Antibody-Dependent Cell Cytotoxicity
"Antibody-Dependent Cell Cytotoxicity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
| Descriptor ID |
D000920
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| MeSH Number(s) |
G12.287.070
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| Concept/Terms |
Antibody-Dependent Cell Cytotoxicity- Antibody-Dependent Cell Cytotoxicity
- Antibody Dependent Cell Cytotoxicity
- Cell Cytoxicity, Antibody-Dependent
- Antibody-Dependent Cell Cytoxicities
- Antibody-Dependent Cell Cytoxicity
- Cell Cytoxicities, Antibody-Dependent
- Cell Cytoxicity, Antibody Dependent
- Cytoxicities, Antibody-Dependent Cell
- Cytoxicity, Antibody-Dependent Cell
- ADCC
- Cytotoxicity, Antibody-Dependent Cell
- Antibody-Dependent Cell Cytotoxicities
- Cell Cytotoxicities, Antibody-Dependent
- Cell Cytotoxicity, Antibody-Dependent
- Cytotoxicities, Antibody-Dependent Cell
- Cytotoxicity, Antibody Dependent Cell
|
Below are MeSH descriptors whose meaning is more general than "Antibody-Dependent Cell Cytotoxicity".
Below are MeSH descriptors whose meaning is more specific than "Antibody-Dependent Cell Cytotoxicity".
This graph shows the total number of publications written about "Antibody-Dependent Cell Cytotoxicity" by people in this website by year, and whether "Antibody-Dependent Cell Cytotoxicity" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2005 | 2 | 0 | 2 |
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 0 | 2 | 2 |
| 2015 | 2 | 0 | 2 |
| 2016 | 2 | 1 | 3 |
| 2017 | 5 | 3 | 8 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 2 | 4 |
| 2020 | 0 | 2 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Antibody-Dependent Cell Cytotoxicity" by people in Profiles.
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Engineered human antibodies for the opsonization and killing of Staphylococcus aureus. Proc Natl Acad Sci U S A. 2022 01 25; 119(4).
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The protective potential of Fc-mediated antibody functions against influenza virus and other viral pathogens. Immunol Cell Biol. 2020 04; 98(4):253-263.
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Sacituzumab govitecan, an antibody-drug conjugate targeting trophoblast cell-surface antigen 2, shows cytotoxic activity against poorly differentiated endometrial adenocarcinomas in vitro and in vivo. Mol Oncol. 2020 03; 14(3):645-656.
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In vitro and in vivo activity of sacituzumab govitecan, an antibody-drug conjugate targeting trophoblast cell-surface antigen 2 (Trop-2) in uterine serous carcinoma. Gynecol Oncol. 2020 02; 156(2):430-438.
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Efficient ADCC killing of meningioma by avelumab and a high-affinity natural killer cell line, haNK. JCI Insight. 2019 10 17; 4(20).
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Knowns and Unknowns of Assaying Antibody-Dependent Cell-Mediated Cytotoxicity Against HIV-1. Front Immunol. 2019; 10:1025.
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Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV-1-Infected Cells. J Virol. 2019 02 01; 93(3).
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A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA. Nat Commun. 2018 07 10; 9(1):2669.
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Antibody-Dependent Cellular Cytotoxicity Responses to Seasonal Influenza Vaccination in Older Adults. J Infect Dis. 2017 12 27; 217(1):12-23.
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HIV-1 Env- and Vpu-Specific Antibody-Dependent Cellular Cytotoxicity Responses Associated with Elite Control of HIV. J Virol. 2017 09 15; 91(18).