Severe Combined Immunodeficiency
"Severe Combined Immunodeficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. It is inherited as an X-linked or autosomal recessive defect. Mutations occurring in many different genes cause human Severe Combined Immunodeficiency (SCID).
| Descriptor ID |
D016511
|
| MeSH Number(s) |
C16.614.815 C18.452.284.800 C20.673.815
|
| Concept/Terms |
Severe Combined Immunodeficiency- Severe Combined Immunodeficiency
- Combined Immunodeficiencies, Severe
- Combined Immunodeficiency, Severe
- Immunodeficiencies, Severe Combined
- Severe Combined Immunodeficiencies
- Immunodeficiency, Severe Combined
- Severe Combined Immune Deficiency
- Severe Combined Immunodeficiency Syndrome
- Severe Combined Immunologic Deficiency
- Immunodeficiency Syndrome, Severe Combined
- Immunologic Deficiency, Severe Combined
Bare Lymphocyte Syndrome- Bare Lymphocyte Syndrome
- Bare Lymphocyte Syndromes
- Lymphocyte Syndrome, Bare
- Lymphocyte Syndromes, Bare
- Syndrome, Bare Lymphocyte
- Syndromes, Bare Lymphocyte
Omenn Syndrome- Omenn Syndrome
- Syndrome, Omenn
- Reticuloendotheliosis, Familial
- Familial Reticuloendothelioses
- Familial Reticuloendotheliosis
- Reticuloendothelioses, Familial
- Omenn's Syndrome
- Omenns Syndrome
- Syndrome, Omenn's
|
Below are MeSH descriptors whose meaning is more general than "Severe Combined Immunodeficiency".
Below are MeSH descriptors whose meaning is more specific than "Severe Combined Immunodeficiency".
This graph shows the total number of publications written about "Severe Combined Immunodeficiency" by people in this website by year, and whether "Severe Combined Immunodeficiency" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 2 | 0 | 2 |
| 1997 | 2 | 0 | 2 |
| 1999 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 2 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 2 | 0 | 2 |
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Below are the most recent publications written about "Severe Combined Immunodeficiency" by people in Profiles.
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Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation. J Allergy Clin Immunol. 2023 01; 151(1):260-271.
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Positive and negative selection shape the human naive B cell repertoire. J Clin Invest. 2022 01 18; 132(2).
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Expanding the Nude SCID/CID Phenotype Associated with FOXN1 Homozygous, Compound Heterozygous, or Heterozygous Mutations. J Clin Immunol. 2021 05; 41(4):756-768.
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Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells. J Immunol. 2015 Aug 01; 195(3):1202-17.
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Role for Artemis nuclease in the repair of radiation-induced DNA double strand breaks by alternative end joining. DNA Repair (Amst). 2015 Jul; 31:29-40.
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Universal state newborn screening programs can reduce health disparities. JAMA Pediatr. 2015 Jan; 169(1):7-8.
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Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency. Proc Natl Acad Sci U S A. 2014 May 20; 111(20):7260-5.
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Index of suspicion. Pediatr Rev. 2014 Feb; 35(2):88-93.
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PRKDC mutations in a SCID patient with profound neurological abnormalities. J Clin Invest. 2013 Jul; 123(7):2969-80.
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Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents. Exp Hematol. 2006 Feb; 34(2):140-9.