Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy.
Iida M, Brand TM, Starr MM, Huppert EJ, Luthar N, Bahrar H, Coan JP, Pearson HE, Salgia R, Wheeler DL. Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy. Mol Cancer. 2014 Oct 24; 13:242.
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Animals
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Antibodies, Neutralizing
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Antineoplastic Agents
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Carcinoma, Non-Small-Cell Lung
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Cell Line, Tumor
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Cell Proliferation
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Drug Resistance, Neoplasm
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Humans
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Lung Neoplasms
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Male
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Mice
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Mice, Nude
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Phosphatidylinositol 3-Kinases
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Proto-Oncogene Proteins c-akt
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Receptor, erbB-2
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Receptor, erbB-3
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Signal Transduction
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Xenograft Model Antitumor Assays