"Fumarate Hydratase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the reversible hydration of fumaric acid to yield L-malic acid. It is one of the citric acid cycle enzymes. EC 4.2.1.2.
| Descriptor ID |
D005649
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| MeSH Number(s) |
D08.811.520.241.300.300
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Fumarate Hydratase".
Below are MeSH descriptors whose meaning is more specific than "Fumarate Hydratase".
This graph shows the total number of publications written about "Fumarate Hydratase" by people in this website by year, and whether "Fumarate Hydratase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
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Below are the most recent publications written about "Fumarate Hydratase" by people in Profiles.
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Proteogenomic landscape of uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer patients. Sci Rep. 2021 04 30; 11(1):9371.
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Computational Saturation Screen Reveals the Landscape of Mutations in Human Fumarate Hydratase. J Chem Inf Model. 2021 04 26; 61(4):1970-1980.
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Reappraisal of Morphologic Differences Between Renal Medullary Carcinoma, Collecting Duct Carcinoma, and Fumarate Hydratase-deficient Renal Cell Carcinoma. Am J Surg Pathol. 2018 03; 42(3):279-292.
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Leiomyoma with bizarre nuclei: a morphological, immunohistochemical and molecular analysis of 31 cases. Mod Pathol. 2017 10; 30(10):1476-1488.
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Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. J Exp Med. 2017 03 06; 214(3):719-735.
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Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity. J Am Chem Soc. 2015 Jan 21; 137(2):564-7.
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Multiple cutaneous and uterine leiomyomatosis (Reed's syndrome). Dermatol Online J. 2005 Dec 30; 11(4):21.