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Michael Z. Ludwig

TitleResearch Associate Professor
InstitutionUniversity of Chicago
DepartmentEcology and Evolution
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wu C, Ludwig MZ, Rebay I, Boisclair Lachance JF. A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition. PLoS Genet. 2020 11; 16(11):e1009216. PMID: 33253156; PMCID: PMC7728396.
      Citations: 3     Fields:    Translation:AnimalsCells
    2. Zhang R, Gehlen J, Kawalia A, Melissari MT, Dakal TC, Menon AM, Riedhammer K, Waffenschmidt L, Fabian J, Breuer K, Kalanithy J, Hilger AC, Sharma A, Boemers TM, Pauly M, Leutner A, Seitz G, Ludwikowski BM, Gomez B, Hubertus J, Heydweiller A, Kurz R, Leonhardt J, Holland-Cunz S, Ure B, Schmiedeke E, Degenhardt P, Kleine K, Deffaa OJ, Gosemann JH, Lacher M, Heilmann-Heimbach S, Zwink N, Jenetzky E, Ludwig M, Grote P, Schumacher J, Thiele H, Reutter H, Höfele J, Hölscher A, Fuchs J, Kosch F, Münsterer O, Neser J, Märzheuser S, Schäfer M, Spychalski N. Human exome and mouse embryonic expression data implicate ZFHX3, TRPS1, and CHD7 in human esophageal atresia. PLoS One. 2020; 15(6):e0234246. PMID: 32502225; PMCID: PMC7274392.
      Citations: 6     Fields:    Translation:HumansAnimals
    3. Xu J, Vanderzalm PJ, Ludwig M, Su T, Tokamov SA, Fehon RG. Yorkie Functions at the Cell Cortex to Promote Myosin Activation in a Non-transcriptional Manner. Dev Cell. 2018 08 06; 46(3):271-284.e5. PMID: 30032991; PMCID: PMC6086586.
      Citations: 25     Fields:    Translation:AnimalsCells
    4. Fitzwalter BE, Towers CG, Sullivan KD, Andrysik Z, Hoh M, Ludwig M, O'Prey J, Ryan KM, Espinosa JM, Morgan MJ, Thorburn A. Autophagy Inhibition Mediates Apoptosis Sensitization in Cancer Therapy by Relieving FOXO3a Turnover. Dev Cell. 2018 03 12; 44(5):555-565.e3. PMID: 29533771; PMCID: PMC5866042.
      Citations: 102     Fields:    Translation:HumansCells
    5. Su T, Ludwig MZ, Xu J, Fehon RG. Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded. Dev Cell. 2017 03 13; 40(5):478-490.e3. PMID: 28292426; PMCID: PMC5414729.
      Citations: 55     Fields:    Translation:AnimalsCells
    6. Zhang R, Knapp M, Suzuki K, Kajioka D, Schmidt JM, Winkler J, Pleschka M, Kockum CC, Barker G, Holmdahl G, Beaman G, Keene D, Woolf AS, Cervellione RM, Cheng W, Wilkins S, Gearhart JP, Di Grazia M, Ebert AK, Jenetzky E, Zwink N, Feitz WF, Marcelis C, Schumacher J, Hibberd ML, Khor CC, Heilmann-Heimbach S, Barth S, Boyadjiev SA, Ludwig M, Newman W, Yamada G, Odermatt B, Reutter H, Yilmaz Ö, Cao J, Sirchia F, Rösch W, Ellinger J, Martinón-Torres F, Brusco A, Nordenskjöld A. ISL1 is a major susceptibility gene for classic bladder exstrophy and a regulator of urinary tract development. Sci Rep. 2017 02 08; 7:42170. PMID: 28176844; PMCID: PMC5296905.
      Citations: 12     Fields:    Translation:HumansAnimals
    7. Heinemann B, Strohmaier J, Pfohl MA, Giegling I, Hofmann A, Ludwig KU, Witt SH, Ludwig M, Forstner AJ, Albus M, Schwab SG, Borrmann-Hassenbach M, Lennertz L, Wagner M, Hoffmann P, Rujescu D, Maier W, Cichon S, Rietschel M, Degenhardt F, Nöthen MM. Identification of rare variants in KCTD13 at the schizophrenia risk locus 16p11.2. Psychiatr Genet. 2016 12; 26(6):293-296. PMID: 27668412; PMCID: PMC5087564.
      Citations: 3     Fields:    Translation:HumansCells
    8. Hilger AC, Halbritter J, Pennimpede T, van der Ven A, Sarma G, Braun DA, Porath JD, Kohl S, Hwang DY, Dworschak GC, Hermann BG, Pavlova A, El-Maarri O, Ludwig M, Reutter H, Hildebrandt F, Nöthen MM. Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association. Hum Mutat. 2015 Dec; 36(12):1150-4. PMID: 26294094; PMCID: PMC4643331.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    9. Jiang P, Ludwig MZ, Kreitman M, Reinitz J. Natural variation of the expression pattern of the segmentation gene even-skipped in melanogaster. Dev Biol. 2015 Sep 01; 405(1):173-81. PMID: 26129990; PMCID: PMC4529771.
      Citations: 10     Fields:    Translation:Animals
    10. Hofmeister W, Markljung E, Cao J, Nilsson D, Ludwig M, Draaken M, Holmdahl G, Barker G, Reutter H, Vukojevic V, Clementson Kockum C, Lundin J, Lindstrand A, Baranowska Körberg I, Nordenskjöld A. WNT3 involvement in human bladder exstrophy and cloaca development in zebrafish. Hum Mol Genet. 2015 Sep 15; 24(18):5069-78. PMID: 26105184.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    11. Draaken M, Knapp M, Pennimpede T, Schmidt JM, Ebert AK, Stein R, Utsch B, Boemers TM, Mangold E, Heilmann S, Ludwig KU, Jenetzky E, Zwink N, Moebus S, Herrmann BG, Mattheisen M, Ludwig M, Reutter H, Rösch W, Hirsch K, Nöthen MM. Genome-wide association study and meta-analysis identify ISL1 as genome-wide significant susceptibility gene for bladder exstrophy. PLoS Genet. 2015 Mar; 11(3):e1005024. PMID: 25763902; PMCID: PMC4357422.
      Citations: 20     Fields:    Translation:HumansAnimals
    12. Chick WS, Ludwig M, Zhao X, Kitzenberg D, Williams K, Johnson TE. Screening for stress-resistance mutations in the mouse. Front Genet. 2014; 5:310. PMID: 25250048; PMCID: PMC4157564.
      Citations: 3     
    13. Reutter H, Draaken M, Pennimpede T, Wittler L, Brockschmidt FF, Ebert AK, Bartels E, Boemers TM, Schmiedeke E, Meesters C, Becker T, Stein R, Mangold E, Barker G, Kockum CC, Zwink N, Holmdahl G, Jenetzky E, Feitz WF, Marcelis C, Wijers CH, Van Rooij IA, Gearhart JP, Herrmann BG, Ludwig M, Boyadjiev SA, Mattheisen M, Rösch W, Hirsch K, Utsch B, Nordenskjöld A, Läckgren G, Nöthen MM. Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder. Hum Mol Genet. 2014 Oct 15; 23(20):5536-44. PMID: 24852367; PMCID: PMC4168827.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    14. Palsson A, Wesolowska N, Ludwig MZ, Kreitman M, Reynisdóttir S. Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer. PLoS One. 2014; 9(5):e91924. PMID: 24786295; PMCID: PMC4006794.
      Citations: 6     Fields:    Translation:AnimalsCells
    15. Draaken M, Baudisch F, Timmermann B, Kuhl H, Kerick M, Proske J, Wittler L, Pennimpede T, Ebert AK, Stein R, Bartels E, von Lowtzow C, Boemers TM, Herms S, Gearhart JP, Lakshmanan Y, Kockum CC, Holmdahl G, Boyadjiev SA, Herrmann BG, Ludwig M, Reutter H, Rösch W, Läckgren G, Nordenskjöld A, Nöthen MM. Classic bladder exstrophy: Frequent 22q11.21 duplications and definition of a 414 kb phenocritical region. Birth Defects Res A Clin Mol Teratol. 2014 Jun; 100(6):512-7. PMID: 24764164.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    16. Martinez C, Rest JS, Kim AR, Ludwig M, Kreitman M, White K, Reinitz J. Ancestral resurrection of the Drosophila S2E enhancer reveals accessible evolutionary paths through compensatory change. Mol Biol Evol. 2014 Apr; 31(4):903-16. PMID: 24408913; PMCID: PMC3969564.
      Citations: 9     Fields:    Translation:AnimalsCells
    17. He BZ, Ludwig MZ, Dickerson DA, Barse L, Arun B, Jiang P, Park SY, Tamarina NA, Selleck SB, Wittkopp PJ, Bell GI, Kreitman M, Vilhjálmsson BJ. Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin. Genetics. 2014 Feb; 196(2):557-67. PMID: 24281155; PMCID: PMC3914626.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    18. Park SY, Ludwig MZ, Tamarina NA, He BZ, Carl SH, Dickerson DA, Barse L, Arun B, Williams CL, Miles CM, Philipson LH, Steiner DF, Bell GI, Kreitman M. Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Genetics. 2014 Feb; 196(2):539-55. PMID: 24281154; PMCID: PMC3914625.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    19. Dworschak GC, Draaken M, Hilger A, Born M, Reutter H, Ludwig M. An incompletely penetrant novel MAFB (p.Ser56Phe) variant in autosomal dominant multicentric carpotarsal osteolysis syndrome. Int J Mol Med. 2013 Jul; 32(1):174-8. PMID: 23670161.
      Citations: 14     Fields:    Translation:HumansCells
    20. Kim AR, Martinez C, Ionides J, Ramos AF, Ludwig MZ, Ogawa N, Sharp DH, Reinitz J. Rearrangements of 2.5 kilobases of noncoding DNA from the Drosophila even-skipped locus define predictive rules of genomic cis-regulatory logic. PLoS Genet. 2013; 9(2):e1003243. PMID: 23468638; PMCID: PMC3585115.
      Citations: 35     Fields:    Translation:AnimalsCells
    21. Ludwig MZ, Kreitman M. Sex-specific pattern formation during early Drosophila development. Genetics. 2013 May; 194(1):163-73. PMID: 23410834; PMCID: PMC3632464.
      Citations: 7     Fields:    Translation:Animals
    22. Schulz AC, Mora NW, Pineda-Alvarez DE, Wijers CHW, Marcelis CM, Ritgen J, Schmiedeke E, Mattheisen M, Draaken M, Hoffmann P, Hilger AC, Dworschak GC, Baudisch F, Ludwig M, Bagci S, Gembruch U, Geipel A, Berg C, Bartmann P, van Rooij IALM, Solomon BD, Reutter HM, Bartels E, Stressig R, Müller A, Nöthen MM. VATER/VACTERL association: identification of seven new twin pairs, a systematic review of the literature, and a classical twin analysis. Clin Dysmorphol. 2012 Oct; 21(4):191-195. PMID: 22895008; PMCID: PMC4126840.
      Citations: 6     Fields:    Translation:Humans
    23. Wittler L, Hilger A, Proske J, Pennimpede T, Draaken M, Ebert AK, Stein R, Reutter H, Ludwig M, Rösch W, Nöthen MM. Murine expression and mutation analyses of the prostate androgen-regulated mucin-like protein 1 (Parm1) gene, a candidate for human epispadias. Gene. 2012 Sep 15; 506(2):392-5. PMID: 22766399.
      Citations: 1     Fields:    Translation:HumansAnimals
    24. Weber S, Thiele H, Mir S, Toliat MR, Reutter H, Draaken M, Ludwig M, Frommolt P, Stuart HM, Ranjzad P, Hanley NA, Jennings R, Newman WG, Wilcox DT, Thiel U, Schlingmann KP, Beetz R, Hoyer PF, Konrad M, Schaefer F, Woolf AS, Sozeri B, Altmüller J, Nürnberg P. Muscarinic Acetylcholine Receptor M3 Mutation Causes Urinary Bladder Disease and a Prune-Belly-like Syndrome. Am J Hum Genet. 2011 Nov 11; 89(5):668-74. PMID: 22077972; PMCID: PMC3213389.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    25. Ludwig MZ, Kittler R, White KP, Kreitman M. Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness. PLoS Genet. 2011 Nov; 7(11):e1002364. PMID: 22102826; PMCID: PMC3213169.
      Citations: 43     Fields:    Translation:AnimalsCells
    26. Miles CM, Lott SE, Hendriks CL, Ludwig MZ, Williams CL, Kreitman M. Artificial selection on egg size perturbs early pattern formation in Drosophila melanogaster. Evolution. 2011 Jan; 65(1):33-42. PMID: 20636356; PMCID: PMC2988983.
      Citations: 24     Fields:    Translation:AnimalsCells
    27. Lott SE, Ludwig MZ, Kreitman M. Evolution and inheritance of early embryonic patterning in Drosophila simulans and D. sechellia. Evolution. 2011 May; 65(5):1388-99. PMID: 21121913; PMCID: PMC3083464.
      Citations: 4     Fields:    Translation:Animals
    28. Ching BJ, Wittler L, Proske J, Yagnik G, Qi L, Draaken M, Reutter H, Gearhart JP, Ludwig M, Boyadjiev SA. p63 (TP73L) a key player in embryonic urogenital development with significant dysregulation in human bladder exstrophy tissue. Int J Mol Med. 2010 Dec; 26(6):861-7. PMID: 21042780.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    29. Draaken M, Proske J, Schramm C, Wittler L, Bartels E, Reutter H, Ludwig M, Nöthen MM. Embryonic expression of the cysteine rich protein 61 (CYR61) gene: A candidate for the development of human epispadias. Birth Defects Res A Clin Mol Teratol. 2010 Jul; 88(7):546-50. PMID: 20641097.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    30. Liu J, Ghanim M, Xue L, Brown CD, Iossifov I, Angeletti C, Hua S, Ludwig M, Stricker T, Al-Ahmadie HA, Tretiakova M, Camp RL, Perera-Alberto M, Rimm DL, Xu T, Rzhetsky A, White KP, Nègre N. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Science. 2009 Feb 27; 323(5918):1218-22. PMID: 19164706; PMCID: PMC2756524.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    31. Buiting K, Zeschnigk M, Ludwig M, Horsthemke B, Kanber D. Low frequency of imprinting defects in ICSI children born small for gestational age. Eur J Hum Genet. 2009 Jan; 17(1):22-9. PMID: 18941474; PMCID: PMC2985955.
      Citations: 18     Fields:    Translation:HumansCells
    32. Lott SE, Kreitman M, Palsson A, Alekseeva E, Ludwig MZ. Canalization of segmentation and its evolution in Drosophila. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10926-31. PMID: 17569783; PMCID: PMC1891814.
      Citations: 50     Fields:    Translation:AnimalsCells
    33. deJong M, van Wijk JA, Block D, van Hagen JM, Ludwig M, Bökenkamp A. R561C missense mutation in the SMARCAL1 gene associated with mild Schimke immuno-osseous dysplasia. Pediatr Nephrol. 2005 Dec; 20(12):1724-8. PMID: 16237566.
      Citations: 10     Fields:    Translation:HumansCells
    34. Ludwig MZ, Palsson A, Alekseeva E, Bergman CM, Nathan J, Kreitman M. Functional evolution of a cis-regulatory module. PLoS Biol. 2005 Apr; 3(4):e93. PMID: 15757364; PMCID: PMC1064851.
      Citations: 116     Fields:    Translation:AnimalsCells
    35. Innis JW, Mortlock D, Chen Z, Ludwig M, Williams ME, Williams TM, Doyle CD, Shao Z, Glynn M, Mikulic D, Lehmann K, Mundlos S, Utsch B. Polyalanine expansion in HOXA13: three new affected families and the molecular consequences in a mouse model. Hum Mol Genet. 2004 Nov 15; 13(22):2841-51. PMID: 15385446.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    36. Lall S, Ludwig MZ, Patel NH. Nanos plays a conserved role in axial patterning outside of the Diptera. Curr Biol. 2003 Feb 04; 13(3):224-9. PMID: 12573218.
      Citations: 10     Fields:    Translation:AnimalsCells
    37. Ludwig M, Waldegger S, Nuutinen M, Reissinger A, Steckelbroeck S, Utsch B, Bökenkamp A. Four additional CLCN5 exons encode a widely expressed novel long CLC-5 isoform but fail to explain Dent's phenotype in patients without mutations in the short variant. Kidney Blood Press Res. 2003; 26(3):176-84. PMID: 12886045.
      Citations: 6     Fields:    Translation:HumansCells
    38. Utsch B, Kaya A, Ozburun A, Lentze MJ, Albers N, Ludwig M. Exclusion of WTAP and HOXA13 as candidate genes for isolated hypospadias. Scand J Urol Nephrol. 2003; 37(6):498-501. PMID: 14675924.
      Citations: 5     Fields:    Translation:Humans
    39. Ludwig MZ, Ludwig MZ. Functional evolution of noncoding DNA. Curr Opin Genet Dev. 2002 Dec; 12(6):634-9. PMID: 12433575.
      Citations: 54     Fields:    Translation:AnimalsCells
    40. Utsch B, Becker K, Brock D, Lentze MJ, Bidlingmaier F, Ludwig M, Utsch B, Becker K, Brock D, Lentze MJ, Bidlingmaier F, Ludwig M. A novel stable polyalanine [poly(A)] expansion in the HOXA13 gene associated with hand-foot-genital syndrome: proper function of poly(A)-harbouring transcription factors depends on a critical repeat length? Hum Genet. 2002 May; 110(5):488-94. PMID: 12073020.
      Citations: 22     Fields:    Translation:HumansCells
    41. Hilgers MT, Ludwig ML. Crystal structure of the quorum-sensing protein LuxS reveals a catalytic metal site. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11169-74. PMID: 11553770; PMCID: PMC58702.
      Citations: 37     Fields:    Translation:Cells
    42. Ludwig MZ, Bergman C, Patel NH, Kreitman M. Evidence for stabilizing selection in a eukaryotic enhancer element. Nature. 2000 Feb 03; 403(6769):564-7. PMID: 10676967.
      Citations: 252     Fields:    Translation:AnimalsCells
    43. Weber CH, Park YS, Sanker S, Kent C, Ludwig ML. A prototypical cytidylyltransferase: CTP:glycerol-3-phosphate cytidylyltransferase from bacillus subtilis. Structure. 1999 Sep 15; 7(9):1113-24. PMID: 10508782.
      Citations: 26     Fields:    Translation:Cells
    44. Guenther BD, Sheppard CA, Tran P, Rozen R, Matthews RG, Ludwig ML. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia. Nat Struct Biol. 1999 Apr; 6(4):359-65. PMID: 10201405.
      Citations: 109     Fields:    Translation:HumansCells
    45. Lanciotti RS, Ludwig ML, Rwaguma EB, Lutwama JJ, Kram TM, Karabatsos N, Cropp BC, Miller BR. Emergence of epidemic O'nyong-nyong fever in Uganda after a 35-year absence: genetic characterization of the virus. Virology. 1998 Dec 05; 252(1):258-68. PMID: 9875334.
      Citations: 49     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    46. Ludwig MZ, Patel NH, Kreitman M. Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change. Development. 1998 Mar; 125(5):949-58. PMID: 9449677.
      Citations: 142     Fields:    Translation:AnimalsCells
    47. Tamarina NA, Ludwig MZ, Richmond RC. Divergent and conserved features in the spatial expression of the Drosophila pseudoobscura esterase-5B gene and the esterase-6 gene of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1997 Jul 22; 94(15):7735-41. PMID: 9223257; PMCID: PMC33691.
      Citations: 6     Fields:    Translation:AnimalsCells
    48. Drennan CL, Matthews RG, Rosenblatt DS, Ledley FD, Fenton WA, Ludwig ML. Molecular basis for dysfunction of some mutant forms of methylmalonyl-CoA mutase: deductions from the structure of methionine synthase. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5550-5. PMID: 8643613; PMCID: PMC39284.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    49. Ludwig MZ, Kreitman M. Evolutionary dynamics of the enhancer region of even-skipped in Drosophila. Mol Biol Evol. 1995 Nov; 12(6):1002-11. PMID: 8524036.
      Citations: 64     Fields:    Translation:AnimalsCells
    50. Ludwig MZ, Tamarina NA, Richmond RC. Localization of sequences controlling the spatial, temporal, and sex-specific expression of the esterase 6 locus in Drosophila melanogaster adults. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6233-7. PMID: 8327503; PMCID: PMC46902.
      Citations: 13     Fields:    Translation:Animals
    51. Ludwig MZ, Uspensky II, Ivanov AI, Kopantseva MR, Dianov CM, Tamarina NA, Korochkin LI. Genetic control and expression of the major ejaculatory bulb protein (PEB-me) in Drosophila melanogaster. Biochem Genet. 1991 Jun; 29(5-6):215-39. PMID: 1772395.
      Citations: 12     Fields:    Translation:Animals
    52. Yenikolopov GN, Kuzin BA, Evgen'ev NB, Ludwig MZ, Korochkin LI, Georgiev GP. The cloning and expression of the gene encoding organ-specific esterase S from the genome of Drosophila virilis. EMBO J. 1983; 2(1):1-7. PMID: 11894894; PMCID: PMC555077.
      Citations: 1     Fields:    Translation:AnimalsCells
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