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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism.
PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism. Nature. 2021 06; 594(7862):271-276.
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PubMed
subject areas
Animals
Animals, Newborn
Class I Phosphatidylinositol 3-Kinases
Disease Models, Animal
Endothelial Cells
Gain of Function Mutation
Hemangioma, Cavernous, Central Nervous System
Humans
Kruppel-Like Transcription Factors
Loss of Function Mutation
Male
MAP Kinase Kinase Kinase 3
Mechanistic Target of Rapamycin Complex 1
Mice
Mutation
Neoplasms
Sirolimus
TOR Serine-Threonine Kinases
authors with profiles
Issam Awad
Robert Shenkar
Romuald Girard