"Pyrococcus horikoshii" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Anaerobic hyperthermophilic species of ARCHAEA, isolated from hydrothermal fluid samples. It is obligately heterotrophic with coccoid cells that require TRYPTOPHAN for growth.
| Descriptor ID |
D043902
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| MeSH Number(s) |
B02.200.825.800.650.400
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Pyrococcus horikoshii".
Below are MeSH descriptors whose meaning is more specific than "Pyrococcus horikoshii".
This graph shows the total number of publications written about "Pyrococcus horikoshii" by people in this website by year, and whether "Pyrococcus horikoshii" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 3 | 0 | 3 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 1 | 3 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pyrococcus horikoshii" by people in Profiles.
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The asymmetric function of Dph1-Dph2 heterodimer in diphthamide biosynthesis. J Biol Inorg Chem. 2019 09; 24(6):777-782.
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Noncanonical Radical SAM Enzyme Chemistry Learned from Diphthamide Biosynthesis. Biochemistry. 2018 06 26; 57(25):3454-3459.
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Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis. Science. 2018 03 16; 359(6381):1247-1250.
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Methods for Studying the Radical SAM Enzymes in Diphthamide Biosynthesis. Methods Enzymol. 2018; 606:421-438.
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Substrate-Dependent Cleavage Site Selection by Unconventional Radical S-Adenosylmethionine Enzymes in Diphthamide Biosynthesis. J Am Chem Soc. 2017 04 26; 139(16):5680-5683.
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Organometallic Complex Formed by an Unconventional Radical S-Adenosylmethionine Enzyme. J Am Chem Soc. 2016 08 10; 138(31):9755-8.
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Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis. J Am Chem Soc. 2014 Feb 05; 136(5):1754-7.
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Reconstitution of diphthine synthase activity in vitro. Biochemistry. 2010 Nov 09; 49(44):9649-57.
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Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis. Mol Biosyst. 2011 Jan; 7(1):74-81.
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Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature. 2010 Jun 17; 465(7300):891-6.