"Complement C1s" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
| Descriptor ID |
D003173
|
| MeSH Number(s) |
D08.811.277.300.290 D12.776.124.486.274.045.290 D12.776.124.486.274.050.290
|
| Concept/Terms |
Complement C1s- Complement C1s
- C1s, Complement
- Complement 1s
- C 1 Esterase
- Esterase, C 1
- C1s Complement
- Complement, C1s
- Complement Component 1s
- Component 1s, Complement
- Complement 1 Esterase
- Esterase, Complement 1
- C1 Esterase
- Esterase, C1
|
Below are MeSH descriptors whose meaning is more general than "Complement C1s".
Below are MeSH descriptors whose meaning is more specific than "Complement C1s".
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Below are the most recent publications written about "Complement C1s" by people in Profiles.