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James Holaska

TitleAssistant Professor
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hansen E, Holaska JM. The nuclear envelope and metastasis. Oncotarget. 2023 04 14; 14:317-320. PMID: 37057891; PMCID: PMC10103595.
      Citations:    Fields:    Translation:HumansCells
    2. Marano N, Holaska JM. Emerin interacts with histone methyltransferases to regulate repressive chromatin at the nuclear periphery. Front Cell Dev Biol. 2022; 10:1007120. PMID: 36274837; PMCID: PMC9583931.
    3. Liddane AG, Holaska JM. The Role of Emerin in Cancer Progression and Metastasis. Int J Mol Sci. 2021 Oct 19; 22(20). PMID: 34681951; PMCID: PMC8537873.
      Citations: 5     Fields:    Translation:HumansAnimals
    4. Liddane AG, McNamara CA, Campbell MC, Mercier I, Holaska JM. Defects in Emerin-Nucleoskeleton Binding Disrupt Nuclear Structure and Promote Breast Cancer Cell Motility and Metastasis. Mol Cancer Res. 2021 07; 19(7):1196-1207. PMID: 33771882; PMCID: PMC8254762.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    5. Holaska JM, Winder SJ, Brancaccio A, Gómez-Monsivais WL, Monterrubio-Ledezma F, Huerta-Cantillo J, Mondragon-Gonzalez R, Alamillo-Iniesta A, García-Aguirre I, Azuara-Medina PM, Arguello-García R, Rivera-Monroy JE, Hernández-Méndez JME, Garrido E, Magaña JJ, Martínez-Vieyra I, Navarro-Garcia F, Cisneros B. The Molecular Basis and Biologic Significance of the ß-Dystroglycan-Emerin Interaction. Int J Mol Sci. 2020 Aug 19; 21(17). PMID: 32824881; PMCID: PMC7504044.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Iyer A, Holaska JM. EDMD-Causing Emerin Mutant Myogenic Progenitors Exhibit Impaired Differentiation Using Similar Mechanisms. Cells. 2020 06 15; 9(6). PMID: 32549231; PMCID: PMC7349064.
      Citations: 1     Fields:    Translation:HumansCells
    7. Bossone KA, Ellis JA, Holaska JM. Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors. Muscle Nerve. 2020 07; 62(1):128-136. PMID: 32304242; PMCID: PMC7382944.
      Citations: 5     Fields:    Translation:AnimalsCells
    8. Iyer A, Koch AJ, Holaska JM. Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation. Cells. 2017 Oct 22; 6(4). PMID: 29065506; PMCID: PMC5755497.
      Citations: 8     Fields:    
    9. Collins CM, Ellis JA, Holaska JM. MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells. Dis Model Mech. 2017 04 01; 10(4):385-397. PMID: 28188262; PMCID: PMC5399572.
      Citations: 12     Fields:    Translation:AnimalsCells
    10. Holaska JM. Diseases of the Nucleoskeleton. Compr Physiol. 2016 09 15; 6(4):1655-1674. PMID: 27783855; PMCID: PMC6075693.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    11. Depreux FF, Puckelwartz MJ, Augustynowicz A, Wolfgeher D, Labno CM, Pierre-Louis D, Cicka D, Kron SJ, Holaska J, McNally EM. Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations. Hum Mol Genet. 2015 Aug 01; 24(15):4284-95. PMID: 25948554; PMCID: PMC4492393.
      Citations: 16     Fields:    Translation:HumansCells
    12. Mull A, Kim G, Holaska JM. LMO7-null mice exhibit phenotypes consistent with emery-dreifuss muscular dystrophy. Muscle Nerve. 2015 Feb; 51(2):222-8. PMID: 24825363.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    13. Koch AJ, Holaska JM. Emerin in health and disease. Semin Cell Dev Biol. 2014 May; 29:95-106. PMID: 24365856; PMCID: PMC4384519.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    14. Demmerle J, Koch AJ, Holaska JM. Emerin and histone deacetylase 3 (HDAC3) cooperatively regulate expression and nuclear positions of MyoD, Myf5, and Pax7 genes during myogenesis. Chromosome Res. 2013 Dec; 21(8):765-79. PMID: 24062260; PMCID: PMC4829207.
      Citations: 47     Fields:    Translation:AnimalsCells
    15. Koch AJ, Holaska JM. Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors. PLoS One. 2012; 7(5):e37262. PMID: 22606356; PMCID: PMC3350500.
      Citations: 19     Fields:    Translation:AnimalsCells
    16. Demmerle J, Koch AJ, Holaska JM. The nuclear envelope protein emerin binds directly to histone deacetylase 3 (HDAC3) and activates HDAC3 activity. J Biol Chem. 2012 Jun 22; 287(26):22080-8. PMID: 22570481; PMCID: PMC3381166.
      Citations: 85     Fields:    Translation:AnimalsCells
    17. Dedeic Z, Cetera M, Cohen TV, Holaska JM. Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes. J Cell Sci. 2011 May 15; 124(Pt 10):1691-702. PMID: 21525034.
      Citations: 36     Fields:    Translation:AnimalsCells
    18. Puckelwartz MJ, Kessler EJ, Kim G, Dewitt MM, Zhang Y, Earley JU, Depreux FF, Holaska J, Mewborn SK, Pytel P, McNally EM. Nesprin-1 mutations in human and murine cardiomyopathy. J Mol Cell Cardiol. 2010 Apr; 48(4):600-8. PMID: 19944109; PMCID: PMC2837775.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    19. Puckelwartz MJ, Kessler E, Zhang Y, Hodzic D, Randles KN, Morris G, Earley JU, Hadhazy M, Holaska JM, Mewborn SK, Pytel P, McNally EM. Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice. Hum Mol Genet. 2009 Feb 15; 18(4):607-20. PMID: 19008300; PMCID: PMC2722216.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    20. Holaska JM. Emerin and the nuclear lamina in muscle and cardiac disease. Circ Res. 2008 Jul 03; 103(1):16-23. PMID: 18596264.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    21. Holaska JM, Wilson KL. An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. Biochemistry. 2007 Jul 31; 46(30):8897-908. PMID: 17620012; PMCID: PMC2635128.
      Citations: 93     Fields:    Translation:HumansCells
    22. Holaska JM, Rais-Bahrami S, Wilson KL. Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes. Hum Mol Genet. 2006 Dec 01; 15(23):3459-72. PMID: 17067998.
      Citations: 76     Fields:    Translation:HumansCells
    23. Holaska JM, Wilson KL. Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy. Anat Rec A Discov Mol Cell Evol Biol. 2006 Jul; 288(7):676-80. PMID: 16761279; PMCID: PMC2559942.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    24. Wilson KL, Holaska JM, Montes de Oca R, Tifft K, Zastrow M, Segura-Totten M, Mansharamani M, Bengtsson L. Nuclear membrane protein emerin: roles in gene regulation, actin dynamics and human disease. Novartis Found Symp. 2005; 264:51-58; discussion 58-62, 227-30. PMID: 15773747.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    25. Holaska JM, Kowalski AK, Wilson KL. Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane. PLoS Biol. 2004 Sep; 2(9):E231. PMID: 15328537; PMCID: PMC509406.
      Citations: 109     Fields:    Translation:HumansCells
    26. Haraguchi T, Holaska JM, Yamane M, Koujin T, Hashiguchi N, Mori C, Wilson KL, Hiraoka Y. Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy. Eur J Biochem. 2004 Mar; 271(5):1035-45. PMID: 15009215.
      Citations: 60     Fields:    Translation:HumansCells
    27. Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE. Emerin interacts in vitro with the splicing-associated factor, YT521-B. Eur J Biochem. 2003 Jun; 270(11):2459-66. PMID: 12755701.
      Citations: 34     Fields:    Translation:HumansCells
    28. Holaska JM, Lee KK, Kowalski AK, Wilson KL. Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro. J Biol Chem. 2003 Feb 28; 278(9):6969-75. PMID: 12493765.
      Citations: 87     Fields:    Translation:HumansCells
    29. Holaska JM, Black BE, Rastinejad F, Paschal BM. Ca2+-dependent nuclear export mediated by calreticulin. Mol Cell Biol. 2002 Sep; 22(17):6286-97. PMID: 12167720; PMCID: PMC133999.
      Citations: 45     Fields:    Translation:AnimalsCells
    30. Mislow JM, Holaska JM, Kim MS, Lee KK, Segura-Totten M, Wilson KL, McNally EM. Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro. FEBS Lett. 2002 Aug 14; 525(1-3):135-40. PMID: 12163176.
      Citations: 118     Fields:    Translation:HumansAnimalsCells
    31. Holaska JM, Wilson KL, Mansharamani M, Holaska JM, Wilson KL, Mansharamani M. The nuclear envelope, lamins and nuclear assembly. Curr Opin Cell Biol. 2002 Jun; 14(3):357-64. PMID: 12067659.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    32. Brownawell AM, Holaska JM, Macara IG, Paschal BM. The use of permeabilized cell systems to study nuclear transport. Methods Mol Biol. 2002; 189:209-29. PMID: 12094589.
      Citations: 1     Fields:    Translation:HumansCells
    33. Black BE, Holaska JM, Rastinejad F, Paschal BM. DNA binding domains in diverse nuclear receptors function as nuclear export signals. Curr Biol. 2001 Nov 13; 11(22):1749-58. PMID: 11719216.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    34. Lindsay ME, Holaska JM, Welch K, Paschal BM, Macara IG. Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export. J Cell Biol. 2001 Jun 25; 153(7):1391-402. PMID: 11425870; PMCID: PMC2150735.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    35. Holaska JM, Black BE, Love DC, Hanover JA, Leszyk J, Paschal BM. Calreticulin Is a receptor for nuclear export. J Cell Biol. 2001 Jan 08; 152(1):127-40. PMID: 11149926; PMCID: PMC2193655.
      Citations: 79     Fields:    Translation:HumansCells
    36. Black BE, Holaska JM, Ossareh-Nazari B, Gwizdek C, Dargemont C, Paschal BM, Lévesque L. NXT1 is necessary for the terminal step of Crm1-mediated nuclear export. J Cell Biol. 2001 Jan 08; 152(1):141-55. PMID: 11149927; PMCID: PMC2193657.
      Citations: 20     Fields:    Translation:AnimalsCells
    37. Black BE, Holaska JM, Wood TC, Paschal BM, Lévesque L. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export. Mol Cell Biol. 1999 Dec; 19(12):8616-24. PMID: 10567585; PMCID: PMC84993.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    38. Holaska JM, Paschal BM. A cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14739-44. PMID: 9843959; PMCID: PMC24519.
      Citations: 20     Fields:    Translation:HumansCells
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