"Clozapine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
| Descriptor ID |
D003024
|
| MeSH Number(s) |
D03.633.300.240.220
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Clozapine".
Below are MeSH descriptors whose meaning is more specific than "Clozapine".
This graph shows the total number of publications written about "Clozapine" by people in this website by year, and whether "Clozapine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 0 | 2 |
| 1997 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Clozapine" by people in Profiles.
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Clozapine-Associated Aspiration During Electroconvulsive Therapy. J ECT. 2019 Jun; 35(2):133-134.
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REM obstructive sleep apnea: risk for adverse health outcomes and novel treatments. Sleep Breath. 2019 Jun; 23(2):413-423.
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Muscarinic receptor signaling contributes to atypical antipsychotic drug reversal of the phencyclidine-induced deficit in novel object recognition in rats. J Psychopharmacol. 2017 12; 31(12):1588-1604.
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Dopamine D4 receptor stimulation contributes to novel object recognition: Relevance to cognitive impairment in schizophrenia. J Psychopharmacol. 2017 04; 31(4):442-452.
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Endocannabinoid Modulation of Orbitostriatal Circuits Gates Habit Formation. Neuron. 2016 06 15; 90(6):1312-1324.
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Antipsychotic prescribing pathways, polypharmacy, and clozapine use in treatment of schizophrenia. Psychiatr Serv. 2013 Jun; 64(6):527-33.
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Antipsychotic exposure and type 2 diabetes among patients with schizophrenia: a matched case-control study of California Medicaid claims. Pharmacoepidemiol Drug Saf. 2005 Jun; 14(6):417-25.
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Pharmacology of antipsychotics in the elderly: a focus on atypicals. J Am Geriatr Soc. 2004 Dec; 52(12 Suppl):S258-65.
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Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats. Neurorehabil Neural Repair. 2002 Dec; 16(4):321-5.
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Managing the behavioral and psychological signs and symptoms of dementia. Int Clin Psychopharmacol. 1997 Sep; 12 Suppl 4:S25-8.