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Septimiu Murgu

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary/Critical Care
AddressChicago IL 60637
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    Septimiu Murgu is an interventional pulmonologist with specific expertise in minimally invasive diagnostic and therapeutic bronchoscopic and pleural procedures. He is currently Associate Professor of Medicine at the University of Chicago, Division of Pulmonary and Critical Care Medicine.

    Over the years, Dr Murgu has contributed to the current knowledge in the field of tracheobronchomalacia (TBM) and excessive dynamic airway collapse (EDAC). His projects lead to a better understanding of airflow dynamics, nomenclature and classification of these disorders. As a result of his work, EDAC is recognized as a pathophysiologic entity distinct from TBM. In collaboration with international researchers and biomedical engineers, he initiated the evaluation of multimodal bronchoscopic imaging including optical coherence tomography and radial endobronchial ultrasound in the study of benign central airway disorders. He serves in the Board of Directors of the American Association for Bronchology and Interventional Pulmonology (AABIP). He served as the American College of Chest Physicians (ACCP) governor for California South and Illinois, and was a member of writing panel for the 3rd edition of the ACCP Lung Cancer Guidelines. He is an active member of the ACCP Pulmonary Procedures Workgroup and is involved in educational projects with the World Association for Bronchology and Interventional Pulmonology (WABIP), ACCP and AABIP. He serves as an Associate Editor for the WABIP Newsletter and Associate Editor for the Journal of Bronchology and Interventional Pulmonology.

    His clinical and research interests include minimally invasive diagnostic and therapeutic interventions for patients suffering from benign and malignant airway obstruction. He is actively involved in bronchoscopy and lung cancer education projects. Over the years, he has contributed to the international impact of new curricula for bronchoscopy and lung cancer-related education under the auspices of Bronchoscopy International, WABIP and ACCP. These educational projects use simulation technology, interactive step- by-step teaching, problem-based learning and flipped classroom educational methodologies. His current research interests include molecular profiling of lung cancer at diagnosis and disease progression, airflow physiology in TBM and EDAC, application of novel acoustic and optical imaging for airway processes and outcomes of interventional airway and pleural procedures using minimally invasive techniques.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Schneider BJ, Ismaila N, Aerts J, Chiles C, Daly ME, Detterbeck FC, Hearn JWD, Katz SI, Leighl NB, Levy B, Meyers B, Murgu S, Nekhlyudov L, Santos ES, Singh N, Tashbar J, Yankelevitz D, Altorki N. Lung Cancer Surveillance After Definitive Curative-Intent Therapy: ASCO Guideline. J Clin Oncol. 2019 Dec 12; JCO1902748. PMID: 31829901.
      View in: PubMed
    2. Chaddha U, Kovacs SP, Manley C, Hogarth DK, Cumbo-Nacheli G, Bhavani SV, Kumar R, Shende M, Egan JP, Murgu S. Robot-assisted bronchoscopy for pulmonary lesion diagnosis: results from the initial multicenter experience. BMC Pulm Med. 2019 Dec 11; 19(1):243. PMID: 31829148.
      View in: PubMed
    3. Bermea RS, Miller J, Wilson WW, Dugan K, Frye L, Murgu S, Hogarth DK. One-Way Endobronchial Valves as Management for Persistent Air Leaks: A Preview of What's to Come? Am J Respir Crit Care Med. 2019 Nov 15; 200(10):1318-1320. PMID: 31310162.
      View in: PubMed
    4. Jayadevappa R, Chhatre S, Soukiasian HJ, Murgu S. Outcomes of patients with advanced non-small cell lung cancer and airway obstruction treated with photodynamic therapy and non-photodynamic therapy ablation modalities. J Thorac Dis. 2019 Oct; 11(10):4389-4399. PMID: 31737325.
      View in: PubMed
    5. Chaddha U, Hogarth DK, Murgu S. Bronchoscopic Ablative Therapies for Malignant Central Airway Obstruction and Peripheral Lung Tumors. Ann Am Thorac Soc. 2019 Oct; 16(10):1220-1229. PMID: 31194922.
      View in: PubMed
    6. Chaddha U, Hogarth DK, Murgu S. The role of endobronchial ultrasound transbronchial needle aspiration for programmed death ligand 1 testing and next generation sequencing in advanced non-small cell lung cancer. Ann Transl Med. 2019 Aug; 7(15):351. PMID: 31516897.
      View in: PubMed
    7. Murgu SD. Robotic assisted-bronchoscopy: technical tips and lessons learned from the initial experience with sampling peripheral lung lesions. BMC Pulm Med. 2019 May 09; 19(1):89. PMID: 31072355.
      View in: PubMed
    8. Chaddha U, Hogarth DK, Murgu S. Perspective on airway stenting in inoperable patients with tracheoesophageal fistula after curative-intent treatment for esophageal cancer. J Thorac Dis. 2019 May; 11(5):2165-2174. PMID: 31285911.
      View in: PubMed
    9. Folch EE, Pritchett MA, Nead MA, Bowling MR, Murgu SD, Krimsky WS, Murillo BA, LeMense GP, Minnich DJ, Bansal S, Ellis BQ, Mahajan AK, Gildea TR, Bechara RI, Sztejman E, Flandes J, Rickman OB, Benzaquen S, Hogarth DK, Linden PA, Wahidi MM, Mattingley JS, Hood KL, Lin H, Wolvers JJ, Khandhar SJ. Electromagnetic Navigation Bronchoscopy for Peripheral Pulmonary Lesions: One-Year Results of the Prospective, Multicenter NAVIGATE Study. J Thorac Oncol. 2019 03; 14(3):445-458. PMID: 30476574.
      View in: PubMed
    10. Murgu SD, Kurman JS, Hasan O. Bronchoscopy Education: An Experiential Learning Theory Perspective. Clin Chest Med. 2018 03; 39(1):99-110. PMID: 29433728.
      View in: PubMed
    11. Kurman JS, Murgu SD. Hyperprogressive disease in patients with non-small cell lung cancer on immunotherapy. J Thorac Dis. 2018 Feb; 10(2):1124-1128. PMID: 29607190.
      View in: PubMed
    12. Murgu S, Rabito R, Lasko G, Jackson C, Mino-Kenudson M, Ettinger DS, Ramalingam SS, Edell ES. Impact of a Non-small Cell Lung Cancer Educational Program for Interdisciplinary Teams. Chest. 2018 04; 153(4):876-887. PMID: 29246769.
      View in: PubMed
    13. Stoy SP, Segal JP, Mueller J, Furtado LV, Vokes EE, Patel JD, Murgu S. Feasibility of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Cytology Specimens for Next Generation Sequencing in Non-small-cell Lung Cancer. Clin Lung Cancer. 2018 05; 19(3):230-238.e2. PMID: 29277564.
      View in: PubMed
    14. Stoy SP, Rosen L, Mueller J, Murgu S. Programmed death-ligand 1 testing of lung cancer cytology specimens obtained with bronchoscopy. Cancer Cytopathol. 2018 02; 126(2):122-128. PMID: 29053224.
      View in: PubMed
    15. Akthar AS, Koshy M, Ferguson MK, Murgu S, Hogarth DK, Golden DW, Connell PP, Davies EM, Kowalski E, Malik R. Effect of Endoscopic Bronchial Ultrasound on Outcomes for Stage I Non-Small-Cell Lung Cancer Patients Receiving Hypofractionated Radiotherapy. Clin Lung Cancer. 2018 03; 19(2):e227-e233. PMID: 28939097.
      View in: PubMed
    16. Dugan KC, Laxmanan B, Murgu S, Hogarth DK. Response. Chest. 2017 08; 152(2):450. PMID: 28797392.
      View in: PubMed
    17. Stoy S, Rosen L, Murgu S. The Use of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Cytology Specimens for Programmed Death Ligand 1 Immunohistochemistry Testing in Non-Small Cell Lung Cancer. J Bronchology Interv Pulmonol. 2017 Jul; 24(3):181-183. PMID: 28696962.
      View in: PubMed
    18. Khandhar SJ, Bowling MR, Flandes J, Gildea TR, Hood KL, Krimsky WS, Minnich DJ, Murgu SD, Pritchett M, Toloza EM, Wahidi MM, Wolvers JJ, Folch EE. Electromagnetic navigation bronchoscopy to access lung lesions in 1,000 subjects: first results of the prospective, multicenter NAVIGATE study. BMC Pulm Med. 2017 04 11; 17(1):59. PMID: 28399830.
      View in: PubMed
    19. Stoy S, Murgu S. The use of endobronchial ultrasound guided transbronchial needle aspiration specimens for next generation sequencing in non-small cell lung cancer: a clinical perspective. J Thorac Dis. 2017 Apr; 9(4):E398-E401. PMID: 28523189.
      View in: PubMed
    20. Dugan KC, Laxmanan B, Murgu S, Hogarth DK. Management of Persistent Air Leaks. Chest. 2017 08; 152(2):417-423. PMID: 28267436.
      View in: PubMed
    21. Morris MJ, Murgu S. Reply: Excessive Dynamic Airway Collapse: Fact, Fiction, or Flow Limitation. Ann Am Thorac Soc. 2017 02; 14(2):302-303. PMID: 28146375.
      View in: PubMed
    22. Caliskan T, Sungurlu S, Murgu S. Personalized interventions for tracheobronchomalacia. J Thorac Dis. 2016 Dec; 8(12):3486-3489. PMID: 28149539.
      View in: PubMed
    23. Murgu S, Stoy S. The When, the How and the Why of Metallic Stent Removal. J Bronchology Interv Pulmonol. 2016 Oct; 23(4):266-271. PMID: 27764004.
      View in: PubMed
    24. Murgu S, Stoy S. Excessive Dynamic Airway Collapse: A Standalone Cause of Exertional Dyspnea? Ann Am Thorac Soc. 2016 09; 13(9):1437-9. PMID: 27627468.
      View in: PubMed
    25. Folch EE, Bowling MR, Gildea TR, Hood KL, Murgu SD, Toloza EM, Wahidi MM, Williams T, Khandhar SJ. Design of a prospective, multicenter, global, cohort study of electromagnetic navigation bronchoscopy. BMC Pulm Med. 2016 Apr 26; 16(1):60. PMID: 27113209.
      View in: PubMed
    26. Vigneswaran J, Tan YH, Murgu SD, Won BM, Patton KA, Villaflor VM, Hoffman PC, Hensing T, Hogarth DK, Malik R, MacMahon H, Mueller J, Simon CA, Vigneswaran WT, Wigfield CH, Ferguson MK, Husain AN, Vokes EE, Salgia R. Comprehensive genetic testing identifies targetable genomic alterations in most patients with non-small cell lung cancer, specifically adenocarcinoma, single institute investigation. Oncotarget. 2016 Apr 05; 7(14):18876-86. PMID: 26934441.
      View in: PubMed
    27. Murgu SD, Laxmanan B. Biomechanical Properties of Airway Stents: Implications for Clinical Practice. J Bronchology Interv Pulmonol. 2016 Apr; 23(2):89-91. PMID: 27058709.
      View in: PubMed
    28. Laxmanan B, Egressy K, Murgu SD, White SR, Hogarth DK. Advances in Bronchial Thermoplasty. Chest. 2016 09; 150(3):694-704. PMID: 27006157.
      View in: PubMed
    29. Murgu SD, Egressy K, Laxmanan B, Doblare G, Ortiz-Comino R, Hogarth DK. Central Airway Obstruction: Benign Strictures, Tracheobronchomalacia, and Malignancy-related Obstruction. Chest. 2016 08; 150(2):426-41. PMID: 26874192.
      View in: PubMed
    30. Lennon FE, Cianci GC, Cipriani NA, Hensing TA, Zhang HJ, Chen CT, Murgu SD, Vokes EE, Vannier MW, Salgia R. Lung cancer-a fractal viewpoint. Nat Rev Clin Oncol. 2015 Nov; 12(11):664-75. PMID: 26169924.
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    31. Murgu SD. Diagnosing and staging lung cancer involving the mediastinum. Chest. 2015 May; 147(5):1401-1412. PMID: 25940251.
      View in: PubMed
    32. Egressy K, Murgu S. Medical thoracoscopy versus closed pleural biopsy: should this saga continue in the era of competency-oriented training? J Bronchology Interv Pulmonol. 2015 Apr; 22(2):95-6. PMID: 25887002.
      View in: PubMed
    33. Egressy KV, Murgu SD. Current approaches to assessing the degree of airway narrowing in central airway obstruction. Ann Am Thorac Soc. 2015 Jan; 12(1):109-10. PMID: 25635656.
      View in: PubMed
    34. Miller RJ, Murgu SD. Interventional pulmonology for asthma and emphysema: bronchial thermoplasty and bronchoscopic lung volume reduction. Semin Respir Crit Care Med. 2014 Dec; 35(6):655-70. PMID: 25463157.
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    35. Murgu S. Invited commentary. Ann Thorac Surg. 2014 Nov; 98(5):1768. PMID: 25441786.
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    36. Toma TP, Murgu S. Pieces to the puzzle of endobronchial valve insertion for emphysema. J Bronchology Interv Pulmonol. 2014 Oct; 21(4):281-3. PMID: 25321445.
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    37. Murgu SD. Pneumatic stenting for tracheobronchomalacia. J Bronchology Interv Pulmonol. 2014 Apr; 21(2):109-12. PMID: 24739682.
      View in: PubMed
    38. Fielding DI, Maldonado F, Murgu S. Achieving competency in bronchoscopy: challenges and opportunities. Respirology. 2014 May; 19(4):472-82. PMID: 24689877.
      View in: PubMed
    39. Miller RJ, Murgu SD. Bronchoscopic resection of an exophytic endoluminal tracheal mass. Ann Am Thorac Soc. 2013 Dec; 10(6):697-700. PMID: 24364776.
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    40. Murgu S, Colt H. Role of the pulmonologist in ordering post-procedure molecular markers in non-small-cell lung cancer: implications for personalized medicine. Clin Lung Cancer. 2013 Nov; 14(6):609-26. PMID: 24188629.
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    41. Handa H, Huang J, Murgu SD, Mineshita M, Kurimoto N, Colt HG, Miyazawa T. Assessment of central airway obstruction using impulse oscillometry before and after interventional bronchoscopy. Respir Care. 2014 Feb; 59(2):231-40. PMID: 23882104.
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    42. Murgu S, Colt H. Tracheobronchomalacia and excessive dynamic airway collapse. Clin Chest Med. 2013 Sep; 34(3):527-55. PMID: 23993822.
      View in: PubMed
    43. Murgu SD, Colt HG. Combined optical coherence tomography and endobronchial ultrasonography for laser-assisted treatment of postintubation laryngotracheal stenosis. Ann Otol Rhinol Laryngol. 2013 May; 122(5):299-307. PMID: 23815046.
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    44. Colt HG, Murgu SD, Korst RJ, Slatore CG, Unger M, Quadrelli S. Follow-up and surveillance of the patient with lung cancer after curative-intent therapy: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013 May; 143(5 Suppl):e437S-e454S. PMID: 23649451.
      View in: PubMed
    45. Murgu S, Colt H. Subjective assessment using still bronchoscopic images misclassifies airway narrowing in laryngotracheal stenosis. Interact Cardiovasc Thorac Surg. 2013 May; 16(5):655-60. PMID: 23407694.
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    46. Murgu S, Langer S, Colt H. Bronchoscopic intervention obviates the need for continued mechanical ventilation in patients with airway obstruction and respiratory failure from inoperable non-small-cell lung cancer. Respiration. 2012; 84(1):55-61. PMID: 22759948.
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    47. Handa H, Miyazawa T, Murgu SD, Nishine H, Kurimoto N, Huang J, Colt HG. Novel multimodality imaging and physiologic assessments clarify choke-point physiology and airway wall structure in expiratory central airway collapse. Respir Care. 2012 Apr; 57(4):634-41. PMID: 22005343.
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    48. Hou R, Le T, Murgu SD, Chen Z, Brenner M. Recent advances in optical coherence tomography for the diagnoses of lung disorders. Expert Rev Respir Med. 2011 Oct; 5(5):711-24. PMID: 21955240.
      View in: PubMed
    49. Colt HG, Davoudi M, Murgu S. Scientific evidence and principles for the use of endobronchial ultrasound and transbronchial needle aspiration. Expert Rev Med Devices. 2011 Jul; 8(4):493-513. PMID: 21728734.
      View in: PubMed
    50. Murgu SD, Pecson J, Colt HG. Flexible bronchoscopy assisted by noninvasive positive pressure ventilation. Crit Care Nurse. 2011 Jun; 31(3):70-6. PMID: 21632594.
      View in: PubMed
    51. Jung B, Murgu S, Colt H. Rigid bronchoscopy for malignant central airway obstruction from small cell lung cancer complicated by SVC syndrome. Ann Thorac Cardiovasc Surg. 2011; 17(1):53-7. PMID: 21587130.
      View in: PubMed
    52. Murgu SD, Colt HG, Mukai D, Brenner M. Multimodal imaging guidance for laser ablation in tracheal stenosis. Laryngoscope. 2010 Sep; 120(9):1840-6. PMID: 20593421.
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    53. Colt HG, Davoudi M, Murgu S, Zamanian Rohani N. Measuring learning gain during a one-day introductory bronchoscopy course. Surg Endosc. 2011 Jan; 25(1):207-16. PMID: 20585964.
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    54. Murgu SD, Pecson J, Colt HG. Bronchoscopy during noninvasive ventilation: indications and technique. Respir Care. 2010 May; 55(5):595-600. PMID: 20420731.
      View in: PubMed
    55. Murgu SD, Colt HG. Interventional bronchoscopy from bench to bedside: new techniques for central and peripheral airway obstruction. Clin Chest Med. 2010 Mar; 31(1):101-15, Table of Contents. PMID: 20172436.
      View in: PubMed
    56. Colt HG, Murgu SD, Jung B, Ahn YC, Brenner M. Multimodality bronchoscopic imaging of recurrent respiratory papillomatosis. Laryngoscope. 2010 Mar; 120(3):468-72. PMID: 19924771.
      View in: PubMed
    57. Colt HG, Murgu SD. Interventional bronchoscopy from bench to bedside: new techniques for early lung cancer detection. Clin Chest Med. 2010 Mar; 31(1):29-37, Table of Contents. PMID: 20172430.
      View in: PubMed
    58. Colt HG, Murgu SD. Closure of pneumonectomy stump fistula using custom Y and cuff-link-shaped silicone prostheses. Ann Thorac Cardiovasc Surg. 2009 Oct; 15(5):339-42. PMID: 19901891.
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    59. Murgu S, Colt HG. Morphometric bronchoscopy in adults with central airway obstruction: case illustrations and review of the literature. Laryngoscope. 2009 Jul; 119(7):1318-24. PMID: 19444886.
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    60. Murgu SD, Colt HG. Tracheobronchoplasty for severe tracheobronchomalacia. Chest. 2009 May; 135(5):1403-1404. PMID: 19420215.
      View in: PubMed
    61. Colt H, Murgu SD, Ahn YC, Brenner M. Multimodality bronchoscopic [corrected] imaging of tracheopathica osteochondroplastica. J Biomed Opt. 2009 May-Jun; 14(3):034035. PMID: 19566328.
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    62. Murgu SD, Colt HG. Silicone Y stent placement at secondary left carina for malignant central airway obstruction. J Thorac Cardiovasc Surg. 2010 Feb; 139(2):494-5. PMID: 19660328.
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    63. Pornsuriyasak P, Murgu S, Colt H. Pseudomembranous aspergillus tracheobronchitis superimposed on post-tuberculosis tracheal stenosis. Respirology. 2009 Jan; 14(1):144-7. PMID: 19144060.
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    64. Murgu S, Kurimoto N, Colt H. Endobronchial ultrasound morphology of expiratory central airway collapse. Respirology. 2008 Mar; 13(2):315-9. PMID: 18339038.
      View in: PubMed
    65. Murgu SD, Colt HG. Complications of silicone stent insertion in patients with expiratory central airway collapse. Ann Thorac Surg. 2007 Dec; 84(6):1870-7. PMID: 18036901.
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    66. Murgu SD, Colt HG. Description of a multidimensional classification system for patients with expiratory central airway collapse. Respirology. 2007 Jul; 12(4):543-50. PMID: 17587421.
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    67. Murgu SD, Cherrison LJ, Colt HG. Respiratory failure due to expiratory central airway collapse. Respir Care. 2007 Jun; 52(6):752-4. PMID: 17521465.
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    68. Cho YJ, Murgu SD, Colt HG. Bronchoscopy for bevacizumab-related hemoptysis. Lung Cancer. 2007 Jun; 56(3):465-8. PMID: 17368626.
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    69. Murgu SD, Colt HG. Expiratory collapse of the central airways. Ann Thorac Surg. 2006 Aug; 82(2):768; author reply 768-9. PMID: 16863821.
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    70. Murgu SD, Colt HG. Tracheobronchomalacia and excessive dynamic airway collapse. Respirology. 2006 Jul; 11(4):388-406. PMID: 16771908.
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    71. Murgu SD, Colt HG. A 68-year-old man with intractable dyspnea and wheezing 45 years after a pneumonectomy. Chest. 2006 Apr; 129(4):1107-11. PMID: 16608964.
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    72. Murgu SD, Colt HG. Treatment of adult tracheobronchomalacia and excessive dynamic airway collapse : an update. Treat Respir Med. 2006; 5(2):103-15. PMID: 16512691.
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