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Nathan Schoettler

TitleAssistant Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary and Critical Care
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Nathan Schoettler specializes in the care of patients with acute and chronic respiratory diseases, including asthma, as well as critically ill patients. His clinical practice focuses on delivering comprehensive, evidence-based care.
    Dr. Schoettler’s research centers on the immunologic and genetic mechanisms that drive asthma and related respiratory diseases. His work integrates human cohort studies with mechanistic approaches to uncover how airway inflammation varies across disease phenotypes. He aims to identify molecular pathways that could inform precision medicine strategies and improve therapeutic responses. Ultimately, his research seeks to translate biological insights into targeted interventions for patients with difficult-to-treat asthma.

    Collapse Biography 
    Collapse education and training
    University of Chicago, Chicago, ILPostdoctoral research06/2019Human Genetics
    University of Chicago, Chicago, ILMD06/2012Medicine
    University of Chicago, Chicago, ILPhD12/2009Immunology
    University of California, Los Angeles, Los Angeles, CAMS06/2003Molecular, Cellular and Developmental Biology

    Collapse Research 
    Collapse research activities and funding
    K08HL153955     (SCHOETTLER, NATHAN R)Aug 15, 2020 - Jul 31, 2025
    NIH
    Genetics of Asthma Sub-Phenotypes Impact Gene Regulation in Cell-Specific Patterns
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gallagher EJ, Kazmierczak BI, Kisielewski M, Schoettler N, Steer CJ, Baiocchi RA, Vyas JM, Rhee KY, Hu PJ, Isales CM, Conlin PR, Kontos CD, Melfe M, McDonald FS, Rockey DC, Williams CS. Navigating physician-scientist careers: insights from American Board of Internal Medicine Research Pathway graduates. JCI Insight. 2026 08 24; 11(16). PMID: 42635045; PMCID: PMC13502166.
      Citations:    
    2. Prichina AY, Seroogy CM, Eapen AA, Singh S, Visness CM, Bacharier LB, Gold DR, Herbstman JB, Kattan M, Miller RL, O'Connor GT, Rivera-Spoljaric K, VanWormer JJ, Weiss ST, Wood RA, Oken E, Lasky-Su J, Schoettler N, Levin AM, Jackson DJ, Gern JE, DeMeo DL, McKennan CG, Ober C, Thompson EE, CADRE Investigators. Epigenetic gestational age acceleration in cord blood is associated with activated inflammatory gene pathways and childhood asthma. J Allergy Clin Immunol. 2026 Jun 16. PMID: 42302975.
      Citations:    Fields:    
    3. Jasper EA, McKennan CG, Thompson EE, Schoettler N, Gebretsadik T, Hellwege JN, Edwards TL, Ober C, Velez Edwards DR, Hartert TV, Snyder BM. S-PrediXcan predicted gene expression in human placenta is associated with childhood-onset asthma risk. Sci Rep. 2026 May 13; 16(1). PMID: 42129325; PMCID: PMC13365522.
      Citations:    Fields:    Translation:Humans
    4. Hollinger MK, Howard CL, Decker DC, Blaine KM, Aneas I, Grayson EM, Velez TE, Oliveira FA, Hannan RT, Camacho DF, Verhoef PA, Hrusch CL, Griffes RS, Sturek JM, Nobrega MA, Schoettler N, Sperling AI. Negative regulation of human IL-33 in endothelium during allergic airway inflammation. JCI Insight. 2026 05 08; 11(9). PMID: 42100869; PMCID: PMC13232004.
      Citations:    Fields:    Translation:HumansAnimals
    5. Viswanathan M, Castro CD, Broughton AE, Ramesh A, Asby N, Bergquist A, Kaiser C, Luna A, Huang J, Bissonnette M, Koh A, Hibino N, Schoettler N, Sperling A, Adams EJ. TCR? constant usage tunes human ?d T cell antigen sensitivity, thymic programming, and peripheral function. Sci Immunol. 2026 Feb 13; 11(116):eadr7167. PMID: 41686911; PMCID: PMC13065098.
      Citations:    Fields:    Translation:Humans
    6. Velez TE, Yoon YM, Upadhyay V, Vazquez SE, Lee CT, Selvan KC, Law CS, Blaine KM, Hollinger MK, Decker DM, Bingham GC, Pastore CF, Bonham CA, Clark MR, Schoettler NR, Strek ME, Guzy RD, Adegunsoye A, Noth I, Wolters PJ, Barker TH, Anderson MS, DeRisi JL, Shum AK, Sperling AI. Active Antigen-Specific Adaptive Immune Responses Are Shared among Patients with Progressive Fibrotic Interstitial Lung Disease. Am J Respir Crit Care Med. 2025 10; 211(10):1823-1834. PMID: 40815686; PMCID: PMC12555057.
      Citations: 1     Fields:    Translation:Humans
    7. Schoettler N, Gebretsadik T, Singh S, Gress L, Mendonça EA, Snyder BM, Eapen AA, LeBeau P, Gangnon R, Seroogy CM, Bacharier LB, Lemanske RF, Lynch SV, Gold DR, Miller RL, Jackson DJ, Hershey GKK, Johnson CC, Martinez FD, Ober C, Hartert TV, Gern JE, ECHO Children's Respiratory and Environmental Workgroup. Genotypes in the 17q12-q21 asthma risk locus and early-life viral wheezing illnesses. Pediatr Allergy Immunol. 2025 Aug; 36(8):e70165. PMID: 40755347; PMCID: PMC12319653.
      Citations:    Fields:    
    8. Salamone IM, Zhong X, Sakabe NJ, Mitchell R, Wentworth-Sheilds W, Zhang L, Thompson EE, Decker DC, Rische CH, Liu X, Schoettler N, Ober C, He X, Nóbrega MA. Shared loci but distinct variants underlie genetic architecture of allergic diseases. medRxiv. 2025 Jun 07. PMID: 40502601; PMCID: PMC12155002.
      Citations:    
    9. Zhong X, Mitchell R, Billstrand C, Thompson EE, Sakabe NJ, Aneas I, Salamone IM, Gu J, Sperling AI, Schoettler N, Nóbrega MA, He X, Ober C. Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations. Genome Med. 2025 04 10; 17(1):35. PMID: 40205616; PMCID: PMC11983851.
      Citations: 5     Fields:    Translation:HumansCells
    10. Phelan KJ, Roskin KM, Burkle JW, Chang WC, Martin LJ, Biagini JM, Satish L, Haslam DB, Spagna D, Jenkins S, Parmar E, Bacharier LB, Gebretsadik T, Gill M, Gold DR, Jackson DJ, Johnson CC, Lynch SV, McCauley KE, McKennan CG, Miller R, Ober C, Ownby DR, Ryan PH, Schoettler N, Singh S, Visness CM, Altman MC, Gern JE, Khurana Hershey GK, Environmental Influences on Child Health Outcomes–Children’s Respiratory and Environmental Workgroup. Early-life wheeze trajectories are associated with distinct asthma transcriptomes later in life. J Allergy Clin Immunol. 2025 Sep; 156(3):640-650. PMID: 40189159; PMCID: PMC12354082.
      Citations: 1     Fields:    Translation:HumansCells
    11. Non AL, Li X, Jones MR, Oken E, Hartert T, Schoettler N, Gold DR, Ramratnam S, Schauberger EM, Tantisira K, Bacharier LB, Conrad DJ, Carroll KN, Nkoy FL, Luttmann-Gibson H, Gilliland FD, Breton CV, Kattan M, Lemanske RF, Litonjua AA, McEvoy CT, Rivera-Spoljaric K, Rosas-Salazar C, Joseph CLM, Palmore M, Ryan PH, Sitarik AR, Singh AM, Miller RL, Zoratti EM, Ownby D, Camargo CA, Aschner JL, Stroustrup A, Farzan SF, Karagas MR, Jackson DJ, Gern JE. Comparison of Race-Neutral versus Race-Specific Spirometry Equations for Evaluation of Child Asthma. Am J Respir Crit Care Med. 2025 03; 211(3):464-476. PMID: 39642347; PMCID: PMC11936140.
      Citations: 1     Fields:    Translation:Humans
    12. Zhong X, Mitchell R, Billstrand C, Thompson E, Sakabe NJ, Aneas I, Salamone IM, Gu J, Sperling AI, Schoettler N, Nóbrega MA, He X, Ober C. Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations. medRxiv. 2025 Feb 17. PMID: 40034789; PMCID: PMC11875274.
      Citations:    
    13. Schoettler N. Advances in asthma and allergic disease genetics. Curr Opin Allergy Clin Immunol. 2025 02 01; 25(1):58-65. PMID: 39641751.
      Citations: 2     Fields:    Translation:Humans
    14. Tian F, Decker DC, Sperling AI, Schoettler N. Dynamic responses of human lung innate and adaptive immune cells highlight the roles of genes at asthma risk loci. bioRxiv. 2024 Sep 24. PMID: 39386483; PMCID: PMC11463610.
      Citations:    
    15. Hamilton RG, Holbreich M, Bronzert C, Anderson RL, Schoettler N, Ober C. Screening asthmatics for atopic status using the ALergy EXplorer (ALEX2) macroarray. J Asthma. 2024 09; 61(9):1050-1057. PMID: 38415683.
      Citations: 3     Fields:    Translation:HumansAnimalsPHPublic Health
    16. Dapas M, Lee YL, Wentworth-Sheilds W, Im HK, Ober C, Schoettler N. Revealing polygenic pleiotropy using genetic risk scores for asthma. HGG Adv. 2023 10 12; 4(4):100233. PMID: 37663543; PMCID: PMC10474095.
      Citations: 9     Fields:    Translation:Humans
    17. Jia G, Zhong X, Im HK, Schoettler N, Pividori M, Hogarth DK, Sperling AI, White SR, Naureckas ET, Lyttle CS, Terao C, Kamatani Y, Akiyama M, Matsuda K, Kubo M, Cox NJ, Ober C, Rzhetsky A, Solway J. Discerning asthma endotypes through comorbidity mapping. Nat Commun. 2022 11 07; 13(1):6712. PMID: 36344522; PMCID: PMC9640644.
      Citations: 14     Fields:    Translation:Humans
    18. Schoettler N, Dissanayake E, Craven MW, Yee JS, Eliason J, Schauberger EM, Lemanske RF, Ober C, Gern JE. New Insights Relating Gasdermin B to the Onset of Childhood Asthma. Am J Respir Cell Mol Biol. 2022 Oct; 67(4):430-437. PMID: 35580164; PMCID: PMC9564923.
      Citations: 15     Fields:    Translation:Humans
    19. Clay SM, Schoettler N, Goldstein AM, Carbonetto P, Dapas M, Altman MC, Rosasco MG, Gern JE, Jackson DJ, Im HK, Stephens M, Nicolae DL, Ober C. Fine-mapping studies distinguish genetic risks for childhood- and adult-onset asthma in the HLA region. Genome Med. 2022 05 24; 14(1):55. PMID: 35606880; PMCID: PMC9128203.
      Citations: 10     Fields:    Translation:HumansCells
    20. Aneas I, Decker DC, Howard CL, Sakabe NJ, Blaine KM, Stein MM, Hrusch CL, Montefiori LE, Magnaye KM, Clay SM, Gern JE, Jackson DJ, Altman MC, Naureckas ET, Hogarth DK, White SR, Schoetler N, Ober C, Sperling AI, Sobreira DR, Tena J, Gomez-Skarmeta JL, Nóbrega MA. Asthma-associated genetic variants induce IL33 differential expression through an enhancer-blocking regulatory region. Nat Commun. 2021 10 21; 12(1):6115. PMID: 34675193; PMCID: PMC8531453.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    21. Wu D, Lee TH, Huang RT, D Guzy R, Schoettler N, Adegunsoye A, Mueller J, Husain A, I Sperling A, Fang Y, Mutlu GM. SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy. Am J Respir Cell Mol Biol. 2021 08; 65(2):222-226. PMID: 33971111; PMCID: PMC8399572.
      Citations: 8     Fields:    Translation:HumansCells
    22. Kim KW, Kim DY, Yoon D, Kim KK, Jang H, Schoettler N, Kim EG, Kim MN, Hong JY, Lee JK, Kim S, Ober C, Gee HY, Sohn MH. Genome-wide association study identifies TNFSF15 associated with childhood asthma. Allergy. 2022 01; 77(1):218-229. PMID: 34022066; PMCID: PMC8606614.
      Citations: 9     Fields:    Translation:Humans
    23. McMullen P, Pytel P, Snyder A, Smith H, Vickery J, Brainer J, Guzy R, Wu D, Schoettler N, Adegunsoye A, Sperling A, Hart J, Alpert L, Chang A, Gurbuxani S, Krausz T, Husain AN, Mueller J. A series of COVID-19 autopsies with clinical and pathologic comparisons to both seasonal and pandemic influenza. J Pathol Clin Res. 2021 09; 7(5):459-470. PMID: 33960723; PMCID: PMC8239851.
      Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
    24. Lee TH, Wu D, Guzy R, Schoettler N, Adegunsoye A, Mueller J, Hussein A, Sperling A, Mutlu GM, Fang Y. SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy. bioRxiv. 2021 Jan 18. PMID: 33469586; PMCID: PMC7814823.
      Citations:    
    25. Schoettler N, Hrusch CL, Blaine KM, Sperling AI, Ober C. Transcriptional programming and T cell receptor repertoires distinguish human lung and lymph node memory T cells. Commun Biol. 2019; 2:411. PMID: 31754641; PMCID: PMC6853923.
      Citations: 14     Translation:HumansCells
    26. Schoettler N, Weidinger S, Ober C, Rodríguez E. Advances in asthma and allergic disease genetics: Is bigger always better? J Allergy Clin Immunol. 2019 12; 144(6):1495-1506. PMID: 31677964; PMCID: PMC6900451.
      Citations: 45     Fields:    Translation:Humans
    27. Schoettler N, Strek ME. Recent Advances in Severe Asthma: From Phenotypes to Personalized Medicine. Chest. 2020 03; 157(3):516-528. PMID: 31678077; PMCID: PMC7609962.
      Citations: 92     Fields:    Translation:HumansPHPublic Health
    28. Schoettler N, Ober C. Genetic architecture of moderate-to-severe asthma mirrors that of mild asthma. J Allergy Clin Immunol. 2019 12; 144(6):1521-1523. PMID: 31541629.
      Citations: 3     Fields:    Translation:Humans
    29. Pividori M, Schoettler N, Nicolae DL, Ober C, Im HK. Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. Lancet Respir Med. 2019 06; 7(6):509-522. PMID: 31036433; PMCID: PMC6534440.
      Citations: 173     Fields:    Translation:HumansCells
    30. Waage J, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N, 23andMe Research Team, AAGC collaborators, Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS, Arnold A, Barreto-Luis A, van Beijsterveldt CEM, Bleecker ER, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Duijts L, Ege MJ, Gauderman WJ, Gilliland F, Granell R, Gui H, Hansen T, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Kabesch M, Kaprio J, Kumar A, Levin AM, Li X, Lorenzo-Diaz F, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pino-Yanes M, Probst-Hensch NM, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Standl M, Antó JM, Baurecht H, Bonàs-Guarch S, Dmitrieva J, Georges M, Gieger C, Heinrich J, Jónsdóttir I, Lee YA, Melén E, Pershagen G, Rüschendorf F, Thiering E, Bønnelykke K. Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018 09; 50(9):1343. PMID: 30116036.
      Citations:    Fields:    
    31. Waage J, Curtin JA, Jessen LE, Thorsen J, Tian C, Schoettler N, 23andMe Research Team, AAGC collaborators, Flores C, Abdellaoui A, Ahluwalia TS, Alves AC, Amaral AFS, Arnold A, Barreto-Luis A, van Beijsterveldt CEM, Bleecker ER, Boomsma DI, Brix S, Bunyavanich S, Burchard EG, Chen Z, Curjuric I, Custovic A, den Dekker HT, Dharmage SC, Duijts L, Ege MJ, Gauderman WJ, Gilliland F, Granell R, Gui H, Hansen T, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe VWV, Jarvelin MR, Jarvis DL, Jensen KK, Kabesch M, Kaprio J, Kumar A, Levin AM, Li X, Lorenzo-Diaz F, Mercader JM, Meyers DA, Myers R, Nicolae DL, Nohr EA, Palviainen T, Paternoster L, Pennell CE, Pino-Yanes M, Probst-Hensch NM, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thompson PJ, Torrent M, Torrents D, Tung JY, Wang CA, Weidinger S, Weiss S, Willemsen G, Williams LK, Ober C, Hinds DA, Ferreira MA, Bisgaard H, Strachan DP, Standl M, Antó JM, Baurecht H, Bonàs-Guarch S, Dmitrieva J, Georges M, Gieger C, Heinrich J, Jónsdóttir I, Lee YA, Melén E, Pershagen G, Rüschendorf F, Thiering E, Bønnelykke K. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. Nat Genet. 2018 08; 50(8):1072-1080. PMID: 30013184; PMCID: PMC7068780.
      Citations: 73     Fields:    Translation:Humans
    32. Stein MM, Thompson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, Igartua C, Washington C, Nicolae D, Ober C, Morin A, Bønnelykke K. A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol. 2018 09; 142(3):749-764.e3. PMID: 29307657; PMCID: PMC6172038.
      Citations: 99     Fields:    Translation:HumansCells
    33. Schoettler N, Ni D, Weigert M. B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients. Mol Immunol. 2012 Jul; 51(3-4):273-82. PMID: 22516082; PMCID: PMC4264353.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    34. Schoettler N, Brahn E. Angiogenesis inhibitors for the treatment of chronic autoimmune inflammatory arthritis. Curr Opin Investig Drugs. 2009 May; 10(5):425-33. PMID: 19431075.
      Citations: 4     Fields:    Translation:HumansAnimals
    35. Brahn E, Schoettler N, Lee S, Banquerigo ML. Involution of collagen-induced arthritis with an angiogenesis inhibitor, PPI-2458. J Pharmacol Exp Ther. 2009 May; 329(2):615-24. PMID: 19218530; PMCID: PMC2672877.
      Citations: 6     Fields:    Translation:AnimalsCells
    36. Pine PR, Chang B, Schoettler N, Banquerigo ML, Wang S, Lau A, Zhao F, Grossbard EB, Payan DG, Brahn E. Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clin Immunol. 2007 Sep; 124(3):244-57. PMID: 17537677.
      Citations: 85     Fields:    Translation:AnimalsCells
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