Amino Acyl-tRNA Synthetases
"Amino Acyl-tRNA Synthetases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subclass of enzymes that aminoacylate AMINO ACID-SPECIFIC TRANSFER RNA with their corresponding AMINO ACIDS.
| Descriptor ID |
D000604
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| MeSH Number(s) |
D08.811.464.263.200
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| Concept/Terms |
Amino Acyl-tRNA Synthetases- Amino Acyl-tRNA Synthetases
- Acyl-tRNA Synthetases, Amino
- Amino Acyl tRNA Synthetases
- Synthetases, Amino Acyl-tRNA
- Amino Acyl-tRNA Ligases
- Acyl-tRNA Ligases, Amino
- Amino Acyl tRNA Ligases
- Ligases, Amino Acyl-tRNA
- tRNA Synthetase
- Synthetase, tRNA
- Aminoacyl-tRNA Synthetase
- Aminoacyl tRNA Synthetase
- Synthetase, Aminoacyl-tRNA
- Transfer RNA Synthetase
- RNA Synthetase, Transfer
- Synthetase, Transfer RNA
- Amino Acyl T RNA Synthetases
- Aminoacyl Transfer RNA Synthetase
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Below are MeSH descriptors whose meaning is more general than "Amino Acyl-tRNA Synthetases".
Below are MeSH descriptors whose meaning is more specific than "Amino Acyl-tRNA Synthetases".
This graph shows the total number of publications written about "Amino Acyl-tRNA Synthetases" by people in this website by year, and whether "Amino Acyl-tRNA Synthetases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Amino Acyl-tRNA Synthetases" by people in Profiles.
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Cross-editing by a tRNA synthetase allows vertebrates to abundantly express mischargeable tRNA without causing mistranslation. Nucleic Acids Res. 2020 07 09; 48(12):6445-6457.
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Mutations in ArgS Arginine-tRNA Synthetase Confer Additional Antibiotic Tolerance Protection to Extended-Spectrum-ß-Lactamase-Producing Burkholderia thailandensis. Antimicrob Agents Chemother. 2020 05 21; 64(6).
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CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells. Proc Natl Acad Sci U S A. 2019 09 24; 116(39):19440-19448.
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Clinical characteristics of dermatomyosits/polymyositis associated interstitial lung disease according to the autoantibody. J Med Invest. 2018; 65(3.4):251-257.
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Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair. J Am Chem Soc. 2016 10 05; 138(39):12948-12955.
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Determining the fidelity of tRNA aminoacylation via microarrays. Methods. 2017 01 15; 113:27-33.
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Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet. 2014 Apr 03; 94(4):547-58.
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A self-defeating anabolic program leads to ß-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux. J Biol Chem. 2013 Jun 14; 288(24):17202-13.
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Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis. Dev Biol. 2008 Feb 15; 314(2):376-92.
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Pre-transfer editing by class II prolyl-tRNA synthetase: role of aminoacylation active site in "selective release" of noncognate amino acids. J Biol Chem. 2006 Sep 22; 281(38):27862-72.