"4-Quinolones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
QUINOLONES containing a 4-oxo (a carbonyl in the para position to the nitrogen). They inhibit the A subunit of DNA GYRASE and are used as antimicrobials. Second generation 4-quinolones are also substituted with a 1-piperazinyl group at the 7-position and a fluorine at the 6-position.
| Descriptor ID |
D042462
|
| MeSH Number(s) |
D03.633.100.810.835.055
|
| Concept/Terms |
4-Quinolones- 4-Quinolones
- 4 Quinolones
- 4-Quinolinones
- 4 Quinolinones
- 4-Oxoquinolines
- 4 Oxoquinolines
|
Below are MeSH descriptors whose meaning is more general than "4-Quinolones".
Below are MeSH descriptors whose meaning is more specific than "4-Quinolones".
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Below are the most recent publications written about "4-Quinolones" by people in Profiles.
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Quinolone molecular structure-activity relationships: what we have learned about improving antimicrobial activity. Clin Infect Dis. 2001 Sep 15; 33 Suppl 3:S180-6.