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Wim Van Drongelen

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Research Interests- Understanding mechanisms underlying Epilepsy

    Epilepsy is a serious neurological disorder characterized by seizures. About 1% of the world population is affected by this disease and a fraction of 1/3 of patients does not respond to medication. In order to help us understand the pathological behavior we observe during the brain’s epileptiform activity, our group applies a variety of engineering techniques including advanced statistical and digital signal processing, non-linear dynamics, and modeling (link to basic texts) (link to second edition text). The ultimate goal of the research in our lab is to address this enormous problem by improved understanding of the mechanisms that govern different types of epilepsy.

    See the lab website for further details, teaching, and videos on lectures

    Our research approach is interdisciplinary, including:
    Mathematical modeling
    Computational modeling
    Animal models
    Study of tissue from patients with epilepsy
    Analysis of clinical recordings
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Merricks EM, Deshpande SS, Agopyan-Miu AH, Smith EH, Schlafly ED, McKhann GM, Goodman RR, Sheth SA, Greger B, House PA, Eskandar EN, Madsen JR, Cash SS, Trevelyan AJ, van Drongelen W, Schevon CA. Aberrant fast spiking interneuronal activity precedes seizure transitions in humans. medRxiv. 2024 Jan 26. PMID: 38343792; PMCID: PMC10854323.
    2. Deshpande SS, van Drongelen W. A Novel Quantitative Metric Based on a Complete and Unique Characterization of Neural Network Activity: 4D Shannon's Entropy. bioRxiv. 2023 Sep 15. PMID: 37745513; PMCID: PMC10516034.
    3. Suresh J, Saddler M, Bindokas V, Bhansali A, Pesce L, Wang J, Marks J, van Drongelen W. Emerging Activity Patterns and Synaptogenesis in Dissociated Hippocampal Cultures. bioRxiv. 2023 May 18. PMID: 37292953; PMCID: PMC10245748.
    4. Lee S, Deshpande SS, Merricks EM, Schlafly E, Goodman R, McKhann GM, Eskandar EN, Madsen JR, Cash SS, van Putten MJAM, Schevon CA, van Drongelen W. Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures. Commun Biol. 2023 03 25; 6(1):317. PMID: 36966217; PMCID: PMC10039941.
      Citations: 1     Translation:HumansCells
    5. Deshpande SS, Smith GA, van Drongelen W. Third-order motifs are sufficient to fully and uniquely characterize spatiotemporal neural network activity. Sci Rep. 2023 Jan 05; 13(1):238. PMID: 36604489; PMCID: PMC9816122.
      Citations:    Fields:    
    6. Lee S, Henry J, Tryba AK, Esengul Y, Warnke P, Wu S, van Drongelen W. Digital reconstruction of infraslow activity in human intracranial ictal recordings using a deconvolution-based inverse filter. Sci Rep. 2022 08 11; 12(1):13701. PMID: 35953580; PMCID: PMC9372169.
      Citations:    Fields:    Translation:Humans
    7. Lee S, Wu S, Tao JX, Rose S, Warnke PC, Issa NP, van Drongelen W. Manifestation of Hippocampal Interictal Discharges on Clinical Scalp EEG Recordings. J Clin Neurophysiol. 2023 Feb 01; 40(2):144-150. PMID: 34010227; PMCID: PMC8590709.
      Citations: 2     Fields:    Translation:Humans
    8. Tryba AK, Merricks EM, Lee S, Pham T, Cho S, Nordli DR, Eissa TL, Goodman RR, McKhann GM, Emerson RG, Schevon CA, van Drongelen W. Role of paroxysmal depolarization in focal seizure activity. J Neurophysiol. 2019 11 01; 122(5):1861-1873. PMID: 31461373; PMCID: PMC6879965.
      Citations: 9     Fields:    Translation:HumansCells
    9. Lee S, Issa NP, Rose S, Tao JX, Warnke PC, Towle VL, van Drongelen W, Wu S. DC shifts, high frequency oscillations, ripples and fast ripples in relation to the seizure onset zone. Seizure. 2020 Apr; 77:52-58. PMID: 31101405; PMCID: PMC6825882.
      Citations: 11     Fields:    Translation:Humans
    10. Issa NP, Lee S, Wu S, Rose S, Towle VL, Warnke PC, van Drongelen W, Tao JX. Reply to "which small sharp spikes are benign epileptiform transients of sleep?" Clin Neurophysiol. 2018 11; 129(11):2495-2496. PMID: 30268708.
      Citations:    Fields:    Translation:Humans
    11. Smith G, Lee S, van Drongelen W. A glimpse into the future of clinical neurophysiology: Can we use machines to interpret EEG? Clin Neurophysiol. 2018 10; 129(10):2186-2187. PMID: 30087004.
      Citations:    Fields:    
    12. Eissa TL, Schevon CA, Emerson RG, Mckhann GM, Goodman RR, Van Drongelen W. The Relationship Between Ictal Multi-Unit Activity and the Electrocorticogram. Int J Neural Syst. 2018 Dec; 28(10):1850027. PMID: 30001641.
      Citations: 4     Fields:    Translation:HumansCells
    13. Eissa TL, Dijkstra K, Brune C, Emerson RG, van Putten MJAM, Goodman RR, McKhann GM, Schevon CA, van Drongelen W, van Gils SA. Cross-scale effects of neural interactions during human neocortical seizure activity. Proc Natl Acad Sci U S A. 2017 10 03; 114(40):10761-10766. PMID: 28923948; PMCID: PMC5635869.
      Citations: 22     Fields:    Translation:Humans
    14. Eissa TL, Tryba AK, Marcuccilli CJ, Ben-Mabrouk F, Smith EH, Lew SM, Goodman RR, McKhann GM, Frim DM, Pesce LL, Kohrman MH, Emerson RG, Schevon CA, van Drongelen W. Multiscale Aspects of Generation of High-Gamma Activity during Seizures in Human Neocortex. eNeuro. 2016 Mar-Apr; 3(2). PMID: 27257623; PMCID: PMC4876490.
      Citations: 16     Fields:    Translation:Humans
    15. Suresh J, Radojicic M, Pesce LL, Bhansali A, Wang J, Tryba AK, Marks JD, van Drongelen W. Network burst activity in hippocampal neuronal cultures: the role of synaptic and intrinsic currents. J Neurophysiol. 2016 06 01; 115(6):3073-89. PMID: 26984425; PMCID: PMC4946605.
      Citations: 26     Fields:    Translation:AnimalsCells
    16. Cowan JD, Neuman J, van Drongelen W. Wilson-Cowan Equations for Neocortical Dynamics. J Math Neurosci. 2016 Dec; 6(1):1. PMID: 26728012; PMCID: PMC4733815.
      Citations: 35     
    17. Meijer HG, Eissa TL, Kiewiet B, Neuman JF, Schevon CA, Emerson RG, Goodman RR, McKhann GM, Marcuccilli CJ, Tryba AK, Cowan JD, van Gils SA, van Drongelen W. Modeling focal epileptic activity in the Wilson-cowan model with depolarization block. J Math Neurosci. 2015; 5:7. PMID: 25852982; PMCID: PMC4385301.
      Citations: 17     
    18. Mogul DJ, van Drongelen W. Electrical control of epilepsy. Annu Rev Biomed Eng. 2014 Jul 11; 16:483-504. PMID: 25014790.
      Citations: 13     Fields:    Translation:HumansAnimals
    19. Pesce LL, Lee HC, Hereld M, Visser S, Stevens RL, Wildeman A, van Drongelen W. Large-scale modeling of epileptic seizures: scaling properties of two parallel neuronal network simulation algorithms. Comput Math Methods Med. 2013; 2013:182145. PMID: 24416069; PMCID: PMC3876705.
      Citations: 1     Fields:    Translation:HumansCells
    20. Dwyer J, Lee H, Martell A, van Drongelen W. Resonance in neocortical neurons and networks. Eur J Neurosci. 2012 Dec; 36(12):3698-708. PMID: 23009328.
      Citations: 10     Fields:    Translation:AnimalsCells
    21. Martell AL, Ramirez JM, Lasky RE, Dwyer JE, Kohrman M, van Drongelen W. The role of voltage dependence of the NMDA receptor in cellular and network oscillation. Eur J Neurosci. 2012 Jul; 36(2):2121-36. PMID: 22805058; PMCID: PMC3400125.
      Citations: 2     Fields:    Translation:AnimalsCells
    22. Grinberg YY, van Drongelen W, Kraig RP. Insulin-like growth factor-1 lowers spreading depression susceptibility and reduces oxidative stress. J Neurochem. 2012 Jul; 122(1):221-9. PMID: 22524542; PMCID: PMC3629097.
      Citations: 30     Fields:    Translation:Animals
    23. Rana P, Lipor J, Lee H, van Drongelen W, Kohrman MH, Van Veen B. Seizure detection using the phase-slope index and multichannel ECoG. IEEE Trans Biomed Eng. 2012 Apr; 59(4):1125-34. PMID: 22271828; PMCID: PMC3369624.
      Citations: 9     Fields:    Translation:Humans
    24. Butler TC, Benayoun M, Wallace E, van Drongelen W, Goldenfeld N, Cowan J. Evolutionary constraints on visual cortex architecture from the dynamics of hallucinations. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):606-9. PMID: 22203969; PMCID: PMC3258647.
      Citations: 10     Fields:    Translation:HumansCells
    25. Cheung BL, Nowak R, Lee HC, van Drongelen W, Van Veen BD. Cross validation for selection of cortical interaction models from scalp EEG or MEG. IEEE Trans Biomed Eng. 2012 Feb; 59(2):504-14. PMID: 22084038; PMCID: PMC3339867.
      Citations: 5     Fields:    Translation:Humans
    26. Wallace E, Benayoun M, van Drongelen W, Cowan JD. Emergent oscillations in networks of stochastic spiking neurons. PLoS One. 2011 May 06; 6(5):e14804. PMID: 21573105; PMCID: PMC3089610.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    27. Margoliash D, van Drongelen W, Kohrman M. Introducing songbirds as a model system for epilepsy research. J Clin Neurophysiol. 2010 Dec; 27(6):433-7. PMID: 21076334.
      Citations: 2     Fields:    Translation:Animals
    28. van Drongelen W. Tools for epilepsy research. J Clin Neurophysiol. 2010 Dec; 27(6):359. PMID: 21076320.
      Citations:    Fields:    Translation:HumansAnimals
    29. Martell A, Dwyer J, Koch H, Zanella S, Kohrman M, Frim D, Ramirez JM, van Drongelen W. N-methyl-D-aspartate-induced oscillatory properties in neocortical pyramidal neurons from patients with epilepsy. J Clin Neurophysiol. 2010 Dec; 27(6):398-405. PMID: 21076319.
      Citations: 5     Fields:    Translation:HumansCells
    30. Marcuccilli CJ, Tryba AK, van Drongelen W, Koch H, Viemari JC, Doren EL, Pytel P, Chevalier M, Mrejeru A, Kohrman MH, Lasky RE, Lew SM, Frim DM, Ramirez JM, Peña-Ortega F. Neuronal bursting properties in focal and parafocal regions in pediatric neocortical epilepsy stratified by histology. J Clin Neurophysiol. 2010 Dec; 27(6):387-97. PMID: 21076335.
      Citations: 14     Fields:    Translation:HumansCells
    31. Theyel BB, Kohrman MH, Frim DM, van Drongelen W. Network variability across human tissue samples in vitro: the problem and a solution. J Clin Neurophysiol. 2010 Dec; 27(6):412-7. PMID: 21076332.
      Citations: 1     Fields:    Translation:Humans
    32. Visser S, Meijer HG, Lee HC, van Drongelen W, van Putten MJ, van Gils SA. Comparing epileptiform behavior of mesoscale detailed models and population models of neocortex. J Clin Neurophysiol. 2010 Dec; 27(6):471-8. PMID: 21076324.
      Citations: 4     Fields:    Translation:HumansCells
    33. Benayoun M, Kohrman M, Cowan J, van Drongelen W. EEG, temporal correlations, and avalanches. J Clin Neurophysiol. 2010 Dec; 27(6):458-64. PMID: 21076326.
      Citations: 9     Fields:    Translation:HumansCells
    34. Lasky RE, van Drongelen W. Is sucrose an effective analgesic for newborn babies? Lancet. 2010 Oct 09; 376(9748):1201-3. PMID: 20817245.
      Citations: 2     Fields:    Translation:Humans
    35. Bai X, Towle VL, van Drongelen W, He B. Cortical potential imaging of somatosensory evoked potentials by means of the boundary element method in pediatric epilepsy patients. Brain Topogr. 2011 Jan; 23(4):333-43. PMID: 20652392; PMCID: PMC3033454.
      Citations: 3     Fields:    Translation:Humans
    36. Lai Y, Zhang X, van Drongelen W, Korhman M, Hecox K, Ni Y, He B. Noninvasive cortical imaging of epileptiform activities from interictal spikes in pediatric patients. Neuroimage. 2011 Jan 01; 54(1):244-52. PMID: 20643212; PMCID: PMC3033450.
      Citations: 13     Fields:    Translation:Humans
    37. Benayoun M, Cowan JD, van Drongelen W, Wallace E. Avalanches in a stochastic model of spiking neurons. PLoS Comput Biol. 2010 Jul 08; 6(7):e1000846. PMID: 20628615; PMCID: PMC2900286.
      Citations: 62     Fields:    Translation:Animals
    38. Dwyer J, Lee H, Martell A, Stevens R, Hereld M, van Drongelen W. Oscillation in a Network Model of Neocortex. Neurocomputing. 2010 Mar 01; 73(7-9):1051-1056. PMID: 20368744; PMCID: PMC2847187.
      Citations: 2     
    39. Wilke C, van Drongelen W, Kohrman M, He B. Neocortical seizure foci localization by means of a directed transfer function method. Epilepsia. 2010 Apr; 51(4):564-72. PMID: 19817817; PMCID: PMC2855748.
      Citations: 43     Fields:    Translation:Humans
    40. Wilke C, van Drongelen W, Kohrman M, He B. Identification of epileptogenic foci from causal analysis of ECoG interictal spike activity. Clin Neurophysiol. 2009 Aug; 120(8):1449-56. PMID: 19616474; PMCID: PMC2727575.
      Citations: 31     Fields:    Translation:Humans
    41. Franz M, van Drongelen W, Grosse-Wentrup M, Barbero A, Dorronsoro JR, Schölkopf B. Implicit Wiener series analysis of epileptic seizure recordings. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:5304-7. PMID: 19963892.
      Citations: 3     Fields:    Translation:Humans
    42. van Drongelen W, Williams AL, Lasky RE. Spectral analysis of time series of events: effect of respiration on heart rate in neonates. Physiol Meas. 2009 Jan; 30(1):43-61. PMID: 19075368.
      Citations:    Fields:    Translation:Humans
    43. Zhang Y, van Drongelen W, Kohrman M, He B. Three-dimensional brain current source reconstruction from intra-cranial ECoG recordings. Neuroimage. 2008 Aug 15; 42(2):683-95. PMID: 18579412; PMCID: PMC2574578.
      Citations: 26     Fields:    Translation:Humans
    44. Trevelyan AJ, Baldeweg T, van Drongelen W, Yuste R, Whittington M. The source of afterdischarge activity in neocortical tonic-clonic epilepsy. J Neurosci. 2007 Dec 05; 27(49):13513-9. PMID: 18057209; PMCID: PMC6673106.
      Citations: 27     Fields:    Translation:HumansAnimals
    45. Williams AL, van Drongelen W, Lasky RE. Noise in contemporary neonatal intensive care. J Acoust Soc Am. 2007 May; 121(5 Pt1):2681-90. PMID: 17550168.
      Citations: 19     Fields:    Translation:HumansPHPublic Health
    46. Ding L, Wilke C, Xu B, Xu X, van Drongelen W, Kohrman M, He B. EEG source imaging: correlating source locations and extents with electrocorticography and surgical resections in epilepsy patients. J Clin Neurophysiol. 2007 Apr; 24(2):130-6. PMID: 17414968; PMCID: PMC2758789.
      Citations: 11     Fields:    Translation:Humans
    47. Lee HC, van Drongelen W, McGee AB, Frim DM, Kohrman MH. Comparison of seizure detection algorithms in continuously monitored pediatric patients. J Clin Neurophysiol. 2007 Apr; 24(2):137-46. PMID: 17414969.
      Citations: 4     Fields:    Translation:Humans
    48. van Drongelen W, Lee HC, Stevens RL, Hereld M. propagation of seizure-like activity in a model of neocortex. J Clin Neurophysiol. 2007 Apr; 24(2):182-8. PMID: 17414974.
      Citations: 12     Fields:    Translation:HumansAnimals
    49. Hereld M, Stevens RL, Lee HC, van Drongelen W. Framework for interactive million-neuron simulation. J Clin Neurophysiol. 2007 Apr; 24(2):189-96. PMID: 17414975.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    50. Lai Y, van Drongelen W, Hecox K, Frim D, Kohrman M, He B. Cortical activation mapping of epileptiform activity derived from interictal ECoG spikes. Epilepsia. 2007 Feb; 48(2):305-14. PMID: 17295624.
      Citations: 10     Fields:    Translation:Humans
    51. van Drongelen W, Koch H, Elsen FP, Lee HC, Mrejeru A, Doren E, Marcuccilli CJ, Hereld M, Stevens RL, Ramirez JM. Role of persistent sodium current in bursting activity of mouse neocortical networks in vitro. J Neurophysiol. 2006 Nov; 96(5):2564-77. PMID: 16870839.
      Citations: 35     Fields:    Translation:AnimalsCells
    52. Zhang Y, Ding L, van Drongelen W, Hecox K, Frim DM, He B. A cortical potential imaging study from simultaneous extra- and intracranial electrical recordings by means of the finite element method. Neuroimage. 2006 Jul 15; 31(4):1513-24. PMID: 16631381; PMCID: PMC1866308.
      Citations: 26     Fields:    Translation:Humans
    53. Zhang Y, van Drongelen W, He B. Estimation of in vivo brain-to-skull conductivity ratio in humans. Appl Phys Lett. 2006; 89(22):223903-2239033. PMID: 17492058; PMCID: PMC1867457.
      Citations: 49     
    54. van Drongelen W, Lee HC, Hereld M, Chen Z, Elsen FP, Stevens RL. Emergent epileptiform activity in neural networks with weak excitatory synapses. IEEE Trans Neural Syst Rehabil Eng. 2005 Jun; 13(2):236-41. PMID: 16003905.
      Citations: 17     Fields:    Translation:AnimalsCells
    55. Lai Y, van Drongelen W, Ding L, Hecox KE, Towle VL, Frim DM, He B. Estimation of in vivo human brain-to-skull conductivity ratio from simultaneous extra- and intra-cranial electrical potential recordings. Clin Neurophysiol. 2005 Feb; 116(2):456-65. PMID: 15661122.
      Citations: 69     Fields:    Translation:Humans
    56. Hereld M, Stevens RL, van Drongelen W, Lee HC. Developing a petascale neural simulation. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:3999-4002. PMID: 17271175.
      Citations: 3     Fields:    
    57. van Drongelen W, Lee HC, Koch H, Elsen F, Carroll MS, Hereld M, Stevens RL. Interaction between cellular voltage-sensitive conductance and network parameters in a model of neocortex can generate epileptiform bursting. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:4003-5a. PMID: 17271176.
      Citations: 1     Fields:    
    58. Fontanarosa JB, Lasky RE, Lee HC, van Drongelen W. Localization of brainstem auditory evoked potentials in primates: a comparison of localization techniques applied to deep brain sources. Brain Topogr. 2004; 17(2):99-108. PMID: 15754875.
      Citations: 3     Fields:    Translation:Animals
    59. Zhang X, van Drongelen W, Hecox KE, Towle VL, Frim DM, McGee AB, He B. High-resolution EEG: cortical potential imaging of interictal spikes. Clin Neurophysiol. 2003 Oct; 114(10):1963-73. PMID: 14499758.
      Citations: 16     Fields:    Translation:Humans
    60. van Drongelen W, Nayak S, Frim DM, Kohrman MH, Towle VL, Lee HC, McGee AB, Chico MS, Hecox KE. Seizure anticipation in pediatric epilepsy: use of Kolmogorov entropy. Pediatr Neurol. 2003 Sep; 29(3):207-13. PMID: 14629902.
      Citations: 19     Fields:    Translation:Humans
    61. Van Drongelen W, Koch H, Marcuccilli C, Pena F, Ramirez JM. Synchrony levels during evoked seizure-like bursts in mouse neocortical slices. J Neurophysiol. 2003 Sep; 90(3):1571-80. PMID: 12750417.
      Citations: 16     Fields:    Translation:Animals
    62. Van Veen BD, van Drongelen W, Yuchtman M, Suzuki A. Localization of brain electrical activity via linearly constrained minimum variance spatial filtering. IEEE Trans Biomed Eng. 1997 Sep; 44(9):867-80. PMID: 9282479.
      Citations: 843     Fields:    Translation:Humans
    63. van Drongelen W, Pagnotte Y, Hendriks MH. Primary events in odour detection. Bull Math Biol. 1982; 44(3):411-23. PMID: 7104511.
      Citations: 1     Fields:    Translation:HumansCells
    64. van Drongelen W, Dullemeijer P. The feeding apparatus of Caiman crocodilus; a functional-morphological study. Anat Anz. 1982; 151(4):337-66. PMID: 7103110.
      Citations: 4     Fields:    Translation:Animals
    65. van Drongelen W, Holley A, Døving KB. Convergence in the olfactory system: quantitative aspects of odour sensitivity. J Theor Biol. 1978 Mar 07; 71(1):39-48. PMID: 642521.
      Citations: 13     Fields:    Translation:AnimalsCells
    66. Van Drongelen W, Dullemeijer P. A paradigm for the mandibula of Caiman crocodilus [proceedings]. Acta Morphol Neerl Scand. 1977 Oct; 15(3):236-7. PMID: 920291.
      Citations:    Fields:    Translation:Animals
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