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Elizabeth Grove

InstitutionUniversity of Chicago
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    Collapse Overview 
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    Determining the mechanisms of cerebral cortical development is essential to understanding the functions, disorders, and evolution of the brain. My research focuses on the embryonic and early postnatal development of cerebral cortex in the mouse. Specific questions include: how part of the embryonic neuroepithelium is divided, or “patterned” into the neocortex and hippocampus; how different hippocampal neuronal cell types are specified; and how a consistent map of functionally distinct areas is laid out in neocortex. To a developmental biologist the cerebral cortex may seem too complex a system for studies of tissue patterning and cell type specification. My lab, however, has contributed to a model in which the embryonic cortex is initially patterned by secreted signaling molecules, including Fibroblast Growth Factor (FGF) 8, and the Wnt protein, Wnt3a, together with downstream transcription factors, in much the same way as in the rest of the embryo. FGF8 disperses from an anterior source to establish the anterior to posterior (A/P) axis of the neocortical area map. Wnt3a influences the medial to lateral (M/L) axis and is also required for development of the hippocampus. Together, FGF8 and Wnt3a shape expression gradients of transcription factor genes that control the size and position of neocortical areas as well as hippocampal growth. This model is still incomplete. For example, how sharp area boundaries arise from graded gene expression is unclear. Classically, for this step, a mechanism specific to the nervous system is proposed, namely the growth of axons from the thalamus into the neocortex. Yet previous findings indicate that precise guidance cues lie within nascent neocortical areas. To identify area-specific axon guidance molecules, we plan to harvest in cells from a mouse in which sensory areas are marked by green fluorescence, and compare the transcriptomes of different areas using RNA-Seq. A major outstanding task is to determine if our model of cortical patterning, based on studies of the mouse, holds for larger, multi-folded (gyrencephalic) brains of carnivores and primates. Common features of the area map, conserved across mammals, suggest the model could generalize, and early evidence from a study of the gyrencephalic ferret supports this hypothesis.
    Methods: Candidate genes are identified and their function altered using mouse genetics and a fine-scale method of in utero microelectroporation that we pioneered. The cortical phenotype of mice in which gene function is altered is analyzed by area-specific gene and protein expression and connectivity, and occasionally by behavior. We discovered, for instance, that part of the hippocampus is shrunken in mice deficient in BMP signaling, and that these mice were "fearless" in situations that would normally induce anxiety, supporting a new view of hippocampal function. Cell type specific transcriptomes will be identified with single cell RNA-Seq.

    Collapse Biography 
    Collapse education and training
    Yale, New Haven, CtBA06/1977Philosophy
    M.I.T, Boston, MAPhD06/1987Neuroscience
    University College, London, London UKpostdoc01/1989Neurophysiology
    National Institute for Medical Research, Mill Hill, London,UKpostdoc12/1993Developmental Neurobiology
    Collapse awards and honors
    2003Special Lecture, Society for Neuroscience Annual Meeting, Society for Neuroscience
    2003 - 2008Associate Editor, Journal of Neuroscience
    2004 - 2014MERIT award from NIMH, NIMH
    2005Speaker in Director's Seminar Series, NIMH
    2010 - 2014Editorial Board, Journal of Comparative Neurology
    2011 - presBoard of Reviewing Editors, Science
    2013 - 2018Member, Faculty of 1000
    2017Krieg Cortical Kudos Discoverer Award, Contribution to Understanding Cortical Development, Cajal Club

    Collapse Research 
    Collapse research activities and funding
    R21MH119555     (GROVE, ELIZABETH ELIZABETH)Mar 1, 2019 - Jan 31, 2021
    Development of the neocortical area map
    Role: Principal Investigator

    R56DC016879     (GROVE, ELIZABETH ELIZABETH)Aug 6, 2018 - Jul 31, 2019
    Genetic Induction of the Olfactory Bulb and Regulation of Olfactory Axon Guidepost Cells
    Role: Principal Investigator

    R03NS101630     (GROVE, ELIZABETH ELIZABETH)Mar 1, 2017 - Feb 28, 2019
    Cortical control over area-specific thalamic input
    Role: Principal Investigator

    R21NS085679     (GROVE, ELIZABETH ANN)Sep 1, 2013 - Aug 31, 2016
    Specifying the Neocortical Area Map in the Ferret
    Role: Principal Investigator

    R01MH103211     (GROVE, ELIZABETH ELIZABETH)Feb 25, 2002 - Nov 30, 2018
    Molecular Mechanisms of Cerebral Cortical Patterning
    Role: Principal Investigator

    R01HD042330     (GROVE, ELIZABETH ANN)Feb 25, 2002 - Mar 31, 2012
    Molecular Mechanisms of Cerebral Cortical Patterning
    Role: Principal Investigator

    R37MH059962     (GROVE, ELIZABETH ANN)Jun 1, 1999 - Feb 28, 2014
    Role Of The Cortical Hem In Patterning The Telencephalon
    Role: Principal Investigator

    R01MH059962     (GROVE, ELIZABETH A)Jun 1, 1999 - May 31, 2004
    Role: Principal Investigator

    R29NS035622     (GROVE, ELIZABETH A)Jul 1, 1996 - Apr 30, 2002
    Role: Principal Investigator

    F32NS007966     (GROVE, ELIZABETH A)Sep 26, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jones WD, Guadiana SM, Grove EA. A model of neocortical area patterning in the lissencephalic mouse may hold for larger gyrencephalic brains. J Comp Neurol. 2019 05 15; 527(9):1461-1477. PMID: 30689213; PMCID: PMC6546435.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    2. Assimacopoulos S, Nan X, Roychoudhury K, Qin S, Zarkower D, Mallamaci A, Theil T, Campbell K, Li M, Grove EA, Desmaris E, Keruzore M, Saulnier A, Ratié L, De Clercq S, Kricha S, Chevalier C, Lingner T, Henningfeld KA, Pieler T, Bellefroid EJ. DMRT5, DMRT3, and EMX2 Cooperatively Repress Gsx2 at the Pallium-Subpallium Boundary to Maintain Cortical Identity in Dorsal Telencephalic Progenitors. J Neurosci. 2018 10 17; 38(42):9105-9121. PMID: 30143575; PMCID: PMC6191521.
      Citations: 13     Fields:    Translation:AnimalsCells
    3. Assimacopoulos S, Matson CK, Lee M, Nan X, Li M, Nakagawa Y, Hochepied T, Zarkower D, Grove EA, De Clercq S, Keruzore M, Desmaris E, Pollart C, Preillon J, Ascenzo S, Bellefroid EJ. DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation. Cereb Cortex. 2018 02 01; 28(2):493-509. PMID: 28031177; PMCID: PMC6059253.
      Citations: 17     Fields:    Translation:Animals
    4. Huilgol D, Grove EA, Tole S, Theil T, Ruiz-Reig N, Andrés B, Tissir F, Herrera E, Fairén A. Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells. Cereb Cortex. 2017 05 01; 27(5):2841-2856. PMID: 27178193; PMCID: PMC6248457.
      Citations: 15     Fields:    Translation:AnimalsCells
    5. Hirata T, Riethmacher D, Grove EA, Tissir F, de Frutos CA, Bouvier G, Arai Y, Thion MS, Lokmane L, Keita M, Garcia-Dominguez M, Charnay P, Casado M, Pierani A, Garel S. Reallocation of Olfactory Cajal-Retzius Cells Shapes Neocortex Architecture. Neuron. 2016 Oct 19; 92(2):435-448. PMID: 27693257.
      Citations: 20     Fields:    Translation:AnimalsCells
    6. Qu Y, Huang Y, Feng J, Alvarez-Bolado G, Grove EA, Yang Y, Tissir F, Zhou L, Goffinet AM. Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):E2996-3004. PMID: 25002511; PMCID: PMC4115502.
      Citations: 43     Fields:    Translation:AnimalsCells
    7. Caronia-Brown G, Yoshida M, Gulden F, Assimacopoulos S, Grove EA. The cortical hem regulates the size and patterning of neocortex. Development. 2014 Jul; 141(14):2855-65. PMID: 24948604; PMCID: PMC4197624.
      Citations: 34     Fields:    Translation:AnimalsCells
    8. Lokmane L, Chauvet S, Mailhes C, Keita M, Niquille M, Yoshida M, Yoshida Y, Mann F, Grove EA, Garel S, Deck M, Lebrand C. Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections. Neuron. 2013 Feb 06; 77(3):472-84. PMID: 23395374; PMCID: PMC3756696.
      Citations: 49     Fields:    Translation:AnimalsCells
    9. Assimacopoulos S, Kao T, Issa NP, Grove EA. Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography. J Neurosci. 2012 May 23; 32(21):7191-201. PMID: 22623663; PMCID: PMC3466079.
      Citations: 24     Fields:    Translation:Animals
    10. Pani AM, Mullarkey EE, Aronowicz J, Assimacopoulos S, Grove EA, Lowe CJ. Ancient deuterostome origins of vertebrate brain signalling centres. Nature. 2012 Mar 14; 483(7389):289-94. PMID: 22422262; PMCID: PMC3719855.
      Citations: 94     Fields:    Translation:AnimalsCells
    11. Rash BG, Grove EA. Shh and Gli3 regulate formation of the telencephalic-diencephalic junction and suppress an isthmus-like signaling source in the forebrain. Dev Biol. 2011 Nov 15; 359(2):242-50. PMID: 21925158; PMCID: PMC3213684.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    12. Grove EA. Wnt signaling meets internal dissent. Genes Dev. 2011 Sep 01; 25(17):1759-62. PMID: 21896652; PMCID: PMC3175712.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    13. Louvi A, Grove EA. Cilia in the CNS: the quiet organelle claims center stage. Neuron. 2011 Mar 24; 69(6):1046-60. PMID: 21435552; PMCID: PMC3070490.
      Citations: 125     Fields:    Translation:HumansAnimalsCells
    14. Toyoda R, Assimacopoulos S, Wilcoxon J, Taylor A, Feldman P, Suzuki-Hirano A, Shimogori T, Grove EA. FGF8 acts as a classic diffusible morphogen to pattern the neocortex. Development. 2010 Oct; 137(20):3439-48. PMID: 20843859; PMCID: PMC2947756.
      Citations: 55     Fields:    Translation:Animals
    15. Caronia-Brown G, Grove EA. Timing of cortical interneuron migration is influenced by the cortical hem. Cereb Cortex. 2011 Apr; 21(4):748-55. PMID: 20713502; PMCID: PMC3059882.
      Citations: 9     Fields:    Translation:AnimalsCells
    16. Caronia G, Wilcoxon J, Feldman P, Grove EA. Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior. J Neurosci. 2010 May 05; 30(18):6291-301. PMID: 20445055; PMCID: PMC2905858.
      Citations: 32     Fields:    Translation:AnimalsCells
    17. Grove EA. Turning neurons into a nervous system. Development. 2008 Jul; 135(13):2203-6. PMID: 18539920.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    18. Grove EA. Neuroscience. Organizing the source of memory. Science. 2008 Jan 18; 319(5861):288-9. PMID: 18202278.
      Citations: 6     Fields:    Translation:AnimalsCells
    19. Rash BG, Grove EA. Patterning the dorsal telencephalon: a role for sonic hedgehog? J Neurosci. 2007 Oct 24; 27(43):11595-603. PMID: 17959802; PMCID: PMC6673221.
      Citations: 49     Fields:    Translation:Animals
    20. Louvi A, Yoshida M, Grove EA. The derivatives of the Wnt3a lineage in the central nervous system. J Comp Neurol. 2007 Oct 10; 504(5):550-69. PMID: 17701978.
      Citations: 39     Fields:    Translation:Animals
    21. Yoshida M, Assimacopoulos S, Jones KR, Grove EA. Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order. Development. 2006 Feb; 133(3):537-45. PMID: 16410414.
      Citations: 108     Fields:    Translation:AnimalsCells
    22. Rash BG, Grove EA. Area and layer patterning in the developing cerebral cortex. Curr Opin Neurobiol. 2006 Feb; 16(1):25-34. PMID: 16426837.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    23. Grove EA. Local axon guidance in cerebral cortex and thalamus: are we there yet? Neuron. 2005 Nov 23; 48(4):522-4. PMID: 16301165.
      Citations: 1     Fields:    Translation:AnimalsCells
    24. Shimogori T, Grove EA. Fibroblast growth factor 8 regulates neocortical guidance of area-specific thalamic innervation. J Neurosci. 2005 Jul 13; 25(28):6550-60. PMID: 16014716; PMCID: PMC6725424.
      Citations: 44     Fields:    Translation:AnimalsCells
    25. Belmadani A, Tran PB, Ren D, Assimacopoulos S, Grove EA, Miller RJ. The chemokine stromal cell-derived factor-1 regulates the migration of sensory neuron progenitors. J Neurosci. 2005 Apr 20; 25(16):3995-4003. PMID: 15843601; PMCID: PMC4461238.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    26. Shimogori T, Banuchi V, Ng HY, Strauss JB, Grove EA. Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex. Development. 2004 Nov; 131(22):5639-47. PMID: 15509764.
      Citations: 115     Fields:    Translation:AnimalsCells
    27. Abu-Khalil A, Fu L, Grove EA, Zecevic N, Geschwind DH. Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning. J Comp Neurol. 2004 Jun 21; 474(2):276-88. PMID: 15164427.
      Citations: 38     Fields:    Translation:HumansAnimals
    28. Shimogori T, VanSant J, Paik E, Grove EA. Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex. J Comp Neurol. 2004 Jun 07; 473(4):496-510. PMID: 15116386.
      Citations: 65     Fields:    Translation:AnimalsCells
    29. Louvi A, Sisodia SS, Grove EA. Presenilin 1 in migration and morphogenesis in the central nervous system. Development. 2004 Jul; 131(13):3093-105. PMID: 15163631.
      Citations: 16     Fields:    Translation:AnimalsCells
    30. Fukuchi-Shimogori T, Grove EA. Emx2 patterns the neocortex by regulating FGF positional signaling. Nat Neurosci. 2003 Aug; 6(8):825-31. PMID: 12872126.
      Citations: 75     Fields:    Translation:AnimalsCells
    31. Assimacopoulos S, Grove EA, Ragsdale CW. Identification of a Pax6-dependent epidermal growth factor family signaling source at the lateral edge of the embryonic cerebral cortex. J Neurosci. 2003 Jul 23; 23(16):6399-403. PMID: 12878679; PMCID: PMC6740631.
      Citations: 62     Fields:    Translation:AnimalsCells
    32. McClintock JM, Jozefowicz C, Assimacopoulos S, Grove EA, Louvi A, Prince VE. Conserved expression of Hoxa1 in neurons at the ventral forebrain/midbrain boundary of vertebrates. Dev Genes Evol. 2003 Aug; 213(8):399-406. PMID: 12748854.
      Citations: 7     Fields:    Translation:AnimalsCells
    33. Ligon KL, Echelard Y, Assimacopoulos S, Danielian PS, Kaing S, Grove EA, McMahon AP, Rowitch DH. Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development. 2003 May; 130(10):2275-87. PMID: 12668639.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    34. Grove EA, Fukuchi-Shimogori T. Generating the cerebral cortical area map. Annu Rev Neurosci. 2003; 26:355-80. PMID: 14527269.
      Citations: 101     Fields:    Translation:AnimalsCells
    35. Grove E. The telencephalon saved by TLC. Neuron. 2002 Jul 18; 35(2):215-7. PMID: 12160739.
      Citations: 1     Fields:    Translation:AnimalsCells
    36. Lu M, Grove EA, Miller RJ. Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):7090-5. PMID: 11983855; PMCID: PMC124533.
      Citations: 164     Fields:    Translation:AnimalsCells
    37. Fukuchi-Shimogori T, Grove EA. Neocortex patterning by the secreted signaling molecule FGF8. Science. 2001 Nov 02; 294(5544):1071-4. PMID: 11567107.
      Citations: 259     Fields:    Translation:AnimalsCells
    38. Tole S, Grove EA. Detailed field pattern is intrinsic to the embryonic mouse hippocampus early in neurogenesis. J Neurosci. 2001 Mar 01; 21(5):1580-9. PMID: 11222648; PMCID: PMC6762964.
      Citations: 20     Fields:    Translation:AnimalsCells
    39. Ragsdale CW, Grove EA. Patterning the mammalian cerebral cortex. Curr Opin Neurobiol. 2001 Feb; 11(1):50-8. PMID: 11179872.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    40. Bulchand S, Grove EA, Porter FD, Tole S. LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem. Mech Dev. 2001 Feb; 100(2):165-75. PMID: 11165475.
      Citations: 75     Fields:    Translation:AnimalsCells
    41. Tole S, Goudreau G, Assimacopoulos S, Grove EA. Emx2 is required for growth of the hippocampus but not for hippocampal field specification. J Neurosci. 2000 Apr 01; 20(7):2618-25. PMID: 10729342; PMCID: PMC6772228.
      Citations: 18     Fields:    Translation:Animals
    42. Lee SM, Tole S, Grove E, McMahon AP. A local Wnt-3a signal is required for development of the mammalian hippocampus. Development. 2000 Feb; 127(3):457-67. PMID: 10631167.
      Citations: 222     Fields:    Translation:AnimalsCells
    43. Tole S, Ragsdale CW, Grove EA. Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev Biol. 2000 Jan 15; 217(2):254-65. PMID: 10625551.
      Citations: 58     Fields:    Translation:Animals
    44. Grove EA, Tole S. Patterning events and specification signals in the developing hippocampus. Cereb Cortex. 1999 Sep; 9(6):551-61. PMID: 10498273.
      Citations: 40     Fields:    Translation:AnimalsCells
    45. Grove EA, Tole S, Limon J, Yip L, Ragsdale CW. The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice. Development. 1998 Jun; 125(12):2315-25. PMID: 9584130.
      Citations: 215     Fields:    Translation:AnimalsCells
    46. Tole S, Christian C, Grove EA. Early specification and autonomous development of cortical fields in the mouse hippocampus. Development. 1997 Dec; 124(24):4959-70. PMID: 9362459.
      Citations: 40     Fields:    Translation:AnimalsCells
    47. Price J, Grove E, Williams B, Hajihosseini M, Iavachev L, McNaughton L, Götz M. Labelling neural precursor cells with retroviruses. Gene Ther. 1994; 1 Suppl 1:S4-5. PMID: 8542393.
      Citations: 1     Fields:    Translation:AnimalsCells
    48. Grove EA, Williams BP, Li DQ, Hajihosseini M, Friedrich A, Price J. Multiple restricted lineages in the embryonic rat cerebral cortex. Development. 1993 Feb; 117(2):553-61. PMID: 8330526.
      Citations: 30     Fields:    Translation:AnimalsCells
    49. Kirkwood TB, Price J, Grove EA. The dispersion of neuronal clones across the cerebral cortex. Science. 1992 Oct 09; 258(5080):317-20. PMID: 1411530.
      Citations: 6     Fields:    Translation:AnimalsCells
    50. Grove EA. Patterning the developing cerebral cortex. Curr Biol. 1992 Mar; 2(3):142-4. PMID: 15335990.
      Citations:    Fields:    
    51. Grove EA, Kirkwood TB, Price J. Neuronal precursor cells in the rat hippocampal formation contribute to more than one cytoarchitectonic area. Neuron. 1992 Feb; 8(2):217-29. PMID: 1739459.
      Citations: 8     Fields:    Translation:AnimalsCells
    52. Price J, Williams B, Grove E. The generation of cellular diversity in the cerebral cortex. Brain Pathol. 1992 Jan; 2(1):23-9. PMID: 1341944.
      Citations: 3     Fields:    Translation:AnimalsCells
    53. Price J, Williams B, Moore R, Read J, Grove E. Analysis of cell lineage in the rat cerebral cortex. Ann N Y Acad Sci. 1991; 633:56-63. PMID: 1789580.
      Citations:    Fields:    Translation:AnimalsCells
    54. Price J, Williams B, Grove E. Cell lineage in the cerebral cortex. Dev Suppl. 1991; Suppl 2:23-8. PMID: 1842355.
      Citations: 4     Fields:    Translation:AnimalsCells
    55. Grove EA. Neural associations of the substantia innominata in the rat: afferent connections. J Comp Neurol. 1988 Nov 15; 277(3):315-46. PMID: 2461972.
      Citations: 54     Fields:    Translation:AnimalsCells
    56. Grove EA. Efferent connections of the substantia innominata in the rat. J Comp Neurol. 1988 Nov 15; 277(3):347-64. PMID: 2461973.
      Citations: 43     Fields:    Translation:AnimalsCells
    57. Haber SN, Groenewegen HJ, Grove EA, Nauta WJ. Efferent connections of the ventral pallidum: evidence of a dual striato pallidofugal pathway. J Comp Neurol. 1985 May 15; 235(3):322-35. PMID: 3998213.
      Citations: 75     Fields:    Translation:Animals
    58. Davis HP, Rosenzweig MR, Grove EA, Bennett EL. Investigation of the reported protective effect of cycloheximide on memory. Pharmacol Biochem Behav. 1984 Mar; 20(3):405-13. PMID: 6709675.
      Citations: 1     Fields:    Translation:Animals
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