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Ricardo Lastra

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Lastra is a surgical pathologist and cytopathologist with subspecialty focus in gynecologic pathology.


    Collapse Biography 
    Collapse education and training
    Universidad Central de VenezuelaMD2005
    Pennsylvania HospitalResidency2012Anatomic and Clinical Pathology
    Hospital of the University of PennsylvaniaFellowship2013Surgical Pathology
    Hospital of the University of PennsylvaniaFellowship2014Cytopathology
    The Johns Hopkins HospitalAdvanced Specialty Training Program2015Gynecologic Pathology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Bennett JA, Ritterhouse LL, Furtado LV, Lastra RR, Pesci A, Newell JM, Burandt E, Kooreman L, Van de Vijver K, Krausz T, Felix A, Zannoni GF, Young RH, Oliva E. Female adnexal tumors of probable Wolffian origin: morphological, immunohistochemical, and molecular analysis of 15 cases. Mod Pathol. 2019 Oct 07. PMID: 31591497.
      View in: PubMed
    2. Tonsing-Carter E, Hernandez KM, Kim CR, Harkless RV, Oh A, Bowie KR, West-Szymanski DC, Betancourt-Ponce MA, Green BD, Lastra RR, Fleming GF, Chandarlapaty S, Conzen SD. Glucocorticoid receptor modulation decreases ER-positive breast cancer cell proliferation and suppresses wild-type and mutant ER chromatin association. Breast Cancer Res. 2019 07 24; 21(1):82. PMID: 31340854.
      View in: PubMed
    3. Chapel DB, Choy B, Pytel P, Husain AN, Lastra RR. Mucolipidosis Type II Affecting 1 Fetus and Placental Disk of a Dichorionic-Diamnionic Twin Gestation: A Case Report and Review of the Literature. Int J Gynecol Pathol. 2019 Jul; 38(4):346-352. PMID: 29620587.
      View in: PubMed
    4. Chapel DB, Patil SA, Plagov A, Puranik R, Mendybaeva A, Steinhardt G, Wanjari P, Lastra RR, Kadri S, Segal JP, Ritterhouse LL. Quantitative next-generation sequencing-based analysis indicates progressive accumulation of microsatellite instability between atypical hyperplasia/endometrial intraepithelial neoplasia and paired endometrioid endometrial carcinoma. Mod Pathol. 2019 Oct; 32(10):1508-1520. PMID: 31186530.
      View in: PubMed
    5. Brooks RA, Fleming GF, Lastra RR, Lee NK, Moroney JW, Son CH, Tatebe K, Veneris JL. Current recommendations and recent progress in endometrial cancer. CA Cancer J Clin. 2019 Jul; 69(4):258-279. PMID: 31074865.
      View in: PubMed
    6. Eckert MA, Coscia F, Chryplewicz A, Chang JW, Hernandez KM, Pan S, Tienda SM, Nahotko DA, Li G, Blaženovic I, Lastra RR, Curtis M, Yamada SD, Perets R, McGregor SM, Andrade J, Fiehn O, Moellering RE, Mann M, Lengyel E. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature. 2019 05; 569(7758):723-728. PMID: 31043742.
      View in: PubMed
    7. Olivas AD, Barroeta JE, Lastra RR. Role of Ancillary Techniques in Gynecologic Cytopathology Specimens. Acta Cytol. 2019 Mar 19; 1-8. PMID: 30889579.
      View in: PubMed
    8. Choy B, Venkataraman G, Biernacka A, Lastra RR, Mueller J, Setia N, Reeves W, Antic T. Correlation of cytopathology with flow cytometry and histopathology for the diagnosis of hematologic malignancies in young adults presenting with cervical lymphadenopathy. Diagn Cytopathol. 2019 Jun; 47(6):579-583. PMID: 30794347.
      View in: PubMed
    9. Chapel DB, Lengyel E, Ritterhouse LL, Lastra RR. Interpretation of Mismatch Repair Protein Immunohistochemistry in Endometrial Carcinoma Should Consider Both Lynch Syndrome Screening and Immunotherapy Susceptibility: An Illustrative Case Report. Int J Gynecol Pathol. 2019 Feb 21. PMID: 30807370.
      View in: PubMed
    10. Hart PC, Chiyoda T, Liu X, Weigert M, Curtis M, Chiang CY, Loth R, Lastra R, McGregor SM, Locasale JW, Lengyel E, Romero IL. SPHK1 Is a Novel Target of Metformin in Ovarian Cancer. Mol Cancer Res. 2019 04; 17(4):870-881. PMID: 30655321.
      View in: PubMed
    11. Johnson DN, Cavallo AB, Uraizee I, Tanager K, Lastra RR, Antic T, Cipriani NA. A Proposal for Separation of Nuclear Atypia and Architectural Atypia in Bethesda Category III (AUS/FLUS) Based on Differing Rates of Thyroid Malignancy. Am J Clin Pathol. 2019 01 01; 151(1):86-94. PMID: 30212867.
      View in: PubMed
    12. Tran L, Antic T, Lastra RR. Incidental Gynecologic Tract Neoplasms in Women Undergoing Anterior Pelvic Exenteration for Urothelial Carcinoma. Int J Gynecol Pathol. 2019 Jan; 38(1):97-102. PMID: 29257039.
      View in: PubMed
    13. Fidai SS, Sharma AE, Johnson DN, Segal JP, Lastra RR. Dihydropyrimidine dehydrogenase deficiency as a cause of fatal 5-Fluorouracil toxicity. Autops Case Rep. 2018 Oct-Dec; 8(4):e2018049. PMID: 30775324.
      View in: PubMed
    14. McGregor SM, Furtado LV, Montag AG, Brooks R, Lastra RR. Epithelioid Trophoblastic Tumor: Expanding the Clinicopathologic Spectrum of a Rare Malignancy. Int J Gynecol Pathol. 2018 Nov 21. PMID: 30480644.
      View in: PubMed
    15. Chapel DB, Joseph NM, Krausz T, Lastra RR. An Ovarian Adenocarcinoma With Combined Low-grade Serous and Mesonephric Morphologies Suggests a Müllerian Origin for Some Mesonephric Carcinomas. Int J Gynecol Pathol. 2018 Sep; 37(5):448-459. PMID: 28863071.
      View in: PubMed
    16. Curtis M, Kenny HA, Ashcroft B, Mukherjee A, Johnson A, Zhang Y, Helou Y, Batlle R, Liu X, Gutierrez N, Gao X, Yamada SD, Lastra R, Montag A, Ahsan N, Locasale JW, Salomon AR, Nebreda AR, Lengyel E. Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. Cell Metab. 2019 01 08; 29(1):141-155.e9. PMID: 30174305.
      View in: PubMed
    17. Cowan M, Suntum T, Olivas AD, Perpich M, Applebaum MA, Lastra RR, Yamada SD. Second primary rhabdomyosarcoma of the uterine cervix presenting with synchronous ovarian Sertoli-Leydig cell tumor: An illustrative case of DICER1 syndrome. Gynecol Oncol Rep. 2018 Aug; 25:94-97. PMID: 30014022.
      View in: PubMed
    18. Johnson MB, Hoffmann JN, You HM, Lastra RR, Fernandez S, Strober JW, Allaw AB, Brady MJ, Conzen SD, McClintock MK. Psychosocial Stress Exposure Disrupts Mammary Gland Development. J Mammary Gland Biol Neoplasia. 2018 06; 23(1-2):59-73. PMID: 29687293.
      View in: PubMed
    19. Chapel DB, Yamada SD, Cowan M, Lastra RR. Immunohistochemistry for mismatch repair protein deficiency in endometrioid endometrial carcinoma yields equivalent results when performed on endometrial biopsy/curettage or hysterectomy specimens. Gynecol Oncol. 2018 06; 149(3):570-574. PMID: 29656794.
      View in: PubMed
    20. West DC, Kocherginsky M, Tonsing-Carter EY, Dolcen DN, Hosfield DJ, Lastra RR, Sinnwell JP, Thompson KJ, Bowie KR, Harkless RV, Skor MN, Pierce CF, Styke SC, Kim CR, de Wet L, Greene GL, Boughey JC, Goetz MP, Kalari KR, Wang L, Fleming GF, Györffy B, Conzen SD. Discovery of a Glucocorticoid Receptor (GR) Activity Signature Using Selective GR Antagonism in ER-Negative Breast Cancer. Clin Cancer Res. 2018 07 15; 24(14):3433-3446. PMID: 29636357.
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    21. Lwanga A, Kamson DO, Wilkins TE, Sharma V, Schulte JJ, Miller J, Hassan I, Lastra RR. Occult teratoma in a case of N-methyl-D-aspartate receptor encephalitis. Neuroradiol J. 2018 Aug; 31(4):415-419. PMID: 29513076.
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    22. Lastra RR, Birdsong G, Hwang DH, Jorda M, Kerr DA, McGrath C, Odronic S, Rao R, VanderLaan PA, Walker JW, Antic T. Preoperative cytologic interpretation of noninvasive follicular thyroid neoplasm with papillary-like nuclear features: a 1-year multi-institutional experience. J Am Soc Cytopathol. 2018 Mar - Apr; 7(2):79-85. PMID: 31043256.
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    23. Johnson DN, Barroeta JE, Antic T, Lastra RR. Cytomorphologic features of metastatic endometrioid carcinoma by fine needle aspiration. Diagn Cytopathol. 2018 Feb; 46(2):105-110. PMID: 29105363.
      View in: PubMed
    24. McGregor SM, Schoolmeester JK, Lastra RR. Collision Signet-Ring Stromal Tumor and Steroid Cell Tumor of the Ovary: Report of the First Case. Int J Gynecol Pathol. 2017 May; 36(3):261-264. PMID: 27513075.
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    25. Veneris JT, Darcy KM, Mhawech-Fauceglia P, Tian C, Lengyel E, Lastra RR, Pejovic T, Conzen SD, Fleming GF. High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer. Gynecol Oncol. 2017 07; 146(1):153-160. PMID: 28456378.
      View in: PubMed
    26. Kach J, Long TM, Selman P, Tonsing-Carter EY, Bacalao MA, Lastra RR, de Wet L, Comiskey S, Gillard M, VanOpstall C, West DC, Chan WC, Griend DV, Conzen SD, Szmulewitz RZ. Selective Glucocorticoid Receptor Modulators (SGRMs) Delay Castrate-Resistant Prostate Cancer Growth. Mol Cancer Ther. 2017 08; 16(8):1680-1692. PMID: 28428441.
      View in: PubMed
    27. Chiyoda T, Hart PC, Eckert MA, McGregor SM, Lastra RR, Hamamoto R, Nakamura Y, Yamada SD, Olopade OI, Lengyel E, Romero IL. Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention. Cancer Prev Res (Phila). 2017 Apr; 10(4):255-266. PMID: 28264838.
      View in: PubMed
    28. Eckert MA, Pan S, Hernandez KM, Loth RM, Andrade J, Volchenboum SL, Faber P, Montag A, Lastra R, Peter ME, Yamada SD, Lengyel E. Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube. Cancer Discov. 2016 12; 6(12):1342-1351. PMID: 27856443.
      View in: PubMed
    29. Schulte JJ, Lastra RR. Abdominopelvic washings in gynecologic pathology: A comprehensive review. Diagn Cytopathol. 2016 Dec; 44(12):1039-1057. PMID: 27578056.
      View in: PubMed
    30. Coscia F, Watters KM, Curtis M, Eckert MA, Chiang CY, Tyanova S, Montag A, Lastra RR, Lengyel E, Mann M. Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status. Nat Commun. 2016 08 26; 7:12645. PMID: 27561551.
      View in: PubMed
    31. Parra-Herran C, Taljaard M, Djordjevic B, Reyes MC, Schwartz L, Schoolmeester JK, Lastra RR, Quick CM, Laury A, Rasty G, Nucci MR, Howitt BE. Pattern-based classification of invasive endocervical adenocarcinoma, depth of invasion measurement and distinction from adenocarcinoma in situ: interobserver variation among gynecologic pathologists. Mod Pathol. 2016 08; 29(8):879-92. PMID: 27174588.
      View in: PubMed
    32. Lastra RR, Park KJ, Schoolmeester JK. Invasive Stratified Mucin-producing Carcinoma and Stratified Mucin-producing Intraepithelial Lesion (SMILE): 15 Cases Presenting a Spectrum of Cervical Neoplasia With Description of a Distinctive Variant of Invasive Adenocarcinoma. Am J Surg Pathol. 2016 Feb; 40(2):262-9. PMID: 26523540.
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    33. Schoolmeester JK, Lastra RR. Granular cell tumors overexpress TFE3 without corollary gene rearrangement. Hum Pathol. 2015 Aug; 46(8):1242-3. PMID: 26009539.
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    34. Lastra RR, Pramick MR, Crammer CJ, LiVolsi VA, Baloch ZW. Implications of a suspicious afirma test result in thyroid fine-needle aspiration cytology: an institutional experience. Cancer Cytopathol. 2014 Oct; 122(10):737-44. PMID: 25123499.
      View in: PubMed
    35. Lastra RR, Meykler SE, Baloch ZW, Barroeta JE. Increasing the sensitivity of endocervical curettings by performing ThinPrep® Pap on transport container fluid: is diagnostic material going down the drain? Cytopathology. 2015 Dec; 26(6):368-72. PMID: 25123326.
      View in: PubMed
    36. Lastra RR, Newman JG, Brooks JS, Huang JH. Ossifying fibromyxoid tumor metastatic to the thyroid: a case report and review of the literature. Ear Nose Throat J. 2014 Jun; 93(6):221-3. PMID: 24932821.
      View in: PubMed
    37. Motz GT, Santoro SP, Wang LP, Garrabrant T, Lastra RR, Hagemann IS, Lal P, Feldman MD, Benencia F, Coukos G. Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors. Nat Med. 2014 Jun; 20(6):607-15. PMID: 24793239.
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    38. Lastra RR, LiVolsi VA, Baloch ZW. Aggressive variants of follicular cell-derived thyroid carcinomas: a cytopathologist's perspective. Cancer Cytopathol. 2014 Jul; 122(7):484-503. PMID: 24664970.
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    39. Lastra RR, Pramick MR, Nakashima MO, Weinstein GS, Montone KT, Livolsi VA, Baloch ZW. Adequacy of fine-needle aspiration specimens for human papillomavirus infection molecular testing in head and neck squamous cell carcinoma. Cytojournal. 2013; 10:21. PMID: 24403949.
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    40. Lastra RR, Ou JJ, Reilly ME, Lawrence WD, Baloch ZW, Brooks JS, Barroeta JE. Utility of ProExC and IMP3 immunocytochemical staining in atypical glandular cells of undetermined significance in liquid-based cervical cytology. Diagn Cytopathol. 2014 May; 42(5):375-9. PMID: 23904388.
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    41. Lastra RR, Bavuso N, Randall TC, Brooks JS, Barroeta JE. Neurofibroma of the cervix presenting as cervical stenosis in a patient with neurofibromatosis type 1: a case report. Int J Gynecol Pathol. 2012 Mar; 31(2):192-194. PMID: 22317879.
      View in: PubMed
    42. Ferenczi K, Lastra RR, Farkas T, Elenitsas R, Xu X, Roberts S, Brooks JS, Zhang PJ. MUM-1 expression differentiates tumors in the PEComa family from clear cell sarcoma and melanoma. Int J Surg Pathol. 2012 Feb; 20(1):29-36. PMID: 21903680.
      View in: PubMed
    43. Lastra RR, Saldanha V, Balasubramanian M, Handal J. Fatal fat embolism in isolated vertebral compression fracture. Eur Spine J. 2010 Jul; 19 Suppl 2:S200-2. PMID: 20229119.
      View in: PubMed
    44. Alvarez-Busto I, Alcedo J, Vera J, Borderias L, Ligorred L, Quiles D, Lastra R, Martínez Moya L. [Intestinal obstruction as early clinic manifestation of lung adenocarcinoma]. Rev Esp Enferm Dig. 2008 Mar; 100(3):180-2. PMID: 18416647.
      View in: PubMed
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