"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
|
| MeSH Number(s) |
G02.111.820 G04.835
|
| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 10 | 12 | 22 |
| 1997 | 24 | 15 | 39 |
| 1998 | 12 | 23 | 35 |
| 1999 | 18 | 29 | 47 |
| 2000 | 16 | 27 | 43 |
| 2001 | 16 | 38 | 54 |
| 2002 | 37 | 47 | 84 |
| 2003 | 26 | 58 | 84 |
| 2004 | 32 | 52 | 84 |
| 2005 | 19 | 68 | 87 |
| 2006 | 29 | 66 | 95 |
| 2007 | 27 | 63 | 90 |
| 2008 | 37 | 72 | 109 |
| 2009 | 52 | 79 | 131 |
| 2010 | 53 | 98 | 151 |
| 2011 | 48 | 103 | 151 |
| 2012 | 48 | 99 | 147 |
| 2013 | 38 | 101 | 139 |
| 2014 | 38 | 100 | 138 |
| 2015 | 48 | 102 | 150 |
| 2016 | 32 | 116 | 148 |
| 2017 | 37 | 86 | 123 |
| 2018 | 29 | 91 | 120 |
| 2019 | 23 | 74 | 97 |
| 2020 | 29 | 55 | 84 |
| 2021 | 19 | 57 | 76 |
| 2022 | 4 | 23 | 27 |
| 2023 | 4 | 32 | 36 |
| 2024 | 20 | 42 | 62 |
| 2025 | 11 | 27 | 38 |
To return to the timeline,
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling. Proc Natl Acad Sci U S A. 2025 Dec 02; 122(48):e2409184122.
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Genome-wide CRISPR Screen Identifies Sec31A as a Key Regulator of Alpha Cell Survival. Nat Commun. 2025 Oct 15; 16(1):9159.
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Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells. Nat Immunol. 2025 Nov; 26(11):1946-1961.
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Static Magnetic Field Promotes Wheat Nitrogen Assimilation by Repressing Jasmonates Biosynthesis Through TaHY5. Plant Biotechnol J. 2026 Feb; 24(2):424-441.
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PARP7 inhibition stabilizes STAT1/STAT2 and relieves experimental autoimmune encephalomyelitis in mice. Cell Rep. 2025 Aug 26; 44(8):116130.
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Circular RNA Profiling Identifies circ5078 as a BMPR2-Derived Regulator of Endothelial Proliferation and Stress Responses. Arterioscler Thromb Vasc Biol. 2025 Sep; 45(9):1546-1561.
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The dark side of radiotherapy. Cancer Cell. 2025 Aug 11; 43(8):1385-1389.
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Renal Tumorigenesis via RAS/RAF/MAPK Pathway Alterations Beyond Papillary Renal Neoplasm With Reverse Polarity. Am J Surg Pathol. 2025 Dec 01; 49(12):1266-1278.
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Arginine promotes the activation of human lung fibroblasts independent of its metabolism. Biochem J. 2025 Jun 17; 482(12).
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Conformation-specific synthetic intrabodies modulate mTOR signaling with subcellular spatial resolution. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2424679122.