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Cheng-Kai Kao

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Hospital Medicine
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Cheng-Kai Kao, MD, is an academic hospitalist board-certified in clinical informatics. In addition to clinical practice and residency education, his areas of interest in informatics include clinical decision support systems, documentation improvement, clinical pathways, mobile health, and healthcare innovation. As Chief Medical Information Officer, he leads multiple initiatives that leverage information technology to provide decision support for the frontline clinicians to ensure patient safety, optimize clinical workflow to increase work efficiency, enhance usability of the electronic health record system to reduce screen time, and make innovations to improve care quality and patient experience. He is the course instructor of clinical informatics at Pritzker School of Medicine and master program of biomedical informatics at University of Chicago.

    Dr. Kao also serves as the medical director in the office of international programs. He oversees the clinical course of international patients from all over the world, optimizes their care quality and patient experience, promotes the knowledge transfer service, and fosters collaboration with overseas academic medical centers and healthcare organizations.

    Dr. Kao is also the site principal investigator of several phase III clinical trials on novel oral anticoagulants, one of which led to the FDA approval of the new oral anticoagulant. Dr. Kao is named Top Hospitalist by American College of Physicians Hospitalist magazine in 2017.

    Medical Director, Office of International Programs, University of Chicago Medicine (2014-present)
    Medical Director of Informatics, University of Chicago Medicine (2014-2017)
    Associate Chief Medical Information Officer, University of Chicago Medicine (2017-2022)
    Chief Clinical Informatics Innovation Officer (2022-)

    Course Director, ‘Leadership and Innovation’ and ‘Decision Support Systems and Health Care,’ Master of Science in Biomedical Informatics (MScBMI), University of Chicago Graham School
    Course Director, ‘Building the Business Plan,’ Certificate in the Business of Biotechnology Program, University of Chicago Graham School
    Course Director, ‘Overview of Medical Informatics’, Medical Student 4th Year Elective, University of Chicago Pritzker School of Medicine
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    Collapse Biography 
    Collapse education and training
    National Taiwan University, TaiwanMD06/2006Medicine
    Albert Einstein Medical Center, PhiladelphiaResidency06/2011Internal Medicine
    Oregon Health and Science University, Oregon11/2012AMIA 10x10
    University of Chicago Booth School of Business, Chicago10/2013D4Lab Fellowship
    National Library of Medicine, Georgia07/2016Biomedical Informatics
    Collapse awards and honors
    1999Gold Medal, International Chemistry Olympiad
    2004Presidential Award, National Taiwan University
    2005Outstanding College Youth, National Taiwan University
    2006Excellent Practical Training Award of Internship, National Taiwan University
    2006Student Service Education Award, National Taiwan University
    2017American College of Physician Top Hospitalist, ACP Hospitalist

    Collapse Research 
    Collapse research activities and funding
    ACTION III Concept     (Barry Blumenfeld)Oct 1, 2019 - Sep 30, 2021
    Clinical Decision Support for Chronic Pain Management
    Role: Site Co-Principal Investigator

    NCT03196349     (Cheng-Kai Kao)Dec 1, 2018 - Mar 30, 2019

    Comparison of Oral Anticoagulants for Extended VEnous Thromboembolism (COVET)
    Role: Site Principal Investigator

    NCT02111564     (Cheng-Kai Kao)Apr 1, 2016 - Aug 31, 2018

    Medically Ill Patient Assessment of Rivaroxaban Versus Placebo in Reducing Post-Discharge Venous Thrombo-Embolism Risk (MARINER)
    Role: Site Principal Investigator

    NCT01583218     (Cheng-Kai Kao)Jul 1, 2015 - Feb 28, 2016

    Acute Medically Ill VTE Prevention with Extended Duration Betrixaban Study (APEX)
    Role: Site Principal Investigator

    CDPH     (David Pitrak)Jul 1, 2014 - Jun 30, 2020

    Chicago Department of Public Health (CDPH) HIV Prevention Grant
    Role: Inpatient Lead

    NCT01337063     (Jeffrey L. Schnipper)Sep 1, 2011 - Sep 30, 2012

    Multi-Center Medication Reconciliation Quality Improvement Study
    Role: Site Adjudicator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cerasale MT, Mansour A, Molitch-Hou E, Bernstein S, Nguyen T, Kao CK. Implementation of a Real-Time Documentation Assistance Tool: Automated Diagnosis (AutoDx). Appl Clin Inform. 2024 May; 15(3):501-510. PMID: 38701857; PMCID: PMC11208109.
      Citations:    Fields:    Translation:Humans
    2. Makhni S, Andrews B, Maxey S, Scales K, Bernstein S, Georginis P, Shah S, Kao CK, Weber S, Arora VM. A crowdsourced campaign in IT optimization to improve ease of practice. J Hosp Med. 2023 12; 18(12):1144-1147. PMID: 37753838.
      Citations:    Fields:    
    3. Bartlett AH, Makhni S, Ruokis S, Kate Selling M, Hall L, Umscheid CA, Kao CK. Use of clinical pathways integrated into the electronic health record to address the coronavirus disease 2019 (COVID-19) pandemic. Infect Control Hosp Epidemiol. 2023 02; 44(2):260-267. PMID: 35314010; PMCID: PMC9043631.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    4. Thomas CC, Dolan UM, Jerger NM, Williams RM, Holland BA, Mikat-Stevens NA, Kolek JL, Szwak JA, Kao CK, Davis AM. Reducing Inpatient Hypoglycemic Events: A Focus on Mealtime Insulin. Clin Diabetes. 2022; 40(3):366-369. PMID: 35983427; PMCID: PMC9331613.
    5. MARINER Investigators, Spyropoulos AC, Ageno W, Albers GW, Elliott CG, Halperin JL, Hiatt WR, Maynard GA, Steg PG, Weitz JI, Suh E, Spiro TE, Barnathan ES, Raskob GE. Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness. N Engl J Med. 2018 Sep 20; 379(12):1118-1127. PMID: 30145946.
      Citations: 104     Fields:    Translation:Humans
    6. Gibson CM, Korjian S, Chi G, Daaboul Y, Jain P, Arbetter D, Goldhaber SZ, Hull R, Hernandez AF, Lopes RD, Gold A, Cohen AT, Harrington RA, APEX Investigators. Comparison of Fatal or Irreversible Events With Extended-Duration Betrixaban Versus Standard Dose Enoxaparin in Acutely Ill Medical Patients: An APEX Trial Substudy. J Am Heart Assoc. 2017 Jul 11; 6(7). PMID: 28698258; PMCID: PMC5586307.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    7. Kao CK., Arora V., Yu R., Pahwa A., Agrawal A., Dalal A. The eDoctor: Effective Use of Mobile Technology to Advance Care and Learning. Journal of Health & Medical Informatics. 2017; 8(3):270.
    8. Kao CK, Liebovitz DM. Consumer Mobile Health Apps: Current State, Barriers, and Future Directions. PM R. 2017 May; 9(5S):S106-S115. PMID: 28527495.
      Citations: 110     Fields:    Translation:Humans
    9. Prasad R., Airan-Javia S., Barazi H., Bodoutchian A., Briones A., Clay B., El-Kareh R., Feterik K., Gershanik E., Iroku-Malize T., Kao CK., Kaushik S., Lineberger R., Lupu R., Palabindala V., Premkumar P., Rogers K., Young A., Yu R., Vulgamore P. Society of Hospital Medicine (SHM) Whitepaper. Hospitalist Perspectives on Electronic Medical Records. 2017. View Publication.
    10. Gibson CM, Halaby R, Korjian S, Daaboul Y, Arbetter DF, Yee MK, Goldhaber SZ, Hull R, Hernandez AF, Lu SP, Bandman O, Leeds JM, Gold A, Harrington RA, Cohen AT, APEX Investigators. The safety and efficacy of full- versus reduced-dose betrixaban in the Acute Medically Ill VTE (Venous Thromboembolism) Prevention With Extended-Duration Betrixaban (APEX) trial. Am Heart J. 2017 Mar; 185:93-100. PMID: 28267480.
      Citations: 21     Fields:    Translation:Humans
    11. Gibson CM, Chi G, Halaby R, Korjian S, Daaboul Y, Jain P, Arbetter D, Goldhaber SZ, Hull R, Hernandez AF, Gold A, Bandman O, Harrington RA, Cohen AT, APEX Investigators. Extended-Duration Betrixaban Reduces the Risk of Stroke Versus Standard-Dose Enoxaparin Among Hospitalized Medically Ill Patients: An APEX Trial Substudy (Acute Medically Ill Venous Thromboembolism Prevention With Extended Duration Betrixaban). Circulation. 2017 02 14; 135(7):648-655. PMID: 27881569.
      Citations: 29     Fields:    Translation:Humans
    12. Cohen AT, Harrington RA, Goldhaber SZ, Hull RD, Wiens BL, Gold A, Hernandez AF, Gibson CM, APEX Investigators. Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients. N Engl J Med. 2016 08 11; 375(6):534-44. PMID: 27232649.
      Citations: 158     Fields:    Translation:Humans
    13. IMS Institute for Healthcare Informatics. Patient Adoption of mHealth- Use, Evidence and Remaining Barriers to Mainstream Acceptance. 2015. View Publication.
    14. Kao CK., Rogers K. The Hospitalist. Hospitalists Can Lead Health Information Technology Field. 2015; (6). View Publication.
    15. IMS Institute for Healthcare Informatics (now IQVIA Institute for Human Data Science). Patient Apps for Improved Healthcare- From Novelty to Mainstream. 2013. View Publication.
    16. Saunders M., Jung A., Kao CK., Paesch E., Pho M., Soni N. The Hospitalist. In the Lit: Physician Reviews of Hospital Medicine-Relevant Research. 2012; (5). View Publication.
    17. Sa Leitao D, Mendonca D, Iyer H, Kao CK. Neurologic complication after a roller coaster ride. Am J Emerg Med. 2012 Jan; 30(1):249.e5-7. PMID: 20980120.
      Citations: 3     Fields:    Translation:Humans
    18. Yang YH, Lai HJ, Kao CK, Lin YT, Chiang BL. The association between transforming growth factor-beta gene promoter C-509T polymorphism and Chinese children with Henoch-Schönlein purpura. Pediatr Nephrol. 2004 Sep; 19(9):972-5. PMID: 15257453.
      Citations: 11     Fields:    Translation:HumansCells
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