"E-Box Elements" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
DNA locations with the consensus sequence CANNTG. ENHANCER ELEMENTS may contain multiple copies of this element. E-boxes play a regulatory role in the control of transcription. They bind with basic helix-loop-helix (bHLH) type TRANSCRIPTION FACTORS. Binding specificity is determined by the specific bHLH heterodimer or homodimer combination and by the specific nucleotides at the 3rd and 4th position of the E-box sequence.
| Descriptor ID |
D024721
|
| MeSH Number(s) |
G02.111.570.080.689.330.240 G05.360.080.689.330.240 G05.360.340.024.340.137.750.249.240
|
| Concept/Terms |
E-Box Elements- E-Box Elements
- E Box Elements
- E-Box Element
- Element, E-Box
- Elements, E-Box
- E-Box Sequences
- E Box Sequences
- E-Box Sequence
- Sequence, E-Box
- Sequences, E-Box
- E-Box Sites
- E Box Sites
- E-Box Site
- Site, E-Box
- Sites, E-Box
- E-Box Motifs
- E Box Motifs
- E-Box Motif
- Motif, E-Box
- Motifs, E-Box
|
Below are MeSH descriptors whose meaning is more general than "E-Box Elements".
Below are MeSH descriptors whose meaning is more specific than "E-Box Elements".
This graph shows the total number of publications written about "E-Box Elements" by people in this website by year, and whether "E-Box Elements" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
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Below are the most recent publications written about "E-Box Elements" by people in Profiles.
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Upstream stimulatory factor 1 activates GATA5 expression through an E-box motif. Biochem J. 2012 Aug 15; 446(1):89-98.
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c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells. BMC Cancer. 2011 Jun 13; 11:246.
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Elevated vitamin D receptor levels in genetic hypercalciuric stone-forming rats are associated with downregulation of Snail. J Bone Miner Res. 2010 Apr; 25(4):830-40.