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Peleg Horowitz

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentSurgery-Neurosurgery
AddressChicago IL 60637
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    Collapse Overview 
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    Peleg Horowitz is a neurosurgeon with expertise in brain and skull base tumors as well as endoscopic and open surgical approaches to the skull base. This includes incorporation of advanced stereotactic and 3-D surgical planning for operative treatment and radiosurgery of both benign and malignant brain and skull base tumors, including gliomas, meningiomas, schwannomas, and pituitary tumors. Along with Endocrinologist Susan Sam, MD, he leads the neurosurgical efforts of the University of Chicago Pituitary and Neuroendocrine Disorders program.

    In addition to his interest in neurosurgical oncology, he also practices general neurosurgery, treating patients with a wide range of diseases, including head trauma in adults and children, and served as the Interim Director of Neurosurgical Trauma for the opening of the University of Chicago Level One Trauma Center.

    His past scholarly work has focused on the pathogenesis and management of nervous system tumors, and his research has identified several novel genes that drive the formation of meningiomas and pediatric gliomas. His research on tumor genetics has been published in Nature Genetics and Proceedings of the National Academy of Sciences of the United States of America, and has been funded by the Brain Science Foundation and the US Department of Defense Neurofibromatosis Research Program.

    Horowitz received his bachelor’s degree in biology and a PhD in neuroscience from Northwestern University, as well as an MD from the Feinberg School of Medicine at Northwestern University. He completed his internship and residency at Brigham and Women’s Hospital/Children’s Hospital Boston, and a skull base surgical neurooncology fellowship at the University of Texas MD Anderson Cancer Center.


    Collapse Biography 
    Collapse education and training
    MD Anderson Cancer Center, Houston, TX06/2016Skull Base Neurosurgical Oncology Fellowship
    Brigham and Women's Hospital / Boston Children's Hospital / Harvard Medical School, Boston, MA06/2015Neurosurgical Residency
    Northwestern University School of Medicine, Chicago, ILMD / PhD05/2008Neuroscience, Medicine
    Northwestern University, Evanston, ILBA05/2000Biology (Neuroscience)

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ginat DT, Trzcinska A, Horowitz P. Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma. AJNR Am J Neuroradiol. 2020 07; 41(7):1156-1159. PMID: 32467185.
      View in: PubMed
    2. Platt A, Collins J, Horowitz PM. Cranial Vault Reconstruction and Evacuation of Hemorrhage After a Bifrontal Gunshot Wound to the Brain. World Neurosurg. 2020 06; 138:408-410. PMID: 32247791.
      View in: PubMed
    3. Loggini A, Vasenina VI, Mansour A, Das P, Horowitz PM, Goldenberg FD, Kramer C, Lazaridis C. Management of civilians with penetrating brain injury: A systematic review. J Crit Care. 2020 Apr; 56:159-166. PMID: 31923862.
      View in: PubMed
    4. Ginat DT, Pytel P, Horowitz PM. Radiological and pathological features of orbital cranial fasciitis. Orbit. 2020 Oct; 39(5):390. PMID: 31509037.
      View in: PubMed
    5. Lukas RV, Riedell P, Horowitz PM, Pytel P, Kamson DO. Diagnostic Evaluation in Primary CNS Lymphoma. Neurologist. 2018 Mar; 23(2):53-54. PMID: 29494436.
      View in: PubMed
    6. Bi WL, Horowitz P, Greenwald NF, Abedalthagafi M, Agarwalla PK, Gibson WJ, Mei Y, Schumacher SE, Ben-David U, Chevalier A, Carter S, Tiao G, Brastianos PK, Ligon AH, Ducar M, MacConaill L, Laws ER, Santagata S, Beroukhim R, Dunn IF. Landscape of Genomic Alterations in Pituitary Adenomas. Clin Cancer Res. 2017 Apr 01; 23(7):1841-1851. PMID: 27707790.
      View in: PubMed
    7. Bandopadhayay P, Ramkissoon LA, Jain P, Bergthold G, Wala J, Zeid R, Schumacher SE, Urbanski L, O'Rourke R, Gibson WJ, Pelton K, Ramkissoon SH, Han HJ, Zhu Y, Choudhari N, Silva A, Boucher K, Henn RE, Kang YJ, Knoff D, Paolella BR, Gladden-Young A, Varlet P, Pages M, Horowitz PM, Federation A, Malkin H, Tracy AA, Seepo S, Ducar M, Van Hummelen P, Santi M, Buccoliero AM, Scagnet M, Bowers DC, Giannini C, Puget S, Hawkins C, Tabori U, Klekner A, Bognar L, Burger PC, Eberhart C, Rodriguez FJ, Hill DA, Mueller S, Haas-Kogan DA, Phillips JJ, Santagata S, Stiles CD, Bradner JE, Jabado N, Goren A, Grill J, Ligon AH, Goumnerova L, Waanders AJ, Storm PB, Kieran MW, Ligon KL, Beroukhim R, Resnick AC. MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. Nat Genet. 2016 Mar; 48(3):273-82. PMID: 26829751.
      View in: PubMed
    8. Horowitz PM, DiNapoli V, Su SY, Raza SM. Complication Avoidance in Endoscopic Skull Base Surgery. Otolaryngol Clin North Am. 2016 Feb; 49(1):227-35. PMID: 26614840.
      View in: PubMed
    9. Bi WL, Abedalthagafi M, Horowitz P, Agarwalla PK, Mei Y, Aizer AA, Brewster R, Dunn GP, Al-Mefty O, Alexander BM, Santagata S, Beroukhim R, Dunn IF. Genomic landscape of intracranial meningiomas. J Neurosurg. 2016 09; 125(3):525-35. PMID: 26771848.
      View in: PubMed
    10. Brastianos PK, Carter SL, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT, Van Allen EM, Lawrence MS, Horowitz PM, Cibulskis K, Ligon KL, Tabernero J, Seoane J, Martinez-Saez E, Curry WT, Dunn IF, Paek SH, Park SH, McKenna A, Chevalier A, Rosenberg M, Barker FG, Gill CM, Van Hummelen P, Thorner AR, Johnson BE, Hoang MP, Choueiri TK, Signoretti S, Sougnez C, Rabin MS, Lin NU, Winer EP, Stemmer-Rachamimov A, Meyerson M, Garraway L, Gabriel S, Lander ES, Beroukhim R, Batchelor TT, Baselga J, Louis DN, Getz G, Hahn WC. Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discov. 2015 Nov; 5(11):1164-1177. PMID: 26410082.
      View in: PubMed
    11. Majumder B, Baraneedharan U, Thiyagarajan S, Radhakrishnan P, Narasimhan H, Dhandapani M, Brijwani N, Pinto DD, Prasath A, Shanthappa BU, Thayakumar A, Surendran R, Babu GK, Shenoy AM, Kuriakose MA, Bergthold G, Horowitz P, Loda M, Beroukhim R, Agarwal S, Sengupta S, Sundaram M, Majumder PK. Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity. Nat Commun. 2015 Feb 27; 6:6169. PMID: 25721094.
      View in: PubMed
    12. Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8188-93. PMID: 23633565.
      View in: PubMed
    13. Horowitz PM, Chiocca EA. Nanotechnology-based strategies for the diagnosis and treatment of intracranial neoplasms. World Neurosurg. 2013 Jul-Aug; 80(1-2):53-5. PMID: 23416779.
      View in: PubMed
    14. Horowitz PM, Chi J. Adult low-grade gliomas: surgery vs biopsy? Neurosurgery. 2013 Feb; 72(2):N19. PMID: 23328659.
      View in: PubMed
    15. Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, Beroukhim R. Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet. 2013 Mar; 45(3):285-9. PMID: 23334667.
      View in: PubMed
    16. Lapointe NE, Horowitz PM, Guillozet-Bongaarts AL, Silva A, Andreadis A, Binder LI. Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro. Biochemistry. 2009 Dec 29; 48(51):12290-7. PMID: 19919107.
      View in: PubMed
    17. Reyes JF, Reynolds MR, Horowitz PM, Fu Y, Guillozet-Bongaarts AL, Berry R, Binder LI. A possible link between astrocyte activation and tau nitration in Alzheimer's disease. Neurobiol Dis. 2008 Aug; 31(2):198-208. PMID: 18562203.
      View in: PubMed
    18. Sengupta S, Horowitz PM, Karsten SL, Jackson GR, Geschwind DH, Fu Y, Berry RW, Binder LI. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry. 2006 Dec 19; 45(50):15111-9. PMID: 17154549.
      View in: PubMed
    19. Horowitz PM, LaPointe N, Guillozet-Bongaarts AL, Berry RW, Binder LI. N-terminal fragments of tau inhibit full-length tau polymerization in vitro. Biochemistry. 2006 Oct 24; 45(42):12859-66. PMID: 17042504.
      View in: PubMed
    20. Guillozet-Bongaarts AL, Garcia-Sierra F, Reynolds MR, Horowitz PM, Fu Y, Wang T, Cahill ME, Bigio EH, Berry RW, Binder LI. Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease. Neurobiol Aging. 2005 Jul; 26(7):1015-22. PMID: 15748781.
      View in: PubMed
    21. Horowitz PM, Patterson KR, Guillozet-Bongaarts AL, Reynolds MR, Carroll CA, Weintraub ST, Bennett DA, Cryns VL, Berry RW, Binder LI. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. J Neurosci. 2004 Sep 08; 24(36):7895-902. PMID: 15356202.
      View in: PubMed
    22. Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, Jones BW, Fernandez SJ, Lacor PN, Horowitz P, Finch CE, Krafft GA, Klein WL. Self-assembly of Abeta(1-42) into globular neurotoxins. Biochemistry. 2003 Nov 11; 42(44):12749-60. PMID: 14596589.
      View in: PubMed
    23. Edwards L, Fishman D, Horowitz P, Bourbon N, Kester M, Ernsberger P. The I1-imidazoline receptor in PC12 pheochromocytoma cells activates protein kinases C, extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK). J Neurochem. 2001 Dec; 79(5):931-40. PMID: 11739604.
      View in: PubMed
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