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CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.
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CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors.
CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors. Nature. 2024 Nov; 635(8038):462-471.
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PubMed
subject areas
Animals
Antibodies, Monoclonal
B7-H1 Antigen
Carcinoma, Non-Small-Cell Lung
Clinical Trials, Phase III as Topic
CTLA-4 Antigen
Drug Resistance, Neoplasm
Female
Genes, Tumor Suppressor
Humans
Kelch-Like ECH-Associated Protein 1
Lung Neoplasms
Male
Mice
Mutation
Nitric Oxide Synthase Type II
T-Lymphocytes
Tumor Microenvironment
Tumor Suppressor Proteins
authors with profiles
Marina Chiara Garassino
Benjamin Levy
Christine Bestvina