An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)

Descriptor ID	D020513
MeSH Number(s)	C05.651.701.600 C10.668.491.650.600 C16.320.565.618.711.600 C18.452.648.618.711.600
Concept/Terms	Paralysis, Hyperkalemic Periodic Paralysis, Hyperkalemic Periodic Adynamia Episodica Hereditaria with or without Myotonia Familial Hyperkalemic Periodic Paralysis Gamstorp Disease Disease, Gamstorp Gamstorp Episodic Adynamy Sodium Channel Muscle Disease Hyperkalemic Periodic Paralysis, Familial HyperKPP HyperPP Myotonic Periodic Paralysis Paralysis, Periodic, Hyperkalemic, Familial Primary Hyperkalemic Periodic Paralysis Adynamia Episodica Hereditaria Hyperkalemic Periodic Paralysis Hyperkalemic Periodic Paralysis Type 2 Hyperkalemic Periodic Paralysis Type 2 Hyperkaliemic Periodic Paralysis Type 2

Below are MeSH descriptors whose meaning is more general than "Paralysis, Hyperkalemic Periodic".

Below are MeSH descriptors whose meaning is related to "Paralysis, Hyperkalemic Periodic".

Below are MeSH descriptors whose meaning is more specific than "Paralysis, Hyperkalemic Periodic".