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Brian Budke

TitlePostdoctoral Scholar
InstitutionUniversity of Chicago
DepartmentRadiation Oncology
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Budke B, Zhong A, Sullivan K, Park C, Gittin DI, Kountz TS, Connell PP. Noncanonical NF-?B factor p100/p52 regulates homologous recombination and modulates sensitivity to DNA-damaging therapy. Nucleic Acids Res. 2022 06 24; 50(11):6251-6263. PMID: 35689636; PMCID: PMC9226503.
      Citations: 4     Fields:    Translation:HumansCells
    2. Pointer KB, Budke B, Connell PP. Targeting Non-Canonical NF?B2 to Determine the Effects on Radiation Sensitization. Int J Radiat Oncol Biol Phys. 2021 Nov 01; 111(3S):e229-e230. PMID: 34700966.
    3. Budke B, Tueckmantel W, Miles K, Kozikowski AP, Connell PP. Optimization of Drug Candidates That Inhibit the D-Loop Activity of RAD51. ChemMedChem. 2019 05 17; 14(10):1031-1040. PMID: 30957434; PMCID: PMC6525040.
      Citations: 5     Fields:    Translation:HumansCells
    4. Chlenski A, Park C, Dobratic M, Salwen HR, Budke B, Park JH, Miller R, Applebaum MA, Wilkinson E, Nakamura Y, Connell PP, Cohn SL. Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma. Mol Cancer Ther. 2019 03; 18(3):507-516. PMID: 30674566; PMCID: PMC6398941.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    5. Budke B, Lv W, Kozikowski AP, Connell PP. Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy? ChemMedChem. 2016 11 21; 11(22):2468-2473. PMID: 27781374; PMCID: PMC5472043.
      Citations: 25     Fields:    Translation:HumansCells
    6. Lv W, Budke B, Pawlowski M, Connell PP, Kozikowski AP. Development of Small Molecules that Specifically Inhibit the D-loop Activity of RAD51. J Med Chem. 2016 05 26; 59(10):4511-25. PMID: 27049177; PMCID: PMC5473336.
      Citations: 16     Fields:    Translation:HumansCells
    7. Thierry S, Thierry E, Budke B, Ciuffi A, Sung P, Connell P, Hauber I, Hauber J, Delelis O, Benleulmi MS, Sinzelle L, Calmels C, Chaignepain S, Waffo-Teguo P, Merillon JM, Pasquet JM, Litvak S, Andreola ML, Parissi V. Dual and Opposite Effects of hRAD51 Chemical Modulation on HIV-1 Integration. Chem Biol. 2015 Jun 18; 22(6):712-23. PMID: 26051216; PMCID: PMC4889029.
      Citations: 8     Fields:    Translation:HumansCells
    8. Mason JM, Dusad K, Wright WD, Grubb J, Budke B, Heyer WD, Connell PP, Weichselbaum RR, Bishop DK. RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells. Nucleic Acids Res. 2015 Mar 31; 43(6):3180-96. PMID: 25765654; PMCID: PMC4381078.
      Citations: 39     Fields:    Translation:HumansCells
    9. Mason JM, Logan HL, Budke B, Wu M, Pawlowski M, Weichselbaum RR, Kozikowski AP, Bishop DK, Connell PP. The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors. Cancer Res. 2014 Jul 01; 74(13):3546-55. PMID: 24753542; PMCID: PMC4079730.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    10. Pitroda SP, Pashtan IM, Logan HL, Budke B, Darga TE, Weichselbaum RR, Connell PP. DNA repair pathway gene expression score correlates with repair proficiency and tumor sensitivity to chemotherapy. Sci Transl Med. 2014 Mar 26; 6(229):229ra42. PMID: 24670686; PMCID: PMC4889008.
      Citations: 44     Fields:    Translation:HumansCells
    11. Budke B, Chan YL, Bishop DK, Connell PP. Real-time solution measurement of RAD51- and RecA-mediated strand assimilation without background annealing. Nucleic Acids Res. 2013 Jul; 41(13):e130. PMID: 23666628; PMCID: PMC3711447.
      Citations: 10     Fields:    Translation:HumansCells
    12. Budke B, Kalin JH, Pawlowski M, Zelivianskaia AS, Wu M, Kozikowski AP, Connell PP. An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity. J Med Chem. 2013 Jan 10; 56(1):254-63. PMID: 23231413; PMCID: PMC3619390.
      Citations: 42     Fields:    Translation:HumansCells
    13. Cloud V, Chan YL, Grubb J, Budke B, Bishop DK. Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis. Science. 2012 Sep 07; 337(6099):1222-5. PMID: 22955832; PMCID: PMC4056682.
      Citations: 173     Fields:    Translation:AnimalsCells
    14. Budke B, Logan HL, Kalin JH, Zelivianskaia AS, Cameron McGuire W, Miller LL, Stark JM, Kozikowski AP, Bishop DK, Connell PP. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 2012 Aug; 40(15):7347-57. PMID: 22573178; PMCID: PMC3424541.
      Citations: 92     Fields:    Translation:HumansCells
    15. Budke B, Kuzminov A. Production of clastogenic DNA precursors by the nucleotide metabolism in Escherichia coli. Mol Microbiol. 2010 Jan; 75(1):230-45. PMID: 19943897; PMCID: PMC4433007.
      Citations: 18     Fields:    Translation:Cells
    16. Budke B, Kuzminov A. Hypoxanthine incorporation is nonmutagenic in Escherichia coli. J Bacteriol. 2006 Sep; 188(18):6553-60. PMID: 16952947; PMCID: PMC1595496.
      Citations: 18     Fields:    Translation:Cells
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