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Elaine M. Worcester

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Overview 

    Collapse Biography 
    Collapse education and training
    University of Chicago, Chicago, IL06/1986Fellowship, Nephrology
    Loyola University, Maywood, IL06/1982Residency, Internal Medicine
    University of Illinois, Chicago, ILMD06/1979
    Augustana College, Rock Island, ILBS06/1974Biology

    Collapse Research 
    Collapse research activities and funding
    P01DK056788     (WORCESTER, ELAINE M)Aug 1, 2000 - Jul 31, 2022
    Pathogenesis of Calcium Nephrolithiasis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Worcester E, Prochaska M, Steely A. Contrasting Response of Urine Stone Risk to Medical Treatment in Calcium Oxalate versus Calcium Phosphate Stone Formers. Kidney360. 2024 Feb 01; 5(2):228-236. PMID: 38251931; PMCID: PMC10914189.
      Citations:    Fields:    Translation:Humans
    2. Prochaska M, Menezes C, Ko BS, Coe F, Worcester E. Contribution of thick ascending limb and distal convoluted tubule to glucose-induced hypercalciuria in healthy controls. Am J Physiol Renal Physiol. 2023 12 01; 325(6):F811-F816. PMID: 37823200; PMCID: PMC10874680.
      Citations:    Fields:    Translation:Humans
    3. Kowalczyk NS, Prochaska ML, Worcester EM. Metabolomic profiles and pathogenesis of nephrolithiasis. Curr Opin Nephrol Hypertens. 2023 09 01; 32(5):490-495. PMID: 37530089; PMCID: PMC10403267.
      Citations:    Fields:    Translation:Humans
    4. Canela VH, Bowen WS, Ferreira RM, Syed F, Lingeman JE, Sabo AR, Barwinska D, Winfree S, Lake BB, Cheng YH, Gaut JP, Ferkowicz M, LaFavers KA, Zhang K, Coe FL, Worcester E, Kidney Precision Medicine Project, Jain S, Eadon MT, Williams JC, El-Achkar TM. A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease. Nat Commun. 2023 07 19; 14(1):4140. PMID: 37468493; PMCID: PMC10356953.
      Citations: 3     Fields:    Translation:HumansCells
    5. Langman CB, Assimos D, Blank M, Calle J, Grauer A, Kausz A, Milliner D, Nazzal L, Smith K, Tasian G, Thompson A, Wood KD, Worcester E, Yang S, Malley MA, Knauf F, Lieske JC, Rare Kidney Stone Consortium (RKSC) Kidney Health Initiative (KHI) Oxalosis and Hyperoxaluria Founda. End Point Considerations for Clinical Trials in Enteric Hyperoxaluria. Clin J Am Soc Nephrol. 2023 12 01; 18(12):1637-1644. PMID: 37342976; PMCID: PMC10723917.
      Citations:    Fields:    Translation:Humans
    6. LaFavers KA, Gaddy AR, Micanovic R, Lingeman J, Williams JC, Coe FL, El-Achkar TM, Worcester E. Water Loading and Uromodulin Secretion in Healthy Individuals and Idiopathic Calcium Stone Formers. Clin J Am Soc Nephrol. 2023 08 01; 18(8):1059-1067. PMID: 37256909; PMCID: PMC10564375.
      Citations: 2     Fields:    Translation:Humans
    7. Gutbrod J, Keys McKay CC, Coe L, Bergsland K, Coe F, Worcester E, Prochaska M. Clinical Effectiveness of Calcium Oxalate Stone Treatments. Am J Nephrol. 2022; 53(10):761-766. PMID: 36412567; PMCID: PMC9877156.
      Citations: 2     Fields:    Translation:Humans
    8. Bianco J, Chu F, Bergsland K, Coe F, Worcester E, Prochaska M. What treatments reduce kidney stone risk in patients with bowel disease? Urolithiasis. 2022 Oct; 50(5):557-565. PMID: 35976425; PMCID: PMC9972896.
      Citations:    Fields:    Translation:Humans
    9. Dhillon-Jhattu S, McGill RL, Ennis JL, Worcester EM, Zisman AL, Coe FL. Vitamin D and Parathyroid Hormone Levels in CKD. Am J Kidney Dis. 2023 01; 81(1):122-124. PMID: 35926776.
      Citations: 1     Fields:    Translation:Humans
    10. Williams JC, Al-Awadi H, Muthenini M, Bledsoe SB, El-Achkar T, Evan AP, Coe F, Lingeman JE, Worcester EM. Stone Morphology Distinguishes Two Pathways of Idiopathic Calcium Oxalate Stone Pathogenesis. J Endourol. 2022 05; 36(5):694-702. PMID: 34915736; PMCID: PMC9145590.
      Citations: 1     Fields:    Translation:Humans
    11. Canela VH, Bledsoe SB, Worcester EM, Lingeman JE, El-Achkar TM, Williams JC. Collagen fibrils and cell nuclei are entrapped within Randall's plaques but not in CaOx matrix overgrowth: A microscopic inquiry into Randall's plaque stone pathogenesis. Anat Rec (Hoboken). 2022 07; 305(7):1701-1711. PMID: 34825513; PMCID: PMC9130344.
      Citations:    Fields:    Translation:HumansCells
    12. Prochaska ML, Moe OW, Coe FL, Worcester EM, Asplin JR. Evidence for abnormal linkage between urine oxalate and citrate excretion in human kidney stone formers. Physiol Rep. 2021 07; 9(13):e14943. PMID: 34231328; PMCID: PMC9814525.
      Citations: 2     Fields:    Translation:Humans
    13. Huo J, Li D, McKay C, Hoke M, Worcester E, Coe F. Relative contributions of urine sulfate, titratable urine anion, and GI anion to net acid load and effects of age. Physiol Rep. 2021 05; 9(10):e14870. PMID: 34042292; PMCID: PMC8157790.
      Citations: 2     Fields:    Translation:Humans
    14. Bergsland KJ, Coe FL, El-Achkar TM, Worcester EM. Increased Urinary Leukocyte Esterase Distinguishes Patients With Brushite Kidney Stones. Kidney Int Rep. 2021 Jun; 6(6):1729-1731. PMID: 34169214; PMCID: PMC8207319.
    15. Prochaska M, Asplin J, Chapman A, Worcester E. Sex Differences of Kidney Stone Urine Risk Factors after Roux-en-Y Gastric Bypass. Am J Nephrol. 2021; 52(2):173-176. PMID: 33765680; PMCID: PMC8049982.
      Citations:    Fields:    Translation:Humans
    16. Canela VH, Bledsoe SB, Lingeman JE, Gerber G, Worcester EM, El-Achkar TM, Williams JC. Demineralization and sectioning of human kidney stones: A molecular investigation revealing the spatial heterogeneity of the stone matrix. Physiol Rep. 2021 01; 9(1):e14658. PMID: 33403824; PMCID: PMC7786195.
      Citations: 4     Fields:    Translation:Humans
    17. Prochaska M, Worcester E. Risk Factors for Kidney Stone Formation following Bariatric Surgery. Kidney360. 2020 12; 1(12):1456-1461. PMID: 34085046; PMCID: PMC8171111.
      Citations: 1     Fields:    Translation:Humans
    18. Winfree S, Weiler C, Bledsoe SB, Gardner T, Evan AP, Lingeman JE, Krambeck AE, Worcester EM, El-Achkar TM, Williams JC, Sommer AJ. Multimodal imaging reveals a unique autofluorescence signature of Randall's plaque. Urolithiasis. 2021 Apr; 49(2):123-135. PMID: 33026465; PMCID: PMC7965236.
      Citations: 10     Fields:    Translation:Humans
    19. Witting C, Langman CB, Assimos D, Baum MA, Kausz A, Milliner D, Tasian G, Worcester E, Allain M, West M, Lieske JC, Knauf F. Pathophysiology and Treatment of Enteric Hyperoxaluria. Clin J Am Soc Nephrol. 2021 03 08; 16(3):487-495. PMID: 32900691; PMCID: PMC8011014.
      Citations: 28     Fields:    Translation:Humans
    20. Coe FL, Cohen AJ, Riedinger CB, Worcester EM, Zisman AL. Racial Differences in Risk Factors for Kidney Stone Formation. Clin J Am Soc Nephrol. 2020 08 07; 15(8):1166-1173. PMID: 32561654; PMCID: PMC7409744.
      Citations: 5     Fields:    Translation:Humans
    21. Makki MS, Winfree S, Lingeman JE, Witzmann FA, Worcester EM, Krambeck AE, Coe FL, Evan AP, Bledsoe S, Bergsland KJ, Khochare S, Barwinska D, Williams JC, El-Achkar TM. A Precision Medicine Approach Uncovers a Unique Signature of Neutrophils in Patients With Brushite Kidney Stones. Kidney Int Rep. 2020 May; 5(5):663-677. PMID: 32405588; PMCID: PMC7210605.
      Citations: 11     
    22. Evan AP, Coe FL, Worcester EM, Williams JC, Heiman J, Bledsoe S, Sommer A, Philips CL, Lingeman JE. Discrepancy Between Stone and Tissue Mineral Type in Patients with Idiopathic Uric Acid Stones. J Endourol. 2020 03; 34(3):385-393. PMID: 31880949; PMCID: PMC7099420.
      Citations: 1     Fields:    Translation:Humans
    23. Borofsky MS, Handa RK, Evan AP, Williams JC, Bledsoe S, Coe FL, Worcester EM, Lingeman JE. In Vivo Renal Tubule pH in Stone-Forming Human Kidneys. J Endourol. 2020 02; 34(2):203-208. PMID: 31760802; PMCID: PMC7047079.
      Citations: 2     Fields:    Translation:Humans
    24. Worcester EM, Bergsland KJ, Gillen DL, Coe FL. Evidence for disordered acid-base handling in calcium stone-forming patients. Am J Physiol Renal Physiol. 2020 02 01; 318(2):F363-F374. PMID: 31790303; PMCID: PMC7052659.
      Citations: 3     Fields:    Translation:HumansCells
    25. Menezes CJ, Worcester EM, Coe FL, Asplin J, Bergsland KJ, Ko B. Mechanisms for falling urine pH with age in stone formers. Am J Physiol Renal Physiol. 2019 07 01; 317(7):F65-F72. PMID: 31017011; PMCID: PMC6692718.
      Citations: 10     Fields:    Translation:Humans
    26. Borofsky MS, Williams JC, Dauw CA, Cohen A, Evan AC, Coe FL, Worcester E, Lingeman JE. Association Between Randall's Plaque Stone Anchors and Renal Papillary Pits. J Endourol. 2019 04; 33(4):337-342. PMID: 30793930; PMCID: PMC6482910.
      Citations: 4     Fields:    Translation:Humans
    27. Evan AP, Coe FL, Lingeman J, Bledsoe S, Worcester EM. Randall's plaque in stone formers originates in ascending thin limbs. Am J Physiol Renal Physiol. 2018 11 01; 315(5):F1236-F1242. PMID: 30066583; PMCID: PMC6293286.
      Citations: 15     Fields:    Translation:Humans
    28. Bergsland KJ, Coe FL, Parks JH, Asplin JR, Worcester EM. Evidence for a role of PDZ domain-containing proteins to mediate hypophosphatemia in calcium stone formers. Nephrol Dial Transplant. 2018 05 01; 33(5):759-770. PMID: 29126251; PMCID: PMC6251596.
      Citations: 2     Fields:    Translation:HumansCells
    29. Worcester EM, Bergsland KJ, Gillen DL, Coe FL. Mechanism for higher urine pH in normal women compared with men. Am J Physiol Renal Physiol. 2018 04 01; 314(4):F623-F629. PMID: 29357436; PMCID: PMC5966764.
      Citations: 26     Fields:    Translation:Humans
    30. Williams JC, Borofsky MS, Bledsoe SB, Evan AP, Coe FL, Worcester EM, Lingeman JE. Papillary Ductal Plugging is a Mechanism for Early Stone Retention in Brushite Stone Disease. J Urol. 2018 01; 199(1):186-192. PMID: 28822796; PMCID: PMC5871923.
      Citations: 10     Fields:    Translation:Humans
    31. Cohen AJ, Borofsky MS, Anderson BB, Dauw CA, Gillen DL, Gerber GS, Worcester EM, Coe FL, Lingeman JE. Endoscopic Evidence That Randall's Plaque is Associated with Surface Erosion of the Renal Papilla. J Endourol. 2017 01; 31(1):85-90. PMID: 27824271; PMCID: PMC5220550.
      Citations: 4     Fields:    Translation:Humans
    32. Williams JC, Worcester E, Lingeman JE. What can the microstructure of stones tell us? Urolithiasis. 2017 Feb; 45(1):19-25. PMID: 27913855; PMCID: PMC5253090.
      Citations: 12     Fields:    Translation:HumansCells
    33. Coe FL, Worcester EM, Evan AP. Idiopathic hypercalciuria and formation of calcium renal stones. Nat Rev Nephrol. 2016 09; 12(9):519-33. PMID: 27452364; PMCID: PMC5837277.
      Citations: 80     Fields:    Translation:Humans
    34. Witzmann FA, Evan AP, Coe FL, Worcester EM, Lingeman JE, Williams JC. Label-free proteomic methodology for the analysis of human kidney stone matrix composition. Proteome Sci. 2016; 14:4. PMID: 26924944; PMCID: PMC4769560.
      Citations: 16     
    35. Borofsky MS, Paonessa JE, Evan AP, Williams JC, Coe FL, Worcester EM, Lingeman JE. Introduction of a Renal Papillary Grading System for Patients with Nephrolithiasis. J Endourol B Videourol. 2015; 29(6). PMID: 32292640; PMCID: PMC6964239.
      Citations: 2     
    36. Gillen D, Rubenstein A, Worcester E, Coe F, Ennis J, Brecher ME, Asplin J. Clinical decision support improves physician guideline adherence for laboratory monitoring of chronic kidney disease: a matched cohort study. BMC Nephrol. 2015 Oct 15; 16:163. PMID: 26471846; PMCID: PMC4608162.
      Citations: 13     Fields:    Translation:Humans
    37. Borofsky MS, Paonessa JE, Evan AP, Williams JC, Coe FL, Worcester EM, Lingeman JE. A Proposed Grading System to Standardize the Description of Renal Papillary Appearance at the Time of Endoscopy in Patients with Nephrolithiasis. J Endourol. 2016 Jan; 30(1):122-7. PMID: 26414908; PMCID: PMC4744462.
      Citations: 15     Fields:    Translation:Humans
    38. Zisman AL, Evan AP, Coe FL, Worcester EM. Do kidney stone formers have a kidney disease? Kidney Int. 2015 Dec; 88(6):1240-1249. PMID: 26376133; PMCID: PMC4675687.
      Citations: 23     Fields:    
    39. Bhojani N, Paonessa JE, Hameed TA, Worcester EM, Evan AP, Coe FL, Borofsky MS, Lingeman JE. Nephrocalcinosis in Calcium Stone Formers Who Do Not have Systemic Disease. J Urol. 2015 Nov; 194(5):1308-12. PMID: 25988516; PMCID: PMC5774334.
      Citations: 4     Fields:    Translation:Humans
    40. Ko B, Bergsland K, Gillen DL, Evan AP, Clark DL, Baylock J, Coe FL, Worcester EM. Sex differences in proximal and distal nephron function contribute to the mechanism of idiopathic hypercalcuria in calcium stone formers. Am J Physiol Regul Integr Comp Physiol. 2015 Jul 01; 309(1):R85-92. PMID: 25947170; PMCID: PMC4491535.
      Citations: 8     Fields:    Translation:Humans
    41. Worcester EM, Coe FL, Sprague SM, Ennis JL. Current recommended 25-hydroxyvitamin D targets for chronic kidney disease management may be too low. J Nephrol. 2016 Feb; 29(1):63-70. PMID: 25736620.
      Citations: 14     Fields:    Translation:Humans
    42. Evan AP, Worcester EM, Williams JC, Sommer AJ, Lingeman JE, Phillips CL, Coe FL. Biopsy proven medullary sponge kidney: clinical findings, histopathology, and role of osteogenesis in stone and plaque formation. Anat Rec (Hoboken). 2015 May; 298(5):865-77. PMID: 25615853; PMCID: PMC4405475.
      Citations: 21     Fields:    Translation:Humans
    43. Evan AP, Coe FL, Connors BA, Handa RK, Lingeman JE, Worcester EM. Mechanism by which shock wave lithotripsy can promote formation of human calcium phosphate stones. Am J Physiol Renal Physiol. 2015 Apr 15; 308(8):F938-49. PMID: 25656372; PMCID: PMC4398833.
      Citations: 9     Fields:    Translation:HumansAnimals
    44. Taksande SR, Worcester EM. Calcium supplementation in chronic kidney disease. Expert Opin Drug Saf. 2014 Sep; 13(9):1175-85. PMID: 25134623.
      Citations: 2     Fields:    Translation:Humans
    45. Evan AP, Worcester EM, Coe FL, Williams J, Lingeman JE. Mechanisms of human kidney stone formation. Urolithiasis. 2015 Jan; 43 Suppl 1:19-32. PMID: 25108546; PMCID: PMC4285570.
      Citations: 70     Fields:    Translation:Humans
    46. Williams JC, Lingeman JE, Coe FL, Worcester EM, Evan AP. Micro-CT imaging of Randall's plaques. Urolithiasis. 2015 Jan; 43 Suppl 1:13-7. PMID: 25096802; PMCID: PMC4285664.
      Citations: 14     Fields:    Translation:Humans
    47. Evan AP, Lingeman JE, Worcester EM, Sommer AJ, Phillips CL, Williams JC, Coe FL. Contrasting histopathology and crystal deposits in kidneys of idiopathic stone formers who produce hydroxy apatite, brushite, or calcium oxalate stones. Anat Rec (Hoboken). 2014 Apr; 297(4):731-48. PMID: 24478243; PMCID: PMC4014063.
      Citations: 34     Fields:    Translation:Humans
    48. Worcester EM, Evan AP, Coe FL, Lingeman JE, Krambeck A, Sommers A, Phillips CL, Milliner D. A test of the hypothesis that oxalate secretion produces proximal tubule crystallization in primary hyperoxaluria type I. Am J Physiol Renal Physiol. 2013 Dec 01; 305(11):F1574-84. PMID: 24089413; PMCID: PMC3882369.
      Citations: 24     Fields:    Translation:Humans
    49. Worcester EM, Bergsland KJ, Gillen DL, Coe FL. Evidence for increased renal tubule and parathyroid gland sensitivity to serum calcium in human idiopathic hypercalciuria. Am J Physiol Renal Physiol. 2013 Sep 15; 305(6):F853-60. PMID: 23863465; PMCID: PMC3761284.
      Citations: 9     Fields:    Translation:Humans
    50. Bergsland KJ, Worcester EM, Coe FL. Role of proximal tubule in the hypocalciuric response to thiazide of patients with idiopathic hypercalciuria. Am J Physiol Renal Physiol. 2013 Aug 15; 305(4):F592-9. PMID: 23720347; PMCID: PMC3891266.
      Citations: 18     Fields:    Translation:Humans
    51. Xu H, Zisman AL, Coe FL, Worcester EM. Kidney stones: an update on current pharmacological management and future directions. Expert Opin Pharmacother. 2013 Mar; 14(4):435-47. PMID: 23438422; PMCID: PMC3772648.
      Citations: 42     Fields:    Translation:HumansPHPublic Health
    52. Ennis J, Worcester E, Coe F. Contribution of calcium, phosphorus and 25-hydroxyvitamin D to the excessive severity of secondary hyperparathyroidism in African-Americans with CKD. Nephrol Dial Transplant. 2012 Jul; 27(7):2847-53. PMID: 22505656.
      Citations: 9     Fields:    Translation:Humans
    53. Coe FL, Evan A, Worcester E. Pathophysiology-based treatment of idiopathic calcium kidney stones. Clin J Am Soc Nephrol. 2011 Aug; 6(8):2083-92. PMID: 21825103; PMCID: PMC5825183.
      Citations: 29     Fields:    Translation:HumansCellsPHPublic Health
    54. Bergsland KJ, Zisman AL, Asplin JR, Worcester EM, Coe FL. Evidence for net renal tubule oxalate secretion in patients with calcium kidney stones. Am J Physiol Renal Physiol. 2011 Feb; 300(2):F311-8. PMID: 21123489; PMCID: PMC3043999.
      Citations: 24     Fields:    Translation:Humans
    55. Evan AP, Weinman EJ, Wu XR, Lingeman JE, Worcester EM, Coe FL. Comparison of the pathology of interstitial plaque in human ICSF stone patients to NHERF-1 and THP-null mice. Urol Res. 2010 Dec; 38(6):439-52. PMID: 21063698; PMCID: PMC3035321.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    56. Worcester EM, Coe FL. Clinical practice. Calcium kidney stones. N Engl J Med. 2010 Sep 02; 363(10):954-63. PMID: 20818905; PMCID: PMC3192488.
      Citations: 122     Fields:    Translation:Humans
    57. Koyner JL, Vaidya VS, Bennett MR, Ma Q, Worcester E, Akhter SA, Raman J, Jeevanandam V, O'Connor MF, Devarajan P, Bonventre JV, Murray PT. Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol. 2010 Dec; 5(12):2154-65. PMID: 20798258; PMCID: PMC2994075.
      Citations: 142     Fields:    Translation:Humans
    58. Worcester EM, Coe FL. Evidence for altered renal tubule function in idiopathic calcium stone formers. Urol Res. 2010 Aug; 38(4):263-9. PMID: 20632168; PMCID: PMC3641150.
      Citations: 7     Fields:    Translation:HumansAnimals
    59. Coe FL, Evan AP, Lingeman JE, Worcester EM. Plaque and deposits in nine human stone diseases. Urol Res. 2010 Aug; 38(4):239-47. PMID: 20625890; PMCID: PMC3175811.
      Citations: 51     Fields:    Translation:Humans
    60. Evan AP, Lingeman JE, Worcester EM, Bledsoe SB, Sommer AJ, Williams JC, Krambeck AE, Philips CL, Coe FL. Renal histopathology and crystal deposits in patients with small bowel resection and calcium oxalate stone disease. Kidney Int. 2010 Aug; 78(3):310-7. PMID: 20428098; PMCID: PMC3787699.
      Citations: 38     Fields:    Translation:Humans
    61. Coe FL, Evan AP, Worcester EM, Lingeman JE. Three pathways for human kidney stone formation. Urol Res. 2010 Jun; 38(3):147-60. PMID: 20411383; PMCID: PMC3169174.
      Citations: 86     Fields:    Translation:Humans
    62. Evan AP, Lingeman JE, Coe FL, Bledsoe SB, Sommer AJ, Williams JC, Krambeck AE, Worcester EM. Intra-tubular deposits, urine and stone composition are divergent in patients with ileostomy. Kidney Int. 2009 Nov; 76(10):1081-8. PMID: 19710630; PMCID: PMC3780771.
      Citations: 28     Fields:    Translation:Humans
    63. Bergsland KJ, Coe FL, Gillen DL, Worcester EM. A test of the hypothesis that the collecting duct calcium-sensing receptor limits rise of urine calcium molarity in hypercalciuric calcium kidney stone formers. Am J Physiol Renal Physiol. 2009 Oct; 297(4):F1017-23. PMID: 19640901; PMCID: PMC2775565.
      Citations: 20     Fields:    Translation:Humans
    64. Worcester EM, Coe FL. Does idiopathic hypercalciuria trigger calcium-sensing receptor-mediated protection from urinary supersaturation? J Am Soc Nephrol. 2009 Aug; 20(8):1657-9. PMID: 19578005.
      Citations: 2     Fields:    Translation:HumansAnimals
    65. Miller NL, Williams JC, Evan AP, Bledsoe SB, Coe FL, Worcester EM, Munch LC, Handa SE, Lingeman JE. In idiopathic calcium oxalate stone-formers, unattached stones show evidence of having originated as attached stones on Randall's plaque. BJU Int. 2010 Jan; 105(2):242-5. PMID: 19549258; PMCID: PMC2807918.
      Citations: 24     Fields:    Translation:Humans
    66. Ennis J, Kocherginsky M, Schumm LP, Worcester E, Coe FL, Josephson MA. Trends in kidney donation among kidney stone formers: a survey of US transplant centers. Am J Nephrol. 2009; 30(1):12-8. PMID: 19169005.
      Citations: 7     Fields:    Translation:Humans
    67. Miller NL, Gillen DL, Williams JC, Evan AP, Bledsoe SB, Coe FL, Worcester EM, Matlaga BR, Munch LC, Lingeman JE. A formal test of the hypothesis that idiopathic calcium oxalate stones grow on Randall's plaque. BJU Int. 2009 Apr; 103(7):966-71. PMID: 19021625; PMCID: PMC3459677.
      Citations: 43     Fields:    Translation:Humans
    68. Parks JH, Coe FL, Evan AP, Worcester EM. Clinical and laboratory characteristics of calcium stone-formers with and without primary hyperparathyroidism. BJU Int. 2009 Mar; 103(5):670-8. PMID: 18793297.
      Citations: 25     Fields:    Translation:Humans
    69. Worcester EM, Coe FL, Evan AP, Bergsland KJ, Parks JH, Willis LR, Clark DL, Gillen DL. Evidence for increased postprandial distal nephron calcium delivery in hypercalciuric stone-forming patients. Am J Physiol Renal Physiol. 2008 Nov; 295(5):F1286-94. PMID: 18715937; PMCID: PMC2584913.
      Citations: 37     Fields:    Translation:Humans
    70. Parks JH, Coe FL, Evan AP, Worcester EM. Urine pH in renal calcium stone formers who do and do not increase stone phosphate content with time. Nephrol Dial Transplant. 2009 Jan; 24(1):130-6. PMID: 18662977; PMCID: PMC2721421.
      Citations: 34     Fields:    Translation:Humans
    71. Koyner JL, Bennett MR, Worcester EM, Ma Q, Raman J, Jeevanandam V, Kasza KE, O'Connor MF, Konczal DJ, Trevino S, Devarajan P, Murray PT. Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery. Kidney Int. 2008 Oct; 74(8):1059-69. PMID: 18650797; PMCID: PMC2745082.
      Citations: 130     Fields:    
    72. Worcester EM, Coe FL. Nephrolithiasis. Prim Care. 2008 Jun; 35(2):369-91, vii. PMID: 18486720; PMCID: PMC2518455.
      Citations: 66     Fields:    Translation:Humans
    73. Evan AE, Lingeman JE, Coe FL, Miller NL, Bledsoe SB, Sommer AJ, Williams JC, Shao Y, Worcester EM. Histopathology and surgical anatomy of patients with primary hyperparathyroidism and calcium phosphate stones. Kidney Int. 2008 Jul; 74(2):223-9. PMID: 18449170.
      Citations: 37     Fields:    Translation:Humans
    74. Worcester EM, Coe FL. New insights into the pathogenesis of idiopathic hypercalciuria. Semin Nephrol. 2008 Mar; 28(2):120-32. PMID: 18359393; PMCID: PMC2362396.
      Citations: 62     Fields:    Translation:HumansAnimals
    75. Evan AP, Coe FL, Gillen D, Lingeman JE, Bledsoe S, Worcester EM. Renal intratubular crystals and hyaluronan staining occur in stone formers with bypass surgery but not with idiopathic calcium oxalate stones. Anat Rec (Hoboken). 2008 Mar; 291(3):325-34. PMID: 18286613.
      Citations: 26     Fields:    Translation:HumansCells
    76. Evan AP, Lingeman JE, Coe FL, Worcester EM. Role of interstitial apatite plaque in the pathogenesis of the common calcium oxalate stone. Semin Nephrol. 2008 Mar; 28(2):111-9. PMID: 18359392; PMCID: PMC2329574.
      Citations: 23     Fields:    Translation:Humans
    77. Evan AP, Coe FL, Lingeman JE, Shao Y, Sommer AJ, Bledsoe SB, Anderson JC, Worcester EM. Mechanism of formation of human calcium oxalate renal stones on Randall's plaque. Anat Rec (Hoboken). 2007 Oct; 290(10):1315-23. PMID: 17724713.
      Citations: 87     Fields:    Translation:Humans
    78. Evan AP, Bledsoe S, Worcester EM, Coe FL, Lingeman JE, Bergsland KJ. Renal inter-alpha-trypsin inhibitor heavy chain 3 increases in calcium oxalate stone-forming patients. Kidney Int. 2007 Dec; 72(12):1503-11. PMID: 17898697.
      Citations: 23     Fields:    Translation:HumansCells
    79. Stankus N, Hammes M, Gillen D, Worcester E. African American ESRD patients have a high pre-dialysis prevalence of kidney stones compared to NHANES III. Urol Res. 2007 Apr; 35(2):83-7. PMID: 17310350.
      Citations: 15     Fields:    Translation:Humans
    80. Evan AP, Lingeman J, Coe F, Shao Y, Miller N, Matlaga B, Phillips C, Sommer A, Worcester E. Renal histopathology of stone-forming patients with distal renal tubular acidosis. Kidney Int. 2007 Apr; 71(8):795-801. PMID: 17264873.
      Citations: 49     Fields:    Translation:Humans
    81. Worcester EM, Gillen DL, Evan AP, Parks JH, Wright K, Trumbore L, Nakagawa Y, Coe FL. Evidence that postprandial reduction of renal calcium reabsorption mediates hypercalciuria of patients with calcium nephrolithiasis. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F66-75. PMID: 17210796.
      Citations: 35     Fields:    Translation:Humans
    82. Worcester E, Evan A, Bledsoe S, Lyon M, Chuang M, Orvieto M, Gerber G, Coe F. Pathophysiological correlates of two unique renal tubule lesions in rats with intestinal resection. Am J Physiol Renal Physiol. 2006 Nov; 291(5):F1061-9. PMID: 17028259.
      Citations: 3     Fields:    Translation:AnimalsCells
    83. Worcester EM, Parks JH, Evan AP, Coe FL. Renal function in patients with nephrolithiasis. J Urol. 2006 Aug; 176(2):600-3; discussion 603. PMID: 16813897.
      Citations: 38     Fields:    Translation:Humans
    84. Worcester EM, Coe FL, Evan AP, Parks JH. Reduced renal function and benefits of treatment in cystinuria vs other forms of nephrolithiasis. BJU Int. 2006 Jun; 97(6):1285-90. PMID: 16686727.
      Citations: 23     Fields:    Translation:Humans
    85. Evan AP, Coe FL, Lingeman JE, Shao Y, Matlaga BR, Kim SC, Bledsoe SB, Sommer AJ, Grynpas M, Phillips CL, Worcester EM. Renal crystal deposits and histopathology in patients with cystine stones. Kidney Int. 2006 Jun; 69(12):2227-35. PMID: 16710357.
      Citations: 57     Fields:    Translation:HumansCells
    86. Matlaga BR, Williams JC, Kim SC, Kuo RL, Evan AP, Bledsoe SB, Coe FL, Worcester EM, Munch LC, Lingeman JE. Endoscopic evidence of calculus attachment to Randall's plaque. J Urol. 2006 May; 175(5):1720-4; discussion 1724. PMID: 16600740.
      Citations: 32     Fields:    Translation:Humans
    87. Evan A, Lingeman J, Coe FL, Worcester E. Randall's plaque: pathogenesis and role in calcium oxalate nephrolithiasis. Kidney Int. 2006 Apr; 69(8):1313-8. PMID: 16614720.
      Citations: 97     Fields:    Translation:Humans
    88. Stankus N, Worcester E, Hammes M, Coe FL. Evidence against a contribution of conventional urine risk factors to de novo ESRD renal stones. Nephrol Dial Transplant. 2006 Mar; 21(3):701-6. PMID: 16326738.
      Citations: 1     Fields:    Translation:Humans
    89. Worcester EM, Chuang M, Laven B, Orvieto M, Coe FL, Evan AP, Gerber GS. A new animal model of hyperoxaluria and nephrolithiasis in rats with small bowel resection. Urol Res. 2005 Nov; 33(5):380-2. PMID: 16284881.
      Citations: 2     Fields:    Translation:Animals
    90. Coe FL, Evan A, Worcester E. Kidney stone disease. J Clin Invest. 2005 Oct; 115(10):2598-608. PMID: 16200192; PMCID: PMC1236703.
      Citations: 222     Fields:    Translation:HumansAnimals
    91. Evan AP, Coe FL, Lingeman JE, Worcester E. Insights on the pathology of kidney stone formation. Urol Res. 2005 Nov; 33(5):383-9. PMID: 16078085.
      Citations: 20     Fields:    Translation:Humans
    92. Gillen DL, Coe FL, Worcester EM. Nephrolithiasis and increased blood pressure among females with high body mass index. Am J Kidney Dis. 2005 Aug; 46(2):263-9. PMID: 16112044.
      Citations: 25     Fields:    Translation:Humans
    93. Evan AP, Coe FL, Rittling SR, Bledsoe SM, Shao Y, Lingeman JE, Worcester EM. Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization. Kidney Int. 2005 Jul; 68(1):145-54. PMID: 15954903.
      Citations: 52     Fields:    Translation:Humans
    94. O'Connor RC, Worcester EM, Evan AP, Meehan S, Kuznetsov D, Laven B, Sommer AJ, Bledsoe SB, Parks JH, Coe FL, Grynpas M, Gerber GS. Nephrolithiasis and nephrocalcinosis in rats with small bowel resection. Urol Res. 2005 May; 33(2):105-15. PMID: 15815943.
      Citations: 11     Fields:    Translation:Animals
    95. Gillen DL, Worcester EM, Coe FL. Decreased renal function among adults with a history of nephrolithiasis: a study of NHANES III. Kidney Int. 2005 Feb; 67(2):685-90. PMID: 15673317.
      Citations: 50     Fields:    Translation:Humans
    96. Evan AP, Lingeman JE, Coe FL, Shao Y, Parks JH, Bledsoe SB, Phillips CL, Bonsib S, Worcester EM, Sommer AJ, Kim SC, Tinmouth WW, Grynpas M. Crystal-associated nephropathy in patients with brushite nephrolithiasis. Kidney Int. 2005 Feb; 67(2):576-91. PMID: 15673305.
      Citations: 82     Fields:    Translation:HumansCells
    97. Parks JH, Worcester EM, Coe FL, Evan AP, Lingeman JE. Clinical implications of abundant calcium phosphate in routinely analyzed kidney stones. Kidney Int. 2004 Aug; 66(2):777-85. PMID: 15253733.
      Citations: 80     Fields:    Translation:Humans
    98. Khan MW, Worcester EM, Straus FH, Khan S, Staszak V, Kaplan EL. Parathyroid carcinoma in secondary and tertiary hyperparathyroidism. J Am Coll Surg. 2004 Aug; 199(2):312-9. PMID: 15275889.
      Citations: 16     Fields:    Translation:Humans
    99. Worcester E, Parks JH, Josephson MA, Thisted RA, Coe FL. Causes and consequences of kidney loss in patients with nephrolithiasis. Kidney Int. 2003 Dec; 64(6):2204-13. PMID: 14633144.
      Citations: 34     Fields:    Translation:Humans
    100. Parks JH, Worcester EM, O'Connor RC, Coe FL. Urine stone risk factors in nephrolithiasis patients with and without bowel disease. Kidney Int. 2003 Jan; 63(1):255-65. PMID: 12472791.
      Citations: 38     Fields:    Translation:Humans
    101. Worcester EM. Stones from bowel disease. Endocrinol Metab Clin North Am. 2002 Dec; 31(4):979-99. PMID: 12474641.
      Citations: 46     Fields:    Translation:HumansCells
    102. Beshensky AM, Wesson JA, Worcester EM, Sorokina EJ, Snyder CJ, Kleinman JG. Effects of urinary macromolecules on hydroxyapatite crystal formation. J Am Soc Nephrol. 2001 Oct; 12(10):2108-2116. PMID: 11562409.
      Citations: 12     Fields:    Translation:HumansCells
    103. Wesson JA, Worcester EM, Kleinman JG. Role of anionic proteins in kidney stone formation: interaction between model anionic polypeptides and calcium oxalate crystals. J Urol. 2000 Apr; 163(4):1343-8. PMID: 10737541.
      Citations: 10     Fields:    Translation:Cells
    104. Wesson JA, Worcester EM, Wiessner JH, Mandel NS, Kleinman JG. Control of calcium oxalate crystal structure and cell adherence by urinary macromolecules. Kidney Int. 1998 Apr; 53(4):952-7. PMID: 9551403.
      Citations: 37     Fields:    Translation:HumansCells
    105. Worcester EM. Inhibitors of stone formation. Semin Nephrol. 1996 Sep; 16(5):474-86. PMID: 8890402.
      Citations: 12     Fields:    Translation:HumansCells
    106. Wesson JA, Worcester E. Formation of hydrated calcium oxalates in the presence of poly-L-aspartic acid. Scanning Microsc. 1996; 10(2):415-23; 423-4. PMID: 9813620.
      Citations: 8     Fields:    Translation:HumansCells
    107. Lemann J, Pleuss JA, Worcester EM, Hornick L, Schrab D, Hoffmann RG. Urinary oxalate excretion increases with body size and decreases with increasing dietary calcium intake among healthy adults. Kidney Int. 1996 Jan; 49(1):200-8. PMID: 8770968.
      Citations: 71     Fields:    Translation:Humans
    108. Kleinman JG, Beshensky A, Worcester EM, Brown D. Expression of osteopontin, a urinary inhibitor of stone mineral crystal growth, in rat kidney. Kidney Int. 1995 Jun; 47(6):1585-96. PMID: 7643527.
      Citations: 19     Fields:    Translation:AnimalsCells
    109. Worcester EM, Kleinman JG, Beshensky AM. Osteopontin production by cultured kidney cells. Ann N Y Acad Sci. 1995 Apr 21; 760:266-78. PMID: 7785901.
      Citations: 2     Fields:    Translation:AnimalsCells
    110. Worcester EM, Beshensky AM. Osteopontin inhibits nucleation of calcium oxalate crystals. Ann N Y Acad Sci. 1995 Apr 21; 760:375-7. PMID: 7785921.
      Citations: 19     Fields:    Translation:AnimalsCells
    111. Kleinman JG, Worcester EM, Beshensky AM, Sheridan AM, Bonventre JV, Brown D. Upregulation of osteopontin expression by ischemia in rat kidney. Ann N Y Acad Sci. 1995 Apr 21; 760:321-3. PMID: 7785909.
      Citations: 3     Fields:    Translation:Animals
    112. Worcester EM. Urinary calcium oxalate crystal growth inhibitors. J Am Soc Nephrol. 1994 Nov; 5(5 Suppl 1):S46-53. PMID: 7873744.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    113. Worcester EM, Fellner SK, Nakagawa Y, Coe FL. Effect of renal transplantation on serum oxalate and urinary oxalate excretion. Nephron. 1994; 67(4):414-8. PMID: 7969673.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    114. Worcester EM, Sebastian JL, Hiatt JG, Beshensky AM, Sadowski JA. The effect of warfarin on urine calcium oxalate crystal growth inhibition and urinary excretion of calcium and nephrocalcin. Calcif Tissue Int. 1993 Oct; 53(4):242-8. PMID: 8275352.
      Citations: 5     Fields:    Translation:HumansCells
    115. Worcester EM, Blumenthal SS, Beshensky AM, Lewand DL. The calcium oxalate crystal growth inhibitor protein produced by mouse kidney cortical cells in culture is osteopontin. J Bone Miner Res. 1992 Sep; 7(9):1029-36. PMID: 1414495.
      Citations: 21     Fields:    Translation:AnimalsCells
    116. Lemann J, Worcester EM, Gray RW. Hypercalciuria and stones. Am J Kidney Dis. 1991 Apr; 17(4):386-91. PMID: 2008904.
      Citations: 26     Fields:    Translation:Humans
    117. Worcester EM, Nakagawa Y, Wabner CL, Kumar S, Coe FL. Crystal adsorption and growth slowing by nephrocalcin, albumin, and Tamm-Horsfall protein. Am J Physiol. 1988 Dec; 255(6 Pt 2):F1197-205. PMID: 3202183.
      Citations: 21     Fields:    Translation:HumansCells
    118. Worcester EM, Nakagawa Y, Coe FL. Glycoprotein calcium oxalate crystal growth inhibitor in urine. Miner Electrolyte Metab. 1987; 13(4):267-72. PMID: 3306319.
      Citations: 7     Fields:    Translation:Humans
    119. Worcester EM, Nakagawa Y, Bushinsky DA, Coe FL. Evidence that serum calcium oxalate supersaturation is a consequence of oxalate retention in patients with chronic renal failure. J Clin Invest. 1986 Jun; 77(6):1888-96. PMID: 3711339; PMCID: PMC370548.
      Citations: 13     Fields:    Translation:Humans
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