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Peleg Horowitz

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentNeurological Surgery
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Peleg Horowitz is a neurosurgeon with expertise in brain and skull base tumors as well as endoscopic and open surgical approaches to the skull base. This includes incorporation of advanced stereotactic and 3-D surgical planning for operative treatment and radiosurgery of both benign and malignant brain and skull base tumors, including gliomas, meningiomas, schwannomas, and pituitary tumors. Along with Endocrinologist Susan Sam, MD, he leads the neurosurgical efforts of the University of Chicago Pituitary and Neuroendocrine Disorders program.

    In addition to his interest in neurosurgical oncology, he also practices general neurosurgery, treating patients with a wide range of diseases, including head trauma in adults and children, and served as the Interim Director of Neurosurgical Trauma for the opening of the University of Chicago Level One Trauma Center.

    His past scholarly work has focused on the pathogenesis and management of nervous system tumors, and his research has identified several novel genes that drive the formation of meningiomas and pediatric gliomas. His research on tumor genetics has been published in Nature Genetics and Proceedings of the National Academy of Sciences of the United States of America, and has been funded by the Brain Science Foundation and the US Department of Defense Neurofibromatosis Research Program.

    Horowitz received his bachelor’s degree in biology and a PhD in neuroscience from Northwestern University, as well as an MD from the Feinberg School of Medicine at Northwestern University. He completed his internship and residency at Brigham and Women’s Hospital/Children’s Hospital Boston, and a skull base surgical neurooncology fellowship at the University of Texas MD Anderson Cancer Center.

    Collapse Biography 
    Collapse education and training
    MD Anderson Cancer Center, Houston, TX06/2016Skull Base Neurosurgical Oncology Fellowship
    Brigham and Women's Hospital / Boston Children's Hospital / Harvard Medical School, Boston, MA06/2015Neurosurgical Residency
    Northwestern University School of Medicine, Chicago, ILMD / PhD05/2008Neuroscience, Medicine
    Northwestern University, Evanston, ILBA05/2000Biology (Neuroscience)

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mansour A, Powla PP, Alvarado-Dyer R, Fakhri F, Das P, Horowitz P, Goldenberg FD, Lazaridis C. Comparative Analysis of Clinical Severity and Outcomes in Penetrating Versus Blunt Traumatic Brain Injury Propensity Matched Cohorts. Neurotrauma Rep. 2024; 5(1):348-358. PMID: 38595793; PMCID: PMC11002325.
    2. Dimitroyannis RC, Cyberski TF, Kondamuri NS, Polster SP, Das P, Horowitz PM, Roxbury CR. The Time Burden of Office Visits in Contemporary Pituitary Care, 2016 to 2019. Am J Rhinol Allergy. 2024 Mar 27; 19458924241242198. PMID: 38544422.
      Citations:    Fields:    
    3. Mansour A, Powla PP, Fakhri F, Alvarado-Dyer R, Das P, Horowitz P, Goldenberg FD, Lazaridis C. Comparative Effectiveness of Early Neurosurgical Intervention in Civilian Penetrating Brain Injury Management. Neurosurgery. 2024 Mar 01; 94(3):470-477. PMID: 37847039.
      Citations:    Fields:    Translation:Humans
    4. Fenton D, Diaz A, Chen H, Armstrong M, Auger S, Bujnowski D, Pedroza A, Polster S, Das P, Horowitz P, Roxbury C. Determining the association of insurance coverage and survival outcomes in patients with olfactory neuroblastoma utilizing machine learning. Int Forum Allergy Rhinol. 2023 Nov; 13(11):2082-2085. PMID: 37132277.
      Citations:    Fields:    
    5. Hage S, Hagan M, Bi D, Stadnik A, Lee J, Romanos S, Srinath A, Shenkar R, Lee C, Horowitz PM, Girard R, Awad IA. Impact of socioeconomics and race on clinical follow-up and trial enrollment and adherence in cerebral cavernous malformation. J Stroke Cerebrovasc Dis. 2023 Jul; 32(7):107167. PMID: 37146402; PMCID: PMC10201538.
      Citations:    Fields:    Translation:Humans
    6. Mansour A, Rowell S, Powla PP, Horowitz P, Goldenberg FD, Lazaridis C. Comparative Effectiveness of Intracranial Pressure Monitoring vs No Monitoring in Severe Penetrating Brain Injury Management. JAMA Netw Open. 2023 03 01; 6(3):e231077. PMID: 36961466; PMCID: PMC10313150.
      Citations: 1     Fields:    Translation:Humans
    7. Papazian E, Adams D, Du M, Wang E, Caballero N, Das P, Horowitz P, Pinto J, Portugal L, Yamini B, Roxbury CR. Practice patterns and provider satisfaction in a virtual rhinology and skull base surgery clinic. Int Forum Allergy Rhinol. 2023 05; 13(5):946-949. PMID: 36174968.
      Citations:    Fields:    Translation:Humans
    8. Zakrison TL, Essig R, Polcari A, McKinley W, Arnold D, Beyene R, Wilson K, Rogers S, Matthews JB, Millis JM, Angelos P, O'Connor M, Mansour A, Goldenberg F, Spiegel T, Horowitz P, Das P, Slidell M, Chokshi N, Okeke I, Barth R, Wilkins HE, Kass-Hout T, Lazaridis C. Review Paper on Penetrating Brain Injury: Ethical Quandaries in the Trauma Bay and Beyond. Ann Surg. 2023 Jan 01; 277(1):66-72. PMID: 35997268; PMCID: PMC9762724.
      Citations:    Fields:    Translation:Humans
    9. Diaz A, Bujnowski D, Chen H, Pendergrast K, Horowitz P, Das P, Roxbury C. Health Insurance Coverage and Survival Outcomes among Nasopharyngeal Carcinoma Patients: A SEER Retrospective Analysis. J Neurol Surg B Skull Base. 2023 Jun; 84(3):240-247. PMID: 37180866; PMCID: PMC10171937.
    10. Adams DR, Ramirez-Garcia R, Ginat DT, Agrawal N, Seible D, Cipriani NA, Horowitz P, Pinto JM, Chiu BL. Multimodality management of sinonasal teratocarcinosarcoma in a 76-year-old Alaska Native female during the COVID-19 pandemic. Clin Case Rep. 2022 Mar; 10(3):e05635. PMID: 35356171; PMCID: PMC8956855.
      Citations: 1     
    11. Du M, Papazian E, Adams D, Caballero N, Portugal L, Das P, Horowitz P, Yamini B, Pinto JM, Roxbury CR. Patient satisfaction with telemedicine is noninferior to in-office visits: Lessons from a tertiary rhinology and endoscopic skull base surgery practice. Int Forum Allergy Rhinol. 2022 05; 12(5):802-804. PMID: 34596970.
      Citations: 3     Fields:    Translation:Humans
    12. Mansour A, Loggini A, Goldenberg FD, Kramer C, Naidech AM, Ammar FE, Vasenina V, Castro B, Das P, Horowitz PM, Karrison T, Zakrison T, Hampton D, Rogers SO, Lazaridis C. Coagulopathy as a Surrogate of Severity of Injury in Penetrating Brain Injury. J Neurotrauma. 2021 Jun 01; 38(13):1821-1826. PMID: 33238820; PMCID: PMC9208722.
      Citations: 3     Fields:    Translation:Humans
    13. Mansour A, Loggini A, El Ammar F, Ginat D, Awad IA, Lazaridis C, Kramer C, Vasenina V, Polster SP, Huang A, Olivera Perez H, Das P, Horowitz PM, Zakrison T, Hampton D, Rogers SO, Goldenberg FD. Cerebrovascular Complications in Early Survivors of Civilian Penetrating Brain Injury. Neurocrit Care. 2021 06; 34(3):918-926. PMID: 33025542; PMCID: PMC9159343.
      Citations: 5     Fields:    Translation:Humans
    14. Ginat DT, Trzcinska A, Horowitz P. Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma. AJNR Am J Neuroradiol. 2020 07; 41(7):1156-1159. PMID: 32467185; PMCID: PMC7357654.
      Citations: 1     Fields:    Translation:Humans
    15. Platt A, Collins J, Horowitz PM. Cranial Vault Reconstruction and Evacuation of Hemorrhage After a Bifrontal Gunshot Wound to the Brain. World Neurosurg. 2020 06; 138:408-410. PMID: 32247791.
      Citations:    Fields:    Translation:Humans
    16. Loggini A, Vasenina VI, Mansour A, Das P, Horowitz PM, Goldenberg FD, Kramer C, Lazaridis C. Management of civilians with penetrating brain injury: A systematic review. J Crit Care. 2020 04; 56:159-166. PMID: 31923862.
      Citations: 10     Fields:    Translation:Humans
    17. Ginat DT, Pytel P, Horowitz PM. Radiological and pathological features of orbital cranial fasciitis. Orbit. 2020 Oct; 39(5):390. PMID: 31509037.
      Citations: 1     Fields:    Translation:Humans
    18. Polster SP, Horowitz PM, Awad IA, Gluth MB. Combined petrosal approach. Curr Opin Otolaryngol Head Neck Surg. 2018 Oct; 26(5):293-301. PMID: 30045103.
      Citations: 3     Fields:    Translation:Humans
    19. Lukas RV, Riedell P, Horowitz PM, Pytel P, Kamson DO. Diagnostic Evaluation in Primary CNS Lymphoma. Neurologist. 2018 Mar; 23(2):53-54. PMID: 29494436.
      Citations: 1     Fields:    Translation:Humans
    20. Bi WL, Horowitz P, Greenwald NF, Abedalthagafi M, Agarwalla PK, Gibson WJ, Mei Y, Schumacher SE, Ben-David U, Chevalier A, Carter S, Tiao G, Brastianos PK, Ligon AH, Ducar M, MacConaill L, Laws ER, Santagata S, Beroukhim R, Dunn IF. Landscape of Genomic Alterations in Pituitary Adenomas. Clin Cancer Res. 2017 Apr 01; 23(7):1841-1851. PMID: 27707790; PMCID: PMC5380512.
      Citations: 54     Fields:    Translation:HumansCells
    21. Bandopadhayay P, Ramkissoon LA, Jain P, Bergthold G, Wala J, Zeid R, Schumacher SE, Urbanski L, O'Rourke R, Gibson WJ, Pelton K, Ramkissoon SH, Han HJ, Zhu Y, Choudhari N, Silva A, Boucher K, Henn RE, Kang YJ, Knoff D, Paolella BR, Gladden-Young A, Horowitz PM, Federation A, Malkin H, Tracy AA, Seepo S, Ducar M, Van Hummelen P, Santi M, Buccoliero AM, Scagnet M, Bowers DC, Giannini C, Hawkins C, Tabori U, Klekner A, Bognar L, Burger PC, Eberhart C, Rodriguez FJ, Hill DA, Mueller S, Haas-Kogan DA, Phillips JJ, Santagata S, Stiles CD, Bradner JE, Jabado N, Goren A, Ligon AH, Goumnerova L, Waanders AJ, Storm PB, Kieran MW, Ligon KL, Beroukhim R, Resnick AC, Varlet P, Pages M, Puget S, Grill J. MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. Nat Genet. 2016 Mar; 48(3):273-82. PMID: 26829751; PMCID: PMC4767685.
      Citations: 124     Fields:    Translation:HumansCells
    22. Horowitz PM, DiNapoli V, Su SY, Raza SM. Complication Avoidance in Endoscopic Skull Base Surgery. Otolaryngol Clin North Am. 2016 Feb; 49(1):227-35. PMID: 26614840.
      Citations: 3     Fields:    Translation:Humans
    23. Bi WL, Abedalthagafi M, Horowitz P, Agarwalla PK, Mei Y, Aizer AA, Brewster R, Dunn GP, Al-Mefty O, Alexander BM, Santagata S, Beroukhim R, Dunn IF. Genomic landscape of intracranial meningiomas. J Neurosurg. 2016 09; 125(3):525-35. PMID: 26771848.
      Citations: 47     Fields:    Translation:Humans
    24. Brastianos PK, Carter SL, Santagata S, Cahill DP, Taylor-Weiner A, Jones RT, Van Allen EM, Lawrence MS, Horowitz PM, Cibulskis K, Ligon KL, Tabernero J, Seoane J, Martinez-Saez E, Curry WT, Dunn IF, Paek SH, Park SH, McKenna A, Chevalier A, Rosenberg M, Barker FG, Gill CM, Van Hummelen P, Thorner AR, Johnson BE, Hoang MP, Choueiri TK, Signoretti S, Sougnez C, Rabin MS, Lin NU, Winer EP, Stemmer-Rachamimov A, Meyerson M, Garraway L, Gabriel S, Lander ES, Beroukhim R, Batchelor TT, Baselga J, Louis DN, Getz G, Hahn WC. Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discov. 2015 Nov; 5(11):1164-1177. PMID: 26410082; PMCID: PMC4916970.
      Citations: 470     Fields:    Translation:HumansCells
    25. Majumder B, Baraneedharan U, Thiyagarajan S, Radhakrishnan P, Narasimhan H, Dhandapani M, Brijwani N, Pinto DD, Prasath A, Shanthappa BU, Thayakumar A, Surendran R, Babu GK, Shenoy AM, Kuriakose MA, Bergthold G, Horowitz P, Loda M, Beroukhim R, Agarwal S, Sengupta S, Sundaram M, Majumder PK. Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity. Nat Commun. 2015 Feb 27; 6:6169. PMID: 25721094; PMCID: PMC4351621.
      Citations: 143     Fields:    Translation:Humans
    26. Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8188-93. PMID: 23633565; PMCID: PMC3657784.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    27. Horowitz PM, Chiocca EA. Nanotechnology-based strategies for the diagnosis and treatment of intracranial neoplasms. World Neurosurg. 2013 Jul-Aug; 80(1-2):53-5. PMID: 23416779.
      Citations: 1     Fields:    Translation:Humans
    28. Horowitz PM, Chi J. Adult low-grade gliomas: surgery vs biopsy? Neurosurgery. 2013 Feb; 72(2):N19. PMID: 23328659.
      Citations: 2     Fields:    Translation:Humans
    29. Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, Beroukhim R. Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations. Nat Genet. 2013 Mar; 45(3):285-9. PMID: 23334667; PMCID: PMC3739288.
      Citations: 283     Fields:    Translation:HumansCells
    30. Lapointe NE, Horowitz PM, Guillozet-Bongaarts AL, Silva A, Andreadis A, Binder LI. Tau 6D and 6P isoforms inhibit polymerization of full-length tau in vitro. Biochemistry. 2009 Dec 29; 48(51):12290-7. PMID: 19919107; PMCID: PMC2866057.
      Citations: 9     Fields:    Translation:HumansCells
    31. Reyes JF, Reynolds MR, Horowitz PM, Fu Y, Guillozet-Bongaarts AL, Berry R, Binder LI. A possible link between astrocyte activation and tau nitration in Alzheimer's disease. Neurobiol Dis. 2008 Aug; 31(2):198-208. PMID: 18562203; PMCID: PMC2766349.
      Citations: 36     Fields:    Translation:HumansCells
    32. Sengupta S, Horowitz PM, Karsten SL, Jackson GR, Geschwind DH, Fu Y, Berry RW, Binder LI. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry. 2006 Dec 19; 45(50):15111-9. PMID: 17154549.
      Citations: 34     Fields:    Translation:HumansCells
    33. Horowitz PM, LaPointe N, Guillozet-Bongaarts AL, Berry RW, Binder LI. N-terminal fragments of tau inhibit full-length tau polymerization in vitro. Biochemistry. 2006 Oct 24; 45(42):12859-66. PMID: 17042504.
      Citations: 39     Fields:    Translation:HumansCells
    34. Guillozet-Bongaarts AL, Garcia-Sierra F, Reynolds MR, Horowitz PM, Fu Y, Wang T, Cahill ME, Bigio EH, Berry RW, Binder LI. Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease. Neurobiol Aging. 2005 Jul; 26(7):1015-22. PMID: 15748781.
      Citations: 122     Fields:    Translation:HumansCells
    35. Horowitz PM, Patterson KR, Guillozet-Bongaarts AL, Reynolds MR, Carroll CA, Weintraub ST, Bennett DA, Cryns VL, Berry RW, Binder LI. Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease. J Neurosci. 2004 Sep 08; 24(36):7895-902. PMID: 15356202; PMCID: PMC6729917.
      Citations: 102     Fields:    Translation:HumansCells
    36. Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, Jones BW, Fernandez SJ, Lacor PN, Horowitz P, Finch CE, Krafft GA, Klein WL. Self-assembly of Abeta(1-42) into globular neurotoxins. Biochemistry. 2003 Nov 11; 42(44):12749-60. PMID: 14596589.
      Citations: 184     Fields:    Translation:HumansAnimalsCells
    37. Edwards L, Fishman D, Horowitz P, Bourbon N, Kester M, Ernsberger P. The I1-imidazoline receptor in PC12 pheochromocytoma cells activates protein kinases C, extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK). J Neurochem. 2001 Dec; 79(5):931-40. PMID: 11739604.
      Citations: 7     Fields:    Translation:AnimalsCells
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