"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Descriptor ID |
D015398
|
MeSH Number(s) |
G02.111.820 G04.835
|
Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 9 | 18 | 27 |
1995 | 14 | 20 | 34 |
1996 | 10 | 12 | 22 |
1997 | 24 | 15 | 39 |
1998 | 12 | 23 | 35 |
1999 | 18 | 29 | 47 |
2000 | 17 | 27 | 44 |
2001 | 16 | 38 | 54 |
2002 | 35 | 43 | 78 |
2003 | 25 | 58 | 83 |
2004 | 30 | 51 | 81 |
2005 | 17 | 65 | 82 |
2006 | 31 | 65 | 96 |
2007 | 25 | 59 | 84 |
2008 | 36 | 72 | 108 |
2009 | 50 | 74 | 124 |
2010 | 50 | 95 | 145 |
2011 | 45 | 96 | 141 |
2012 | 44 | 92 | 136 |
2013 | 36 | 85 | 121 |
2014 | 37 | 95 | 132 |
2015 | 45 | 91 | 136 |
2016 | 26 | 98 | 124 |
2017 | 27 | 74 | 101 |
2018 | 22 | 75 | 97 |
2019 | 19 | 61 | 80 |
2020 | 25 | 46 | 71 |
2021 | 14 | 42 | 56 |
2022 | 3 | 17 | 20 |
2023 | 3 | 23 | 26 |
2024 | 0 | 5 | 5 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells. Nat Commun. 2024 Feb 28; 15(1):1819.
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Midbrain signaling of identity prediction errors depends on orbitofrontal cortex networks. Nat Commun. 2024 Feb 24; 15(1):1704.
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IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFß. Front Immunol. 2024; 15:1293883.
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A mechanism of lysosomal calcium entry. Sci Adv. 2024 Feb 16; 10(7):eadk2317.
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PDGFRß Signaling Cooperates with ß-Catenin to Modulate c-Abl and Biologic Behavior of Desmoid-Type Fibromatosis. Clin Cancer Res. 2024 01 17; 30(2):450-461.
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Bromodomain-Containing Protein 9 Regulates Signaling Pathways and Reprograms the Epigenome in Immortalized Human Uterine Fibroid Cells. Int J Mol Sci. 2024 Jan 11; 25(2).
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Effect of antibiotic monensin on cell proliferation and IGF1R signaling pathway in human colorectal cancer cells. Ann Med. 2023 12; 55(1):954-964.
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Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis. Clin Cancer Res. 2023 12 01; 29(23):4930-4940.
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Processing stimulus dynamics by the NF-?B network in single cells. Exp Mol Med. 2023 12; 55(12):2531-2540.
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Epithelial wound healing in Clytia hemisphaerica provides insights into extracellular ATP signaling mechanisms and P2XR evolution. Sci Rep. 2023 11 01; 13(1):18819.