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Nicholas G. Hatsopoulos

InstitutionUniversity of Chicago
DepartmentOrganismal Biology and Anatomy
AddressChicago IL 60637
Phone+1 (773) 702-5594
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    Collapse Overview 
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    Our research focuses on the cortical basis of motor control and learning. We are investigating what features of motor behavior are encoded and how this information is represented in the collective activity of large neuronal ensembles in the motor, premotor, and somatosensory cortices. We are also interested in what way these representations change as motor learning occurs. Our approach has been to simultaneously record neural activity from large groups of neurons using multi-electrode arrays while performing detailed kinematic, kinetic, and muscle measurements of goal-directed, motor behaviors, and to develop mathematical models that relate neural activity with behavior. These mathematical models provide insights as to what aspects of motor behavior are being encoded in cortical neurons, but also can be used to decipher or “decode” neural activity in order to predict movement which has practical implications for brain-machine interface development. Ultimately, this research may lead to neural prosthetic technologies that will allow people with spinal cord injury, ALS, or amputation to use brain signals to voluntarily control a device so as to interact with the world.
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    Collapse Biography 
    Collapse education and training
    Williams College, Williamstown, MAB.A.1984Physics
    Brown University, Providence, RISc.M.1991Psychology
    Brown University, Providence, RIPh.D.1992Cognitive Science
    California Institute of Technology, Pasadena, CA1995Neuroscience
    Brown University, Providence, RI1998Neuroscience
    Collapse awards and honors
    2016Faculty Award for Excellence in Graduate Teaching and Mentoring, University of Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Greenspon CM, Shelchkova ND, Valle G, Hobbs TG, Berger-Wolf EI, Hutchison BC, Dogruoz E, Verbarschott C, Callier T, Sobinov AR, Okorokova EV, Jordan PM, Prasad D, He Q, Liu F, Miller JP, Lee RC, Satzer D, Gonzalez-Martinez J, Warnke PC, Miller LE, Boninger ML, Ajiboye AB, Graczyk EL, Downey JE, Collinger JL, Hatsopoulos NG, Gaunt RA, Bensmaia SJ, Hobbs T, Sobinov A, Kirsch RF, Warnke P, Boninger ML, Ajiboye BB, Collinger J, Hatsopoulos N, Gaunt R. Tessellation Of Artificial Touch Via Microstimulation Of Human Somatosensory Cortex. bioRxiv. 2023 Jul 15. PMID: 37425877; PMCID: PMC10327055.
    2. Greenspon CM, Valle G, Hobbs TG, Verbaarschot C, Callier T, Shelchkova ND, Sobinov AR, Jordan PM, Weiss JM, Fitzgerald EE, Prasad D, van Driesche A, Lee RC, Satzer D, Gonzalez-Martinez J, Warnke PC, Miller LE, Boninger ML, Collinger JL, Gaunt RA, Downey JE, Hatsopoulos NG, Bensmaia SJ, Greenspon CM, Okorokova EV. Biomimetic multi-channel microstimulation of somatosensory cortex conveys high resolution force feedback for bionic hands. bioRxiv. 2023 Jul 12. PMID: 36824713; PMCID: PMC9949113.
    3. Sundiang M, Hatsopoulos NG, MacLean JN. Dynamic structure of motor cortical neuron coactivity carries behaviorally relevant information. Netw Neurosci. 2023; 7(2):661-678. PMID: 37397877; PMCID: PMC10312288.
    4. Ross CF, Laurence-Chasen JD, Li P, Orsbon C, Hatsopoulos NG. Biomechanical and Cortical Control of Tongue Movements During Chewing and Swallowing. Dysphagia. 2023 Jun 16. PMID: 37326668.
      Citations:    Fields:    
    5. Laurence-Chasen JD, Ross CF, Arce-McShane FI, Hatsopoulos NG. Robust cortical encoding of 3D tongue shape during feeding in macaques. Nat Commun. 2023 05 24; 14(1):2991. PMID: 37225708; PMCID: PMC10209084.
      Citations: 1     Fields:    Translation:Animals
    6. Bachschmid-Romano L, Hatsopoulos NG, Brunel N. Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex. Elife. 2023 05 11; 12. PMID: 37166452; PMCID: PMC10174693.
      Citations:    Fields:    Translation:AnimalsCells
    7. Balasubramanian K, Arce-McShane FI, Dekleva BM, Collinger JL, Hatsopoulos NG. Propagating motor cortical patterns of excitability are ubiquitous across human and non-human primate movement initiation. iScience. 2023 Apr 21; 26(4):106518. PMID: 37070071; PMCID: PMC10105290.
    8. Liang W, Balasubramanian K, Papadourakis V, Hatsopoulos NG. Propagating spatiotemporal activity patterns across macaque motor cortex carry kinematic information. Proc Natl Acad Sci U S A. 2023 01 24; 120(4):e2212227120. PMID: 36652475; PMCID: PMC9942811.
      Citations: 1     Fields:    Translation:Animals
    9. Hatsopoulos NG. The importance of volitional behavior in neuroplasticity. Proc Natl Acad Sci U S A. 2022 07 26; 119(30):e2208739119. PMID: 35858459; PMCID: PMC9335316.
      Citations:    Fields:    Translation:Animals
    10. Laurence-Chasen JD, Arce-McShane FI, Hatsopoulos NG, Ross CF. Loss of oral sensation impairs feeding performance and consistency of tongue-jaw coordination. J Oral Rehabil. 2022 Aug; 49(8):806-816. PMID: 35514258; PMCID: PMC9540871.
      Citations: 2     Fields:    Translation:Animals
    11. Moore DD, Walker JD, MacLean JN, Hatsopoulos NG. Validating markerless pose estimation with 3D X-ray radiography. J Exp Biol. 2022 05 01; 225(9). PMID: 35466360; PMCID: PMC9163444.
      Citations: 3     Fields:    Translation:Animals
    12. Sponheim C, Papadourakis V, Collinger JL, Downey J, Weiss J, Pentousi L, Elliott K, Hatsopoulos NG. Longevity and reliability of chronic unit recordings using the Utah, intracortical multi-electrode arrays. J Neural Eng. 2021 12 28; 18(6). PMID: 34847547; PMCID: PMC8981395.
      Citations: 4     Fields:    Translation:Animals
    13. Walker JD, Pirschel F, Sundiang M, Niekrasz M, MacLean JN, Hatsopoulos NG. Chronic wireless neural population recordings with common marmosets. Cell Rep. 2021 07 13; 36(2):109379. PMID: 34260919; PMCID: PMC8513487.
      Citations: 2     Fields:    Translation:AnimalsCells
    14. Suresh AK, Goodman JM, Okorokova EV, Kaufman M, Hatsopoulos NG, Bensmaia SJ. Neural population dynamics in motor cortex are different for reach and grasp. Elife. 2020 11 17; 9. PMID: 33200745; PMCID: PMC7688308.
      Citations: 22     Fields:    Translation:AnimalsCells
    15. Laurence-Chasen JD, Manafzadeh AR, Hatsopoulos NG, Ross CF, Arce-McShane FI. Integrating XMALab and DeepLabCut for high-throughput XROMM. J Exp Biol. 2020 09 04; 223(Pt 17). PMID: 32665442; PMCID: PMC7490514.
      Citations: 8     Fields:    
    16. Okorokova EV, Goodman JM, Hatsopoulos NG, Bensmaia SJ. Decoding hand kinematics from population responses in sensorimotor cortex during grasping. J Neural Eng. 2020 08 17; 17(4):046035. PMID: 32442987.
      Citations: 13     Fields:    
    17. Balasubramanian K, Papadourakis V, Liang W, Takahashi K, Best MD, Suminski AJ, Hatsopoulos NG. Propagating Motor Cortical Dynamics Facilitate Movement Initiation. Neuron. 2020 05 06; 106(3):526-536.e4. PMID: 32145183; PMCID: PMC7210059.
      Citations: 12     Fields:    Translation:AnimalsCells
    18. Walker JD, Pirschel F, Gidmark N, MacLean JN, Hatsopoulos NG. A platform for semiautomated voluntary training of common marmosets for behavioral neuroscience. J Neurophysiol. 2020 04 01; 123(4):1420-1426. PMID: 32130092; PMCID: PMC7191516.
      Citations: 9     Fields:    Translation:Animals
    19. Laurence-Chasen JD, Manafzadeh AR, Hatsopoulos NG, Ross CF, Arce-McShane FI. Integrating XMALab and DeepLabCut for high-throughput XROMM. J Exp Biol. 2020 Jan 01. PMID: 34005606.
    20. Goodman JM, Tabot GA, Lee AS, Suresh AK, Rajan AT, Hatsopoulos NG, Bensmaia S. Postural Representations of the Hand in the Primate Sensorimotor Cortex. Neuron. 2019 12 04; 104(5):1000-1009.e7. PMID: 31668844; PMCID: PMC7172114.
      Citations: 17     Fields:    Translation:AnimalsCells
    21. Kadmon Harpaz N, Ungarish D, Hatsopoulos NG, Flash T. Movement Decomposition in the Primary Motor Cortex. Cereb Cortex. 2019 04 01; 29(4):1619-1633. PMID: 29668846; PMCID: PMC7302741.
      Citations: 5     Fields:    Translation:AnimalsCells
    22. Liu S, Iriate-Diaz J, Hatsopoulos NG, Ross CF, Takahashi K, Chen Z. Dynamics of motor cortical activity during naturalistic feeding behavior. J Neural Eng. 2019 04; 16(2):026038. PMID: 30721881; PMCID: PMC7367697.
      Citations: 4     Fields:    Translation:Animals
    23. Arce-McShane FI, Sessle BJ, Ross CF, Hatsopoulos NG. Primary sensorimotor cortex exhibits complex dependencies of spike-field coherence on neuronal firing rates, field power, and behavior. J Neurophysiol. 2018 07 01; 120(1):226-238. PMID: 29589815; PMCID: PMC6093958.
      Citations: 4     Fields:    Translation:AnimalsCells
    24. Hatsopoulos NG, Safavi S, Dwarakanath A, Kapoor V, Werner J, Logothetis NK, Panagiotaropoulos TI. Nonmonotonic spatial structure of interneuronal correlations in prefrontal microcircuits. Proc Natl Acad Sci U S A. 2018 04 10; 115(15):E3539-E3548. PMID: 29588415; PMCID: PMC5899496.
      Citations: 6     Fields:    Translation:AnimalsCells
    25. Vaidya M, Balasubramanian K, Southerland J, Badreldin I, Eleryan A, Shattuck K, Gururangan S, Slutzky M, Osborne L, Fagg A, Oweiss K, Hatsopoulos NG. Emergent coordination underlying learning to reach to grasp with a brain-machine interface. J Neurophysiol. 2018 04 01; 119(4):1291-1304. PMID: 29357477; PMCID: PMC5966743.
      Citations: 3     Fields:    Translation:AnimalsCells
    26. Balasubramanian K, Vaidya M, Southerland J, Badreldin I, Eleryan A, Takahashi K, Qian K, Slutzky MW, Fagg AH, Oweiss K, Hatsopoulos NG. Changes in cortical network connectivity with long-term brain-machine interface exposure after chronic amputation. Nat Commun. 2017 11 27; 8(1):1796. PMID: 29180616; PMCID: PMC5703974.
      Citations: 8     Fields:    Translation:AnimalsCells
    27. Dos Anjos LA, Balasubramanian K, Stilson K, Balcer C, Hatsopoulos NG, Kamper DG. Using monkey hand exoskeleton to explore finger passive joint movement response in primary motor cortex. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:3624-3627. PMID: 29060683.
      Citations:    Fields:    Translation:Animals
    28. Omrani M, Kaufman MT, Hatsopoulos NG, Cheney PD. Perspectives on classical controversies about the motor cortex. J Neurophysiol. 2017 09 01; 118(3):1828-1848. PMID: 28615340; PMCID: PMC5599665.
      Citations: 36     Fields:    Translation:HumansAnimals
    29. Nakamura Y, Iriarte-Diaz J, Arce-McShane F, Orsbon CP, Brown KA, Eastment M, Avivi-Arber L, Sessle BJ, Inoue M, Hatsopoulos NG, Ross CF, Takahashi K. Sagittal Plane Kinematics of the Jaw and Hyolingual Apparatus During Swallowing in Macaca mulatta. Dysphagia. 2017 10; 32(5):663-677. PMID: 28528492; PMCID: PMC5767546.
      Citations: 8     Fields:    Translation:HumansAnimals
    30. Best MD, Suminski AJ, Takahashi K, Brown KA, Hatsopoulos NG. Spatio-Temporal Patterning in Primary Motor Cortex at Movement Onset. Cereb Cortex. 2017 02 01; 27(2):1491-1500. PMID: 26759484; PMCID: PMC6375055.
      Citations: 12     Fields:    Translation:AnimalsCells
    31. Dehghani N, Cash SS, Halgren E, Hatsopoulos NG, Telenczuk B, Le Van Quyen M, Destexhe A. Local field potentials primarily reflect inhibitory neuron activity in human and monkey cortex. Sci Rep. 2017 01 11; 7:40211. PMID: 28074856; PMCID: PMC5225490.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    32. Takahashi K, Best MD, Huh N, Brown KA, Tobaa AA, Hatsopoulos NG. Encoding of Both Reaching and Grasping Kinematics in Dorsal and Ventral Premotor Cortices. J Neurosci. 2017 02 15; 37(7):1733-1746. PMID: 28077725; PMCID: PMC5320606.
      Citations: 20     Fields:    Translation:AnimalsCells
    33. Walker J, MacLean J, Hatsopoulos NG. The marmoset as a model system for studying voluntary motor control. Dev Neurobiol. 2017 03; 77(3):273-285. PMID: 27739220.
      Citations: 18     Fields:    Translation:Animals
    34. Muller LE, Halgren E, Cash S, Hatsopoulos NG, Dehghani N, Le Van Quyen M, Telenczuk B, Destexhe A. High-frequency oscillations in human and monkey neocortex during the wake-sleep cycle. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):9363-8. PMID: 27482084; PMCID: PMC4995938.
      Citations: 24     Fields:    Translation:HumansAnimals
    35. Tobaa AA, Best MD, Balasubramanian K, Takahashi K, Hatsopoulos NG. Properties of primary motor cortical local field potentials in the leg and trunk representations during arm movements. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:1636-1639. PMID: 28268643.
      Citations: 1     Fields:    Translation:AnimalsCells
    36. Degenhart AD, Eles J, Dum R, Mischel JL, Smalianchuk I, Endler B, Ashmore RC, Tyler-Kabara EC, Hatsopoulos NG, Wang W, Batista AP, Cui XT. Histological evaluation of a chronically-implanted electrocorticographic electrode grid in a non-human primate. J Neural Eng. 2016 08; 13(4):046019. PMID: 27351722; PMCID: PMC4993459.
      Citations: 35     Fields:    Translation:AnimalsCells
    37. Mochizuki Y, Onaga T, Shimazaki H, Shimokawa T, Tsubo Y, Kimura R, Saiki A, Sakai Y, Isomura Y, Fujisawa S, Shibata K, Hirai D, Furuta T, Kaneko T, Takahashi S, Nakazono T, Ishino S, Sakurai Y, Kitsukawa T, Lee JW, Lee H, Jung MW, Babul C, Maldonado PE, Takahashi K, Arce-McShane FI, Ross CF, Sessle BJ, Hatsopoulos NG, Brochier T, Nishijo H, Ichihara-Takeda S, Funahashi S, Shima K, Mushiake H, Yamane Y, Tamura H, Fujita I, Inaba N, Kawano K, Kurkin S, Fukushima K, Kurata K, Taira M, Tsutsui K, Ogawa T, Komatsu H, Koida K, Toyama K, Richmond BJ, Shinomoto S, Riehle A, Chorley P, Grün S. Similarity in Neuronal Firing Regimes across Mammalian Species. J Neurosci. 2016 05 25; 36(21):5736-47. PMID: 27225764; PMCID: PMC4879195.
      Citations: 32     Fields:    Translation:AnimalsCells
    38. Arce-McShane FI, Ross CF, Takahashi K, Sessle BJ, Hatsopoulos NG. Primary motor and sensory cortical areas communicate via spatiotemporally coordinated networks at multiple frequencies. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):5083-8. PMID: 27091982; PMCID: PMC4983822.
      Citations: 42     Fields:    Translation:AnimalsCells
    39. Dehghani N, Peyrache A, Halgren E, Cash SS, Hatsopoulos NG, Telenczuk B, Le Van Quyen M, Destexhe A. Dynamic Balance of Excitation and Inhibition in Human and Monkey Neocortex. Sci Rep. 2016 Mar 16; 6:23176. PMID: 26980663; PMCID: PMC4793223.
      Citations: 84     Fields:    Translation:HumansAnimals
    40. Best MD, Takahashi K, Suminski AJ, Ethier C, Miller LE, Hatsopoulos NG. Comparing offline decoding performance in physiologically defined neuronal classes. J Neural Eng. 2016 Apr; 13(2):026004. PMID: 26824791; PMCID: PMC4855848.
      Citations: 6     Fields:    Translation:AnimalsCells
    41. Vaidya M, Kording K, Saleh M, Takahashi K, Hatsopoulos NG. Neural coordination during reach-to-grasp. J Neurophysiol. 2015 Sep; 114(3):1827-36. PMID: 26224773; PMCID: PMC4575972.
      Citations: 12     Fields:    Translation:AnimalsCells
    42. Takahashi K, Kim S, Coleman TP, Brown KA, Suminski AJ, Best MD, Hatsopoulos NG. Large-scale spatiotemporal spike patterning consistent with wave propagation in motor cortex. Nat Commun. 2015 May 21; 6:7169. PMID: 25994554; PMCID: PMC4443713.
      Citations: 42     Fields:    Translation:AnimalsCells
    43. Suminski AJ, Mardoum P, Lillicrap TP, Hatsopoulos NG. Temporal evolution of both premotor and motor cortical tuning properties reflect changes in limb biomechanics. J Neurophysiol. 2015 Apr 01; 113(7):2812-23. PMID: 25673733; PMCID: PMC4416622.
      Citations: 13     Fields:    Translation:Animals
    44. Balasubramanian K, Takahashi K, Hatsopoulos NG. Causal network in a deafferented non-human primate brain. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:59-62. PMID: 26736200; PMCID: PMC4851336.
      Citations:    Fields:    Translation:HumansAnimalsCells
    45. Subramaniyam NP, Hyttinen J, Hatsopoulos NG, Ross CF, Takahashi K. Recurrence network analysis of multiple local field potential bands from the orofacial portion of primary motor cortex. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:5343-6. PMID: 26737498; PMCID: PMC5204308.
      Citations:    Fields:    Translation:AnimalsCells
    46. Best MD, Nakamura Y, Kijak NA, Allen MJ, Lever TE, Hatsopoulos NG, Ross CF, Takahashi K. Semiautomatic marker tracking of tongue positions captured by videofluoroscopy during primate feeding. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:5347-50. PMID: 26737499; PMCID: PMC5217178.
      Citations: 3     Fields:    Translation:HumansAnimals
    47. Eleryan A, Vaidya M, Southerland J, Badreldin IS, Balasubramanian K, Fagg AH, Hatsopoulos N, Oweiss K. Tracking single units in chronic, large scale, neural recordings for brain machine interface applications. Front Neuroeng. 2014; 7:23. PMID: 25071546; PMCID: PMC4086297.
      Citations: 11     
    48. Arce-McShane FI, Hatsopoulos NG, Lee JC, Ross CF, Sessle BJ. Modulation dynamics in the orofacial sensorimotor cortex during motor skill acquisition. J Neurosci. 2014 Apr 23; 34(17):5985-97. PMID: 24760857; PMCID: PMC4401283.
      Citations: 22     Fields:    Translation:AnimalsCells
    49. Willett FR, Suminski AJ, Fagg AH, Hatsopoulos NG. Differences in motor cortical representations of kinematic variables between action observation and action execution and implications for brain-machine interfaces. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:1334-7. PMID: 25570214.
      Citations:    Fields:    Translation:AnimalsCells
    50. Best MD, Suminski AJ, Takahashi K, Hatsopoulos NG. Consideration of the functional relationship between cortex and motor periphery improves offline decoding performance. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:4868-71. PMID: 25571082; PMCID: PMC4482223.
      Citations: 1     Fields:    Translation:AnimalsCells
    51. Vaidya M, Dickey A, Best MD, Coles J, Balasubramanian K, Suminski AJ, Hatsopoulos NG. Ultra-long term stability of single units using chronically implanted multielectrode arrays. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:4872-5. PMID: 25571083; PMCID: PMC4482221.
      Citations: 7     Fields:    Translation:AnimalsCells
    52. Balasubramanian K, Takahashi K, Slutzky M, Hatsopoulos NG. Multi-modal decoding: longitudinal coherency changes between spike trains, local field potentials and electrocorticogram signals. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:5192-5. PMID: 25571163; PMCID: PMC4484754.
      Citations: 1     Fields:    Translation:Animals
    53. Hatsopoulos NG, Kaneko T, Shepherd GM, Brecht M. Motor cortex microcircuits. Front Neural Circuits. 2013; 7:196. PMID: 24376400; PMCID: PMC3859911.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    54. Arce FI, Lee JC, Ross CF, Sessle BJ, Hatsopoulos NG. Directional information from neuronal ensembles in the primate orofacial sensorimotor cortex. J Neurophysiol. 2013 Sep; 110(6):1357-69. PMID: 23785133.
      Citations: 14     Fields:    Translation:AnimalsCells
    55. Dickey AS, Amit Y, Hatsopoulos NG. Heterogeneous neural coding of corrective movements in motor cortex. Front Neural Circuits. 2013; 7:51. PMID: 23576955; PMCID: PMC3616342.
      Citations: 7     Fields:    Translation:Animals
    56. Berg JA, Dammann JF, Tenore FV, Tabot GA, Boback JL, Manfredi LR, Peterson ML, Katyal KD, Johannes MS, Makhlin A, Wilcox R, Franklin RK, Vogelstein RJ, Hatsopoulos NG, Bensmaia SJ. Behavioral demonstration of a somatosensory neuroprosthesis. IEEE Trans Neural Syst Rehabil Eng. 2013 May; 21(3):500-7. PMID: 23475375.
      Citations: 40     Fields:    Translation:HumansAnimals
    57. Willett FR, Suminski AJ, Fagg AH, Hatsopoulos NG. Improving brain-machine interface performance by decoding intended future movements. J Neural Eng. 2013 Apr; 10(2):026011. PMID: 23428966; PMCID: PMC4019387.
      Citations: 18     Fields:    Translation:Animals
    58. Balasubramanian K, Southerland J, Vaidya M, Qian K, Eleryan A, Fagg AH, Sluzky M, Oweiss K, Hatsopoulos N. Operant conditioning of a multiple degree-of-freedom brain-machine interface in a primate model of amputation. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:303-6. PMID: 24109684.
      Citations: 7     Fields:    Translation:HumansAnimals
    59. Suminski AJ, Fagg AH, Willett FR, Bodenhamer M, Hatsopoulos NG. Online adaptive decoding of intended movements with a hybrid kinetic and kinematic brain machine interface. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:1583-6. PMID: 24110004.
      Citations: 3     Fields:    Translation:Animals
    60. Stevenson IH, London BM, Oby ER, Sachs NA, Reimer J, Englitz B, David SV, Shamma SA, Blanche TJ, Mizuseki K, Zandvakili A, Hatsopoulos NG, Miller LE, Kording KP. Functional connectivity and tuning curves in populations of simultaneously recorded neurons. PLoS Comput Biol. 2012; 8(11):e1002775. PMID: 23166484; PMCID: PMC3499254.
      Citations: 33     Fields:    Translation:AnimalsCells
    61. Hatsopoulos NG, Haga ZD, Parker RA, Greger B, Halgren E, Cash SS, Destexhe A, Dehghani N. Avalanche Analysis from Multielectrode Ensemble Recordings in Cat, Monkey, and Human Cerebral Cortex during Wakefulness and Sleep. Front Physiol. 2012; 3:302. PMID: 22934053; PMCID: PMC3429073.
      Citations: 47     
    62. Lawhern V, Hatsopoulos NG, Wu W. Coupling Time Decoding and Trajectory Decoding using a Target-Included Model in the Motor Cortex. Neurocomputing. 2012 Apr 01; 82:117-126. PMID: 22379284; PMCID: PMC3286625.
      Citations: 3     
    63. Saleh M, Takahashi K, Hatsopoulos NG. Encoding of coordinated reach and grasp trajectories in primary motor cortex. J Neurosci. 2012 Jan 25; 32(4):1220-32. PMID: 22279207; PMCID: PMC3711866.
      Citations: 37     Fields:    Translation:Animals
    64. Ashmore RC, Endler BM, Smalianchuk I, Degenhart AD, Hatsopoulos NG, Tyler-Kabara EC, Batista AP, Wang W. Stable online control of an electrocorticographic brain-computer interface using a static decoder. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:1740-4. PMID: 23366246.
      Citations: 10     Fields:    Translation:HumansAnimals
    65. Willett FR, Suminski AJ, Fagg AH, Hatsopoulos NG. Compensating for delays in brain-machine interfaces by decoding intended future movement. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:4087-90. PMID: 23366826.
      Citations: 2     Fields:    Translation:Animals
    66. Takahashi K, Pesce L, Iriarte-Diaz J, Kim S, Coleman TP, Hatsopoulos NG, Ross CF. Granger causality analysis of functional connectivity of spiking neurons in orofacial motor cortex during chewing and swallowing. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:4587-90. PMID: 23366949.
      Citations: 1     Fields:    Translation:AnimalsCells
    67. Hatsopoulos NG, Suminski AJ. Sensing with the motor cortex. Neuron. 2011 Nov 03; 72(3):477-87. PMID: 22078507; PMCID: PMC3263767.
      Citations: 72     Fields:    Translation:HumansAnimals
    68. Amarasingham A, Harrison MT, Hatsopoulos NG, Geman S. Conditional modeling and the jitter method of spike resampling. J Neurophysiol. 2012 Jan; 107(2):517-31. PMID: 22031767; PMCID: PMC3349623.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    69. Hatsopoulos NG, Amit Y. Synthesizing complex movement fragment representations from motor cortical ensembles. J Physiol Paris. 2012 May-Aug; 106(3-4):112-9. PMID: 21939762; PMCID: PMC3246072.
      Citations: 7     Fields:    Translation:AnimalsCells
    70. Stevenson IH, Cherian A, London BM, Sachs NA, Lindberg E, Reimer J, Slutzky MW, Hatsopoulos NG, Miller LE, Kording KP. Statistical assessment of the stability of neural movement representations. J Neurophysiol. 2011 Aug; 106(2):764-74. PMID: 21613593; PMCID: PMC3154833.
      Citations: 35     Fields:    Translation:AnimalsCells
    71. Takahashi K, Saleh M, Penn RD, Hatsopoulos NG. Propagating waves in human motor cortex. Front Hum Neurosci. 2011; 5:40. PMID: 21629859; PMCID: PMC3084448.
      Citations: 41     
    72. Suminski AJ, Willett FR, Fagg AH, Bodenhamer M, Hatsopoulos NG. Continuous decoding of intended movements with a hybrid kinetic and kinematic brain machine interface. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:5802-6. PMID: 22255659.
      Citations: 6     Fields:    Translation:Animals
    73. Kim S, Takahashi K, Hatsopoulos NG, Coleman TP. Information transfer between neurons in the motor cortex triggered by visual cues. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:7278-81. PMID: 22256019.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    74. Suminski AJ, Tkach DC, Fagg AH, Hatsopoulos NG. Incorporating feedback from multiple sensory modalities enhances brain-machine interface control. J Neurosci. 2010 Dec 15; 30(50):16777-87. PMID: 21159949; PMCID: PMC3046069.
      Citations: 92     Fields:    Translation:AnimalsCells
    75. Saleh M, Takahashi K, Amit Y, Hatsopoulos NG. Encoding of coordinated grasp trajectories in primary motor cortex. J Neurosci. 2010 Dec 15; 30(50):17079-90. PMID: 21159978; PMCID: PMC3046070.
      Citations: 29     Fields:    Translation:AnimalsCells
    76. Reimer J, Hatsopoulos NG. Periodicity and evoked responses in motor cortex. J Neurosci. 2010 Aug 25; 30(34):11506-15. PMID: 20739573; PMCID: PMC2952881.
      Citations: 27     Fields:    Translation:Animals
    77. Quinn CJ, Coleman TP, Kiyavash N, Hatsopoulos NG. Estimating the directed information to infer causal relationships in ensemble neural spike train recordings. J Comput Neurosci. 2011 Feb; 30(1):17-44. PMID: 20582566; PMCID: PMC3171872.
      Citations: 38     Fields:    Translation:AnimalsCells
    78. Lawhern V, Wu W, Hatsopoulos N, Paninski L. Population decoding of motor cortical activity using a generalized linear model with hidden states. J Neurosci Methods. 2010 Jun 15; 189(2):267-80. PMID: 20359500; PMCID: PMC2921213.
      Citations: 27     Fields:    Translation:Animals
    79. Saleh M, Reimer J, Penn R, Ojakangas CL, Hatsopoulos NG. Fast and slow oscillations in human primary motor cortex predict oncoming behaviorally relevant cues. Neuron. 2010 Feb 25; 65(4):461-71. PMID: 20188651; PMCID: PMC3199221.
      Citations: 112     Fields:    Translation:HumansCells
    80. Fagg AH, Ojakangas GW, Miller LE, Hatsopoulos NG. Kinetic trajectory decoding using motor cortical ensembles. IEEE Trans Neural Syst Rehabil Eng. 2009 Oct; 17(5):487-96. PMID: 19666343.
      Citations: 43     Fields:    Translation:Animals
    81. Dickey AS, Suminski A, Amit Y, Hatsopoulos NG. Single-unit stability using chronically implanted multielectrode arrays. J Neurophysiol. 2009 Aug; 102(2):1331-9. PMID: 19535480; PMCID: PMC2724357.
      Citations: 108     Fields:    Translation:AnimalsCells
    82. Wu W, Kulkarni JE, Hatsopoulos NG, Paninski L. Neural decoding of hand motion using a linear state-space model with hidden states. IEEE Trans Neural Syst Rehabil Eng. 2009 Aug; 17(4):370-8. PMID: 19497822; PMCID: PMC4484239.
      Citations: 26     Fields:    Translation:Humans
    83. Suminski AJ, Tkach DC, Hatsopoulos NG. Exploiting multiple sensory modalities in brain-machine interfaces. Neural Netw. 2009 Nov; 22(9):1224-34. PMID: 19525091; PMCID: PMC2783491.
      Citations: 24     Fields:    Translation:AnimalsCells
    84. Hatsopoulos NG. Columnar organization in the motor cortex. Cortex. 2010 Feb; 46(2):270-1. PMID: 19398100; PMCID: PMC3180956.
      Citations: 4     Fields:    Translation:AnimalsCells
    85. Reimer J, Hatsopoulos NG. The problem of parametric neural coding in the motor system. Adv Exp Med Biol. 2009; 629:243-59. PMID: 19227503; PMCID: PMC4480635.
      Citations: 13     Fields:    Translation:AnimalsCells
    86. Fagg AH, Hatsopoulos NG, London BM, Reimer J, Solla SA, Wang D, Miller LE. Toward a biomimetic, bidirectional, brain machine interface. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:3376-80. PMID: 19963797.
      Citations: 4     Fields:    Translation:HumansCells
    87. Hatsopoulos NG, Donoghue JP. The science of neural interface systems. Annu Rev Neurosci. 2009; 32:249-66. PMID: 19400719; PMCID: PMC2921719.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    88. Stevenson IH, Rebesco JM, Hatsopoulos NG, Haga Z, Miller LE, Körding KP. Bayesian inference of functional connectivity and network structure from spikes. IEEE Trans Neural Syst Rehabil Eng. 2009 Jun; 17(3):203-13. PMID: 19273038; PMCID: PMC3406607.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    89. Tkach D, Reimer J, Hatsopoulos NG. Observation-based learning for brain-machine interfaces. Curr Opin Neurobiol. 2008 Dec; 18(6):589-94. PMID: 18838120; PMCID: PMC2771336.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    90. Wu W, Hatsopoulos NG. Real-time decoding of nonstationary neural activity in motor cortex. IEEE Trans Neural Syst Rehabil Eng. 2008 Jun; 16(3):213-22. PMID: 18586600; PMCID: PMC4484753.
      Citations: 31     Fields:    Translation:Animals
    91. Tkach D, Reimer J, Hatsopoulos NG. Congruent activity during action and action observation in motor cortex. J Neurosci. 2007 Nov 28; 27(48):13241-50. PMID: 18045918; PMCID: PMC6673404.
      Citations: 106     Fields:    Translation:AnimalsCells
    92. Fagg AH, Hatsopoulos NG, de Lafuente V, Moxon KA, Nemati S, Rebesco JM, Romo R, Solla SA, Reimer J, Tkach D, Pohlmeyer EA, Miller LE. Biomimetic brain machine interfaces for the control of movement. J Neurosci. 2007 Oct 31; 27(44):11842-6. PMID: 17978021; PMCID: PMC2586067.
      Citations: 30     Fields:    Translation:HumansAnimals
    93. Hatsopoulos NG, Xu Q, Amit Y. Encoding of movement fragments in the motor cortex. J Neurosci. 2007 May 09; 27(19):5105-14. PMID: 17494696; PMCID: PMC6672361.
      Citations: 91     Fields:    Translation:AnimalsCells
    94. Wu W, Hatsopoulos NG. Coordinate system representations of movement direction in the premotor cortex. Exp Brain Res. 2007 Feb; 176(4):652-7. PMID: 17180398.
      Citations: 17     Fields:    Translation:AnimalsCells
    95. Rubino D, Robbins KA, Hatsopoulos NG. Propagating waves mediate information transfer in the motor cortex. Nat Neurosci. 2006 Dec; 9(12):1549-57. PMID: 17115042.
      Citations: 203     Fields:    Translation:Animals
    96. Chi Z, Wu W, Haga Z, Hatsopoulos NG, Margoliash D. Template-based spike pattern identification with linear convolution and dynamic time warping. J Neurophysiol. 2007 Feb; 97(2):1221-35. PMID: 17108096.
      Citations: 6     Fields:    Translation:AnimalsCells
    97. Wu W, Hatsopoulos N. Evidence against a single coordinate system representation in the motor cortex. Exp Brain Res. 2006 Nov; 175(2):197-210. PMID: 16775704.
      Citations: 37     Fields:    Translation:AnimalsCells
    98. O'Leary JG, Hatsopoulos NG. Early visuomotor representations revealed from evoked local field potentials in motor and premotor cortical areas. J Neurophysiol. 2006 Sep; 96(3):1492-506. PMID: 16738219.
      Citations: 42     Fields:    Translation:Animals
    99. Hatsopoulos NG. Encoding in the motor cortex: was evarts right after all? Focus on "motor cortex neural correlates of output kinematics and kinetics during isometric-force and arm-reaching tasks". J Neurophysiol. 2005 Oct; 94(4):2261-2. PMID: 16160087.
      Citations: 9     Fields:    Translation:Animals
    100. Shoham S, Paninski LM, Fellows MR, Hatsopoulos NG, Donoghue JP, Normann RA. Statistical encoding model for a primary motor cortical brain-machine interface. IEEE Trans Biomed Eng. 2005 Jul; 52(7):1312-22. PMID: 16041995.
      Citations: 34     Fields:    Translation:Animals
    101. Hatsopoulos N, Mukand J, Polykoff G, Friehs G, Donoghue J. Cortically controlled brain-machine interface. Conf Proc IEEE Eng Med Biol Soc. 2005; 2005:7660-3. PMID: 17282055.
      Citations: 6     Fields:    
    102. Paninski L, Shoham S, Fellows MR, Hatsopoulos NG, Donoghue JP. Superlinear population encoding of dynamic hand trajectory in primary motor cortex. J Neurosci. 2004 Sep 29; 24(39):8551-61. PMID: 15456829; PMCID: PMC6729889.
      Citations: 46     Fields:    Translation:AnimalsCells
    103. Hatsopoulos N, Joshi J, O'Leary JG. Decoding continuous and discrete motor behaviors using motor and premotor cortical ensembles. J Neurophysiol. 2004 Aug; 92(2):1165-74. PMID: 15277601.
      Citations: 76     Fields:    Translation:Animals
    104. Fofonoff TA, Martel SM, Hatsopoulos NG, Donoghue JP, Hunter IW. Microelectrode array fabrication by electrical discharge machining and chemical etching. IEEE Trans Biomed Eng. 2004 Jun; 51(6):890-5. PMID: 15188855.
      Citations: 5     Fields:    Translation:AnimalsCells
    105. Gabbiani F, Krapp HG, Hatsopoulos N, Mo CH, Koch C, Laurent G. Multiplication and stimulus invariance in a looming-sensitive neuron. J Physiol Paris. 2004 Jan-Jun; 98(1-3):19-34. PMID: 15477020.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    106. Paninski L, Fellows MR, Hatsopoulos NG, Donoghue JP. Spatiotemporal tuning of motor cortical neurons for hand position and velocity. J Neurophysiol. 2004 Jan; 91(1):515-32. PMID: 13679402.
      Citations: 157     Fields:    Translation:AnimalsCells
    107. Serruya M, Hatsopoulos N, Fellows M, Paninski L, Donoghue J. Robustness of neuroprosthetic decoding algorithms. Biol Cybern. 2003 Mar; 88(3):219-28. PMID: 12647229.
      Citations: 26     Fields:    Translation:AnimalsCells
    108. Hatsopoulos NG, Paninski L, Donoghue JP. Sequential movement representations based on correlated neuronal activity. Exp Brain Res. 2003 Apr; 149(4):478-86. PMID: 12677328.
      Citations: 11     Fields:    Translation:AnimalsCells
    109. Serruya MD, Hatsopoulos NG, Paninski L, Fellows MR, Donoghue JP. Instant neural control of a movement signal. Nature. 2002 Mar 14; 416(6877):141-2. PMID: 11894084.
      Citations: 363     Fields:    Translation:HumansAnimalsCells
    110. Oram MW, Hatsopoulos NG, Richmond BJ, Donoghue JP. Excess synchrony in motor cortical neurons provides redundant direction information with that from coarse temporal measures. J Neurophysiol. 2001 Oct; 86(4):1700-16. PMID: 11600633.
      Citations: 34     Fields:    Translation:AnimalsCells
    111. Hatsopoulos NG, Harrison MT, Donoghue JP, Hatsopoulos NG, Harrison MT, Donoghue JP. Representations based on neuronal interactions in motor cortex. Prog Brain Res. 2001; 130:233-44. PMID: 11480278.
      Citations: 4     Fields:    Translation:AnimalsCells
    112. Gabbiani F, Laurent G, Hatsopoulos N, Krapp HG. The many ways of building collision-sensitive neurons. Trends Neurosci. 1999 Oct; 22(10):437-8. PMID: 10481188.
      Citations: 2     Fields:    Translation:AnimalsCells
    113. Maynard EM, Hatsopoulos NG, Ojakangas CL, Acuna BD, Sanes JN, Normann RA, Donoghue JP. Neuronal interactions improve cortical population coding of movement direction. J Neurosci. 1999 Sep 15; 19(18):8083-93. PMID: 10479708; PMCID: PMC6782478.
      Citations: 91     Fields:    Translation:AnimalsCells
    114. Hatsopoulos NG, Ojakangas CL, Paninski L, Donoghue JP. Information about movement direction obtained from synchronous activity of motor cortical neurons. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15706-11. PMID: 9861034; PMCID: PMC28108.
      Citations: 78     Fields:    Translation:AnimalsCells
    115. Donoghue JP, Sanes JN, Hatsopoulos NG, Gaál G. Neural discharge and local field potential oscillations in primate motor cortex during voluntary movements. J Neurophysiol. 1998 Jan; 79(1):159-73. PMID: 9425187.
      Citations: 174     Fields:    Translation:AnimalsCells
    116. Hatsopoulos NG. Coupling the neural and physical dynamics in rhythmic movements. Neural Comput. 1996 Apr 01; 8(3):567-81. PMID: 8868568.
      Citations: 16     Fields:    Translation:Cells
    117. Hatsopoulos NG, Warren WH. Resonance Tuning in Rhythmic Arm Movements. J Mot Behav. 1996 03; 28(1):3-14. PMID: 12529219.
      Citations: 20     Fields:    
    118. Hatsopoulos N, Gabbiani F, Laurent G. Elementary computation of object approach by wide-field visual neuron. Science. 1995 Nov 10; 270(5238):1000-3. PMID: 15290817.
      Citations: 66     Fields:    Translation:AnimalsCells
    119. Hatsopoulos NG, Burrows M, Laurent G. Hysteresis reduction in proprioception using presynaptic shunting inhibition. J Neurophysiol. 1995 Mar; 73(3):1031-42. PMID: 7608753.
      Citations: 3     Fields:    Translation:AnimalsCells
    120. Hatsopoulos NG. Is a virtual trajectory necessary in reaching movements? Biol Cybern. 1994; 70(6):541-51. PMID: 8068769.
      Citations:    Fields:    Translation:Humans
    121. Warren WH, Blackwell AW, Kurtz KJ, Hatsopoulos NG, Kalish ML. On the sufficiency of the velocity field for perception of heading. Biol Cybern. 1991; 65(5):311-20. PMID: 1742369.
      Citations: 22     Fields:    Translation:Humans
    122. Estes WK, Campbell JA, Hatsopoulos N, Hurwitz JB. Base-rate effects in category learning: a comparison of parallel network and memory storage-retrieval models. J Exp Psychol Learn Mem Cogn. 1989 Jul; 15(4):556-71. PMID: 2526853.
      Citations: 13     Fields:    Translation:Humans
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