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Robert Hamanaka

TitleResearch Associate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary and Critical Care
AddressChicago IL 60637
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    Collapse Research 
    Collapse research activities and funding
    R01HL151680     (HAMANAKA, ROBERT BRIAN)Apr 1, 2020 - Mar 31, 2025
    NIH
    Metabolic Regulation of Myofibroblast Differentiation
    Role: Principal Investigator
    K01AR066579     (HAMANAKA, ROBERT BRIAN)Sep 1, 2014 - Aug 31, 2019
    NIH
    Metabolic Regulation of Epidermal Homeostasis
    Role: Principal Investigator
    F32HL099007     (HAMANAKA, ROBERT BRIAN)Sep 13, 2010 - Sep 12, 2011
    NIH
    Mechanisms of Oxygen Sensing
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cetin-Atalay R, Meliton AY, Tian Y, Sun KA, Woods PS, Shin KWD, Cho T, Gileles-Hillel A, Hamanaka RB, Mutlu GM. Sustained hypoxia but not intermittent hypoxia induces HIF-1a transcriptional response in human aortic endothelial cells. Mol Omics. 2024 Nov 08. PMID: 39513671; PMCID: PMC11563308.
      Citations:    
    2. Woods PS, Cetin-Atalay R, Meliton AY, Sun KA, Shamaa OR, Shin KWD, Tian Y, Haugen B, Hamanaka RB, Mutlu GM, Woods PS, Cetin-Atalay R, Meliton AY, Sun KA, Shamaa OR, Shin KWD, Tian Y, Haugen B, Hamanaka RB, Mutlu GM. HIF-1a regulates mitochondrial function in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages. bioRxiv. 2024 Oct 14. PMID: 39464148; PMCID: PMC11507697.
      Citations:    
    3. Shin KWD, Atalay MV, Cetin-Atalay R, O'Leary EM, Glass ME, Szafran JCH, Woods PS, Meliton AY, Shamaa OR, Tian Y, Mutlu GM, Hamanaka RB. ATF4 and mTOR regulate metabolic reprogramming in TGF-ß-treated lung fibroblasts. bioRxiv. 2024 Jun 13. PMID: 38915485; PMCID: PMC11195155.
      Citations:    
    4. Reed EB, Sitikov A, Hamanaka RB, Cetin-Atalay R, Mutlu GM, Mongin AA, Dulin NO. Critical role of Ga12 and Ga13 proteins in TGF-ß-induced myofibroblast differentiation. bioRxiv. 2024 May 30. PMID: 38854083; PMCID: PMC11160726.
      Citations:    
    5. Shin KWD, Hamanaka RB. Tamping Down the Fire: Taming Pyroptosis through RNA Methylation in Acute Lung Injury. Am J Respir Cell Mol Biol. 2024 May; 70(5):331-333. PMID: 38353587; PMCID: PMC11109585.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Piao L, Fang YH, Fisher M, Hamanaka RB, Ousta A, Wu R, Mutlu GM, Garcia AJ, Archer SL, Sharp WW. Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury. FASEB J. 2024 01; 38(1):e23379. PMID: 38133921.
      Citations: 2     Fields:    Translation:AnimalsCells
    7. Meliton AY, Cetin-Atalay R, Tian Y, Szafran JCH, Shin KWD, Cho T, Sun KA, Woods PS, Shamaa OR, Chen B, Muir A, Mutlu GM, Hamanaka RB. Mitochondrial One-Carbon Metabolism is Required for TGF-ß-Induced Glycine Synthesis and Collagen Protein Production. bioRxiv. 2023 Nov 07. PMID: 37986788; PMCID: PMC10659399.
      Citations:    
    8. Cetin-Atalay R, Meliton AY, Ozcan C, Woods PS, Sun KA, Fang Y, Hamanaka RB, Mutlu GM. Loss of heme oxygenase 2 causes reduced expression of genes in cardiac muscle development and contractility and leads to cardiomyopathy in mice. PLoS One. 2023; 18(10):e0292990. PMID: 37844118; PMCID: PMC10578579.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Cetin-Atalay R, Meliton AY, Sun KA, Glass ME, Woods PS, Peng YJ, Fang Y, Hamanaka RB, Prabhakar NR, Mutlu GM. Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells. Sci Rep. 2022 10 13; 12(1):17167. PMID: 36229484; PMCID: PMC9561121.
      Citations: 3     Fields:    Translation:HumansCells
    10. Hamanaka RB, Mutlu GM. Our Compliments to the Authors: Decay Accelerating Factor and the Complement System in Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2022 10; 67(4):415-416. PMID: 35901283; PMCID: PMC9564930.
      Citations:    Fields:    Translation:Humans
    11. Woods PS, Kimmig LM, Sun KA, Meliton AY, Shamaa OR, Tian Y, Sharp WW, Hamanaka RB, Cetin-Atalay R, Mutlu GM. HIF-1a induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury. Elife. 2022 07 13; 11. PMID: 35822617; PMCID: PMC9323005.
      Citations: 12     Fields:    Translation:AnimalsCells
    12. Cetin-Atalay R, Meliton AY, Wu D, Woods PS, Sun KA, Peng YJ, Nanduri J, Su X, Fang Y, Hamanaka RB, Prabhakar N, Mutlu GM. Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release. Front Physiol. 2021; 12:701995. PMID: 34322038; PMCID: PMC8311436.
      Citations: 4     
    13. Hamanaka RB, Mutlu GM. The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer. Amino Acids. 2021 Dec; 53(12):1851-1862. PMID: 33963932; PMCID: PMC8914507.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    14. Hamanaka RB, Mutlu GM. Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism. FEBS J. 2021 11; 288(22):6331-6352. PMID: 33393204; PMCID: PMC8253875.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    15. O'Leary EM, Tian Y, Nigdelioglu R, Witt LJ, Cetin-Atalay R, Meliton AY, Woods PS, Kimmig LM, Sun KA, Hamanaka RB, Gökalp GA, Mutlu GM. TGF-ß Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation. Am J Respir Cell Mol Biol. 2020 11; 63(5):601-612. PMID: 32668192; PMCID: PMC7605163.
      Citations: 36     Fields:    Translation:HumansCells
    16. Hamanaka RB, Mutlu GM. The Airway Epithelial Response to Air Pollution: It's Not Just Inflammation. Am J Respir Cell Mol Biol. 2020 08; 63(2):139-140. PMID: 32311285; PMCID: PMC7397764.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    17. Sun KA, Li Y, Meliton AY, Woods PS, Kimmig LM, Hamanaka RB, Cetin-Atalay R, Mutlu GM. Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response. Elife. 2020 04 07; 9. PMID: 32255424; PMCID: PMC7185992.
      Citations: 24     Fields:    Translation:AnimalsCells
    18. Woods PS, Kimmig LM, Meliton AY, Sun KA, Tian Y, O'Leary EM, Hamanaka RB, Gökalp GA, Mutlu GM. Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation. Am J Respir Cell Mol Biol. 2020 02; 62(2):243-255. PMID: 31469581; PMCID: PMC6993551.
      Citations: 58     Fields:    Translation:AnimalsCells
    19. Piao L, Fang YH, Hamanaka RB, Dezfulian C, Archer SL, Sharp WW, Mutlu GM. Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. Crit Care Med. 2020 02; 48(2):e133-e140. PMID: 31939812; PMCID: PMC6964871.
      Citations: 13     Fields:    Translation:AnimalsCells
    20. Piao L, Fang YH, Hamanaka RB, Mutlu GM, Dezfulian C, Archer SL, Sharp WW. Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. Crit Care Med. 2019 Nov 13. PMID: 31725436.
      Citations:    
    21. Hamanaka RB, O'Leary EM, Witt LJ, Tian Y, Meliton AY, Dulin NO, Gökalp GA, Mutlu GM. Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts. Am J Respir Cell Mol Biol. 2019 11; 61(5):597-606. PMID: 30973753; PMCID: PMC6827066.
      Citations: 64     Fields:    Translation:HumansCells
    22. Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV, Mutlu GM. Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 06 15; 199(12):1517-1536. PMID: 30554520; PMCID: PMC6580683.
      Citations: 564     Fields:    Translation:HumansAnimalsCells
    23. Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Budinger GRS, Mutlu GM. Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. Cell Metab. 2019 Feb 05; 29(2):503. PMID: 30726761; PMCID: PMC6377562.
      Citations: 8     Fields:    
    24. Hamanaka RB, Mutlu GM. Alveolar Epithelial Cells Burn Fat to Survive Acute Lung Injury. Am J Respir Cell Mol Biol. 2019 02; 60(2):135-136. PMID: 30278142; PMCID: PMC6835041.
      Citations: 1     Fields:    Translation:HumansCells
    25. Hamanaka RB, Mutlu GM. Particulate Matter Air Pollution: Effects on the Cardiovascular System. Front Endocrinol (Lausanne). 2018; 9:680. PMID: 30505291; PMCID: PMC6250783.
      Citations: 130     Fields:    
    26. Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Budinger GRS, Mutlu GM. Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. Cell Metab. 2019 02 05; 29(2):335-347.e5. PMID: 30318339; PMCID: PMC6365216.
      Citations: 45     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    27. Mutlu EA, Comba IY, Cho T, Engen PA, Yazici C, Soberanes S, Hamanaka RB, Nigdelioglu R, Meliton AY, Ghio AJ, Budinger GRS, Mutlu GM. Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome. Environ Pollut. 2018 Sep; 240:817-830. PMID: 29783199; PMCID: PMC6400491.
      Citations: 89     Fields:    Translation:AnimalsPHPublic Health
    28. Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM. Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 05; 58(5):585-593. PMID: 29019702; PMCID: PMC5946329.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    29. Wang T, Pehrsson EC, Purushotham D, Li D, Zhuo X, Zhang B, Lawson HA, Province MA, Krapp C, Lan Y, Coarfa C, Katz TA, Tang WY, Wang Z, Biswal S, Rajagopalan S, Colacino JA, Tsai ZT, Sartor MA, Neier K, Dolinoy DC, Pinto J, Hamanaka RB, Mutlu GM, Patisaul HB, Aylor DL, Crawford GE, Wiltshire T, Chadwick LH, Duncan CG, Garton AE, McAllister KA, TaRGET II Consortium, Bartolomei MS, Walker CL, Tyson FL. The NIEHS TaRGET II Consortium and environmental epigenomics. Nat Biotechnol. 2018 03 06; 36(3):225-227. PMID: 29509741; PMCID: PMC5991835.
      Citations: 52     Fields:    Translation:HumansPHPublic Health
    30. Wu D, Hamanaka RB, Fang Y, Mutlu GM. Letter by Wu et al Regarding Article, "Mechanical Activation of Hypoxia-Inducible Factor 1a Drives Endothelial Dysfunction at Atheroprone Sites". Arterioscler Thromb Vasc Biol. 2017 12; 37(12):e197-e198. PMID: 29162600; PMCID: PMC5777320.
      Citations:    Fields:    Translation:Humans
    31. Wu D, Huang RT, Hamanaka RB, Krause M, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM. HIF-1a is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife. 2017 05 30; 6. PMID: 28556776; PMCID: PMC5495571.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    32. Gileles-Hillel A, Almendros I, Khalyfa A, Nigdelioglu R, Qiao Z, Hamanaka RB, Akbarpour M, Gozal D, Mutlu GM. Prolonged Exposures to Intermittent Hypoxia Promote Visceral White Adipose Tissue Inflammation in a Murine Model of Severe Sleep Apnea: Effect of Normoxic Recovery. Sleep. 2017 03 01; 40(3). PMID: 28329220.
      Citations: 29     Fields:    Translation:AnimalsCells
    33. Huang RT, Wu D, Meliton A, Oh MJ, Krause M, Lloyd JA, Nigdelioglu R, Hamanaka RB, Jain MK, Birukova A, Kress JP, Birukov KG, Fang Y, Mutlu GM. Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling. Am J Respir Crit Care Med. 2017 03 01; 195(5):639-651. PMID: 27855271; PMCID: PMC5363977.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    34. Hamanaka RB, Mutlu GM. PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes. J Invest Dermatol. 2017 06; 137(6):1267-1276. PMID: 28108301; PMCID: PMC5441935.
      Citations: 24     Fields:    Translation:HumansCells
    35. Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM. Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem. 2016 12 30; 291(53):27239-27251. PMID: 27836973; PMCID: PMC5207151.
      Citations: 73     Fields:    Translation:HumansCells
    36. Hamanaka RB, Weinberg SE, Reczek CR, Chandel NS. The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia. Cell Rep. 2016 Apr 19; 15(3):451-459. PMID: 27068470; PMCID: PMC4838509.
      Citations: 32     Fields:    Translation:AnimalsCells
    37. La J, Reed EB, Koltsova S, Akimova O, Hamanaka RB, Orlov SN, Dulin NO, Mutlu GM. Regulation of myofibroblast differentiation by cardiac glycosides. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L815-23. PMID: 26851261; PMCID: PMC4867347.
      Citations: 14     Fields:    Translation:HumansCells
    38. Radigan KA, Morales-Nebreda L, Soberanes S, Nicholson T, Nigdelioglu R, Cho T, Chi M, Hamanaka RB, Misharin AV, Perlman H, Budinger GR, Mutlu GM. Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages. PLoS One. 2014; 9(9):e108138. PMID: 25232724; PMCID: PMC4169489.
      Citations: 36     Fields:    Translation:AnimalsCells
    39. Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS, Chandel NS. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife. 2014 May 13; 3:e02242. PMID: 24843020; PMCID: PMC4017650.
      Citations: 559     Fields:    Translation:HumansCells
    40. Hamanaka RB, Glasauer A, Hoover P, Yang S, Blatt H, Mullen AR, Getsios S, Gottardi CJ, DeBerardinis RJ, Lavker RM, Chandel NS. Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal. 2013 Feb 05; 6(261):ra8. PMID: 23386745; PMCID: PMC4017376.
      Citations: 155     Fields:    Translation:HumansAnimalsCells
    41. Hamanaka RB, Chandel NS. Mitochondrial metabolism as a regulator of keratinocyte differentiation. Cell Logist. 2013 Jan 01; 3(1):e25456. PMID: 24475371; PMCID: PMC3891634.
      Citations: 20     
    42. Peng H, Kaplan N, Hamanaka RB, Katsnelson J, Blatt H, Yang W, Hao L, Bryar PJ, Johnson RS, Getsios S, Chandel NS, Lavker RM. microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14030-4. PMID: 22891326; PMCID: PMC3435188.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    43. Peng H, Hamanaka RB, Katsnelson J, Hao LL, Yang W, Chandel NS, Lavker RM. MicroRNA-31 targets FIH-1 to positively regulate corneal epithelial glycogen metabolism. FASEB J. 2012 Aug; 26(8):3140-7. PMID: 22532441; PMCID: PMC3405266.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    44. Hamanaka RB, Chandel NS. Targeting glucose metabolism for cancer therapy. J Exp Med. 2012 Feb 13; 209(2):211-5. PMID: 22330683; PMCID: PMC3280882.
      Citations: 174     Fields:    Translation:HumansCells
    45. Shimi T, Butin-Israeli V, Adam SA, Hamanaka RB, Goldman AE, Lucas CA, Shumaker DK, Kosak ST, Chandel NS, Goldman RD. The role of nuclear lamin B1 in cell proliferation and senescence. Genes Dev. 2011 Dec 15; 25(24):2579-93. PMID: 22155925; PMCID: PMC3248680.
      Citations: 268     Fields:    Translation:HumansCells
    46. Hamanaka RB, Chandel NS. Cell biology. Warburg effect and redox balance. Science. 2011 Dec 02; 334(6060):1219-20. PMID: 22144609.
      Citations: 61     Fields:    Translation:HumansAnimals
    47. Tormos KV, Anso E, Hamanaka RB, Eisenbart J, Joseph J, Kalyanaraman B, Chandel NS. Mitochondrial complex III ROS regulate adipocyte differentiation. Cell Metab. 2011 Oct 05; 14(4):537-44. PMID: 21982713; PMCID: PMC3190168.
      Citations: 310     Fields:    Translation:HumansCells
    48. Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Chandel NS, Prakriya M, Sznajder JI, Mutlu GM. Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Mol Cell Biol. 2011 Sep; 31(17):3546-56. PMID: 21730292; PMCID: PMC3165547.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    49. Hamanaka RB, Chandel NS. Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci. 2010 Sep; 35(9):505-13. PMID: 20430626; PMCID: PMC2933303.
      Citations: 411     Fields:    Translation:HumansAnimalsCells
    50. Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Budinger GR, Chandel NS, Mutlu GM. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8788-93. PMID: 20421486; PMCID: PMC2889315.
      Citations: 865     Fields:    Translation:HumansAnimalsCells
    51. Hamanaka RB, Chandel NS. Mitochondrial reactive oxygen species regulate hypoxic signaling. Curr Opin Cell Biol. 2009 Dec; 21(6):894-9. PMID: 19781926; PMCID: PMC2787901.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    52. Liu J, HuangFu WC, Kumar KG, Qian J, Casey JP, Hamanaka RB, Grigoriadou C, Aldabe R, Diehl JA, Fuchs SY. Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. Cell Host Microbe. 2009 Jan 22; 5(1):72-83. PMID: 19154989; PMCID: PMC2741731.
      Citations: 95     Fields:    Translation:Cells
    53. Hamanaka RB, Bobrovnikova-Marjon E, Ji X, Liebhaber SA, Diehl JA. PERK-dependent regulation of IAP translation during ER stress. Oncogene. 2009 Feb 12; 28(6):910-20. PMID: 19029953; PMCID: PMC2642534.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    54. Zhang F, Hamanaka RB, Bobrovnikova-Marjon E, Gordan JD, Dai MS, Lu H, Simon MC, Diehl JA. Ribosomal stress couples the unfolded protein response to p53-dependent cell cycle arrest. J Biol Chem. 2006 Oct 06; 281(40):30036-45. PMID: 16893887.
      Citations: 52     Fields:    Translation:HumansCells
    55. Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA. PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. Mol Biol Cell. 2005 Dec; 16(12):5493-501. PMID: 16176978; PMCID: PMC1289396.
      Citations: 133     Fields:    Translation:AnimalsCells
    56. Takai N, Miyazaki T, Fujisawa K, Nasu K, Hamanaka R, Miyakawa I. Polo-like kinase (PLK) expression in endometrial carcinoma. Cancer Lett. 2001 Aug 10; 169(1):41-9. PMID: 11410324.
      Citations: 31     Fields:    Translation:Humans
    57. Takai N, Miyazaki T, Fujisawa K, Nasu K, Hamanaka R, Miyakawa I. Expression of polo-like kinase in ovarian cancer is associated with histological grade and clinical stage. Cancer Lett. 2001 Mar 10; 164(1):41-9. PMID: 11166914.
      Citations: 39     Fields:    Translation:HumansCells
    58. Takai N, Yoshimatsu J, Nishida Y, Narahara H, Miyakawa I, Hamanaka R. Expression of polo-like kinase (PLK) in the mouse placenta and ovary. Reprod Fertil Dev. 1999; 11(1):31-5. PMID: 10681000.
      Citations: 1     Fields:    Translation:AnimalsCells
    59. Smith MR, Wilson ML, Hamanaka R, Chase D, Kung H, Longo DL, Ferris DK. Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase. Biochem Biophys Res Commun. 1997 May 19; 234(2):397-405. PMID: 9177283.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    60. Hamanaka R, Smith MR, O'Connor PM, Maloid S, Mihalic K, Spivak JL, Longo DL, Ferris DK. Polo-like kinase is a cell cycle-regulated kinase activated during mitosis. J Biol Chem. 1995 Sep 08; 270(36):21086-91. PMID: 7673138.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    61. Kohno K, Hamanaka R, Abe T, Nomura Y, Morimoto A, Izumi H, Shimizu K, Ono M, Kuwano M. Morphological change and destabilization of beta-actin mRNA by tumor necrosis factor in human microvascular endothelial cells. Exp Cell Res. 1993 Oct; 208(2):498-503. PMID: 8375478.
      Citations: 6     Fields:    Translation:HumansCells
    62. Okamura K, Morimoto A, Hamanaka R, Ono M, Kohno K, Uchida Y, Kuwano M. A model system for tumor angiogenesis: involvement of transforming growth factor-alpha in tube formation of human microvascular endothelial cells induced by esophageal cancer cells. Biochem Biophys Res Commun. 1992 Aug 14; 186(3):1471-9. PMID: 1380804.
      Citations: 17     Fields:    Translation:HumansCells
    63. Hamanaka R, Kohno K, Seguchi T, Okamura K, Morimoto A, Ono M, Ogata J, Kuwano M. Induction of low density lipoprotein receptor and a transcription factor SP-1 by tumor necrosis factor in human microvascular endothelial cells. J Biol Chem. 1992 Jul 05; 267(19):13160-5. PMID: 1618817.
      Citations: 16     Fields:    Translation:HumansCells
    64. Okamura K, Sato Y, Matsuda T, Hamanaka R, Ono M, Kohno K, Kuwano M. Endogenous basic fibroblast growth factor-dependent induction of collagenase and interleukin-6 in tumor necrosis factor-treated human microvascular endothelial cells. J Biol Chem. 1991 Oct 15; 266(29):19162-5. PMID: 1655776.
      Citations: 17     Fields:    Translation:HumansCells
    65. Hamanaka R, Ono M, Kuratomi Y, Mizoguchi H, Hirai R, Kohno K, Kuwano M. Epidermal growth factor (EGF)-nonresponsive variants of normal rat kidney cell line: response to EGF and transforming growth factor-beta. Exp Cell Res. 1990 Jan; 186(1):83-9. PMID: 2298239.
      Citations: 1     Fields:    Translation:AnimalsCells
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