"Chromosome Fragile Sites" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
| Descriptor ID |
D043283
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| MeSH Number(s) |
G05.360.340.024.189.610
|
| Concept/Terms |
Chromosome Fragile Sites- Chromosome Fragile Sites
- Chromosome Fragile Site
- Fragile Site, Chromosome
- Site, Chromosome Fragile
- Sites, Chromosome Fragile
- Fragile Sites, Chromosome
|
Below are MeSH descriptors whose meaning is more general than "Chromosome Fragile Sites".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Fragile Sites".
This graph shows the total number of publications written about "Chromosome Fragile Sites" by people in this website by year, and whether "Chromosome Fragile Sites" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Chromosome Fragile Sites" by people in Profiles.
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Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors. Nat Commun. 2017 10 31; 8(1):1221.
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Impaired replication dynamics at the FRA3B common fragile site. Hum Mol Genet. 2010 Jan 01; 19(1):99-110.
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Common fragile sites are characterized by histone hypoacetylation. Hum Mol Genet. 2009 Dec 01; 18(23):4501-12.
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The role of late/slow replication of the FRA16D in common fragile site induction. Genes Chromosomes Cancer. 2004 Jan; 39(1):71-6.
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Cytogenetic studies of males with schizophrenia. Screening for the fragile X chromosome and other chromosomal abnormalities. Schizophr Res. 1988 Jul-Aug; 1(4):277-81.
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A heritable fragile 12q24.13 segregating in a family with the fragile X chromosome. Hum Genet. 1987 Jan; 75(1):4-6.