID: 17132942.
      Citations: 6     Fields:    Translation:HumansAnimals
    46. Mutsuddi M, Chaffee B, Cassidy J, Silver SJ, Tootle TL, Rebay I. Using Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absent. Genetics. 2005 Jun; 170(2):687-95. PMID: 15802522; PMCID: PMC1450419.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    47. Rebay I, Silver SJ, Tootle TL. New vision from Eyes absent: transcription factors as enzymes. Trends Genet. 2005 Mar; 21(3):163-71. PMID: 15734575.
      Citations: 37     Fields:    Translation:Animals
    48. Tootle TL, Rebay I. Post-translational modifications influence transcription factor activity: a view from the ETS superfamily. Bioessays. 2005 Mar; 27(3):285-98. PMID: 15714552.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    49. Silver SJ, Rebay I. Signaling circuitries in development: insights from the retinal determination gene network. Development. 2005 Jan; 132(1):3-13. PMID: 15590745.
      Citations: 92     Fields:    Translation:AnimalsCells
    50. Vivekanand P, Tootle TL, Rebay I. MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN. Mech Dev. 2004 Dec; 121(12):1469-79. PMID: 15511639.
      Citations: 17     Fields:    Translation:Cells
    51. Silver SJ, Chen F, Doyon L, Zink AW, Rebay I. New class of Son-of-sevenless (Sos) alleles highlights the complexities of Sos function. Genesis. 2004 Aug; 39(4):263-72. PMID: 15286999.
      Citations: 1     Fields:    Translation:AnimalsCells
    52. Qiao F, Song H, Kim CA, Sawaya MR, Hunter JB, Gingery M, Rebay I, Courey AJ, Bowie JU. Derepression by depolymerization; structural insights into the regulation of Yan by Mae. Cell. 2004 Jul 23; 118(2):163-73. PMID: 15260987.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    53. Mutsuddi M, Marshall CM, Benzow KA, Koob MD, Rebay I. The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila. Curr Biol. 2004 Feb 17; 14(4):302-8. PMID: 14972680.
      Citations: 64     Fields:    Translation:AnimalsCells
    54. Voas MG, Rebay I. Signal integration during development: insights from the Drosophila eye. Dev Dyn. 2004 Jan; 229(1):162-75. PMID: 14699588.
      Citations: 87     Fields:    Translation:AnimalsCells
    55. Voas MG, Rebay I. The novel plant homeodomain protein rhinoceros antagonizes Ras signaling in the Drosophila eye. Genetics. 2003 Dec; 165(4):1993-2006. PMID: 14704181; PMCID: PMC1462918.
      Citations: 9     Fields:    Translation:AnimalsCells
    56. Tootle TL, Silver SJ, Davies EL, Newman V, Latek RR, Mills IA, Selengut JD, Parlikar BE, Rebay I. The transcription factor Eyes absent is a protein tyrosine phosphatase. Nature. 2003 Nov 20; 426(6964):299-302. PMID: 14628053.
      Citations: 109     Fields:    Translation:AnimalsCells
    57. Silver SJ, Davies EL, Doyon L, Rebay I. Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network. Mol Cell Biol. 2003 Sep; 23(17):5989-99. PMID: 12917324; PMCID: PMC180989.
      Citations: 59     Fields:    Translation:AnimalsCells
    58. Lin HV, Doroquez DB, Cho S, Chen F, Rebay I, Cadigan KM. Splits ends is a tissue/promoter specific regulator of Wingless signaling. Development. 2003 Jul; 130(14):3125-35. PMID: 12783785.
      Citations: 16     Fields:    Translation:AnimalsCells
    59. Tootle TL, Lee PS, Rebay I. CRM1-mediated nuclear export and regulated activity of the Receptor Tyrosine Kinase antagonist YAN require specific interactions with MAE. Development. 2003 Mar; 130(5):845-57. PMID: 12538513.
      Citations: 33     Fields:    Translation:AnimalsCells
    60. Badenhorst P, Voas M, Rebay I, Wu C. Biological functions of the ISWI chromatin remodeling complex NURF. Genes Dev. 2002 Dec 15; 16(24):3186-98. PMID: 12502740; PMCID: PMC187504.
      Citations: 108     Fields:    Translation:AnimalsCells
    61. Rebay I, Rebay I. Keeping the receptor tyrosine kinase signaling pathway in check: lessons from Drosophila. Dev Biol. 2002 Nov 01; 251(1):1-17. PMID: 12413894.
      Citations: 23     Fields:    Translation:AnimalsCells
    62. Hsiao FC, Williams A, Davies EL, Rebay I. Eyes absent mediates cross-talk between retinal determination genes and the receptor tyrosine kinase signaling pathway. Dev Cell. 2001 Jul; 1(1):51-61. PMID: 11703923.
      Citations: 23     Fields:    Translation:AnimalsCells
    63. Chen F, Rebay I. split ends, a new component of the Drosophila EGF receptor pathway, regulates development of midline glial cells. Curr Biol. 2000 Jul 27-Aug 10; 10(15):943-6. PMID: 10959845.
      Citations: 26     Fields:    Translation:AnimalsCells
    64. Rebay I, Chen F, Hsiao F, Kolodziej PA, Kuang BH, Laverty T, Suh C, Voas M, Williams A, Rubin GM. A genetic screen for novel components of the Ras/Mitogen-activated protein kinase signaling pathway that interact with the yan gene of Drosophila identifies split ends, a new RNA recognition motif-containing protein. Genetics. 2000 Feb; 154(2):695-712. PMID: 10655223; PMCID: PMC1460949.
      Citations: 66     Fields:    Translation:AnimalsCells
    65. Fox GL, Rebay I, Hynes RO. Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):14978-83. PMID: 10611323; PMCID: PMC24758.
      Citations: 20     Fields:    Translation:AnimalsCells
    66. Rubin GM, Chang HC, Karim F, Laverty T, Michaud NR, Morrison DK, Rebay I, Tang A, Therrien M, Wassarman DA. Signal transduction downstream from Ras in Drosophila. Cold Spring Harb Symp Quant Biol. 1997; 62:347-52. PMID: 9598368.
      Citations: 15     Fields:    Translation:AnimalsCells
    67. Rebay I, Rubin GM. Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell. 1995 Jun 16; 81(6):857-66. PMID: 7781063.
      Citations: 122     Fields:    Translation:AnimalsCells
    68. O'Neill EM, Rebay I, Tjian R, Rubin GM. The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell. 1994 Jul 15; 78(1):137-47. PMID: 8033205.
      Citations: 258     Fields:    Translation:AnimalsCells
    69. Chang HC, Karim FD, O'Neill EM, Rebay I, Solomon NM, Therrien M, Wassarman DA, Wolff T, Rubin GM. Ras signal transduction pathway in Drosophila eye development. Cold Spring Harb Symp Quant Biol. 1994; 59:147-53. PMID: 7587064.
      Citations: 7     Fields:    Translation:AnimalsCells
    70. Fortini ME, Rebay I, Caron LA, Artavanis-Tsakonas S. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature. 1993 Oct 07; 365(6446):555-7. PMID: 8413612.
      Citations: 81     Fields:    Translation:AnimalsCells
    71. Rebay I, Fortini ME, Artavanis-Tsakonas S. Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor in Drosophila development. C R Acad Sci III. 1993 Sep; 316(9):1097-123. PMID: 8076207.
      Citations: 3     Fields:    Translation:Animals
    72. Rebay I, Fehon RG, Artavanis-Tsakonas S. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell. 1993 Jul 30; 74(2):319-29. PMID: 8343959.
      Citations: 133     Fields:    Translation:AnimalsCells
    73. Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell. 1991 Nov 15; 67(4):687-99. PMID: 1657403.
      Citations: 227     Fields:    Translation:AnimalsCells
    74. Fehon RG, Johansen K, Rebay I, Artavanis-Tsakonas S. Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function. J Cell Biol. 1991 May; 113(3):657-69. PMID: 2016340; PMCID: PMC2288958.
      Citations: 74     Fields:    Translation:AnimalsCells
    75. Artavanis-Tsakonas S, Delidakis C, Fehon R, Hartley D, Herndon V, Johansen K, Markopoulou K, Preiss A, Rebay I, Scottgale N, et al. Notch and the molecular genetics of neuroblast segregation in Drosophila. Mol Reprod Dev. 1990 Sep; 27(1):23-7. PMID: 2271182.
      Citations: 3     Fields:    Translation:Animals
    76. Fehon RG, Kooh PJ, Rebay I, Regan CL, Xu T, Muskavitch MA, Artavanis-Tsakonas S. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell. 1990 May 04; 61(3):523-34. PMID: 2185893.
      Citations: 210     Fields:    Translation:AnimalsCells
    77. Xu T, Rebay I, Fleming RJ, Scottgale TN, Artavanis-Tsakonas S. The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. Genes Dev. 1990 Mar; 4(3):464-75. PMID: 2338245.
      Citations: 47     Fields:    Translation:AnimalsCells
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