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James Holaska

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liddane AG, McNamara CA, Campbell MC, Mercier I, Holaska JM. Defects in Emerin-Nucleoskeleton Binding Disrupt Nuclear Structure and Promote Breast Cancer Cell Motility and Metastasis. Mol Cancer Res. 2021 Jul; 19(7):1196-1207. PMID: 33771882.
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    2. Gómez-Monsivais WL, Monterrubio-Ledezma F, Huerta-Cantillo J, Mondragon-Gonzalez R, Alamillo-Iniesta A, García-Aguirre I, Azuara-Medina PM, Arguello-García R, Rivera-Monroy JE, Holaska JM, Hernández-Méndez JME, Garrido E, Magaña JJ, Winder SJ, Brancaccio A, Martínez-Vieyra I, Navarro-Garcia F, Cisneros B. The Molecular Basis and Biologic Significance of the ß-Dystroglycan-Emerin Interaction. Int J Mol Sci. 2020 Aug 19; 21(17). PMID: 32824881.
      View in: PubMed
    3. Iyer A, Holaska JM. EDMD-Causing Emerin Mutant Myogenic Progenitors Exhibit Impaired Differentiation Using Similar Mechanisms. Cells. 2020 06 15; 9(6). PMID: 32549231.
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    4. Bossone KA, Ellis JA, Holaska JM. Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors. Muscle Nerve. 2020 07; 62(1):128-136. PMID: 32304242.
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    5. Iyer A, Koch AJ, Holaska JM. Expression Profiling of Differentiating Emerin-Null Myogenic Progenitor Identifies Molecular Pathways Implicated in Their Impaired Differentiation. Cells. 2017 Oct 22; 6(4). PMID: 29065506.
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    6. Collins CM, Ellis JA, Holaska JM. MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells. Dis Model Mech. 2017 04 01; 10(4):385-397. PMID: 28188262.
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    7. Holaska JM. Diseases of the Nucleoskeleton. Compr Physiol. 2016 09 15; 6(4):1655-1674. PMID: 27783855.
      View in: PubMed
    8. Depreux FF, Puckelwartz MJ, Augustynowicz A, Wolfgeher D, Labno CM, Pierre-Louis D, Cicka D, Kron SJ, Holaska J, McNally EM. Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations. Hum Mol Genet. 2015 Aug 01; 24(15):4284-95. PMID: 25948554.
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    9. Mull A, Kim G, Holaska JM. LMO7-null mice exhibit phenotypes consistent with emery-dreifuss muscular dystrophy. Muscle Nerve. 2015 Feb; 51(2):222-8. PMID: 24825363.
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    10. Koch AJ, Holaska JM. Emerin in health and disease. Semin Cell Dev Biol. 2014 May; 29:95-106. PMID: 24365856.
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    11. Demmerle J, Koch AJ, Holaska JM. Emerin and histone deacetylase 3 (HDAC3) cooperatively regulate expression and nuclear positions of MyoD, Myf5, and Pax7 genes during myogenesis. Chromosome Res. 2013 Dec; 21(8):765-79. PMID: 24062260.
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    12. Koch AJ, Holaska JM. Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors. PLoS One. 2012; 7(5):e37262. PMID: 22606356.
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    13. Demmerle J, Koch AJ, Holaska JM. The nuclear envelope protein emerin binds directly to histone deacetylase 3 (HDAC3) and activates HDAC3 activity. J Biol Chem. 2012 Jun 22; 287(26):22080-8. PMID: 22570481.
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    14. Dedeic Z, Cetera M, Cohen TV, Holaska JM. Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes. J Cell Sci. 2011 May 15; 124(Pt 10):1691-702. PMID: 21525034.
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    15. Puckelwartz MJ, Kessler EJ, Kim G, Dewitt MM, Zhang Y, Earley JU, Depreux FF, Holaska J, Mewborn SK, Pytel P, McNally EM. Nesprin-1 mutations in human and murine cardiomyopathy. J Mol Cell Cardiol. 2010 Apr; 48(4):600-8. PMID: 19944109.
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    16. Puckelwartz MJ, Kessler E, Zhang Y, Hodzic D, Randles KN, Morris G, Earley JU, Hadhazy M, Holaska JM, Mewborn SK, Pytel P, McNally EM. Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice. Hum Mol Genet. 2009 Feb 15; 18(4):607-20. PMID: 19008300.
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    17. Holaska JM. Emerin and the nuclear lamina in muscle and cardiac disease. Circ Res. 2008 Jul 03; 103(1):16-23. PMID: 18596264.
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    18. Holaska JM, Wilson KL. An emerin "proteome": purification of distinct emerin-containing complexes from HeLa cells suggests molecular basis for diverse roles including gene regulation, mRNA splicing, signaling, mechanosensing, and nuclear architecture. Biochemistry. 2007 Jul 31; 46(30):8897-908. PMID: 17620012.
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    19. Holaska JM, Rais-Bahrami S, Wilson KL. Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes. Hum Mol Genet. 2006 Dec 01; 15(23):3459-72. PMID: 17067998.
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    20. Holaska JM, Wilson KL. Multiple roles for emerin: implications for Emery-Dreifuss muscular dystrophy. Anat Rec A Discov Mol Cell Evol Biol. 2006 Jul; 288(7):676-80. PMID: 16761279.
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    21. Wilson KL, Holaska JM, Montes de Oca R, Tifft K, Zastrow M, Segura-Totten M, Mansharamani M, Bengtsson L. Nuclear membrane protein emerin: roles in gene regulation, actin dynamics and human disease. Novartis Found Symp. 2005; 264:51-58; discussion 58-62, 227-30. PMID: 15773747.
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    22. Holaska JM, Kowalski AK, Wilson KL. Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane. PLoS Biol. 2004 Sep; 2(9):E231. PMID: 15328537.
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    23. Haraguchi T, Holaska JM, Yamane M, Koujin T, Hashiguchi N, Mori C, Wilson KL, Hiraoka Y. Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy. Eur J Biochem. 2004 Mar; 271(5):1035-45. PMID: 15009215.
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    24. Wilkinson FL, Holaska JM, Zhang Z, Sharma A, Manilal S, Holt I, Stamm S, Wilson KL, Morris GE. Emerin interacts in vitro with the splicing-associated factor, YT521-B. Eur J Biochem. 2003 Jun; 270(11):2459-66. PMID: 12755701.
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    25. Holaska JM, Lee KK, Kowalski AK, Wilson KL. Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro. J Biol Chem. 2003 Feb 28; 278(9):6969-75. PMID: 12493765.
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    26. Holaska JM, Black BE, Rastinejad F, Paschal BM. Ca2+-dependent nuclear export mediated by calreticulin. Mol Cell Biol. 2002 Sep; 22(17):6286-97. PMID: 12167720.
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    27. Mislow JM, Holaska JM, Kim MS, Lee KK, Segura-Totten M, Wilson KL, McNally EM. Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro. FEBS Lett. 2002 Aug 14; 525(1-3):135-40. PMID: 12163176.
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    28. Holaska JM, Wilson KL, Mansharamani M. The nuclear envelope, lamins and nuclear assembly. Curr Opin Cell Biol. 2002 Jun; 14(3):357-64. PMID: 12067659.
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    29. Brownawell AM, Holaska JM, Macara IG, Paschal BM. The use of permeabilized cell systems to study nuclear transport. Methods Mol Biol. 2002; 189:209-29. PMID: 12094589.
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    30. Black BE, Holaska JM, Rastinejad F, Paschal BM. DNA binding domains in diverse nuclear receptors function as nuclear export signals. Curr Biol. 2001 Nov 13; 11(22):1749-58. PMID: 11719216.
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    31. Lindsay ME, Holaska JM, Welch K, Paschal BM, Macara IG. Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export. J Cell Biol. 2001 Jun 25; 153(7):1391-402. PMID: 11425870.
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    32. Black BE, Holaska JM, Lévesque L, Ossareh-Nazari B, Gwizdek C, Dargemont C, Paschal BM. NXT1 is necessary for the terminal step of Crm1-mediated nuclear export. J Cell Biol. 2001 Jan 08; 152(1):141-55. PMID: 11149927.
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    33. Holaska JM, Black BE, Love DC, Hanover JA, Leszyk J, Paschal BM. Calreticulin Is a receptor for nuclear export. J Cell Biol. 2001 Jan 08; 152(1):127-40. PMID: 11149926.
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    34. Black BE, Lévesque L, Holaska JM, Wood TC, Paschal BM. Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export. Mol Cell Biol. 1999 Dec; 19(12):8616-24. PMID: 10567585.
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    35. Holaska JM, Paschal BM. A cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells. Proc Natl Acad Sci U S A. 1998 Dec 08; 95(25):14739-44. PMID: 9843959.
      View in: PubMed
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