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Jocelyn Malamy

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMolecular Genetics and Cell Biology
AddressChicago IL 60637
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    Collapse Overview 
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    My lab studies epithelial wound healing in the emerging model cnidarian Clytia hemisphaerica. The cnidarian lineage diverged from the bilaterian lineage approximately 600 million years ago, yet many genes and processes are shared between these basal metazoans and more complex animals. Studying wound healing in Clytia allows us to understand the ancient evolutionary origins of mechanisms regulating this process. We have found that epithelial healing is 100x faster in Clytia that in other model systems. Furthermore, the single monolayer of epithelial cells and overall simplicity of Clytia anatomy allows the dynamic process of healing to be visualized at high resolution in live animals. Therefore, Clytia provides a powerful and novel model for wound healing processes that have been conserved over evolutionary time. We are currently focusing on rapid, transcription-independent signaling pathways that regulate cell interactions with the extracellular matrix during epithelial woud closure.

    Collapse Biography 
    Collapse education and training
    Tufts University, Medford, MABS07/1985Biology
    Rutgers, The State University of New Jersey, New Brunswick, NYPh.D.09/1993Microbiology
    New York University, New York, NYPost Doctoral Fellowship1999Plant Biology

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lee EEL, O'Malley-Krohn I, Edsinger E, Wu S, Malamy J. Epithelial wound healing in Clytia hemisphaerica provides insights into extracellular ATP signaling mechanisms and P2XR evolution. Sci Rep. 2023 11 01; 13(1):18819. PMID: 37914720; PMCID: PMC10620158.
      Citations:    Fields:    Translation:AnimalsCells
    2. Lee EEL, Watto E, Malamy J. Characterizing Epithelial Wound Healing In Vivo Using the Cnidarian Model Organism Clytia hemisphaerica. J Vis Exp. 2023 02 10; (192). PMID: 36847403.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Malamy JE, Shribak M. An orientation-independent DIC microscope allows high resolution imaging of epithelial cell migration and wound healing in a cnidarian model. J Microsc. 2018 06; 270(3):290-301. PMID: 29345317; PMCID: PMC5980661.
      Citations: 5     Fields:    Translation:AnimalsCells
    4. Kamran Z, Zellner K, Kyriazes H, Kraus CM, Reynier JB, Malamy JE. In vivo imaging of epithelial wound healing in the cnidarian Clytia hemisphaerica demonstrates early evolution of purse string and cell crawling closure mechanisms. BMC Dev Biol. 2017 12 19; 17(1):17. PMID: 29258421; PMCID: PMC5735930.
      Citations: 15     Fields:    Translation:AnimalsCells
    5. Roycewicz PS, Malamy JE. Cell wall properties play an important role in the emergence of lateral root primordia from the parent root. J Exp Bot. 2014 May; 65(8):2057-69. PMID: 24619997; PMCID: PMC3991740.
      Citations: 10     Fields:    Translation:AnimalsCells
    6. Roycewicz P, Malamy JE. Dissecting the effects of nitrate, sucrose and osmotic potential on Arabidopsis root and shoot system growth in laboratory assays. Philos Trans R Soc Lond B Biol Sci. 2012 Jun 05; 367(1595):1489-500. PMID: 22527391; PMCID: PMC3321681.
      Citations: 25     Fields:    Translation:AnimalsCells
    7. Ingram P, Dettmer J, Helariutta Y, Malamy JE. Arabidopsis Lateral Root Development 3 is essential for early phloem development and function, and hence for normal root system development. Plant J. 2011 Nov; 68(3):455-67. PMID: 21749503.
      Citations: 13     Fields:    Translation:Animals
    8. Macgregor DR, Deak KI, Ingram PA, Malamy JE. Root system architecture in Arabidopsis grown in culture is regulated by sucrose uptake in the aerial tissues. Plant Cell. 2008 Oct; 20(10):2643-60. PMID: 18952782; PMCID: PMC2590740.
      Citations: 65     Fields:    Translation:Animals
    9. Malamy J. Transgene expression in regenerated roots. CSH Protoc. 2007 Feb 01; 2007:pdb.prot4691. PMID: 21357026.
    10. Fitz Gerald JN, Lehti-Shiu MD, Ingram PA, Deak KI, Biesiada T, Malamy JE. Identification of quantitative trait loci that regulate Arabidopsis root system size and plasticity. Genetics. 2006 Jan; 172(1):485-98. PMID: 16157665; PMCID: PMC1456176.
      Citations: 29     Fields:    Translation:AnimalsCells
    11. Little DY, Rao H, Oliva S, Krapp A, Malamy JE, Daniel-Vedele F. The putative high-affinity nitrate transporter NRT2.1 represses lateral root initiation in response to nutritional cues. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13693-8. PMID: 16157886; PMCID: PMC1224627.
      Citations: 126     Fields:    Translation:AnimalsCells
    12. Deak KI, Malamy J. Osmotic regulation of root system architecture. Plant J. 2005 Jul; 43(1):17-28. PMID: 15960613.
      Citations: 87     Fields:    Translation:AnimalsCells
    13. Nawy T, Lee JY, Colinas J, Wang JY, Thongrod SC, Malamy JE, Birnbaum K, Benfey PN. Transcriptional profile of the Arabidopsis root quiescent center. Plant Cell. 2005 Jul; 17(7):1908-25. PMID: 15937229; PMCID: PMC1167541.
      Citations: 144     Fields:    Translation:AnimalsCells
    14. Malamy JE. Intrinsic and environmental response pathways that regulate root system architecture. Plant Cell Environ. 2005 Jan; 28(1):67-77. PMID: 16021787.
      Citations: 266     Fields:    Translation:Cells
    15. Malamy JE, Ryan KS. Environmental regulation of lateral root initiation in Arabidopsis. Plant Physiol. 2001 Nov; 127(3):899-909. PMID: 11706172; PMCID: PMC129261.
      Citations: 95     Fields:    Translation:AnimalsCells
    16. Wysocka-Diller JW, Helariutta Y, Fukaki H, Malamy JE, Benfey PN. Molecular analysis of SCARECROW function reveals a radial patterning mechanism common to root and shoot. Development. 2000 Feb; 127(3):595-603. PMID: 10631180.
      Citations: 151     Fields:    Translation:AnimalsCells
    17. Sabatini S, Beis D, Wolkenfelt H, Murfett J, Guilfoyle T, Malamy J, Benfey P, Leyser O, Bechtold N, Weisbeek P, Scheres B. An auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root. Cell. 1999 Nov 24; 99(5):463-72. PMID: 10589675.
      Citations: 523     Fields:    Translation:Animals
    18. Malamy JE, Benfey PN. Analysis of SCARECROW expression using a rapid system for assessing transgene expression in Arabidopsis roots. Plant J. 1997 Oct; 12(4):957-63. PMID: 9375406.
      Citations: 20     Fields:    Translation:AnimalsCells
    19. Malamy JE, Benfey PN. Organization and cell differentiation in lateral roots of Arabidopsis thaliana. Development. 1997 Jan; 124(1):33-44. PMID: 9006065.
      Citations: 497     Fields:    Translation:Animals
    20. Di Laurenzio L, Wysocka-Diller J, Malamy JE, Pysh L, Helariutta Y, Freshour G, Hahn MG, Feldmann KA, Benfey PN. The SCARECROW gene regulates an asymmetric cell division that is essential for generating the radial organization of the Arabidopsis root. Cell. 1996 Aug 09; 86(3):423-33. PMID: 8756724.
      Citations: 398     Fields:    Translation:AnimalsCells
    21. Chen Z, Malamy J, Henning J, Conrath U, Silva H, Ricigliano J, Klessig DK, Sánchez-Casas P. Induction, modification, and transduction of the salicylic acid signal in plant defense responses. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4134-7. PMID: 11607539; PMCID: PMC41899.
      Citations: 41     Fields:    
    22. Klessig DF, Malamy J. The salicylic acid signal in plants. Plant Mol Biol. 1994 Dec; 26(5):1439-58. PMID: 7858199.
      Citations: 91     Fields:    Translation:Cells
    23. Klessig DF, Malamy J, Hennig J, Sanchez-Casas P, Indulski J, Grynkiewicz G, Chen Z. Induction, modification, and perception of the salicylic acid signal in plant defence. Biochem Soc Symp. 1994; 60:219-29. PMID: 7639781.
      Citations: 1     Fields:    Translation:AnimalsCells
    24. Hennig J, Malamy J, Grynkiewicz G, Indulski J, Klessig DF. Interconversion of the salicylic acid signal and its glucoside in tobacco. Plant J. 1993 Oct; 4(4):593-600. PMID: 8252063.
      Citations: 48     Fields:    Translation:AnimalsCells
    25. Malamy J, Hennig J, Klessig DF, Malamy J, Hennig J, Klessig DF. Temperature-Dependent Induction of Salicylic Acid and Its Conjugates during the Resistance Response to Tobacco Mosaic Virus Infection. Plant Cell. 1992 Mar; 4(3):359-366. PMID: 12297650; PMCID: PMC160135.
      Citations: 84     Fields:    
    26. Malamy J, Carr JP, Klessig DF, Raskin I. Salicylic Acid: a likely endogenous signal in the resistance response of tobacco to viral infection. Science. 1990 Nov 16; 250(4983):1002-4. PMID: 17746925.
      Citations: 327     Fields:    
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