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Derek A. Wainwright

TitlePostdoctoral Scholar
InstitutionUniversity of Chicago
DepartmentSurgery
AddressChicago IL 60637
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    R01NS129835     (WAINWRIGHT, DEREK ALAN)Aug 19, 2023 - Apr 30, 2028
    NIH
    Extratumoral biological determinants that decrease survival in older adults with glioblastoma
    Role: Principal Investigator
    K02AG068617     (WAINWRIGHT, DEREK ALAN)Aug 1, 2020 - May 31, 2025
    NIH
    Aging, immunosenescence and glioblastoma
    Role: Principal Investigator
    R01NS097851     (SCHILTZ, GARY E;WAINWRIGHT, DEREK ALAN)Aug 1, 2016 - Jun 30, 2026
    NIH
    IDO1 and Immunotolerance in Glioblastoma
    Role: Principal Investigator
    R00NS082381     (WAINWRIGHT, DEREK ALAN)Apr 1, 2013 - Aug 31, 2017
    NIH
    The interaction of IDO and Tregs Leads to Immunosuppression in Glioma
    Role: Principal Investigator
    K99NS082381     (WAINWRIGHT, DEREK ALAN)Apr 1, 2013 - Mar 31, 2015
    NIH
    The interaction of IDO and Tregs Leads to Immunosuppression in Glioma
    Role: Principal Investigator
    F32NS073366     (WAINWRIGHT, DEREK ALAN)Aug 1, 2011 - Jul 31, 2014
    NIH
    The role of IDO and Th17 in an experimental mouse model of glioma
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rabin EE, Huang J, Kim M, Mozny A, Lauing KL, Penco-Campillo M, Zhai L, Bommi P, Mi X, Power EA, Prabhu VC, Anderson DE, Barton KP, Walunas TL, Schiltz GE, Amidei C, Sanchez-Gomez P, Thakkar JP, Lukas RV, Wainwright DA. Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma. Brain Behav Immun Health. 2024 Jul; 38:100753. PMID: 38600951; PMCID: PMC11004500.
      Citations:    
    2. Chen S, Fan J, Xie P, Ahn J, Fernandez M, Billingham LK, Miska J, Wu JD, Wainwright DA, Fang D, Sosman JA, Wan Y, Zhang Y, Chandel NS, Zhang B, Chen S, Fan J, Xie P, Ahn J, Fernandez M, Billingham LK, Miska J, Wu JD, Wainwright DA, Fang D, Sosman JA, Wan Y, Zhang Y, Chandel NS, Zhang B. CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4. J Clin Invest. 2024 Mar 05; 134(8). PMID: 38441967; PMCID: PMC11014673.
      Citations:    Fields:    
    3. Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Grant Rowe R, Wainwright DA, McCortney K, Billingham LK, Miska J, Horbinski C, Lesniak MS, Chen P. Lactate dehydrogenase A regulates tumor-macrophage symbiosis to promote glioblastoma progression. Nat Commun. 2024 Mar 05; 15(1):1987. PMID: 38443336; PMCID: PMC10914854.
      Citations: 1     Fields:    Translation:HumansAnimals
    4. Johnson M, Bell A, Lauing KL, Ladomersky E, Zhai L, Penco-Campillo M, Shah Y, Mauer E, Xiu J, Nicolaides T, Drumm M, McCortney K, Elemento O, Kim M, Bommi P, Low JT, Memon R, Wu J, Zhao J, Mi X, Glantz MJ, Sengupta S, Castro B, Yamini B, Horbinski C, Baker DJ, Walunas TL, Schiltz GE, Lukas RV, Wainwright DA, Johnson M, Bell A, Lauing KL, Ladomersky E, Zhai L, Penco-Campillo M, Shah Y, Mauer E, Xiu J, Nicolaides T, Drumm M, McCortney K, Elemento O, Kim M, Bommi P, Low JT, Memon R, Wu J, Zhao J, Mi X, Glantz MJ, Sengupta S, Castro B, Yamini B, Horbinski C, Baker DJ, Walunas TL, Schiltz GE, Lukas RV, Wainwright DA. Advanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence. Clin Cancer Res. 2023 12 01; 29(23):4973-4989. PMID: 37725593; PMCID: PMC10690140.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    5. Khan F, Lin Y, Ali H, Pang L, Dunterman M, Hsu WH, Frenis K, Rowe RG, Wainwright D, McCortney K, Billingham L, Miska J, Horbinski C, Lesniak M, Chen P. LDHA-regulated tumor-macrophage symbiosis promotes glioblastoma progression. Res Sq. 2023 Oct 05. PMID: 37886538; PMCID: PMC10602051.
      Citations:    
    6. Siddiqui A, Ross D, Jani RH, Prabhu VC, Lo S, Wainwright DA, Rouse S, Refaat T, Zhu Y, Thakkar JP. Anti-aquaporin-4 immunoglobulin G/anti-myelin oligodendrocyte glycoprotein immunoglobulin G double-positive paraneoplastic neurological syndrome in a patient with triple-negative breast cancer. Clin Exp Neuroimmunol. 2024 Feb; 15(1):55-60. PMID: 38595690; PMCID: PMC11003753.
      Citations:    
    7. Bollu LR, Bommi PV, Monsen PJ, Zhai L, Lauing KL, Bell A, Kim M, Ladomersky E, Yang X, Platanias LC, Matei DE, Bonini MG, Munshi HG, Hashizume R, Wu JD, Zhang B, James CD, Chen P, Kocherginsky M, Horbinski C, Cameron MD, Grigorescu AA, Yamini B, Lukas RV, Schiltz GE, Wainwright DA. Identification and Characterization of a Novel Indoleamine 2,3-Dioxygenase 1 Protein Degrader for Glioblastoma. J Med Chem. 2022 12 08; 65(23):15642-15662. PMID: 36410047; PMCID: PMC9743093.
      Citations: 4     Fields:    Translation:HumansAnimals
    8. Cao TQ, Wainwright DA, Lee-Chang C, Miska J, Sonabend AM, Heimberger AB, Lukas RV. Next Steps for Immunotherapy in Glioblastoma. Cancers (Basel). 2022 Aug 20; 14(16). PMID: 36011015; PMCID: PMC9406905.
      Citations: 5     
    9. Nguyen TT, Shin DH, Sohoni S, Singh SK, Rivera-Molina Y, Jiang H, Fan X, Gumin J, Lang FF, Alvarez-Breckenridge C, Godoy-Vitorino F, Zhu L, Zheng WJ, Zhai L, Ladomersky E, Lauing KL, Wainwright DA, Gomez-Manzano C, Fueyo J, Alonso MM. Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry. J Immunother Cancer. 2022 07; 10(7). PMID: 35902132; PMCID: PMC9341188.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    10. Xuan W, Hsu WH, Khan F, Dunterman M, Pang L, Wainwright DA, Ahmed AU, Heimberger AB, Lesniak MS, Chen P. Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma. Cancer Immunol Res. 2022 06 03; 10(6):770-784. PMID: 35413115; PMCID: PMC9177794.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    11. Rabin EE, Kim M, Mozny A, Cardoza K, Bell AC, Zhai L, Bommi P, Lauing KL, King AL, Armstrong TS, Walunas TL, Fang D, Roy I, Peipert JD, Sieg E, Mi X, Amidei C, Lukas RV, Wainwright DA. A systematic review of pharmacologic treatment efficacy for depression in older patients with cancer. Brain Behav Immun Health. 2022 May; 21:100449. PMID: 35368609; PMCID: PMC8968450.
      Citations: 3     
    12. Zheng Y, Habes M, Gonzales M, Pomponio R, Nasrallah I, Khan S, Vaughan DE, Davatzikos C, Seshadri S, Launer L, Sorond F, Sedaghat S, Wainwright D, Baccarelli A, Sidney S, Bryan N, Greenland P, Lloyd-Jones D, Yaffe K, Hou L. Mid-life epigenetic age, neuroimaging brain age, and cognitive function: coronary artery risk development in young adults (CARDIA) study. Aging (Albany NY). 2022 02 27; 14(4):1691-1712. PMID: 35220276; PMCID: PMC8908939.
      Citations: 9     Fields:    Translation:Humans
    13. Hine C, Wainwright DA, Lathia JD. Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H2S production: A paradox resolved. Cell Chem Biol. 2021 12 16; 28(12):1665-1668. PMID: 34919842; PMCID: PMC8988164.
      Citations:    Fields:    Translation:Cells
    14. Bi J, Khan A, Tang J, Armando AM, Wu S, Zhang W, Gimple RC, Reed A, Jing H, Koga T, Wong IT, Gu Y, Miki S, Yang H, Prager B, Curtis EJ, Wainwright DA, Furnari FB, Rich JN, Cloughesy TF, Kornblum HI, Quehenberger O, Rzhetsky A, Cravatt BF, Mischel PS. Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. Cell Rep. 2021 11 02; 37(5):109957. PMID: 34731610; PMCID: PMC8856626.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    15. Najem H, Marisetty A, Horbinski C, Long J, Huse JT, Glitza Oliva IC, Ferguson SD, Kumthekar PU, Wainwright DA, Chen P, Lesniak MS, Burks JK, Heimberger AB. CD11c+CD163+ Cells and Signal Transducer and Activator of Transcription 3 (STAT3) Expression Are Common in Melanoma Leptomeningeal Disease. Front Immunol. 2021; 12:745893. PMID: 34691054; PMCID: PMC8531809.
      Citations: 4     Fields:    Translation:HumansCells
    16. Kim M, Ladomersky E, Mozny A, Kocherginsky M, O'Shea K, Reinstein ZZ, Zhai L, Bell A, Lauing KL, Bollu L, Rabin E, Dixit K, Kumthekar P, Platanias LC, Hou L, Zheng Y, Wu J, Zhang B, Hrachova M, Merrill SA, Mrugala MM, Prabhu VC, Horbinski C, James CD, Yamini B, Ostrom QT, Johnson MO, Reardon DA, Lukas RV, Wainwright DA. Glioblastoma as an age-related neurological disorder in adults. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab125. PMID: 34647022; PMCID: PMC8500689.
      Citations: 27     
    17. Zhai L, Bell A, Ladomersky E, Lauing KL, Bollu L, Nguyen B, Genet M, Kim M, Chen P, Mi X, Wu JD, Schipma MJ, Wray B, Griffiths J, Unwin RD, Acharya R, Bao R, Horbinski C, Lukas RV, Schiltz GE, Wainwright DA, Clark SJ. Tumor Cell IDO Enhances Immune Suppression and Decreases Survival Independent of Tryptophan Metabolism in Glioblastoma. Clin Cancer Res. 2021 12 01; 27(23):6514-6528. PMID: 34479957; PMCID: PMC8639612.
      Citations: 30     Fields:    Translation:HumansAnimals
    18. Dhar P, Basher F, Ji Z, Huang L, Qin S, Wainwright DA, Robinson J, Hagler S, Zhou J, MacKay S, Wu JD. Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation. Commun Biol. 2021 07 22; 4(1):905. PMID: 34294876; PMCID: PMC8298432.
      Citations: 4     Translation:HumansCells
    19. Platten M, Friedrich M, Wainwright DA, Panitz V, Opitz CA. Tryptophan metabolism in brain tumors - IDO and beyond. Curr Opin Immunol. 2021 06; 70:57-66. PMID: 33813026; PMCID: PMC8373719.
      Citations: 16     Fields:    Translation:Humans
    20. Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown CE, Chen Y, Fecci PE, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H. Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375. PMID: 33367885; PMCID: PMC7992879.
      Citations: 50     Fields:    Translation:Humans
    21. Liu S, Galat V, Galat Y, Lee YKA, Wainwright D, Wu J. NK cell-based cancer immunotherapy: from basic biology to clinical development. J Hematol Oncol. 2021 01 06; 14(1):7. PMID: 33407739; PMCID: PMC7788999.
      Citations: 193     Fields:    Translation:HumansAnimalsCells
    22. Roh M, Wainwright DA, Wu JD, Wan Y, Zhang B. Targeting CD73 to augment cancer immunotherapy. Curr Opin Pharmacol. 2020 08; 53:66-76. PMID: 32777746; PMCID: PMC7669683.
      Citations: 51     Fields:    Translation:HumansAnimals
    23. Oh MS, Guzner A, Wainwright DA, Mohindra NA, Chae YK, Behdad A, Villaflor VM. The Impact of Beta Blockers on Survival Outcomes in Patients With Non-small-cell Lung Cancer Treated With Immune Checkpoint Inhibitors. Clin Lung Cancer. 2021 01; 22(1):e57-e62. PMID: 32900613; PMCID: PMC7785632.
      Citations: 27     Fields:    Translation:Humans
    24. Li H, Liu T, Heinsberg LW, Lockwood MB, Wainwright DA, Jang MK, Doorenbos AZ. Systematic Review of the Kynurenine Pathway and Psychoneurological Symptoms Among Adult Cancer Survivors. Biol Res Nurs. 2020 10; 22(4):472-484. PMID: 32602357; PMCID: PMC7708728.
      Citations: 8     Fields:    Translation:Humans
    25. Zhai L, Bell A, Ladomersky E, Lauing KL, Bollu L, Sosman JA, Zhang B, Wu JD, Miller SD, Meeks JJ, Lukas RV, Wyatt E, Doglio L, Schiltz GE, McCusker RH, Wainwright DA. Immunosuppressive IDO in Cancer: Mechanisms of Action, Animal Models, and Targeting Strategies. Front Immunol. 2020; 11:1185. PMID: 32612606; PMCID: PMC7308527.
      Citations: 75     Fields:    Translation:HumansAnimals
    26. Ladomersky E, Zhai L, Lauing KL, Bell A, Xu J, Kocherginsky M, Zhang B, Wu JD, Podojil JR, Platanias LC, Mochizuki AY, Prins RM, Kumthekar P, Raizer JJ, Dixit K, Lukas RV, Horbinski C, Wei M, Zhou C, Campisi J, Grohmann U, Prendergast GC, Munn DH, Wainwright DA, Pawelec G. Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma. Clin Cancer Res. 2020 10 01; 26(19):5232-5245. PMID: 32546647; PMCID: PMC7541490.
      Citations: 42     Fields:    Translation:HumansAnimals
    27. Basher F, Dhar P, Wang X, Wainwright DA, Zhang B, Sosman J, Ji Z, Wu JD. Antibody targeting tumor-derived soluble NKG2D ligand sMIC reprograms NK cell homeostatic survival and function and enhances melanoma response to PDL1 blockade therapy. J Hematol Oncol. 2020 06 09; 13(1):74. PMID: 32517713; PMCID: PMC7285527.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    28. Otto-Meyer S, DeFaccio R, Dussold C, Ladomersky E, Zhai L, Lauing KL, Bollu LR, Amidei C, Lukas RV, Scholtens DM, Wainwright DA. A retrospective survival analysis of Glioblastoma patients treated with selective serotonin reuptake inhibitors. Brain Behav Immun Health. 2020 Feb; 2. PMID: 32190845; PMCID: PMC7079579.
      Citations: 19     
    29. Wainwright DA, Horbinski CM, Iwamoto FM, Sonabend AM, Lukas RV. Immunotherapy Against Gliomas: is the Breakthrough Near? Drugs. 2019 Nov; 79(17):1839-1848. PMID: 31598900; PMCID: PMC6868342.
      Citations: 8     Fields:    Translation:Humans
    30. Zhang J, Larrocha PS, Zhang B, Wainwright D, Dhar P, Wu JD. Antibody targeting tumor-derived soluble NKG2D ligand sMIC provides dual co-stimulation of CD8 T cells and enables sMIC+ tumors respond to PD1/PD-L1 blockade therapy. J Immunother Cancer. 2019 08 26; 7(1):223. PMID: 31446896; PMCID: PMC6709558.
      Citations: 16     Fields:    Translation:HumansCells
    31. Zhai L, Ladomersky E, Bell A, Dussold C, Cardoza K, Qian J, Lauing KL, Wainwright DA. Quantification of IDO1 enzyme activity in normal and malignant tissues. Methods Enzymol. 2019; 629:235-256. PMID: 31727243; PMCID: PMC7347075.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    32. Chen S, Wainwright DA, Wu JD, Wan Y, Matei DE, Zhang Y, Zhang B. CD73: an emerging checkpoint for cancer immunotherapy. Immunotherapy. 2019 08; 11(11):983-997. PMID: 31223045; PMCID: PMC6609898.
      Citations: 49     Fields:    Translation:HumansAnimals
    33. Ladomersky E, Scholtens DM, Kocherginsky M, Hibler EA, Bartom ET, Otto-Meyer S, Zhai L, Lauing KL, Choi J, Sosman JA, Wu JD, Zhang B, Lukas RV, Wainwright DA. The Coincidence Between Increasing Age, Immunosuppression, and the Incidence of Patients With Glioblastoma. Front Pharmacol. 2019; 10:200. PMID: 30971917; PMCID: PMC6446059.
      Citations: 55     
    34. Lukas RV, Wainwright DA, Ladomersky E, Sachdev S, Sonabend AM, Stupp R. Newly Diagnosed Glioblastoma: A Review on Clinical Management. Oncology (Williston Park). 2019 Mar 13; 33(3):91-100. PMID: 30866031; PMCID: PMC7278092.
      Citations: 53     Fields:    Translation:Humans
    35. Otto-Meyer S, Lumibao J, Kim E, Ladomersky E, Zhai L, Lauing KL, Scholtens DM, Penedo F, Amidei C, Lukas RV, Wainwright DA. The interplay among psychological distress, the immune system, and brain tumor patient outcomes. Curr Opin Behav Sci. 2019 Aug; 28:44-50. PMID: 31049368; PMCID: PMC6487487.
      Citations: 15     
    36. Zhai L, Ladomersky E, Lauing KL, Wu M, Scholtens DM, Savoor R, Zhang B, Wu JD, Horbinski C, Lukas RV, Binder DC, Wainwright DA. Commentary: preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma by Garg et al. (2017). Oncoimmunology. 2019; 8(3):1548242. PMID: 30723577; PMCID: PMC6350838.
      Citations:    Fields:    Translation:Humans
    37. Lukas RV, Wainwright DA, James CD, Kennedy E, Stupp R, Lesniak MS, Juhász C. Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod. J Neurooncol. 2019 Jan; 141(1):111-120. PMID: 30415456; PMCID: PMC6414051.
      Citations: 12     Fields:    Translation:Humans
    38. Kim JW, Kane JR, Panek WK, Young JS, Rashidi A, Yu D, Kanojia D, Hasan T, Miska J, Ulasov IV, Balyasnikova IV, Ahmed AU, Wainwright DA, Lesniak MS, Gómez-Lim MA. A Dendritic Cell-Targeted Adenoviral Vector Facilitates Adaptive Immune Response Against Human Glioma Antigen (CMV-IE) and Prolongs Survival in a Human Glioma Tumor Model. Neurotherapeutics. 2018 10; 15(4):1127-1138. PMID: 30027430; PMCID: PMC6277295.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    39. Rosenberg AJ, Wainwright DA, Rademaker A, Galvez C, Genet M, Zhai L, Lauing KL, Mulcahy MF, Hayes JP, Odell DD, Horbinski C, Komanduri S, Tetreault MP, Kim KA, Villaflor VM. Indoleamine 2,3-dioxygenase 1 and overall survival of patients diagnosed with esophageal cancer. Oncotarget. 2018 May 04; 9(34):23482-23493. PMID: 29805749; PMCID: PMC5955099.
      Citations: 15     Fields:    
    40. Binder DC, Ladomersky E, Lenzen A, Zhai L, Lauing KL, Otto-Meyer SD, Lukas RV, Wainwright DA. Lessons learned from rindopepimut treatment in patients with EGFRvIII-expressing glioblastoma. Transl Cancer Res. 2018 Apr; 7(Suppl 4):S510-S513. PMID: 30283731; PMCID: PMC6166880.
      Citations: 13     
    41. Ladomersky E, Zhai L, Lenzen A, Lauing KL, Qian J, Scholtens DM, Gritsina G, Sun X, Liu Y, Yu F, Gong W, Liu Y, Jiang B, Tang T, Patel R, Platanias LC, James CD, Stupp R, Lukas RV, Binder DC, Wainwright DA. IDO1 Inhibition Synergizes with Radiation and PD-1 Blockade to Durably Increase Survival Against Advanced Glioblastoma. Clin Cancer Res. 2018 06 01; 24(11):2559-2573. PMID: 29500275; PMCID: PMC5984675.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    42. Zhai L, Ladomersky E, Lenzen A, Nguyen B, Patel R, Lauing KL, Wu M, Wainwright DA. IDO1 in cancer: a Gemini of immune checkpoints. Cell Mol Immunol. 2018 May; 15(5):447-457. PMID: 29375124; PMCID: PMC6068130.
      Citations: 170     Fields:    Translation:HumansAnimals
    43. Zloza A, Karolina Palucka A, Coussens LM, Gotwals PJ, Headley MB, Jaffee EM, Lund AW, Sharpe AH, Sznol M, Wainwright DA, Wong KK, Bosenberg MW. Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer. J Immunother Cancer. 2017 09 19; 5(1):77. PMID: 28923102; PMCID: PMC5604351.
      Citations: 6     Fields:    Translation:HumansAnimals
    44. Young JS, Chmura SJ, Wainwright DA, Yamini B, Peters KB, Lukas RV. Management of glioblastoma in elderly patients. J Neurol Sci. 2017 Sep 15; 380:250-255. PMID: 28870580; PMCID: PMC7328157.
      Citations: 26     Fields:    Translation:Humans
    45. Chae YK, Arya A, Chiec L, Shah H, Rosenberg A, Patel S, Raparia K, Choi J, Wainwright DA, Villaflor V, Cristofanilli M, Giles F. Challenges and future of biomarker tests in the era of precision oncology: Can we rely on immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH) to select the optimal patients for matched therapy? Oncotarget. 2017 Nov 21; 8(59):100863-100898. PMID: 29246028; PMCID: PMC5725070.
      Citations: 7     Fields:    
    46. Zhai L, Ladomersky E, Lauing KL, Wu M, Genet M, Gritsina G, Brastianos PK, Binder DC, Sosman JA, Giles FJ, James CD, Horbinski C, Stupp R, Wainwright DA, Gyorffy B. Infiltrating T Cells Increase IDO1 Expression in Glioblastoma and Contribute to Decreased Patient Survival. Clin Cancer Res. 2017 Nov 01; 23(21):6650-6660. PMID: 28751450; PMCID: PMC5850948.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    47. Binder DC, Wainwright DA. The Boosting Potential of Bacteria in Cancer Immunotherapy. Trends Mol Med. 2017 07; 23(7):580-582. PMID: 28583420; PMCID: PMC5515260.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    48. Wainwright DA, Horbinski CM, Hashizume R, James CD. Therapeutic Hypothesis Testing With Rodent Brain Tumor Models. Neurotherapeutics. 2017 04; 14(2):385-392. PMID: 28321824; PMCID: PMC5398994.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    49. Zhai L, Ladomersky E, Dostal CR, Lauing KL, Swoap K, Billingham LK, Gritsina G, Wu M, McCusker RH, Binder DC, Wainwright DA. Non-tumor cell IDO1 predominantly contributes to enzyme activity and response to CTLA-4/PD-L1 inhibition in mouse glioblastoma. Brain Behav Immun. 2017 May; 62:24-29. PMID: 28179106; PMCID: PMC5514839.
      Citations: 36     Fields:    Translation:Animals
    50. Costa R, Carneiro BA, Wainwright DA, Santa-Maria CA, Kumthekar P, Chae YK, Gradishar WJ, Cristofanilli M, Giles FJ. Developmental therapeutics for patients with breast cancer and central nervous system metastasis: current landscape and future perspectives. Ann Oncol. 2017 01 01; 28(1):44-56. PMID: 28177431; PMCID: PMC7360139.
      Citations: 23     Fields:    Translation:HumansAnimals
    51. Lenzen A, Zhai L, Lauing KL, Gritsina G, Ladomersky E, Genet M, James CD, Bloch O, Wainwright DA. The Kynurenine/Tryptophan Ratio and Glioblastoma Patients Treated with Hsppc-96 Vaccine. Immunotherapy (Los Angel). 2016 Sep; 2(3). PMID: 27819068; PMCID: PMC5095693.
      Citations: 5     
    52. Chang AL, Miska J, Wainwright DA, Dey M, Rivetta CV, Yu D, Kanojia D, Pituch KC, Qiao J, Pytel P, Han Y, Wu M, Zhang L, Horbinski CM, Ahmed AU, Lesniak MS. CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells. Cancer Res. 2016 10 01; 76(19):5671-5682. PMID: 27530322; PMCID: PMC5050119.
      Citations: 302     Fields:    Translation:HumansAnimalsCells
    53. Ladomersky E, Zhai L, Gritsina G, Genet M, Lauing KL, Wu M, James CD, Wainwright DA. Advanced age negatively impacts survival in an experimental brain tumor model. Neurosci Lett. 2016 Sep 06; 630:203-208. PMID: 27493076; PMCID: PMC5006183.
      Citations: 17     Fields:    Translation:AnimalsCells
    54. Ladomersky E, Genet M, Zhai L, Gritsina G, Lauing KL, Lulla RR, Fangusaro J, Lenzen A, Kumthekar P, Raizer JJ, Binder DC, James CD, Wainwright DA. Improving vaccine efficacy against malignant glioma. Oncoimmunology. 2016 Aug; 5(8):e1196311. PMID: 27622066; PMCID: PMC5007967.
      Citations: 11     Fields:    
    55. Klarquist J, Eby JM, Henning SW, Li M, Wainwright DA, Westerhof W, Luiten RM, Nishimura MI, Le Poole IC. Functional cloning of a gp100-reactive T-cell receptor from vitiligo patient skin. Pigment Cell Melanoma Res. 2016 May; 29(3):379-84. PMID: 26824221; PMCID: PMC6095469.
      Citations: 7     Fields:    Translation:HumansCells
    56. Binder DC, Arina A, Wen F, Tu T, Zhao M, Hoffman RM, Wainwright DA, Schreiber H. Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium. Oncoimmunology. 2016 Jun; 5(6):e1130207. PMID: 27471609; PMCID: PMC4938310.
      Citations: 10     Fields:    
    57. Lukas RV, Wainwright DA, Laterra JJ. Updates from the Neuro-Oncology Section of the 2015 American Neurological Association Annual Meeting. Future Oncol. 2016 Jan; 12(2):143-7. PMID: 26616737; PMCID: PMC4743646.
      Citations: 1     Fields:    Translation:HumansAnimals
    58. Zhai L, Spranger S, Binder DC, Gritsina G, Lauing KL, Giles FJ, Wainwright DA. Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy. Clin Cancer Res. 2015 Dec 15; 21(24):5427-33. PMID: 26519060; PMCID: PMC4681601.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    59. Binder DC, Davis AA, Wainwright DA. Immunotherapy for cancer in the central nervous system: Current and future directions. Oncoimmunology. 2016 Feb; 5(2):e1082027. PMID: 27057463; PMCID: PMC4801467.
      Citations: 48     Fields:    
    60. Zhai L, Dey M, Lauing KL, Gritsina G, Kaur R, Lukas RV, Nicholas MK, Rademaker AW, Dostal CR, McCusker RH, Raizer JJ, Parsa AT, Bloch O, Wainwright DA. The kynurenine to tryptophan ratio as a prognostic tool for glioblastoma patients enrolling in immunotherapy. J Clin Neurosci. 2015 Dec; 22(12):1964-8. PMID: 26279502; PMCID: PMC4548799.
      Citations: 39     Fields:    Translation:Humans
    61. Dey M, Chang AL, Miska J, Wainwright DA, Ahmed AU, Balyasnikova IV, Pytel P, Han Y, Tobias A, Zhang L, Qiao J, Lesniak MS. Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma. J Immunol. 2015 Jul 01; 195(1):367-76. PMID: 26026061; PMCID: PMC4475664.
      Citations: 30     Fields:    Translation:AnimalsCellsPHPublic Health
    62. Zhai L, Lauing KL, Chang AL, Dey M, Qian J, Cheng Y, Lesniak MS, Wainwright DA. The role of IDO in brain tumor immunotherapy. J Neurooncol. 2015 Jul; 123(3):395-403. PMID: 25519303; PMCID: PMC4641522.
      Citations: 48     Fields:    Translation:HumansAnimals
    63. Cheng Y, Dai Q, Morshed RA, Fan X, Wegscheid ML, Wainwright DA, Han Y, Zhang L, Auffinger B, Tobias AL, Thaci B, Ahmed AU, Warnke PC, He C, Lesniak MS, Rincón E. Blood-brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging. Small. 2014 Dec 29; 10(24):5137-50. PMID: 25104165; PMCID: PMC4268041.
      Citations: 66     Fields:    Translation:Animals
    64. Wainwright DA, Lesniak MS. Ménage à trois: Sustained therapeutic anti-tumor immunity requires multiple partners in malignant glioma. Oncoimmunology. 2014; 3:e28927. PMID: 25057450; PMCID: PMC4091585.
      Citations: 4     Fields:    
    65. Wainwright DA, Chang AL, Dey M, Balyasnikova IV, Kim CK, Tobias A, Cheng Y, Kim JW, Qiao J, Zhang L, Han Y, Lesniak MS. Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors. Clin Cancer Res. 2014 Oct 15; 20(20):5290-301. PMID: 24691018; PMCID: PMC4182350.
      Citations: 308     Fields:    Translation:AnimalsCells
    66. Thaci B, Ahmed AU, Ulasov IV, Wainwright DA, Nigam P, Auffinger B, Tobias AL, Han Y, Zhang L, Moon KS, Lesniak MS. Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma. Cancer Gene Ther. 2014 Jan; 21(1):38-44. PMID: 24434573; PMCID: PMC4035218.
      Citations: 25     Fields:    Translation:AnimalsCells
    67. Dey M, Chang AL, Wainwright DA, Ahmed AU, Han Y, Balyasnikova IV, Lesniak MS. Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model. J Neuroimmunol. 2014 Jan 15; 266(1-2):33-42. PMID: 24268287; PMCID: PMC3932190.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    68. Chung EJ, Cheng Y, Morshed R, Nord K, Han Y, Wegscheid ML, Auffinger B, Wainwright DA, Lesniak MS, Tirrell MV. Fibrin-binding, peptide amphiphile micelles for targeting glioblastoma. Biomaterials. 2014 Jan; 35(4):1249-56. PMID: 24211079; PMCID: PMC3880134.
      Citations: 54     Fields:    Translation:Animals
    69. Cheng Y, Morshed R, Cheng SH, Tobias A, Auffinger B, Wainwright DA, Zhang L, Yunis C, Han Y, Chen CT, Lo LW, Aboody KS, Ahmed AU, Lesniak MS. Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy. Small. 2013 Dec 20; 9(24):4123-9. PMID: 23873826; PMCID: PMC3879136.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    70. Wainwright DA, Dey M, Chang A, Lesniak MS. Targeting Tregs in Malignant Brain Cancer: Overcoming IDO. Front Immunol. 2013; 4:116. PMID: 23720663; PMCID: PMC3654236.
      Citations: 68     Fields:    
    71. Wainwright DA, Balyasnikova IV, Chang AL, Ahmed AU, Moon KS, Auffinger B, Tobias AL, Han Y, Lesniak MS. IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival. Clin Cancer Res. 2012 Nov 15; 18(22):6110-21. PMID: 22932670; PMCID: PMC3500434.
      Citations: 238     Fields:    Translation:HumansAnimalsCells
    72. Balyasnikova IV, Wainwright DA, Solomaha E, Lee G, Han Y, Thaci B, Lesniak MS. Characterization and immunotherapeutic implications for a novel antibody targeting interleukin (IL)-13 receptor a2. J Biol Chem. 2012 Aug 31; 287(36):30215-27. PMID: 22778273; PMCID: PMC3436275.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    73. Wainwright DA, Nigam P, Thaci B, Dey M, Lesniak MS. Recent developments on immunotherapy for brain cancer. Expert Opin Emerg Drugs. 2012 Jun; 17(2):181-202. PMID: 22533851; PMCID: PMC3361622.
      Citations: 39     Fields:    Translation:HumansAnimals
    74. Xin J, Mesnard NA, Beahrs T, Wainwright DA, Serpe CJ, Alexander TD, Sanders VM, Jones KJ. CD4+ T cell-mediated neuroprotection is independent of T cell-derived BDNF in a mouse facial nerve axotomy model. Brain Behav Immun. 2012 Aug; 26(6):886-90. PMID: 22426430; PMCID: PMC3384748.
      Citations: 8     Fields:    Translation:AnimalsCells
    75. Wainwright DA, Sengupta S, Han Y, Lesniak MS. Thymus-derived rather than tumor-induced regulatory T cells predominate in brain tumors. Neuro Oncol. 2011 Dec; 13(12):1308-23. PMID: 21908444; PMCID: PMC3223094.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    76. Wainwright DA, Balyasnikova IV, Han Y, Lesniak MS. The expression of BST2 in human and experimental mouse brain tumors. Exp Mol Pathol. 2011 Aug; 91(1):440-6. PMID: 21565182; PMCID: PMC3139740.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    77. Thaci B, Ulasov IV, Wainwright DA, Lesniak MS. The challenge for gene therapy: innate immune response to adenoviruses. Oncotarget. 2011 Mar; 2(3):113-21. PMID: 21399236; PMCID: PMC3092742.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    78. Wainwright DA, Sengupta S, Han Y, Ulasov IV, Lesniak MS. The presence of IL-17A and T helper 17 cells in experimental mouse brain tumors and human glioma. PLoS One. 2010 Oct 23; 5(10):e15390. PMID: 21060663; PMCID: PMC2963644.
      Citations: 33     Fields:    Translation:AnimalsCells
    79. Sengupta S, Nandi S, Hindi ES, Wainwright DA, Han Y, Lesniak MS. Short hairpin RNA-mediated fibronectin knockdown delays tumor growth in a mouse glioma model. Neoplasia. 2010 Oct; 12(10):837-47. PMID: 20927322; PMCID: PMC2950333.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    80. Xin J, Wainwright DA, Mesnard NA, Serpe CJ, Sanders VM, Jones KJ. IL-10 within the CNS is necessary for CD4+ T cells to mediate neuroprotection. Brain Behav Immun. 2011 Jul; 25(5):820-9. PMID: 20723599; PMCID: PMC3021103.
      Citations: 33     Fields:    Translation:AnimalsCells
    81. Ahmed AU, Rolle CE, Tyler MA, Han Y, Sengupta S, Wainwright DA, Balyasnikova IV, Ulasov IV, Lesniak MS. Bone marrow mesenchymal stem cells loaded with an oncolytic adenovirus suppress the anti-adenoviral immune response in the cotton rat model. Mol Ther. 2010 Oct; 18(10):1846-56. PMID: 20588259; PMCID: PMC2951553.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    82. Klarquist J, Denman CJ, Hernandez C, Wainwright DA, Wainwright DJ, Strickland FM, Overbeck A, Mehrotra S, Nishimura MI, Le Poole IC. Reduced skin homing by functional Treg in vitiligo. Pigment Cell Melanoma Res. 2010 Apr; 23(2):276-86. PMID: 20175879; PMCID: PMC3778930.
      Citations: 58     Fields:    Translation:HumansCells
    83. Wainwright DA, Xin J, Mesnard NA, Sanders VM, Jones KJ. Toll-like receptor 2 and facial motoneuron survival after facial nerve axotomy. Neurosci Lett. 2010 Feb 26; 471(1):10-4. PMID: 20056129; PMCID: PMC2825370.
      Citations: 4     Fields:    Translation:AnimalsCells
    84. Wainwright DA, Xin J, Mesnard NA, Beahrs TR, Politis CM, Sanders VM, Jones KJ. Exacerbation of facial motoneuron loss after facial nerve axotomy in CCR3-deficient mice. ASN Neuro. 2009 Dec 11; 1(5):e00024. PMID: 19922414; PMCID: PMC2826103.
      Citations: 17     Fields:    
    85. Wainwright DA, Xin J, Mesnard NA, Politis CM, Sanders VM, Jones KJ. Effects of facial nerve axotomy on Th2- and Th1-associated chemokine expression in the facial motor nucleus of wild-type and presymptomatic mSOD1 mice. J Neuroimmunol. 2009 Nov 30; 216(1-2):66-75. PMID: 19818514; PMCID: PMC2783706.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    86. Wainwright DA, Mesnard NA, Xin J, Sanders VM, Jones KJ. Effects of facial nerve axotomy on Th2-associated and Th1-associated chemokine mRNA expression in the facial motor nucleus of wild-type and presymptomatic SOD1 mice. J Neurodegener Regen. 2009 Sep 01; 2(1):39-44. PMID: 20436785; PMCID: PMC2861580.
      Citations: 6     
    87. Wainwright DA, Xin J, Sanders VM, Jones KJ. Differential actions of pituitary adenylyl cyclase-activating polypeptide and interferon gamma on Th2- and Th1-associated chemokine expression in cultured murine microglia. J Neurodegener Regen. 2008 Oct 01; 1(1):31-34. PMID: 20448827; PMCID: PMC2864491.
      Citations: 7     
    88. Xin J, Wainwright DA, Serpe CJ, Sanders VM, Jones KJ. Phenotype of CD4+ T cell subsets that develop following mouse facial nerve axotomy. Brain Behav Immun. 2008 May; 22(4):528-37. PMID: 18024079; PMCID: PMC2396948.
      Citations: 21     Fields:    Translation:AnimalsCells
    89. Calnan M, Wainwright D, O'Neill C, Winterbottom A, Watkins C. Making sense of aches and pains. Fam Pract. 2006 Feb; 23(1):91-105. PMID: 16107493.
      Citations: 6     Fields:    Translation:Humans
    90. Wainwright D, Shandala T, Saint R, Taubert H, Häder T, Brönner G, Jäckle H. Receptor tyrosine kinase signaling regulates different modes of Groucho-dependent control of Dorsal. Curr Biol. 2000 Jan 13; 10(1):51-4. PMID: 10660305.
      Citations: 14     Fields:    Translation:AnimalsCells
    91. Wainwright D, Madden M, Luterman A, Hunt J, Monafo W, Heimbach D, Kagan R, Sittig K, Dimick A, Herndon D. Clinical evaluation of an acellular allograft dermal matrix in full-thickness burns. J Burn Care Rehabil. 1996 Mar-Apr; 17(2):124-36. PMID: 8675502.
      Citations: 65     Fields:    Translation:HumansCellsCTClinical Trials
    92. Thomas R, Robinson J, Waring T, Wainwright D, Maguire S. Information management and technology in England's large acute NHS hospitals. National strategy versus local reality. J Manag Med. 1995; 9(1):40-9. PMID: 10142778.
      Citations:    Fields:    
    93. Newton J, Fraser M, Robinson J, Wainwright D. Fundholding in northern region: the first year. BMJ. 1993 Feb 06; 306(6874):375-8. PMID: 8461685; PMCID: PMC1676438.
      Citations: 8     Fields:    Translation:Humans
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