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David R. Kovar

InstitutionUniversity of Chicago
DepartmentMolecular Genetics and Cell Biology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Cells simultaneously assemble and maintain different actin cytoskeleton networks of distinct organizations and dynamics for fundamental processes such as polarization, endocytosis, motility and division. How does a shared pool of actin monomer building blocks self-organize into distinct actin filament networks of specific densities, sizes and function within a common cellular cytoplasm? Our research group is investigating the molecular mechanisms that govern how diverse actin cytoskeleton networks self-organize through (1) competition for a limited supply of actin monomers, (2) network-specific sorting of actin binding proteins, and (3) the effects of different combinations of actin binding proteins on actin filament network organization, dynamics and function. We take advantage of complementary experiments in live cells and with purified components. These interdisciplinary techniques include genetics, time-lapse fluorescence microscopy of cells, biochemistry, biophysics, in vitro reconstitution and multi-color single molecule TIRF microscopy imaging.

    Collapse Biography 
    Collapse education and training
    Ohio Wesleyan University, Delaware, OHBA05/1995Botany and Microbiology
    Purdue University, West Lafayette, INPhD05/2001Biological Sciences
    Yale University, New Haven, CTPostdoctoral Fellow10/2005Biochemistry and Biophysics
    Collapse awards and honors
    2011BSD Distinguished Educator and Mentor Award, University of Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Homa KE, Hocky GM, Suarez C, Kovar DR. Arp2/3 complex- and formin-mediated actin cytoskeleton networks facilitate actin binding protein sorting in fission yeast. Eur J Cell Biol. 2024 Mar 16; 103(2):151404. PMID: 38493594.
      Citations:    Fields:    
    2. Jorgenson TD, Baboolall KD, Suarez C, Kovar DR, Gardel ML, Rowan SJ. Highly flexible PEG-LifeAct constructs act as tunable biomimetic actin crosslinkers. Soft Matter. 2024 Jan 31; 20(5):971-977. PMID: 38190228; PMCID: PMC10828923.
      Citations:    Fields:    Translation:Cells
    3. McCormick LE, Suarez C, Herring LE, Cannon KS, Kovar DR, Brown NG, Gupton SL. Multi-monoubiquitylation controls VASP-mediated actin dynamics. J Cell Sci. 2024 01 15; 137(2). PMID: 38277158; PMCID: PMC10917064.
      Citations:    Fields:    Translation:Cells
    4. McCormick LE, Suarez C, Herring LE, Cannon KS, Kovar DR, Brown NG, Gupton SL. Multi-monoubiquitination controls VASP-mediated actin dynamics. J Cell Sci. 2024 Jan 12. PMID: 38214186.
      Citations:    Fields:    
    5. Suarez C, Winkelman JD, Harker AJ, Ye HJ, McCall PM, Morganthaler AN, Gardel ML, Kovar DR. Reconstitution of the transition from a lamellipodia- to filopodia-like actin network with purified proteins. Eur J Cell Biol. 2023 Dec; 102(4):151367. PMID: 37890285.
      Citations:    Fields:    Translation:Cells
    6. McCormick LE, Suarez C, Herring LE, Cannon KS, Kovar DR, Brown NG, Gupton SL. Multi-monoubiquitination controls VASP-mediated actin dynamics. bioRxiv. 2023 Jul 17. PMID: 37503134; PMCID: PMC10370145.
    7. Zsolnay V, Gardel ML, Kovar DR, Voth GA. Cracked actin filaments as mechanosensitive receptors. bioRxiv. 2023 Jun 28. PMID: 37425801; PMCID: PMC10327158.
    8. Tang Q, Pollard LW, Homa KE, Kovar DR, Trybus KM. Acetylation of fission yeast tropomyosin does not promote differential association with cognate formins. Cytoskeleton (Hoboken). 2023 03; 80(3-4):77-92. PMID: 36692369; PMCID: PMC10121778.
      Citations:    Fields:    Translation:AnimalsCells
    9. Billault-Chaumartin I, Michon L, Anderson CA, Yde SE, Suarez C, Kovar DR, Martin SG, Iwaszkiewicz J, Zoete V. Actin assembly requirements of the formin Fus1 to build the fusion focus. J Cell Sci. 2022 07 01; 135(13). PMID: 35673994; PMCID: PMC9377709.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Rosenbloom AD, Kovar EW, Kovar DR, Loew LM, Pollard TD. Mechanism of actin filament nucleation. Biophys J. 2021 10 19; 120(20):4399-4417. PMID: 34509503; PMCID: PMC8553669.
      Citations: 7     Fields:    Translation:Cells
    11. Homa KE, Zsolnay V, Anderson CA, O'Connell ME, Neidt EM, Voth GA, Bidone TC, Kovar DR. Formin Cdc12's specific actin assembly properties are tailored for cytokinesis in fission yeast. Biophys J. 2021 08 03; 120(15):2984-2997. PMID: 34214524; PMCID: PMC8390969.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Anderson CA, Kovar DR, Gardel ML, Winkelman JD. LIM domain proteins in cell mechanobiology. Cytoskeleton (Hoboken). 2021 06; 78(6):303-311. PMID: 34028199; PMCID: PMC8603407.
      Citations: 21     Fields:    Translation:Cells
    13. Yde SE, Kadzik RS, Kovar DR. Stir it up: The role of actin in mitochondrial mixing during mitosis. Dev Cell. 2021 04 19; 56(8):1080-1082. PMID: 33878298.
      Citations:    Fields:    Translation:Cells
    14. Kadzik RS, Homa KE, Kovar DR. F-Actin Cytoskeleton Network Self-Organization Through Competition and Cooperation. Annu Rev Cell Dev Biol. 2020 10 06; 36:35-60. PMID: 33021819; PMCID: PMC8675537.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    15. Winkelman JD, Anderson CA, Suarez C, Kovar DR, Gardel ML. Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism. Proc Natl Acad Sci U S A. 2020 10 13; 117(41):25532-25542. PMID: 32989126; PMCID: PMC7568268.
      Citations: 40     Fields:    Translation:AnimalsCells
    16. Mancl JM, Suarez C, Liang WG, Kovar DR, Tang WJ. Pseudomonas aeruginosa exoenzyme Y directly bundles actin filaments. J Biol Chem. 2020 03 13; 295(11):3506-3517. PMID: 32019868; PMCID: PMC7076225.
      Citations: 5     Fields:    Translation:Cells
    17. Christensen JR, Craig EW, Glista MJ, Mueller DM, Li Y, Sees JA, Huang S, Suarez C, Mets LJ, Kovar DR, Avasthi P. Chlamydomonas reinhardtii formin FOR1 and profilin PRF1 are optimized for acute rapid actin filament assembly. Mol Biol Cell. 2019 12 15; 30(26):3123-3135. PMID: 31664873; PMCID: PMC6938247.
      Citations: 4     Fields:    Translation:AnimalsCells
    18. Yadav V, Banerjee DS, Tabatabai AP, Kovar DR, Kim T, Banerjee S, Murrell MP. Filament Nucleation Tunes Mechanical Memory in Active Polymer Networks. Adv Funct Mater. 2019 Dec 05; 29(49). PMID: 32523502; PMCID: PMC7286550.
      Citations: 7     
    19. Freedman SL, Suarez C, Winkelman JD, Kovar DR, Voth GA, Dinner AR, Hocky GM. Mechanical and kinetic factors drive sorting of F-actin cross-linkers on bundles. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16192-16197. PMID: 31346091; PMCID: PMC6697872.
      Citations: 18     Fields:    Translation:AnimalsCells
    20. McCall PM, MacKintosh FC, Kovar DR, Gardel ML. Cofilin drives rapid turnover and fluidization of entangled F-actin. Proc Natl Acad Sci U S A. 2019 06 25; 116(26):12629-12637. PMID: 31189606; PMCID: PMC6600917.
      Citations: 20     Fields:    Translation:AnimalsCells
    21. Christensen JR, Homa KE, Morganthaler AN, Brown RR, Suarez C, Harker AJ, O'Connell ME, Kovar DR. Cooperation between tropomyosin and a-actinin inhibits fimbrin association with actin filament networks in fission yeast. Elife. 2019 06 10; 8. PMID: 31180322; PMCID: PMC6557641.
      Citations: 15     Fields:    Translation:AnimalsCells
    22. Ajeti V, Tabatabai AP, Fleszar AJ, Staddon MF, Seara DS, Suarez C, Yousafzai MS, Bi D, Kovar DR, Banerjee S, Murrell MP. Wound Healing Coordinates Actin Architectures to Regulate Mechanical Work. Nat Phys. 2019; 15:696-705. PMID: 31897085; PMCID: PMC6939997.
      Citations: 19     
    23. Zimmermann D, Kovar DR. Feeling the force: formin's role in mechanotransduction. Curr Opin Cell Biol. 2019 02; 56:130-140. PMID: 30639952.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    24. Harker AJ, Katkar HH, Bidone TC, Aydin F, Voth GA, Applewhite DA, Kovar DR. Ena/VASP processive elongation is modulated by avidity on actin filaments bundled by the filopodia cross-linker fascin. Mol Biol Cell. 2019 03 21; 30(7):851-862. PMID: 30601697; PMCID: PMC6589784.
      Citations: 22     Fields:    Translation:AnimalsCells
    25. Kudryashova E, Heisler DB, Williams B, Harker AJ, Shafer K, Quinlan ME, Kovar DR, Vavylonis D, Kudryashov DS. Actin Cross-Linking Toxin Is a Universal Inhibitor of Tandem-Organized and Oligomeric G-Actin Binding Proteins. Curr Biol. 2018 05 21; 28(10):1536-1547.e9. PMID: 29731300; PMCID: PMC5964048.
      Citations: 14     Fields:    Translation:Cells
    26. McCall PM, Srivastava S, Perry SL, Kovar DR, Gardel ML, Tirrell MV. Partitioning and Enhanced Self-Assembly of Actin in Polypeptide Coacervates. Biophys J. 2018 04 10; 114(7):1636-1645. PMID: 29642033; PMCID: PMC5954293.
      Citations: 28     Fields:    Translation:Cells
    27. Zimmermann D, Homa KE, Hocky GM, Pollard LW, De La Cruz EM, Voth GA, Trybus KM, Kovar DR. Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly. Nat Commun. 2017 09 26; 8(1):703. PMID: 28951543; PMCID: PMC5614989.
      Citations: 39     Fields:    Translation:AnimalsCells
    28. Suarez C, McCall PM, Gardel ML, Kovar DR. When Is "Enough" Enough? Cell Syst. 2017 05 24; 4(5):480-482. PMID: 28544879.
      Citations: 2     Fields:    Translation:Cells
    29. Burke TA, Harker AJ, Dominguez R, Kovar DR. The bacterial virulence factors VopL and VopF nucleate actin from the pointed end. J Cell Biol. 2017 05 01; 216(5):1267-1276. PMID: 28363971; PMCID: PMC5412564.
      Citations: 14     Fields:    Translation:Cells
    30. Christensen JR, Hocky GM, Homa KE, Morganthaler AN, Hitchcock-DeGregori SE, Voth GA, Kovar DR. Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks. Elife. 2017 03 10; 6. PMID: 28282023; PMCID: PMC5404920.
      Citations: 47     Fields:    Translation:AnimalsCells
    31. Winkelman JD, Suarez C, Hocky GM, Harker AJ, Morganthaler AN, Christensen JR, Voth GA, Bartles JR, Kovar DR. Fascin- and a-Actinin-Bundled Networks Contain Intrinsic Structural Features that Drive Protein Sorting. Curr Biol. 2016 10 24; 26(20):2697-2706. PMID: 27666967; PMCID: PMC5119644.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    32. Suarez C, Kovar DR. Internetwork competition for monomers governs actin cytoskeleton organization. Nat Rev Mol Cell Biol. 2016 12; 17(12):799-810. PMID: 27625321; PMCID: PMC5125073.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    33. Li Y, Christensen JR, Homa KE, Hocky GM, Fok A, Sees JA, Voth GA, Kovar DR. The F-actin bundler a-actinin Ain1 is tailored for ring assembly and constriction during cytokinesis in fission yeast. Mol Biol Cell. 2016 06 01; 27(11):1821-33. PMID: 27075176; PMCID: PMC4884072.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    34. Zimmermann D, Morganthaler AN, Kovar DR, Suarez C. In Vitro Biochemical Characterization of Cytokinesis Actin-Binding Proteins. Methods Mol Biol. 2016; 1369:151-79. PMID: 26519312.
      Citations: 9     Fields:    Translation:Cells
    35. Heisler DB, Kudryashova E, Grinevich DO, Suarez C, Winkelman JD, Birukov KG, Kotha SR, Parinandi NL, Vavylonis D, Kovar DR, Kudryashov DS. ACTIN-DIRECTED TOXIN. ACD toxin-produced actin oligomers poison formin-controlled actin polymerization. Science. 2015 Jul 31; 349(6247):535-9. PMID: 26228148; PMCID: PMC4648357.
      Citations: 29     Fields:    Translation:AnimalsCells
    36. Olshina MA, Angrisano F, Marapana DS, Riglar DT, Bane K, Wong W, Catimel B, Yin MX, Holmes AB, Frischknecht F, Kovar DR, Baum J. Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites. Malar J. 2015 Jul 18; 14:280. PMID: 26187846; PMCID: PMC4506582.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    37. Zimmermann D, Santos A, Kovar DR, Rock RS. Actin age orchestrates myosin-5 and myosin-6 run lengths. Curr Biol. 2015 Aug 03; 25(15):2057-62. PMID: 26190073; PMCID: PMC4556227.
      Citations: 21     Fields:    Translation:AnimalsCells
    38. Haase S, Zimmermann D, Olshina MA, Wilkinson M, Fisher F, Tan YH, Stewart RJ, Tonkin CJ, Wong W, Kovar DR, Baum J. Disassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites. Mol Biol Cell. 2015 Sep 01; 26(17):3001-12. PMID: 26157165; PMCID: PMC4551315.
      Citations: 8     Fields:    Translation:AnimalsCells
    39. Bezanilla M, Gladfelter AS, Kovar DR, Lee WL. Cytoskeletal dynamics: a view from the membrane. J Cell Biol. 2015 May 11; 209(3):329-37. PMID: 25963816; PMCID: PMC4427793.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    40. Rotty JD, Wu C, Haynes EM, Suarez C, Winkelman JD, Johnson HE, Haugh JM, Kovar DR, Bear JE. Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways. Dev Cell. 2015 Jan 12; 32(1):54-67. PMID: 25543281; PMCID: PMC4296256.
      Citations: 144     Fields:    Translation:AnimalsCells
    41. Suarez C, Carroll RT, Burke TA, Christensen JR, Bestul AJ, Sees JA, James ML, Sirotkin V, Kovar DR. Profilin regulates F-actin network homeostasis by favoring formin over Arp2/3 complex. Dev Cell. 2015 Jan 12; 32(1):43-53. PMID: 25543282; PMCID: PMC4293355.
      Citations: 130     Fields:    Translation:AnimalsCells
    42. Bestul AJ, Christensen JR, Grzegorzewska AP, Burke TA, Sees JA, Carroll RT, Sirotkin V, Keenan RJ, Kovar DR. Fission yeast profilin is tailored to facilitate actin assembly by the cytokinesis formin Cdc12. Mol Biol Cell. 2015 Jan 15; 26(2):283-93. PMID: 25392301; PMCID: PMC4294675.
      Citations: 3     Fields:    Translation:AnimalsCells
    43. Davies T, Jordan SN, Chand V, Sees JA, Laband K, Carvalho AX, Shirasu-Hiza M, Kovar DR, Dumont J, Canman JC. High-resolution temporal analysis reveals a functional timeline for the molecular regulation of cytokinesis. Dev Cell. 2014 Jul 28; 30(2):209-23. PMID: 25073157; PMCID: PMC4245203.
      Citations: 45     Fields:    Translation:Animals
    44. Kang Y, Jelenska J, Cecchini NM, Li Y, Lee MW, Kovar DR, Greenberg JT. HopW1 from Pseudomonas syringae disrupts the actin cytoskeleton to promote virulence in Arabidopsis. PLoS Pathog. 2014 Jun; 10(6):e1004232. PMID: 24968323; PMCID: PMC4072799.
      Citations: 43     Fields:    Translation:AnimalsCells
    45. Winkelman JD, Bilancia CG, Peifer M, Kovar DR. Ena/VASP Enabled is a highly processive actin polymerase tailored to self-assemble parallel-bundled F-actin networks with Fascin. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4121-6. PMID: 24591594; PMCID: PMC3964058.
      Citations: 81     Fields:    Translation:AnimalsCells
    46. Bilancia CG, Winkelman JD, Tsygankov D, Nowotarski SH, Sees JA, Comber K, Evans I, Lakhani V, Wood W, Elston TC, Kovar DR, Peifer M. Enabled negatively regulates diaphanous-driven actin dynamics in vitro and in vivo. Dev Cell. 2014 Feb 24; 28(4):394-408. PMID: 24576424; PMCID: PMC3992947.
      Citations: 39     Fields:    Translation:AnimalsCells
    47. Burke TA, Christensen JR, Barone E, Suarez C, Sirotkin V, Kovar DR. Homeostatic actin cytoskeleton networks are regulated by assembly factor competition for monomers. Curr Biol. 2014 Mar 03; 24(5):579-85. PMID: 24560576; PMCID: PMC3979332.
      Citations: 122     Fields:    Translation:AnimalsCells
    48. Wong W, Webb AI, Olshina MA, Infusini G, Tan YH, Hanssen E, Catimel B, Suarez C, Condron M, Angrisano F, Nebi T, Kovar DR, Baum J. A mechanism for actin filament severing by malaria parasite actin depolymerizing factor 1 via a low affinity binding interface. J Biol Chem. 2014 Feb 14; 289(7):4043-54. PMID: 24371134; PMCID: PMC3924271.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    49. Zimmermann D, Edelmann FT, Israel L, Kovar DR, Niessing D, Heym RG, Ökten Z. In vitro reconstitution of an mRNA-transport complex reveals mechanisms of assembly and motor activation. J Cell Biol. 2013 Dec 23; 203(6):971-84. PMID: 24368805; PMCID: PMC3871432.
      Citations: 17     Fields:    Translation:AnimalsCells
    50. Bohnert KA, Willet AH, Kovar DR, Gould KL. Formin-based control of the actin cytoskeleton during cytokinesis. Biochem Soc Trans. 2013 Dec; 41(6):1750-4. PMID: 24256286; PMCID: PMC5563852.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    51. Coffman VC, Sees JA, Kovar DR, Wu JQ. The formins Cdc12 and For3 cooperate during contractile ring assembly in cytokinesis. J Cell Biol. 2013 Oct 14; 203(1):101-14. PMID: 24127216; PMCID: PMC3798249.
      Citations: 33     Fields:    Translation:AnimalsCells
    52. Bohnert KA, Grzegorzewska AP, Willet AH, Vander Kooi CW, Kovar DR, Gould KL. SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis. Genes Dev. 2013 Oct 01; 27(19):2164-77. PMID: 24115772; PMCID: PMC3850099.
      Citations: 28     Fields:    Translation:AnimalsCells
    53. Madasu Y, Suarez C, Kast DJ, Kovar DR, Dominguez R. Rickettsia Sca2 has evolved formin-like activity through a different molecular mechanism. Proc Natl Acad Sci U S A. 2013 Jul 16; 110(29):E2677-86. PMID: 23818602; PMCID: PMC3718132.
      Citations: 31     Fields:    Translation:Cells
    54. Falzone TT, Oakes PW, Sees J, Kovar DR, Gardel ML. Actin assembly factors regulate the gelation kinetics and architecture of F-actin networks. Biophys J. 2013 Apr 16; 104(8):1709-19. PMID: 23601318; PMCID: PMC3628567.
      Citations: 8     Fields:    Translation:AnimalsCells
    55. Falzone TT, Lenz M, Kovar DR, Gardel ML. Assembly kinetics determine the architecture of a-actinin crosslinked F-actin networks. Nat Commun. 2012 May 29; 3:861. PMID: 22643888; PMCID: PMC3563296.
      Citations: 49     Fields:    Translation:Animals
    56. Namgoong S, Boczkowska M, Glista MJ, Winkelman JD, Rebowski G, Kovar DR, Dominguez R. Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation. Nat Struct Mol Biol. 2011 Aug 28; 18(9):1060-7. PMID: 21873985; PMCID: PMC3173040.
      Citations: 40     Fields:    Translation:Cells
    57. Scott BJ, Neidt EM, Kovar DR. The functionally distinct fission yeast formins have specific actin-assembly properties. Mol Biol Cell. 2011 Oct; 22(20):3826-39. PMID: 21865598; PMCID: PMC3192862.
      Citations: 33     Fields:    Translation:AnimalsCells
    58. Skau CT, Courson DS, Bestul AJ, Winkelman JD, Rock RS, Sirotkin V, Kovar DR. Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast. J Biol Chem. 2011 Jul 29; 286(30):26964-77. PMID: 21642440; PMCID: PMC3143655.
      Citations: 69     Fields:    Translation:AnimalsCells
    59. Wong W, Skau CT, Marapana DS, Hanssen E, Taylor NL, Riglar DT, Zuccala ES, Angrisano F, Lewis H, Catimel B, Clarke OB, Kershaw NJ, Perugini MA, Kovar DR, Gulbis JM, Baum J. Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9869-74. PMID: 21628589; PMCID: PMC3116436.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    60. Kovar DR, Sirotkin V, Lord M. Three's company: the fission yeast actin cytoskeleton. Trends Cell Biol. 2011 Mar; 21(3):177-87. PMID: 21145239; PMCID: PMC3073536.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    61. Haglund CM, Choe JE, Skau CT, Kovar DR, Welch MD. Rickettsia Sca2 is a bacterial formin-like mediator of actin-based motility. Nat Cell Biol. 2010 Nov; 12(11):1057-63. PMID: 20972427; PMCID: PMC3136050.
      Citations: 86     Fields:    Translation:Cells
    62. Skau CT, Kovar DR. Fimbrin and tropomyosin competition regulates endocytosis and cytokinesis kinetics in fission yeast. Curr Biol. 2010 Aug 24; 20(16):1415-22. PMID: 20705466; PMCID: PMC2926155.
      Citations: 80     Fields:    Translation:AnimalsCells
    63. Rizvi SA, Liu S, Chen Z, Skau C, Pytynia M, Kovar DR, Chmura SJ, Kozmin SA. Rationally simplified bistramide analog reversibly targets actin polymerization and inhibits cancer progression in vitro and in vivo. J Am Chem Soc. 2010 Jun 02; 132(21):7288-90. PMID: 20455580.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    64. Rizvi SA, Neidt EM, Cui J, Feiger Z, Skau CT, Gardel ML, Kozmin SA, Kovar DR. Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. Chem Biol. 2009 Nov 25; 16(11):1158-68. PMID: 19942139; PMCID: PMC2784894.
      Citations: 202     Fields:    Translation:HumansAnimalsCells
    65. Skau CT, Neidt EM, Kovar DR. Role of tropomyosin in formin-mediated contractile ring assembly in fission yeast. Mol Biol Cell. 2009 Apr; 20(8):2160-73. PMID: 19244341; PMCID: PMC2669024.
      Citations: 48     Fields:    Translation:AnimalsCells
    66. Ezezika OC, Younger NS, Lu J, Kaiser DA, Corbin ZA, Nolen BJ, Kovar DR, Pollard TD. Incompatibility with formin Cdc12p prevents human profilin from substituting for fission yeast profilin: insights from crystal structures of fission yeast profilin. J Biol Chem. 2009 Jan 23; 284(4):2088-97. PMID: 19028693; PMCID: PMC2629104.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    67. Neidt EM, Scott BJ, Kovar DR. Formin differentially utilizes profilin isoforms to rapidly assemble actin filaments. J Biol Chem. 2009 Jan 02; 284(1):673-684. PMID: 18978356.
      Citations: 37     Fields:    Translation:AnimalsCells
    68. Neidt EM, Skau CT, Kovar DR. The cytokinesis formins from the nematode worm and fission yeast differentially mediate actin filament assembly. J Biol Chem. 2008 Aug 29; 283(35):23872-83. PMID: 18577519; PMCID: PMC2527105.
      Citations: 44     Fields:    Translation:AnimalsCells
    69. Kovar DR. Intracellular motility: myosin and tropomyosin in actin cable flow. Curr Biol. 2007 Apr 03; 17(7):R244-7. PMID: 17407753.
      Citations: 4     Fields:    Translation:Animals
    70. Blanchoin L, Kovar DR, Martiel JL, Berro J, Michelot A. Attachment conditions control actin filament buckling and the production of forces. Biophys J. 2007 Apr 01; 92(7):2546-58. PMID: 17208983; PMCID: PMC1864840.
      Citations: 23     Fields:    Translation:Cells
    71. Kovar DR. Arp2/3 ATP hydrolysis: to branch or to debranch? Nat Cell Biol. 2006 Aug; 8(8):783-5. PMID: 16880808.
      Citations: 3     Fields:    Translation:AnimalsCells
    72. Kovar DR. Cell polarity: formin on the move. Curr Biol. 2006 Jul 25; 16(14):R535-8. PMID: 16860728.
      Citations: 6     Fields:    Translation:AnimalsCells
    73. Wu JQ, Sirotkin V, Kovar DR, Lord M, Beltzner CC, Kuhn JR, Pollard TD. Assembly of the cytokinetic contractile ring from a broad band of nodes in fission yeast. J Cell Biol. 2006 Jul 31; 174(3):391-402. PMID: 16864655; PMCID: PMC2064235.
      Citations: 161     Fields:    Translation:Animals
    74. Moseley JB, Okada K, Balcer HI, Kovar DR, Pollard TD, Goode BL. Twinfilin is an actin-filament-severing protein and promotes rapid turnover of actin structures in vivo. J Cell Sci. 2006 Apr 15; 119(Pt 8):1547-57. PMID: 16569665.
      Citations: 41     Fields:    Translation:AnimalsCells
    75. Vavylonis D, Kovar DR, O'Shaughnessy B, Pollard TD. Model of formin-associated actin filament elongation. Mol Cell. 2006 Feb 17; 21(4):455-66. PMID: 16483928; PMCID: PMC3716371.
      Citations: 98     Fields:    Translation:AnimalsCells
    76. Kovar DR, Harris ES, Mahaffy R, Higgs HN, Pollard TD. Control of the assembly of ATP- and ADP-actin by formins and profilin. Cell. 2006 Jan 27; 124(2):423-35. PMID: 16439214.
      Citations: 295     Fields:    Translation:Animals
    77. Kovar DR. Molecular details of formin-mediated actin assembly. Curr Opin Cell Biol. 2006 Feb; 18(1):11-7. PMID: 16364624.
      Citations: 102     Fields:    Translation:AnimalsCells
    78. Kovar DR, Wu JQ, Pollard TD. Profilin-mediated competition between capping protein and formin Cdc12p during cytokinesis in fission yeast. Mol Biol Cell. 2005 May; 16(5):2313-24. PMID: 15743909; PMCID: PMC1087237.
      Citations: 67     Fields:    Translation:AnimalsCells
    79. Kovar DR, Pollard TD. Progressing actin: Formin as a processive elongation machine. Nat Cell Biol. 2004 Dec; 6(12):1158-9. PMID: 15573095.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    80. Preuss ML, Kovar DR, Lee YR, Staiger CJ, Delmer DP, Liu B. A plant-specific kinesin binds to actin microfilaments and interacts with cortical microtubules in cotton fibers. Plant Physiol. 2004 Dec; 136(4):3945-55. PMID: 15557092; PMCID: PMC535827.
      Citations: 54     Fields:    Translation:AnimalsCells
    81. Kovar DR, Pollard TD. Insertional assembly of actin filament barbed ends in association with formins produces piconewton forces. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14725-30. PMID: 15377785; PMCID: PMC522035.
      Citations: 204     Fields:    Translation:AnimalsCells
    82. Klein MG, Shi W, Ramagopal U, Tseng Y, Wirtz D, Kovar DR, Staiger CJ, Almo SC. Structure of the actin crosslinking core of fimbrin. Structure. 2004 Jun; 12(6):999-1013. PMID: 15274920.
      Citations: 47     Fields:    Translation:AnimalsCells
    83. Wu JQ, Kuhn JR, Kovar DR, Pollard TD. Spatial and temporal pathway for assembly and constriction of the contractile ring in fission yeast cytokinesis. Dev Cell. 2003 Nov; 5(5):723-34. PMID: 14602073.
      Citations: 219     Fields:    Translation:AnimalsCells
    84. Huang S, Blanchoin L, Kovar DR, Staiger CJ. Arabidopsis capping protein (AtCP) is a heterodimer that regulates assembly at the barbed ends of actin filaments. J Biol Chem. 2003 Nov 07; 278(45):44832-42. PMID: 12947123.
      Citations: 49     Fields:    Translation:AnimalsCells
    85. Kovar DR, Kuhn JR, Tichy AL, Pollard TD. The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin. J Cell Biol. 2003 Jun 09; 161(5):875-87. PMID: 12796476; PMCID: PMC2172974.
      Citations: 171     Fields:    Translation:AnimalsCells
    86. Snowman BN, Kovar DR, Shevchenko G, Franklin-Tong VE, Staiger CJ, Snowman BN, Kovar DR, Shevchenko G, Franklin-Tong VE, Staiger CJ. Signal-mediated depolymerization of actin in pollen during the self-incompatibility response. Plant Cell. 2002 Oct; 14(10):2613-26. PMID: 12368508; PMCID: PMC151239.
      Citations: 75     Fields:    Translation:AnimalsCells
    87. Kovar DR, Yang P, Sale WS, Drobak BK, Staiger CJ. Chlamydomonas reinhardtii produces a profilin with unusual biochemical properties. J Cell Sci. 2001 Dec; 114(Pt 23):4293-305. PMID: 11739661.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    88. Kovar DR, Collings DA, Staiger CJ, Kovar DR, Collings DA, Staiger CJ. The characterization of ligand-specific maize (Zea mays) profilin mutants. Biochem J. 2001 Aug 15; 358(Pt 1):49-57. PMID: 11485551; PMCID: PMC1222031.
      Citations: 11     Fields:    Translation:AnimalsCells
    89. Kovar DR, Gibbon BC, McCurdy DW, Staiger CJ, Kovar DR, Gibbon BC, McCurdy DW, Staiger CJ. Fluorescently-labeled fimbrin decorates a dynamic actin filament network in live plant cells. Planta. 2001 Jul; 213(3):390-5. PMID: 11506361.
      Citations: 18     Fields:    Translation:AnimalsCells
    90. McCurdy DW, Kovar DR, Staiger CJ. Actin and actin-binding proteins in higher plants. Protoplasma. 2001; 215(1-4):89-104. PMID: 11732068.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    91. Kovar DR, Staiger CJ, Weaver EA, McCurdy DW. AtFim1 is an actin filament crosslinking protein from Arabidopsis thaliana. Plant J. 2000 Dec; 24(5):625-36. PMID: 11123801.
      Citations: 52     Fields:    Translation:AnimalsCells
    92. Hu S, Brady SR, Kovar DR, Staiger CJ, Clark GB, Roux SJ, Muday GK. Technical advance: identification of plant actin-binding proteins by F-actin affinity chromatography. Plant J. 2000 Oct; 24(1):127-37. PMID: 11029710.
      Citations: 20     Fields:    Translation:AnimalsCells
    93. Kovar DR, Staiger CJ, Drøbak BK. Maize profilin isoforms are functionally distinct. Plant Cell. 2000 Apr; 12(4):583-98. PMID: 10760246; PMCID: PMC139855.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    94. Schobert C, Gottschalk M, Kovar DR, Staiger CJ, Yoo BC, Lucas WJ. Characterization of Ricinus communis phloem profilin, RcPRO1. Plant Mol Biol. 2000 Mar; 42(5):719-30. PMID: 10809444.
      Citations: 9     Fields:    Translation:AnimalsCells
    95. Gibbon BC, Kovar DR, Staiger CJ. Latrunculin B has different effects on pollen germination and tube growth. Plant Cell. 1999 Dec; 11(12):2349-63. PMID: 10590163; PMCID: PMC144132.
      Citations: 153     Fields:    Translation:AnimalsCells
    96. Gibbon BC, Zonia LE, Kovar DR, Hussey PJ, Staiger CJ. Pollen profilin function depends on interaction with proline-rich motifs. Plant Cell. 1998 Jun; 10(6):981-93. PMID: 9634586; PMCID: PMC144034.
      Citations: 36     Fields:    Translation:AnimalsCells
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