"Mitotane" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.
| Descriptor ID |
D008939
|
| MeSH Number(s) |
D02.455.526.439.681
|
| Concept/Terms |
Mitotane- Mitotane
- o,p-DDD
- Mytotan
- ortho,para-DDD
- ortho,para DDD
|
Below are MeSH descriptors whose meaning is more general than "Mitotane".
Below are MeSH descriptors whose meaning is more specific than "Mitotane".
This graph shows the total number of publications written about "Mitotane" by people in this website by year, and whether "Mitotane" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mitotane" by people in Profiles.
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National Treatment Practice for Adrenocortical Carcinoma: Have They Changed and Have We Made Any Progress? J Clin Endocrinol Metab. 2019 12 01; 104(12):5948-5956.
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The combination of insulin-like growth factor receptor 1 (IGF1R) antibody cixutumumab and mitotane as a first-line therapy for patients with recurrent/metastatic adrenocortical carcinoma: a multi-institutional NCI-sponsored trial. Horm Cancer. 2014 Aug; 5(4):232-9.
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The continued importance of adrenalectomy in the treatment of Cushing's disease. Arch Surg. 1979 Apr; 114(4):481-4.
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Cushing's disease: the role of adrenalectomy and autotransplantation. Surg Clin North Am. 1979 Feb; 59(1):159-65.