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Ishanu Chattopadhyay

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Hospital Medicine
AddressChicago IL 60637
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    Collapse Overview 
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    Ishanu Chattopadhyay’s research focuses on the theory of unsupervised machine learning and the interplay of stochastic processes and formal language theory in exploring the mathematical underpinnings of the question of inferring causality from data. His most visible contributions include the algorithms for data smashing, inverse Gillespie inference, and nonparametric nonlinear and zero-knowledge implementations of Granger causal analysis that have crucial implications for biomedical informatics, data-enabled discovery in biomedicine, and personalized precision health care. His current work focuses on analyzing massive clinical databases of disparate variables to distill patterns indicative of hitherto unknown etiologies, dependencies, and relationships, potentially addressing the daunting computational challenge of scale and making way for ab initio and de novo modeling in an age of ubiquitous data.

    Chattopadhyay received an MS and PhD in mechanical engineering, as well as an MA in mathematics, from the Pennsylvania State University. He completed his postdoctoral training and served as a research associate in the Department of Mechanical Engineering at Penn State. He also held a postdoctoral fellowship simultaneously at the Department of Computer Science and the Sibley School of Mechanical and Aerospace Engineering at Cornell University.


    Collapse Biography 
    Collapse education and training
    Cornell University, NYPostdoctoral Fellow2013Machine Learning
    The Pennsylvania State University, PAPostdoctoral Fellow2011Robotics & Automated Decision-making
    The Pennsylvania State University, PAPhD2006Mechanical Engineering
    The Pennsylvania State University, PAMA2006Mathematics
    The Pennsylvania State University, PAMS2005Mechanical Engineering

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    Collapse Research 
    Collapse research activities and funding
    FP064753-01-PR-CR-01     (Ishanu Chattopadhyay)Jun 29, 2017 - Jun 29, 2021
    DARPA
    ZeD: Zero-Knowledge Discovery Using Data Smashing - Columbia Sub
    Role Description: Automate machine learning pipelines, and design new learning primitives, to achieve transformative breakthroughs in automated problem solving.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Onishchenko D, Huang Y, van Horne J, Smith PJ, Msall ME, Chattopadhyay I. Reduced false positives in autism screening via digital biomarkers inferred from deep comorbidity patterns. Sci Adv. 2021 Oct 08; 7(41):eabf0354. PMID: 34613766.
      View in: PubMed
    2. López-Aranda MF, Chattopadhyay I, Boxx GM, Fraley ER, Silva TK, Zhou M, Phan M, Herrera I, Taloma S, Mandanas R, Bach K, Gandal M, Geschwind DH, Cheng G, Rzhetsky A, White SA, Silva AJ. Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications. Sci Adv. 2021 Sep 17; 7(38):eabf2073. PMID: 34533985.
      View in: PubMed
    3. Brenner LA, Betthauser LM, Penzenik M, Germain A, Li JJ, Chattopadhyay I, Frank E, Kupfer DJ, Gibbons RD. Development and Validation of Computerized Adaptive Assessment Tools for the Measurement of Posttraumatic Stress Disorder Among US Military Veterans. JAMA Netw Open. 2021 Jul 01; 4(7):e2115707. PMID: 34236411.
      View in: PubMed
    4. Gibbons RD, Chattopadhyay I, Meltzer H, Kane JM, Guinart D. Development of a computerized adaptive diagnostic screening tool for psychosis. Schizophr Res. 2021 Apr 06. PMID: 33836922.
      View in: PubMed
    5. Jia G, Li Y, Zhang H, Chattopadhyay I, Boeck Jensen A, Blair DR, Davis L, Robinson PN, Dahlén T, Brunak S, Benson M, Edgren G, Cox NJ, Gao X, Rzhetsky A. Estimating heritability and genetic correlations from large health datasets in the absence of genetic data. Nat Commun. 2019 12 03; 10(1):5508. PMID: 31796735.
      View in: PubMed
    6. Chattopadhyay I, Kiciman E, Elliott JW, Shaman JL, Rzhetsky A. Conjunction of factors triggering waves of seasonal influenza. Elife. 2018 02 27; 7. PMID: 29485041.
      View in: PubMed
    7. Jaideep Dhanoa, Balaji Manicassamy, Ishanu Chattopadhyay. Algorithmic Bio-surveillance For Precise Spatio-temporal Prediction of Zoonotic Emergence. arXiv:1801.07807. 2018.
    8. Chattopadhyay I, Lipson H. Data smashing: uncovering lurking order in data. J R Soc Interface. 2014 Dec 06; 11(101):20140826. PMID: 25401180.
      View in: PubMed
    9. Ishanu Chattopadhyay. Causality Networks. arXiv:1406.6651v1. 2014.
    10. Chattopadhyay I, Kuchina A, Süel GM, Lipson H. Inverse Gillespie for inferring stochastic reaction mechanisms from intermittent samples. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):12990-5. PMID: 23878234.
      View in: PubMed
    11. Chattopadhyay I, Lipson H. Abductive learning of quantized stochastic processes with probabilistic finite automata. Philos Trans A Math Phys Eng Sci. 2013 Feb 13; 371(1984):20110543. PMID: 23277601.
      View in: PubMed
    12. Chattopadhyay I, Ray A. Supervised self-organization of homogeneous swarms using ergodic projections of Markov chains. IEEE Trans Syst Man Cybern B Cybern. 2009 Dec; 39(6):1505-15. PMID: 19447731.
      View in: PubMed
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