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Aaron Turkewitz

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMolecular Genetics and Cell Biology
AddressChicago IL 60637
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    Collapse Overview 
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    A network of membrane-bound organelles, interconnected by dynamic vesicular traffic, is a defining hallmark of eukaryotes. Our laboratory studies membrane traffic in the ciliate Tetrahymena thermophila. Our interest in these cells stems from the fact that Tetrahymena is unicellular and offers a host of experimental advantages; the individual cells are remarkably complex and include features that are usually associated with animal cells but absent in fungi. For example, ciliates have a prominent pathway for regulated secretion of polypeptides from specialized vesicles resembling dense core granules. This is in spite of the fact that ciliates are far more distantly related to animals than are most organisms, including yeast, that are commonly studied by cell biologists. We use genetic, cell biological, informatics and biochemical approaches to dissect this and other pathways of membrane trafficking in these remarkable cells.
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    Collapse Biography 
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    Harvard University, Cambridge, MAPh.D06/1988Biochemistry and Molecular Biology
    UCSF, San Francisco, CA06/1992Cell Biology

    Collapse Research 
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    R01GM105783     (TURKEWITZ, AARON P)May 1, 2014 - Mar 31, 2024
    NIH
    Mechanisms of tether function in endolysosomal trafficking - Renewal - Resubmission 01
    Role: Principal Investigator
    R13HD076526     (COLE, ERIC S.)Mar 1, 2013 - Feb 28, 2014
    NIH
    FASEB SRC on Ciliate Molecular Biology
    Role: Co-Principal Investigator
    R03MH094953     (TURKEWITZ, AARON P)Apr 1, 2012 - Mar 31, 2014
    NIH
    Dissecting neuropeptide secretion via genome sequencing of Tetrahymena mutants
    Role: Principal Investigator
    R01GM077607     (TURKEWITZ, AARON P)Sep 1, 2006 - Aug 31, 2011
    NIH
    Biogenesis of Dense Core Secretory Granules in Tetrahymena
    Role: Principal Investigator
    R01GM059268     (TURKEWITZ, AARON P)Feb 1, 2000 - Jan 31, 2005
    NIH
    FUNCTIONAL ANALYSIS OF CALCIUM STORES IN TETRAHYMENA
    Role: Principal Investigator
    R01GM050946     (TURKEWITZ, AARON P)May 1, 1994 - Apr 30, 2003
    NIH
    MECHANISMS OF REGULATED EXOCYTOSIS IN TETRAHYMENA
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cheng CY, Romero DP, Zoltner M, Yao MC, Turkewitz AP. Structure and dynamics of the contractile vacuole complex in Tetrahymena thermophila. J Cell Sci. 2023 11 15; 136(22). PMID: 37902010; PMCID: PMC10729820.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Cheng CY, Hernández J, Turkewitz AP. VPS8D, a CORVET subunit, is required to maintain the contractile vacuole complex in Tetrahymena thermophila. bioRxiv. 2023 Nov 08. PMID: 37986963; PMCID: PMC10659352.
      Citations:    
    3. Kumar Mageswaran S, Tsypin LM, Theveny L, Striepen B, Turkewitz AP, Chang YW, Sparvoli D, Delabre J, Penarete-Vargas DM, Heckendorn J, Maynadier M, Mendonça Cova M, Berry-Sterkers L, Guérin A, Dubremetz JF, Urbach S, Lebrun M. An apical membrane complex for triggering rhoptry exocytosis and invasion in Toxoplasma. EMBO J. 2022 11 17; 41(22):e111158. PMID: 36245278; PMCID: PMC9670195.
      Citations: 14     Fields:    Translation:AnimalsCells
    4. Kuppannan A, Jiang YY, Maier W, Liu C, Lang CF, Cheng CY, Field MC, Zhao M, Zoltner M, Turkewitz AP. A novel membrane complex is required for docking and regulated exocytosis of lysosome-related organelles in Tetrahymena thermophila. PLoS Genet. 2022 05; 18(5):e1010194. PMID: 35587496; PMCID: PMC9159632.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Mageswaran SK, Striepen B, Chang YW, Turkewitz AP, Aquilini E, Cova MM, Dos Santos Pacheco N, Sparvoli D, Penarete-Vargas DM, Najm R, Graindorge A, Suarez C, Maynadier M, Berry-Sterkers L, Urbach S, Fahy PR, Guérin AN, Dubremetz JF, Lebrun M. An Alveolata secretory machinery adapted to parasite host cell invasion. Nat Microbiol. 2021 04; 6(4):425-434. PMID: 33495622; PMCID: PMC8886610.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    6. Casler JC, Zajac AL, Valbuena FM, Sparvoli D, Jeyifous O, Turkewitz AP, Horne-Badovinac S, Green WN, Glick BS. ESCargo: a regulatable fluorescent secretory cargo for diverse model organisms. Mol Biol Cell. 2020 12 15; 31(26):2892-2903. PMID: 33112725; PMCID: PMC7927198.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    7. Cheng CY, Orias E, Leu JY, Turkewitz AP. The evolution of germ-soma nuclear differentiation in eukaryotic unicells. Curr Biol. 2020 05 18; 30(10):R502-R510. PMID: 32428490.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    8. Nisbet RER, Casacuberta E, Sudek L, Allen AE, Ares M, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Breglia SA, Brownlee C, Cerutti H, Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Freire-Beneitez V, Freyria NJ, Fukuda K, Girguis PR, Gomaa F, Gornik SG, Guo J, Hanawa Y, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Fujimura-Kamada K, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z, Lin S, Luan F, Maruyama S, Miceli C, Minagawa J, Moosburner M, Nanjappa D, Nimmo IC, Noble L, Nowacki M, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Faktorová D, Fernández Robledo JA, Aresté C, Bouget FY, Bowler C, Burger G, Elustondo PA, Federici F, García PA, Hampl V, Ibañez J, Kachale A, Kaur B, Lozano JC, Matute T, Najle SR, Novák Vanclová AMG, Nuñez I, Ruaud A, Ruiz-Trillo I, Turnšek J, Valach M, Vergé V, von Dassow P, Lukeš J. Publisher Correction: Genetic tool development in marine protists: emerging model organisms for experimental cell biology. Nat Methods. 2020 05; 17(5):551. PMID: 32296171; PMCID: PMC7200595.
      Citations:    Fields:    
    9. Nisbet RER, Casacuberta E, Sudek L, Allen AE, Ares M, Balestreri C, Barbrook AC, Beardslee P, Bender S, Booth DS, Breglia SA, Brownlee C, Cerutti H, Cesaroni R, Chiurillo MA, Clemente T, Coles DB, Collier JL, Cooney EC, Coyne K, Docampo R, Dupont CL, Edgcomb V, Einarsson E, Freire-Beneitez V, Freyria NJ, Fukuda K, Girguis PR, Gomaa F, Gornik SG, Guo J, Hanawa Y, Haro-Contreras ER, Hehenberger E, Highfield A, Hirakawa Y, Hopes A, Howe CJ, Hu I, Irwin NAT, Ishii Y, Janowicz NE, Jones AC, Fujimura-Kamada K, Kaye JZ, Kazana E, Keeling PJ, King N, Klobutcher LA, Lander N, Lassadi I, Li Z, Lin S, Luan F, Maruyama S, Miceli C, Minagawa J, Moosburner M, Nanjappa D, Nimmo IC, Noble L, Nowacki M, Pain A, Piersanti A, Pucciarelli S, Pyrih J, Rest JS, Rius M, Robertson D, Sigg MA, Silver PA, Slamovits CH, Jason Smith G, Sprecher BN, Stern R, Swart EC, Tsaousis AD, Tsypin L, Turkewitz A, von der Haar T, Waller RF, Wang L, Wen X, Wheeler G, Woods A, Zhang H, Mock T, Worden AZ, Faktorová D, Fernández Robledo JA, Aresté C, Bouget FY, Bowler C, Burger G, Elustondo PA, Federici F, García PA, Hampl V, Ibañez J, Kachale A, Kaur B, Lozano JC, Matute T, Najle SR, Novák Vanclová AMG, Nuñez I, Ruaud A, Ruiz-Trillo I, Turnšek J, Valach M, Vergé V, von Dassow P, Lukeš J. Genetic tool development in marine protists: emerging model organisms for experimental cell biology. Nat Methods. 2020 05; 17(5):481-494. PMID: 32251396; PMCID: PMC7200600.
      Citations: 44     Fields:    Translation:Animals
    10. Sparvoli D, Zoltner M, Cheng CY, Field MC, Turkewitz AP. Diversification of CORVET tethers facilitates transport complexity in Tetrahymena thermophila. J Cell Sci. 2020 02 12; 133(3). PMID: 31964712; PMCID: PMC7033735.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Sparvoli D, Zoltner M, Cheng CY, Field MC, Turkewitz A. Diversification of CORVET tethers facilitates transport complexity in Tetrahymena thermophila. J Cell Sci. 2020 Jan 01. PMID: 34005156.
      Citations:    
    12. Luo GZ, Hao Z, Luo L, Shen M, Sparvoli D, Zheng Y, Zhang Z, Weng X, Chen K, Cui Q, Turkewitz AP, He C. N6-methyldeoxyadenosine directs nucleosome positioning in Tetrahymena DNA. Genome Biol. 2018 11 19; 19(1):200. PMID: 30454035; PMCID: PMC6245762.
      Citations: 33     Fields:    Translation:AnimalsCells
    13. Sparvoli D, Richardson E, Osakada H, Lan X, Iwamoto M, Bowman GR, Kontur C, Bourland WA, Lynn DH, Pritchard JK, Haraguchi T, Dacks JB, Turkewitz AP. Remodeling the Specificity of an Endosomal CORVET Tether Underlies Formation of Regulated Secretory Vesicles in the Ciliate Tetrahymena thermophila. Curr Biol. 2018 03 05; 28(5):697-710.e13. PMID: 29478853; PMCID: PMC5840023.
      Citations: 11     Fields:    Translation:AnimalsCells
    14. Turkewitz AP, de Francisco P, Martín-González A, Gutiérrez JC. Extreme metal adapted, knockout and knockdown strains reveal a coordinated gene expression among different Tetrahymena thermophila metallothionein isoforms. PLoS One. 2017; 12(12):e0189076. PMID: 29206858; PMCID: PMC5716537.
      Citations: 12     Fields:    Translation:Animals
    15. Tsypin LM, Turkewitz AP. The Co-regulation Data Harvester: automating gene annotation starting from a transcriptome database. SoftwareX. 2017; 6:165-171. PMID: 29104906; PMCID: PMC5663188.
      Citations: 2     
    16. Kaur H, Sparvoli D, Osakada H, Iwamoto M, Haraguchi T, Turkewitz AP. An endosomal syntaxin and the AP-3 complex are required for formation and maturation of candidate lysosome-related secretory organelles (mucocysts) in Tetrahymena thermophila. Mol Biol Cell. 2017 Jun 01; 28(11):1551-1564. PMID: 28381425; PMCID: PMC5449153.
      Citations: 8     Fields:    Translation:AnimalsCells
    17. Guerrier S, Plattner H, Richardson E, Dacks JB, Turkewitz AP. An evolutionary balance: conservation vs innovation in ciliate membrane trafficking. Traffic. 2017 01; 18(1):18-28. PMID: 27696651; PMCID: PMC5182178.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    18. Kontur C, Kumar S, Lan X, Pritchard JK, Turkewitz AP. Whole Genome Sequencing Identifies a Novel Factor Required for Secretory Granule Maturation in Tetrahymena thermophila. G3 (Bethesda). 2016 08 09; 6(8):2505-16. PMID: 27317773; PMCID: PMC4978903.
      Citations: 7     Fields:    Translation:AnimalsCells
    19. Klinger CM, Ramirez-Macias I, Herman EK, Turkewitz AP, Field MC, Dacks JB. Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology. Mol Biochem Parasitol. 2016 Sep - Oct; 209(1-2):88-103. PMID: 27444378; PMCID: PMC5140719.
      Citations: 11     Fields:    Translation:AnimalsCells
    20. Kumar S, Briguglio JS, Turkewitz AP. Secretion of Polypeptide Crystals from Tetrahymena thermophila Secretory Organelles (Mucocysts) Depends on Processing by a Cysteine Cathepsin, Cth4p. Eukaryot Cell. 2015 Aug; 14(8):817-33. PMID: 26092918; PMCID: PMC4519746.
      Citations: 7     Fields:    Translation:AnimalsCells
    21. Lynch M, Field MC, Goodson HV, Malik HS, Roos DS, Turkewitz AP, Sazer S, Pereira-Leal JB. Evolutionary cell biology: two origins, one objective. Proc Natl Acad Sci U S A. 2014 Dec 02; 111(48):16990-4. PMID: 25404324; PMCID: PMC4260604.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    22. Kumar S, Briguglio JS, Turkewitz AP. An aspartyl cathepsin, CTH3, is essential for proprotein processing during secretory granule maturation in Tetrahymena thermophila. Mol Biol Cell. 2014 Aug 15; 25(16):2444-60. PMID: 24943840; PMCID: PMC4142616.
      Citations: 9     Fields:    Translation:AnimalsCells
    23. Briguglio JS, Turkewitz AP. Tetrahymena thermophila: a divergent perspective on membrane traffic. J Exp Zool B Mol Dev Evol. 2014 Nov; 322(7):500-16. PMID: 24634411; PMCID: PMC4719778.
      Citations: 6     Fields:    Translation:AnimalsCells
    24. Turkewitz AP, Amaro F, Martín-González A, Gutiérrez JC. Functional GFP-metallothionein fusion protein from Tetrahymena thermophila: a potential whole-cell biosensor for monitoring heavy metal pollution and a cell model to study metallothionein overproduction effects. Biometals. 2014 Feb; 27(1):195-205. PMID: 24430977; PMCID: PMC4707044.
      Citations: 12     Fields:    Translation:AnimalsCells
    25. Briguglio JS, Kumar S, Turkewitz AP. Lysosomal sorting receptors are essential for secretory granule biogenesis in Tetrahymena. J Cell Biol. 2013 Nov 11; 203(3):537-50. PMID: 24189272; PMCID: PMC3824020.
      Citations: 26     Fields:    Translation:AnimalsCells
    26. Katz LA, Turkewitz AP. Stalking the wild Tetrahymena. Mol Ecol. 2013 Feb; 22(4):912-4. PMID: 23476937.
      Citations:    Fields:    Translation:Animals
    27. Rinaldi MA, Tomazic ML, Favale NO, Turkewitz AP, Nudel CB, Nusblat AD, Poklepovich TJ. The cytochrome b5 dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae. Steroids. 2012 Nov; 77(13):1313-20. PMID: 22982564; PMCID: PMC3501532.
      Citations: 7     Fields:    Translation:AnimalsCells
    28. Bright LJ, Turkewitz AP, Nusblat AD. Conservation and innovation in Tetrahymena membrane traffic: proteins, lipids, and compartments. Methods Cell Biol. 2012; 109:141-75. PMID: 22444145; PMCID: PMC4711351.
      Citations: 13     Fields:    Translation:AnimalsCells
    29. Turkewitz AP, Bright LJ. A Rab-based view of membrane traffic in the ciliate Tetrahymena thermophila. Small GTPases. 2011 Jul; 2(4):222-226. PMID: 22145095; PMCID: PMC3225912.
      Citations: 7     Fields:    
    30. Turkewitz AP, Amaro F, Martín-González A, Gutiérrez JC. Whole-cell biosensors for detection of heavy metal ions in environmental samples based on metallothionein promoters from Tetrahymena thermophila. Microb Biotechnol. 2011 Jul; 4(4):513-22. PMID: 21366892; PMCID: PMC3815263.
      Citations: 18     Fields:    Translation:AnimalsCells
    31. Bright LJ, Kambesis N, Nelson SB, Jeong B, Turkewitz AP. Comprehensive analysis reveals dynamic and evolutionary plasticity of Rab GTPases and membrane traffic in Tetrahymena thermophila. PLoS Genet. 2010 Oct 14; 6(10):e1001155. PMID: 20976245; PMCID: PMC2954822.
      Citations: 33     Fields:    Translation:AnimalsCells
    32. Rahaman A, Miao W, Turkewitz AP. Independent transport and sorting of functionally distinct protein families in Tetrahymena thermophila dense core secretory granules. Eukaryot Cell. 2009 Oct; 8(10):1575-83. PMID: 19684282; PMCID: PMC2756869.
      Citations: 11     Fields:    Translation:AnimalsCells
    33. Rahaman A, Elde NC, Turkewitz AP. A dynamin-related protein required for nuclear remodeling in Tetrahymena. Curr Biol. 2008 Aug 26; 18(16):1227-33. PMID: 18701286; PMCID: PMC2562171.
      Citations: 16     Fields:    Translation:Animals
    34. Elde NC, Long M, Turkewitz AP. A role for convergent evolution in the secretory life of cells. Trends Cell Biol. 2007 Apr; 17(4):157-64. PMID: 17329106.
      Citations: 12     Fields:    Translation:AnimalsCells
    35. Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA, Krieger CJ, del Toro C, Ryder HF, Williamson SC, Barbeau RA, Hamilton EP, Orias E. Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol. 2006 Sep; 4(9):e286. PMID: 16933976; PMCID: PMC1557398.
      Citations: 340     Fields:    Translation:AnimalsCells
    36. Elde NC, Morgan G, Winey M, Sperling L, Turkewitz AP. Elucidation of clathrin-mediated endocytosis in tetrahymena reveals an evolutionarily convergent recruitment of dynamin. PLoS Genet. 2005 Nov; 1(5):e52. PMID: 16276403; PMCID: PMC1277907.
      Citations: 56     Fields:    Translation:Animals
    37. Bowman GR, Smith DG, Michael Siu KW, Pearlman RE, Turkewitz AP. Genomic and proteomic evidence for a second family of dense core granule cargo proteins in Tetrahymena thermophila. J Eukaryot Microbiol. 2005 Jul-Aug; 52(4):291-7. PMID: 16014006.
      Citations: 16     Fields:    Translation:AnimalsCells
    38. Cowan AT, Bowman GR, Edwards KF, Emerson JJ, Turkewitz AP. Genetic, genomic, and functional analysis of the granule lattice proteins in Tetrahymena secretory granules. Mol Biol Cell. 2005 Sep; 16(9):4046-60. PMID: 15958493; PMCID: PMC1196318.
      Citations: 17     Fields:    Translation:AnimalsCells
    39. Bowman GR, Elde NC, Morgan G, Winey M, Turkewitz AP. Core formation and the acquisition of fusion competence are linked during secretory granule maturation in Tetrahymena. Traffic. 2005 Apr; 6(4):303-23. PMID: 15752136; PMCID: PMC4708285.
      Citations: 16     Fields:    Translation:AnimalsCells
    40. Turkewitz AP. Out with a bang! Tetrahymena as a model system to study secretory granule biogenesis. Traffic. 2004 Feb; 5(2):63-8. PMID: 14690495.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    41. Bradshaw NR, Chilcoat ND, Verbsky JW, Turkewitz AP. Proprotein processing within secretory dense core granules of Tetrahymena thermophila. J Biol Chem. 2003 Feb 07; 278(6):4087-95. PMID: 12435750.
      Citations: 7     Fields:    Translation:AnimalsCells
    42. Haddad A, Bowman GR, Turkewitz AP. New class of cargo protein in Tetrahymena thermophila dense core secretory granules. Eukaryot Cell. 2002 Aug; 1(4):583-93. PMID: 12456006; PMCID: PMC117993.
      Citations: 10     Fields:    Translation:AnimalsCells
    43. Fillingham JS, Chilcoat ND, Turkewitz AP, Orias E, Reith M, Pearlman RE. Analysis of expressed sequence tags (ESTs) in the ciliated protozoan Tetrahymena thermophila. J Eukaryot Microbiol. 2002 Mar-Apr; 49(2):99-107. PMID: 12043965.
      Citations: 13     Fields:    Translation:HumansAnimals
    44. Turkewitz AP, Orias E, Kapler G. Functional genomics: the coming of age for Tetrahymena thermophila. Trends Genet. 2002 Jan; 18(1):35-40. PMID: 11750699.
      Citations: 38     Fields:    Translation:Animals
    45. Bowman GR, Turkewitz AP. Analysis of a mutant exhibiting conditional sorting to dense core secretory granules in Tetrahymena thermophila. Genetics. 2001 Dec; 159(4):1605-16. PMID: 11779800; PMCID: PMC1461923.
      Citations: 20     Fields:    Translation:AnimalsCells
    46. Chilcoat ND, Elde NC, Turkewitz AP. An antisense approach to phenotype-based gene cloning in Tetrahymena. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8709-13. PMID: 11438705; PMCID: PMC37500.
      Citations: 12     Fields:    Translation:AnimalsCells
    47. Turkewitz AP, Chilcoat ND, Haddad A, Verbsky JW. Regulated protein secretion in Tetrahymena thermophila. Methods Cell Biol. 2000; 62:347-62. PMID: 10503203.
      Citations: 5     Fields:    Translation:Animals
    48. Verbsky JW, Turkewitz AP. Proteolytic processing and Ca2+-binding activity of dense-core vesicle polypeptides in Tetrahymena. Mol Biol Cell. 1998 Feb; 9(2):497-511. PMID: 9450970; PMCID: PMC25279.
      Citations: 17     Fields:    Translation:AnimalsCells
    49. Melia SM, Cole ES, Turkewitz AP. Mutational analysis of regulated exocytosis in Tetrahymena. J Cell Sci. 1998 Jan; 111 ( Pt 1):131-40. PMID: 9394019.
      Citations: 18     Fields:    Translation:AnimalsCells
    50. Chilcoat ND, Turkewitz AP. In vivo analysis of the major exocytosis-sensitive phosphoprotein in Tetrahymena. J Cell Biol. 1997 Dec 01; 139(5):1197-207. PMID: 9382866; PMCID: PMC2140215.
      Citations: 8     Fields:    Translation:AnimalsCells
    51. Haddad A, Turkewitz AP. Analysis of exocytosis mutants indicates close coupling between regulated secretion and transcription activation in Tetrahymena. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10675-80. PMID: 9380694; PMCID: PMC23444.
      Citations: 14     Fields:    Translation:AnimalsCells
    52. Chilcoat ND, Melia SM, Haddad A, Turkewitz AP. Granule lattice protein 1 (Grl1p), an acidic, calcium-binding protein in Tetrahymena thermophila dense-core secretory granules, influences granule size, shape, content organization, and release but not protein sorting or condensation. J Cell Biol. 1996 Dec; 135(6 Pt 2):1775-87. PMID: 8991090; PMCID: PMC2133959.
      Citations: 27     Fields:    Translation:AnimalsCells
    53. Turkewitz AP, Kelly RB. Immunocytochemical analysis of secretion mutants of Tetrahymena using a mucocyst-specific monoclonal antibody. Dev Genet. 1992; 13(2):151-9. PMID: 1499156.
      Citations: 10     Fields:    Translation:AnimalsCells
    54. Turkewitz AP, Madeddu L, Kelly RB. Maturation of dense core granules in wild type and mutant Tetrahymena thermophila. EMBO J. 1991 Aug; 10(8):1979-87. PMID: 2065648; PMCID: PMC452877.
      Citations: 29     Fields:    Translation:AnimalsCells
    55. Turkewitz AP, Harrison SC. Concentration of transferrin receptor in human placental coated vesicles. J Cell Biol. 1989 Jun; 108(6):2127-35. PMID: 2567737; PMCID: PMC2115582.
      Citations: 4     Fields:    Translation:HumansCells
    56. Turkewitz AP, Schwartz AL, Harrison SC. A pH-dependent reversible conformational transition of the human transferrin receptor leads to self-association. J Biol Chem. 1988 Nov 05; 263(31):16309-15. PMID: 3182794.
      Citations: 14     Fields:    Translation:HumansCells
    57. Turkewitz AP, Amatruda JF, Borhani D, Harrison SC, Schwartz AL. A high yield purification of the human transferrin receptor and properties of its major extracellular fragment. J Biol Chem. 1988 Jun 15; 263(17):8318-25. PMID: 3372526.
      Citations: 19     Fields:    Translation:HumansCells
    58. Schwartz AL, Ciechanover A, Merritt S, Turkewitz A. Antibody-induced receptor loss. Different fates for asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells. J Biol Chem. 1986 Nov 15; 261(32):15225-32. PMID: 3021767.
      Citations: 13     Fields:    Translation:HumansCells
    59. Turkewitz AP, Sullivan CP, Mescher MF. Large-scale purification of murine I-Ak and I-Ek antigens and characterization of the purified proteins. Mol Immunol. 1983 Nov; 20(11):1139-47. PMID: 6581382.
      Citations: 8     Fields:    Translation:AnimalsCells
    60. Mescher MF, Stallcup KC, Sullivan CP, Turkewitz AP, Herrmann SH. Purification of murine MHC antigens by monoclonal antibody affinity chromatography. Methods Enzymol. 1983; 92:86-109. PMID: 6574303.
      Citations: 6     Fields:    Translation:HumansAnimals
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