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Simon Hayward

TitleJean Ruggles Romoser Chair of Cancer Research
InstitutionUniversity of Chicago
DepartmentCancer Biology
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Singh P, Lanman NA, Kendall HLR, Wilson L, Long R, Franco OE, Buskin A, Miles CG, Hayward SW, Heer R, Robson CN. Human prostate organoid generation and the identification of prostate development drivers using inductive rodent tissues. Development. 2023 07 01; 150(13). PMID: 37376888; PMCID: PMC10357030.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Glaser A, Shi Z, Wei J, Lanman NA, Ladson-Gary S, Vickman RE, Franco OE, Crawford SE, Lilly Zheng S, Hayward SW, Isaacs WB, Helfand BT, Xu J. Shared Inherited Genetics of Benign Prostatic Hyperplasia and Prostate Cancer. Eur Urol Open Sci. 2022 Sep; 43:54-61. PMID: 36353071; PMCID: PMC9638770.
      Citations: 4     
    3. Vickman RE, Franco OE, Hayward SW. Could TNF-antagonists be a novel treatment strategy for BPH patients? Cell Stress. 2022 Jun; 6(6):65-67. PMID: 36072128; PMCID: PMC9189611.
      Citations: 2     
    4. Kakarla M, ChallaSivaKanaka S, Dufficy MF, Gil V, Filipovich Y, Vickman R, Crawford SE, Hayward SW, Franco OE. Ephrin B Activate Src Family Kinases in Fibroblasts Inducing Stromal Remodeling in Prostate Cancer. Cancers (Basel). 2022 May 09; 14(9). PMID: 35565468; PMCID: PMC9102363.
      Citations: 4     
    5. Vickman RE, Aaron-Brooks L, Zhang R, Lanman NA, Lapin B, Gil V, Greenberg M, Sasaki T, Cresswell GM, Broman MM, Paez JS, Petkewicz J, Talaty P, Helfand BT, Glaser AP, Wang CH, Franco OE, Ratliff TL, Nastiuk KL, Crawford SE, Hayward SW. TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease. Nat Commun. 2022 04 19; 13(1):2133. PMID: 35440548; PMCID: PMC9018703.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    6. ChallaSivaKanaka S, Vickman RE, Kakarla M, Hayward SW, Franco OE. Fibroblast heterogeneity in prostate carcinogenesis. Cancer Lett. 2022 01 28; 525:76-83. PMID: 34715252; PMCID: PMC8788937.
      Citations: 4     Fields:    Translation:HumansCells
    7. Kakarla M, ChallaSivaKanaka S, Hayward SW, Franco OE. Race as a Contributor to Stromal Modulation of Tumor Progression. Cancers (Basel). 2021 May 28; 13(11). PMID: 34071280; PMCID: PMC8197868.
      Citations: 6     
    8. Fantus RJ, Na R, Wei J, Shi Z, Resurreccion WK, Halpern JA, Franco O, Hayward SW, Isaacs WB, Zheng SL, Xu J, Helfand BT. Genetic Susceptibility for Low Testosterone in Men and Its Implications in Biology and Screening: Data from the UK Biobank. Eur Urol Open Sci. 2021 Jul; 29:36-46. PMID: 34337532; PMCID: PMC8317803.
      Citations: 2     
    9. Morales A, Greenberg M, Nardi F, Gil V, Hayward SW, Crawford SE, Franco OE. Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells. Lab Invest. 2021 07; 101(7):921-934. PMID: 33824421; PMCID: PMC8217088.
      Citations: 13     Fields:    Translation:HumansCells
    10. Vickman RE, Faget DV, Beachy P, Beebe D, Bhowmick NA, Cukierman E, Deng WM, Granneman JG, Hildesheim J, Kalluri R, Lau KS, Lengyel E, Lundeberg J, Moscat J, Nelson PS, Pietras K, Politi K, Scherz-Shouval R, Sherman MH, Tuveson D, Weeraratna AT, White RM, Wong MH, Woodhouse EC, Zheng Y, Hayward SW, Stewart SA, Puré E. Deconstructing tumor heterogeneity: the stromal perspective. Oncotarget. 2020 Oct 06; 11(40):3621-3632. PMID: 33088423; PMCID: PMC7546755.
      Citations: 14     Fields:    
    11. Frankenstein Z, Basanta D, Franco OE, Gao Y, Javier RA, Strand DW, Lee M, Hayward SW, Ayala G, Anderson ARA. Stromal reactivity differentially drives tumour cell evolution and prostate cancer progression. Nat Ecol Evol. 2020 06; 4(6):870-884. PMID: 32393869.
      Citations: 16     Fields:    Translation:HumansCells
    12. Hayward SW. Immunotherapeutic Response in Tumors Is Affected by Microenvironmental ROS. Cancer Res. 2020 05 01; 80(9):1799-1800. PMID: 32366527.
      Citations: 5     Fields:    Translation:HumansCells
    13. Hepburn AC, Curry EL, Moad M, Steele RE, Franco OE, Wilson L, Singh P, Buskin A, Crawford SE, Gaughan L, Mills IG, Hayward SW, Robson CN, Heer R. Propagation of human prostate tissue from induced pluripotent stem cells. Stem Cells Transl Med. 2020 07; 9(7):734-745. PMID: 32170918; PMCID: PMC7308643.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    14. Vickman RE, Broman MM, Lanman NA, Franco OE, Sudyanti PAG, Ni Y, Ji Y, Helfand BT, Petkewicz J, Paterakos MC, Crawford SE, Ratliff TL, Hayward SW. Heterogeneity of human prostate carcinoma-associated fibroblasts implicates a role for subpopulations in myeloid cell recruitment. Prostate. 2020 02; 80(2):173-185. PMID: 31763714.
      Citations: 34     Fields:    Translation:HumansCells
    15. Vickman RE, Franco OE, Moline DC, Vander Griend DJ, Thumbikat P, Hayward SW. The role of the androgen receptor in prostate development and benign prostatic hyperplasia: A review. Asian J Urol. 2020 Jul; 7(3):191-202. PMID: 32742923; PMCID: PMC7385520.
      Citations: 41     
    16. Nardi F, Fitchev P, Brooks KM, Franco OE, Cheng K, Hayward SW, Welte MA, Crawford SE. Lipid droplet velocity is a microenvironmental sensor of aggressive tumors regulated by V-ATPase and PEDF. Lab Invest. 2019 12; 99(12):1822-1834. PMID: 31409893; PMCID: PMC7289525.
      Citations: 10     Fields:    Translation:HumansCells
    17. Aaron-Brooks LM, Sasaki T, Vickman RE, Wei L, Franco OE, Ji Y, Crawford SE, Hayward SW. Hyperglycemia and T Cell infiltration are associated with stromal and epithelial prostatic hyperplasia in the nonobese diabetic mouse. Prostate. 2019 06; 79(9):980-993. PMID: 30999385; PMCID: PMC6591734.
      Citations: 9     Fields:    Translation:AnimalsCells
    18. Nardi F, Franco OE, Fitchev P, Morales A, Vickman RE, Hayward SW, Crawford SE. DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130. Sci Rep. 2019 02 28; 9(1):3035. PMID: 30816200; PMCID: PMC6395665.
      Citations: 19     Fields:    Translation:HumansCells
    19. Sasaki T, Franco OE, Ohishi K, Filipovich Y, Ishii K, Crawford SE, Takahashi N, Katayama N, Sugimura Y, Hayward SW. Tyrosine kinase inhibitor therapy prescribed for non-urologic diseases can modify PSA titers in urology patients. Prostate. 2019 02; 79(3):259-264. PMID: 30370673.
      Citations:    Fields:    Translation:HumansCells
    20. Nardi F, Fitchev P, Franco OE, Ivanisevic J, Scheibler A, Hayward SW, Brendler CB, Welte MA, Crawford SE. PEDF regulates plasticity of a novel lipid-MTOC axis in prostate cancer-associated fibroblasts. J Cell Sci. 2018 07 11; 131(13). PMID: 29792311; PMCID: PMC6051346.
      Citations: 13     Fields:    Translation:HumansCells
    21. Erdogan B, Ao M, White LM, Means AL, Brewer BM, Yang L, Washington MK, Shi C, Franco OE, Weaver AM, Hayward SW, Li D, Webb DJ. Cancer-associated fibroblasts promote directional cancer cell migration by aligning fibronectin. J Cell Biol. 2017 11 06; 216(11):3799-3816. PMID: 29021221; PMCID: PMC5674895.
      Citations: 229     Fields:    Translation:HumansCells
    22. Sasaki T, Franco OE, Hayward SW. Interaction of prostate carcinoma-associated fibroblasts with human epithelial cell lines in vivo. Differentiation. 2017 Jul - Aug; 96:40-48. PMID: 28779656; PMCID: PMC5669818.
      Citations: 11     Fields:    Translation:HumansCells
    23. Na R, Helfand BT, Chen H, Conran CA, Crawford SE, Hayward SW, Tammela TLJ, Hoffman-Bolton J, Zheng SL, Walsh PC, Schleutker J, Platz EA, Isaacs WB, Xu J. A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). Prostate. 2017 Aug; 77(11):1213-1220. PMID: 28656603; PMCID: PMC5565164.
      Citations: 9     Fields:    Translation:Humans
    24. Sameni M, Cavallo-Medved D, Franco OE, Chalasani A, Ji K, Aggarwal N, Anbalagan A, Chen X, Mattingly RR, Hayward SW, Sloane BF. Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ. Breast Cancer Res. 2017 05 15; 19(1):56. PMID: 28506312; PMCID: PMC5433063.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    25. Nash C, Boufaied N, Mills IG, Franco OE, Hayward SW, Thomson AA. Genome-wide analysis of AR binding and comparison with transcript expression in primary human fetal prostate fibroblasts and cancer associated fibroblasts. Mol Cell Endocrinol. 2018 08 15; 471:1-14. PMID: 28483704.
      Citations: 17     Fields:    Translation:HumansCells
    26. Yang S, Jiang M, Grabowska MM, Li J, Connelly ZM, Zhang J, Hayward SW, Cates JM, Han G, Yu X. Androgen receptor differentially regulates the proliferation of prostatic epithelial cells in vitro and in vivo. Oncotarget. 2016 10 25; 7(43):70404-70419. PMID: 27611945; PMCID: PMC5342561.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    27. Henke A, Franco OE, Stewart GD, Riddick AC, Katz E, Hayward SW, Thomson AA. Reduced Contractility and Motility of Prostatic Cancer-Associated Fibroblasts after Inhibition of Heat Shock Protein 90. Cancers (Basel). 2016 Aug 24; 8(9). PMID: 27563925; PMCID: PMC5040979.
      Citations: 11     
    28. Aaron L, Franco OE, Hayward SW. Review of Prostate Anatomy and Embryology and the Etiology of Benign Prostatic Hyperplasia. Urol Clin North Am. 2016 Aug; 43(3):279-88. PMID: 27476121; PMCID: PMC4968575.
      Citations: 54     Fields:    Translation:HumansAnimals
    29. Franco OE, Tyson DR, Konvinse KC, Udyavar AR, Estrada L, Quaranta V, Crawford SE, Hayward SW. Altered TGF-a/ß signaling drives cooperation between breast cancer cell populations. FASEB J. 2016 10; 30(10):3441-3452. PMID: 27383183; PMCID: PMC5024699.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    30. Austin DC, Strand DW, Love HL, Franco OE, Grabowska MM, Miller NL, Hameed O, Clark PE, Matusik RJ, Jin RJ, Hayward SW. NF-?B and androgen receptor variant 7 induce expression of SRD5A isoforms and confer 5ARI resistance. Prostate. 2016 08; 76(11):1004-18. PMID: 27197599; PMCID: PMC4912960.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    31. Bianchi-Frias D, Basom R, Delrow JJ, Coleman IM, Dakhova O, Qu X, Fang M, Franco OE, Ericson NG, Bielas JH, Hayward SW, True L, Morrissey C, Brown L, Bhowmick NA, Rowley D, Ittmann M, Nelson PS. Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations. Mol Cancer Res. 2016 Apr; 14(4):374-84. PMID: 26753621; PMCID: PMC5582956.
      Citations: 27     Fields:    Translation:HumansCells
    32. Austin DC, Strand DW, Love HL, Franco OE, Jang A, Grabowska MM, Miller NL, Hameed O, Clark PE, Fowke JH, Matusik RJ, Jin RJ, Hayward SW. NF-?B and androgen receptor variant expression correlate with human BPH progression. Prostate. 2016 Apr; 76(5):491-511. PMID: 26709083; PMCID: PMC4763342.
      Citations: 26     Fields:    Translation:HumansCells
    33. Grabowska MM, Kelly SM, Reese AL, Cates JM, Case TC, Zhang J, DeGraff DJ, Strand DW, Miller NL, Clark PE, Hayward SW, Gronostajski RM, Anderson PD, Matusik RJ. Nfib Regulates Transcriptional Networks That Control the Development of Prostatic Hyperplasia. Endocrinology. 2016 Mar; 157(3):1094-109. PMID: 26677878; PMCID: PMC4769366.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    34. Strand DW, Aaron L, Henry G, Franco OE, Hayward SW. Isolation and analysis of discreet human prostate cellular populations. Differentiation. 2016 Apr-Jun; 91(4-5):139-51. PMID: 26546040; PMCID: PMC4854811.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    35. Osuala KO, Sameni M, Shah S, Aggarwal N, Simonait ML, Franco OE, Hong Y, Hayward SW, Behbod F, Mattingly RR, Sloane BF. Il-6 signaling between ductal carcinoma in situ cells and carcinoma-associated fibroblasts mediates tumor cell growth and migration. BMC Cancer. 2015 Aug 13; 15:584. PMID: 26268945; PMCID: PMC4535667.
      Citations: 39     Fields:    Translation:HumansCells
    36. Huynh TP, Barwe SP, Lee SJ, McSpadden R, Franco OE, Hayward SW, Damoiseaux R, Grubbs SS, Petrelli NJ, Rajasekaran AK. Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression. PLoS One. 2015; 10(4):e0122442. PMID: 25836370; PMCID: PMC4383530.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    37. Nolan KD, Franco OE, Hance MW, Hayward SW, Isaacs JS. Tumor-secreted Hsp90 subverts polycomb function to drive prostate tumor growth and invasion. J Biol Chem. 2015 Mar 27; 290(13):8271-82. PMID: 25670862; PMCID: PMC4375482.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    38. Singh M, Jha R, Melamed J, Shapiro E, Hayward SW, Lee P. Stromal androgen receptor in prostate development and cancer. Am J Pathol. 2014 Oct; 184(10):2598-607. PMID: 25088980; PMCID: PMC4188859.
      Citations: 40     Fields:    Translation:HumansCells
    39. DeGraff DJ, Grabowska MM, Case TC, Yu X, Herrick MK, Hayward WJ, Strand DW, Cates JM, Hayward SW, Gao N, Walter MA, Buttyan R, Yi Y, Kaestner KH, Matusik RJ. FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype. Lab Invest. 2014 Jul; 94(7):726-39. PMID: 24840332; PMCID: PMC4451837.
      Citations: 26     Fields:    Translation:AnimalsCells
    40. Lin-Tsai O, Clark PE, Miller NL, Fowke JH, Hameed O, Hayward SW, Strand DW. Surgical intervention for symptomatic benign prostatic hyperplasia is correlated with expression of the AP-1 transcription factor network. Prostate. 2014 May; 74(6):669-79. PMID: 24500928; PMCID: PMC4160824.
      Citations: 25     Fields:    Translation:Humans
    41. Hansen AG, Arnold SA, Jiang M, Palmer TD, Ketova T, Merkel A, Pickup M, Samaras S, Shyr Y, Moses HL, Hayward SW, Sterling JA, Zijlstra A. ALCAM/CD166 is a TGF-ß-responsive marker and functional regulator of prostate cancer metastasis to bone. Cancer Res. 2014 Mar 01; 74(5):1404-15. PMID: 24385212; PMCID: PMC4149913.
      Citations: 41     Fields:    Translation:HumansCells
    42. Moad M, Pal D, Hepburn AC, Williamson SC, Wilson L, Lako M, Armstrong L, Hayward SW, Franco OE, Cates JM, Fordham SE, Przyborski S, Carr-Wilkinson J, Robson CN, Heer R. A novel model of urinary tract differentiation, tissue regeneration, and disease: reprogramming human prostate and bladder cells into induced pluripotent stem cells. Eur Urol. 2013 Nov; 64(5):753-61. PMID: 23582880; PMCID: PMC3819995.
      Citations: 40     Fields:    Translation:HumansCells
    43. Strand DW, DeGraff DJ, Jiang M, Sameni M, Franco OE, Love HD, Hayward WJ, Lin-Tsai O, Wang AY, Cates JM, Sloane BF, Matusik RJ, Hayward SW. Deficiency in metabolic regulators PPAR? and PTEN cooperates to drive keratinizing squamous metaplasia in novel models of human tissue regeneration. Am J Pathol. 2013 Feb; 182(2):449-59. PMID: 23219716; PMCID: PMC3562729.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    44. Orr B, Grace OC, Brown P, Riddick AC, Stewart GD, Franco OE, Hayward SW, Thomson AA. Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1. Dis Model Mech. 2013 Mar; 6(2):530-6. PMID: 23136397; PMCID: PMC3597035.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    45. Pruitt FL, He Y, Franco OE, Jiang M, Cates JM, Hayward SW. Cathepsin D acts as an essential mediator to promote malignancy of benign prostatic epithelium. Prostate. 2013 Apr; 73(5):476-88. PMID: 22996917; PMCID: PMC3594371.
      Citations: 15     Fields:    Translation:HumansCells
    46. Wang H, Jiang M, Cui H, Chen M, Buttyan R, Hayward SW, Hai T, Wang Z, Yan C. The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor. Mol Cell Biol. 2012 Aug; 32(16):3190-202. PMID: 22665497; PMCID: PMC3434546.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    47. Ricke EA, Williams K, Lee YF, Couto S, Wang Y, Hayward SW, Cunha GR, Ricke WA. Androgen hormone action in prostatic carcinogenesis: stromal androgen receptors mediate prostate cancer progression, malignant transformation and metastasis. Carcinogenesis. 2012 Jul; 33(7):1391-8. PMID: 22535887; PMCID: PMC3499049.
      Citations: 46     Fields:    Translation:Animals
    48. Anderson PD, McKissic SA, Logan M, Roh M, Franco OE, Wang J, Doubinskaia I, van der Meer R, Hayward SW, Eischen CM, Eltoum IE, Abdulkadir SA. Nkx3.1 and Myc crossregulate shared target genes in mouse and human prostate tumorigenesis. J Clin Invest. 2012 May; 122(5):1907-19. PMID: 22484818; PMCID: PMC3336973.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    49. Franco OE, Hayward SW. Targeting the tumor stroma as a novel therapeutic approach for prostate cancer. Adv Pharmacol. 2012; 65:267-313. PMID: 22959029.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    50. Jiang M, Strand DW, Franco OE, Clark PE, Hayward SW. PPAR?: a molecular link between systemic metabolic disease and benign prostate hyperplasia. Differentiation. 2011 Nov-Dec; 82(4-5):220-36. PMID: 21645960; PMCID: PMC3174339.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    51. Kiskowski MA, Jackson RS, Banerjee J, Li X, Kang M, Iturregui JM, Franco OE, Hayward SW, Bhowmick NA. Role for stromal heterogeneity in prostate tumorigenesis. Cancer Res. 2011 May 15; 71(10):3459-70. PMID: 21444670; PMCID: PMC3096737.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    52. Franco OE, Jiang M, Strand DW, Peacock J, Fernandez S, Jackson RS, Revelo MP, Bhowmick NA, Hayward SW. Altered TGF-ß signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis. Cancer Res. 2011 Feb 15; 71(4):1272-81. PMID: 21303979; PMCID: PMC3076790.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    53. Sun H, Wang Y, Chinnam M, Zhang X, Hayward SW, Foster BA, Nikitin AY, Wills M, Goodrich DW. E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):704-9. PMID: 21187395; PMCID: PMC3021049.
      Citations: 24     Fields:    Translation:HumansAnimals
    54. Orr B, Vanpoucke G, Grace OC, Smith L, Anderson RA, Riddick AC, Franco OE, Hayward SW, Thomson AA. Expression of pleiotrophin in the prostate is androgen regulated and it functions as an autocrine regulator of mesenchyme and cancer associated fibroblasts and as a paracrine regulator of epithelia. Prostate. 2011 Feb 15; 71(3):305-17. PMID: 20812209; PMCID: PMC3045659.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    55. Jiang M, Strand DW, Fernandez S, He Y, Yi Y, Birbach A, Qiu Q, Schmid J, Tang DG, Hayward SW. Functional remodeling of benign human prostatic tissues in vivo by spontaneously immortalized progenitor and intermediate cells. Stem Cells. 2010 Feb; 28(2):344-56. PMID: 20020426; PMCID: PMC2962907.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    56. Tanaka ST, Ishii K, Demarco RT, Pope JC, Brock JW, Hayward SW. Endodermal origin of bladder trigone inferred from mesenchymal-epithelial interaction. J Urol. 2010 Jan; 183(1):386-91. PMID: 19914648; PMCID: PMC2794964.
      Citations: 13     Fields:    Translation:Animals
    57. Love HD, Booton SE, Boone BE, Breyer JP, Koyama T, Revelo MP, Shappell SB, Smith JR, Hayward SW. Androgen regulated genes in human prostate xenografts in mice: relation to BPH and prostate cancer. PLoS One. 2009 Dec 21; 4(12):e8384. PMID: 20027305; PMCID: PMC2793011.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    58. Franco OE, Shaw AK, Strand DW, Hayward SW. Cancer associated fibroblasts in cancer pathogenesis. Semin Cell Dev Biol. 2010 Feb; 21(1):33-9. PMID: 19896548; PMCID: PMC2823834.
      Citations: 181     Fields:    Translation:HumansAnimalsCells
    59. Basanta D, Strand DW, Lukner RB, Franco OE, Cliffel DE, Ayala GE, Hayward SW, Anderson AR. The role of transforming growth factor-beta-mediated tumor-stroma interactions in prostate cancer progression: an integrative approach. Cancer Res. 2009 Sep 01; 69(17):7111-20. PMID: 19706777; PMCID: PMC2748342.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    60. Chu JH, Yu S, Hayward SW, Chan FL. Development of a three-dimensional culture model of prostatic epithelial cells and its use for the study of epithelial-mesenchymal transition and inhibition of PI3K pathway in prostate cancer. Prostate. 2009 Mar 01; 69(4):428-42. PMID: 19107869.
      Citations: 22     Fields:    Translation:HumansCells
    61. Li X, Wang Y, Sharif-Afshar AR, Uwamariya C, Yi A, Ishii K, Hayward SW, Matusik RJ, Bhowmick NA. Urothelial transdifferentiation to prostate epithelia is mediated by paracrine TGF-beta signaling. Differentiation. 2009 Jan; 77(1):95-102. PMID: 19281768; PMCID: PMC2733217.
      Citations: 28     Fields:    Translation:AnimalsCells
    62. Bhatia B, Jiang M, Suraneni M, Patrawala L, Badeaux M, Schneider-Broussard R, Multani AS, Jeter CR, Calhoun-Davis T, Hu L, Hu J, Tsavachidis S, Zhang W, Chang S, Hayward SW, Tang DG. Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells. J Biol Chem. 2008 Oct 10; 283(41):27957-27972. PMID: 18662989; PMCID: PMC2562067.
      Citations: 21     Fields:    Translation:HumansCells
    63. Roh M, Franco OE, Hayward SW, van der Meer R, Abdulkadir SA. A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells. PLoS One. 2008 Jul 02; 3(7):e2572. PMID: 18596907; PMCID: PMC2440349.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    64. Placencio VR, Sharif-Afshar AR, Li X, Huang H, Uwamariya C, Neilson EG, Shen MM, Matusik RJ, Hayward SW, Bhowmick NA. Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity. Cancer Res. 2008 Jun 15; 68(12):4709-18. PMID: 18559517; PMCID: PMC2811537.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    65. Jin RJ, Lho Y, Wang Y, Ao M, Revelo MP, Hayward SW, Wills ML, Logan SK, Zhang P, Matusik RJ. Down-regulation of p57Kip2 induces prostate cancer in the mouse. Cancer Res. 2008 May 15; 68(10):3601-8. PMID: 18483241.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    66. He Y, Franco OE, Jiang M, Williams K, Love HD, Coleman IM, Nelson PS, Hayward SW. Tissue-specific consequences of cyclin D1 overexpression in prostate cancer progression. Cancer Res. 2007 Sep 01; 67(17):8188-97. PMID: 17804732.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    67. Oottamasathien S, Williams K, Franco OE, Wills ML, Thomas JC, Sharif-Afshar AR, DeMarco RT, Brock JW, Bhowmick NA, Hayward SW, Pope JC. Urothelial inhibition of transforming growth factor-beta in a bladder tissue recombination model. J Urol. 2007 Oct; 178(4 Pt 2):1643-9. PMID: 17707033.
      Citations:    Fields:    Translation:AnimalsCells
    68. Ao M, Franco OE, Park D, Raman D, Williams K, Hayward SW. Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res. 2007 May 01; 67(9):4244-53. PMID: 17483336.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    69. Oottamasathien S, Wang Y, Williams K, Franco OE, Wills ML, Thomas JC, Saba K, Sharif-Afshar AR, Makari JH, Bhowmick NA, DeMarco RT, Hipkens S, Magnuson M, Brock JW, Hayward SW, Pope JC, Matusik RJ. Directed differentiation of embryonic stem cells into bladder tissue. Dev Biol. 2007 Apr 15; 304(2):556-66. PMID: 17289017; PMCID: PMC1994155.
      Citations: 33     Fields:    Translation:AnimalsCells
    70. Vanpoucke G, Orr B, Grace OC, Chan R, Ashley GR, Williams K, Franco OE, Hayward SW, Thomson AA. Transcriptional profiling of inductive mesenchyme to identify molecules involved in prostate development and disease. Genome Biol. 2007; 8(10):R213. PMID: 17922897; PMCID: PMC2246287.
      Citations: 18     Fields:    Translation:Animals
    71. Oottamasathien S, Williams K, Franco OE, Thomas JC, Saba K, Bhowmick NA, Staack A, Demarco RT, Brock JW, Hayward SW, Pope JC. Bladder tissue formation from cultured bladder urothelium. Dev Dyn. 2006 Oct; 235(10):2795-801. PMID: 16804891.
      Citations: 10     Fields:    Translation:AnimalsCells
    72. Ao M, Williams K, Bhowmick NA, Hayward SW. Transforming growth factor-beta promotes invasion in tumorigenic but not in nontumorigenic human prostatic epithelial cells. Cancer Res. 2006 Aug 15; 66(16):8007-16. PMID: 16912176; PMCID: PMC4067141.
      Citations: 58     Fields:    Translation:AnimalsCells
    73. Wang Y, Kasper S, Yuan J, Jin RJ, Zhang J, Ishii K, Wills ML, Hayward SW, Matusik RJ. Androgen-dependent prostate epithelial cell selection by targeting ARR(2)PBneo to the LPB-Tag model of prostate cancer. Lab Invest. 2006 Oct; 86(10):1074-88. PMID: 16894353.
      Citations: 8     Fields:    Translation:AnimalsCells
    74. Ricke WA, Ishii K, Ricke EA, Simko J, Wang Y, Hayward SW, Cunha GR. Steroid hormones stimulate human prostate cancer progression and metastasis. Int J Cancer. 2006 May 01; 118(9):2123-31. PMID: 16331600.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    75. Joesting MS, Perrin S, Elenbaas B, Fawell SE, Rubin JS, Franco OE, Hayward SW, Cunha GR, Marker PC. Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer. Cancer Res. 2005 Nov 15; 65(22):10423-30. PMID: 16288033.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    76. Wang Y, Xue H, Cutz JC, Bayani J, Mawji NR, Chen WG, Goetz LJ, Hayward SW, Sadar MD, Gilks CB, Gout PW, Squire JA, Cunha GR, Wang YZ. An orthotopic metastatic prostate cancer model in SCID mice via grafting of a transplantable human prostate tumor line. Lab Invest. 2005 Nov; 85(11):1392-404. PMID: 16155594.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    77. Ishii K, Shappell SB, Matusik RJ, Hayward SW. Use of tissue recombination to predict phenotypes of transgenic mouse models of prostate carcinoma. Lab Invest. 2005 Sep; 85(9):1086-103. PMID: 15980886.
      Citations: 10     Fields:    Translation:Animals
    78. Wang Y, Revelo MP, Sudilovsky D, Cao M, Chen WG, Goetz L, Xue H, Sadar M, Shappell SB, Cunha GR, Hayward SW. Development and characterization of efficient xenograft models for benign and malignant human prostate tissue. Prostate. 2005 Jul 01; 64(2):149-59. PMID: 15678503.
      Citations: 86     Fields:    Translation:HumansAnimals
    79. Gao N, Ishii K, Mirosevich J, Kuwajima S, Oppenheimer SR, Roberts RL, Jiang M, Yu X, Shappell SB, Caprioli RM, Stoffel M, Hayward SW, Matusik RJ. Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development. 2005 Aug; 132(15):3431-43. PMID: 15987773.
      Citations: 104     Fields:    Translation:AnimalsCells
    80. Williams K, Fernandez S, Stien X, Ishii K, Love HD, Lau YF, Roberts RL, Hayward SW. Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype. Prostate. 2005 Jun 01; 63(4):369-84. PMID: 15937962.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    81. Davis JN, McCabe MT, Hayward SW, Park JM, Day ML. Disruption of Rb/E2F pathway results in increased cyclooxygenase-2 expression and activity in prostate epithelial cells. Cancer Res. 2005 May 01; 65(9):3633-42. PMID: 15867358.
      Citations: 11     Fields:    Translation:AnimalsCells
    82. Jin RJ, Wang Y, Masumori N, Ishii K, Tsukamoto T, Shappell SB, Hayward SW, Kasper S, Matusik RJ. NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice. Cancer Res. 2004 Aug 01; 64(15):5489-95. PMID: 15289359.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    83. Ishii K, Otsuka T, Iguchi K, Usui S, Yamamoto H, Sugimura Y, Yoshikawa K, Hayward SW, Hirano K. Evidence that the prostate-specific antigen (PSA)/Zn2+ axis may play a role in human prostate cancer cell invasion. Cancer Lett. 2004 Apr 15; 207(1):79-87. PMID: 15050736.
      Citations: 20     Fields:    Translation:HumansCells
    84. Cunha GR, Hayward SW, Wang YZ, Ricke WA. Role of the stromal microenvironment in carcinogenesis of the prostate. Int J Cancer. 2003 Oct 20; 107(1):1-10. PMID: 12925950.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    85. Staack A, Kassis AP, Olshen A, Wang Y, Wu D, Carroll PR, Grossfeld GD, Cunha GR, Hayward SW. Quantitation of apoptotic activity following castration in human prostatic tissue in vivo. Prostate. 2003 Feb 15; 54(3):212-9. PMID: 12518326.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    86. Hayward SW, Wang Y, Day ML. Rescue and isolation of Rb-deficient prostate epithelium by tissue recombination. Methods Mol Biol. 2003; 218:17-33. PMID: 12616709.
      Citations: 2     Fields:    Translation:AnimalsCells
    87. Kim MJ, Bhatia-Gaur R, Banach-Petrosky WA, Desai N, Wang Y, Hayward SW, Cunha GR, Cardiff RD, Shen MM, Abate-Shen C. Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Res. 2002 Jun 01; 62(11):2999-3004. PMID: 12036903.
      Citations: 100     Fields:    Translation:Animals
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